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Abstracts tagged "rheumatologic disease"

  • Abstract Number: 009 • 2020 Pediatric Rheumatology Symposium

    Emapalumab (Anti-Interferon-Gamma Monoclonal Antibody) in Patients with Macrophage Activation Syndrome (MAS) Complicating Systemic Juvenile Idiopathic Arthritis (sJIA)

    Fabrizio De Benedetti1, Paul Brogan 2, Claudia Bracaglia 1, Manuela Pardeo 1, Giulia Marucci 1, Emanuela Sacco 1, Despina Eleftheriou 3, Charalampia Papadopoulou 3, Alexei Grom 4, Pierre Quartier 5, Rayfel Schneider 6, Philippe Jacqmin 7, Rikke Frederiksen 8, Maria Ballabio 9 and Cristina de Min 8, 1Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesu', Rome, Italy, 2UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, 3UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, Section Head Infection, Immunology, and Rheumatology, London, United Kingdom, 4Cincinnati Children's Hospital Medical Center, Cincinnati, 5Paris-Descartes University, IMAGINE Institute, RAISE reference centre, Pediatric Immuno-Hematology and Rheumatology Unit, Necker hospital, Assistance Publique-Hôpitaux de Paris, Paris, France, 6The Hospital for Sick Children, Toronto, Canada, 7MnS Modelling and Simulation, Dinant, Belgium, 8Swedish Orphan Biovitrum AG (Sobi), Basel, Basel-Stadt, Switzerland, 9Swedish Orphan Biovitrum AG (Sobi), Basel, Switzerland

    Background/Purpose: MAS is a severe complication of rheumatic diseases and occurs most frequently in patients with sJIA. Data from animal models and from observational studies…
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