ACR Meeting Abstracts

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Abstracts tagged "Rheumatoid Factor"

  • Abstract Number: 0511 • ACR Convergence 2024

    Do High Rheumatoid Factor Levels Impact Response to Certolizumab Pegol in Patients with Inadequately Controlled Rheumatoid Arthritis? A Post Hoc Analysis of a Phase 3b Trial

    Josef Smolen1, Ted Mikuls2, James Galloway3, Ulf Müller-Ladner4, Jeffrey Curtis5, Motomu Hashimoto6, Tsutomu Takeuchi7, Ernest Choy8, Yoshiya Tanaka9, Carlos Cara10, Bernard Lauwerys11, Nicola Tilt12, Baran Ufuktepe13 and Peter C. Taylor14, 1Medical University of Vienna, Vienna, Austria, 2University of Nebraska Medical Center, Omaha, NE, 3Centre for Rheumatic Diseases, King's College London, London, United Kingdom, 4Justus-Liebig University Giessen, Bad Nauheim, Germany, 5University of Alabama at Birmingham, Hoover, AL, 6Osaka Metropolitan University, Osaka, Japan, 7Department of Internal Medicine, Keio University, Tokyo, Tokyo, Japan, 8Cardiff University School of Medicine, Cardiff, United Kingdom, 9Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 10UCB Pharma, Madrid, Spain, 11UCB Pharma, Brussels, Belgium, 12UCB Pharma, Slough, United Kingdom, 13UCB Pharma, Istanbul, Turkey, 14University of Oxford, Oxford, United Kingdom

    Background/Purpose: In pts with RA, high RF levels are associated with poor prognosis, higher disease activity, and decreased response to monoclonal antibodies targeting tumor necrosis…
  • Abstract Number: 0777 • ACR Convergence 2024

    Rheumatoid Factor B Cell Clones Proliferate Predominantly as Atypical Memory B Cells in Reactive Cervical Lymph Node Follicles Compared to Extrafollicular Sites in Affected Salivary Glands of SjS Patients

    Theodoros Ioannis Papadimitriou1, Jing Jing Wang2, Xuehui He3, Sidney van der Zade4, Massis Krekorian5, Prashant Singh6, Erik Dik5, Ger Pruijn5, Tom Gordon2, Hans Koenen7, Martijn Huijnen8 and Rogier Thurlings1, 1Radboudumc, Department of Rheumatology, Nijmegen, Gelderland, Netherlands, 2Flinders University, Adeleide, Australia, 3Radboudumc, Nijmegen, Netherlands, 4Radboudumc, Amsterdam, Netherlands, 5Radboudumc, Nijmegen, Gelderland, Netherlands, 6Radboudumc, Department of Medical BioSciences, Nijmegen, Netherlands, 7Radboudumc, Department of Medical Immunology, Nijmegen, Gelderland, Netherlands, 8Radboudumc, Department of Medical BioSciences, Nijmegen, Gelderland, Netherlands

    Background/Purpose: Sjögren’s syndrome (SjS) is a chronic inflammatory disorder, characterized by formation of autoantibodies. Over time rheumatoid factor (RF) clones can give rise to cryoglobulinemic…
  • Abstract Number: 1009 • ACR Convergence 2024

    Immunogenicity of the Recombinant Zoster Vaccine in People with Rheumatoid Arthritis Using Abatacept

    Kevin Winthrop1, Jeremy Hawkins2, Adriana Weinberg3, Sarah Siegel2, Jessica Baxter3, Krystle Garth3, Joseph Huffstutter4, James Loveless5, Suzanne gharib6, Shanmugapriya (Priya) Reddy7, Jayashree Sinha8, Elvia Moreta9, David Ridley10, Ilhem Messaoudi11 and Jeffrey Curtis12, 1School of Medicine, Oregon Health and Science University, Portland, OR, 2Oregon Health & Science University, Portland, OR, 3University of Colorado, Aurora, CO, 4Arthritis Associates PLLC, Signal Mountain, TN, 5St Luke's Health System, Boise, ID, 6Charleston Area Medical Center, Charleston, MD, 7Southwest Florida Rheumatology, Riverview, FL, 8self employed, Clovis, NM, 9St. Paul Rheumatology, Eagan, 10St. Paul Rheumatology, Eagan, MN, 11University of Kentucky, Lexington, 12University of Alabama at Birmingham, Hoover, AL

    Background/Purpose: The adjuvanted recombinant glycoprotein E (gE) herpes zoster vaccine (RZV) received expanded approval for use in 2021 for adults receiving immunosuppression. Despite approval, little…
  • Abstract Number: 1388 • ACR Convergence 2024

    CXC Chemokine Ligand 13 and Rheumatoid Factor as Pharmacodynamic Biomarkers for Abatacept Treatment in Patients with Rheumatoid Arthritis

    Ting Wang1, Ryan Stultz1, Natalia Giltiay2, Christian Lood1 and Bobby Kwanghoon Han1, 1University of Washington, Seattle, WA, 2Division of Rheumatology, University of Washington, Seattle, USA, Seattle, WA

    Background/Purpose: Abatacept, a CTLA-4-Ig fusion protein, is widely used as a treatment for rheumatoid arthritis (RA). We conducted this study to identify novel predictive and…
  • Abstract Number: 1427 • ACR Convergence 2024

    Observed and Simulated Pharmacokinetics and Pharmacodynamics of Nipocalimab, a Fully Human FcRn Blocking Monoclonal Antibody, in Adults with Sjögren’s Disease: Results from a Phase 2, Multicenter, Randomized, Placebo-controlled, Double-blind Study

    Sophia G. Liva1, fudan Zheng1, Jocelyn H. Leu2, Kathy Sivils3, Keying Ma1, He Li4, Steven Leonardo5, Kim Lo1, Jada Idokogi1, Kim Campbell1 and Jonathan J. Hubbard1, 1Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, PA, 2Janssen Research & Development, LLC, a Johnson & Johnson company, Spring House, PA, PA, 3Johnson & Johnson Innovative Medicine, Edmond, OK, 4Janssen Research & Development, LLC, Therapeutics Discovery, Spring House, PA, 5Janssen Research & Development, LLC, a Johnson & Johnson Company, Cambridge, MA

    Background/Purpose: Sjögren’s disease (SjD) is a chronic, progressive autoimmune disease characterized by aberrant B lymphocyte activity, elevated IgG production, and the presence of IgG autoantibodies…
  • Abstract Number: 2210 • ACR Convergence 2024

    Comparison of Dual RF and Anti-CCP Seropositive, Single Seropositive, and Seronegative RA on Radiographic Changes, Flares, and Mortality

    Rebecca Brooks1, Sara Achenbach2, Vanessa Kronzer1, Elena Myasoedova1, Cynthia Crowson1 and John Davis1, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic, Rochester, Rochester, MN

    Background/Purpose: Both RF and anti-CCP are associated with erosive disease, increased disease activity, and adverse outcomes in RA. However, there have been limited studies investigating how…
  • Abstract Number: 2212 • ACR Convergence 2024

    Seropositive Arthralgias: A Comprehensive Analysis of the Reuma-Check Cohort

    Rodrigo Garcia Salinas1, Felicia Almada2, Gisel Reyes-Jara2, Ronald Perez-Andocillas2 and Sebastian Magri3, 1Hospital Italiano La Plata, La Plata, Argentina, 2Hospital Italiano de La Plata, La Plata, Argentina, 3Hospital Italiano La Plata, Melchor Romero, Argentina

    Background/Purpose: To estimate the frequency of seropositive arthralgia (SA) in a large cohort of patients evaluated for arthralgia in Reuma-check program. To compare the features…
  • Abstract Number: 2213 • ACR Convergence 2024

    Microvascular and Macrovascular Endothelial Dysfunction in Rheumatoid Arthritis

    Vanshika Sabharwal, and Dr Ashit syngle and Dr Inderjeet Verma, MMDU, Mullana, Ambala India and Healing Touch city clinic, Chandigarh, India, Chandigarh, Chandigarh, India

    Background/Purpose: RA is a chronic inflammatory disease associated with an excessive premature cardiovascular morbidity and mortality. Endothelial dysfunction is a significant contributor to CVD in…
  • Abstract Number: 2233 • ACR Convergence 2024

    Maximizing Diagnostic Sensitivity: Combined Anti-RA33, Anti-CarP, and Anti-PAD4 Autoantibodies in Seronegative Rheumatoid Arthritis

    Andrew Concoff1, Touba Warsi2, Sepehr Taghavi2, Sudha Kumar2, Abigail Patalinghug2, Christine Schleif2, Brittany Partain3, Joseph Ahearn4, Susan Manzi5, Michael Mahler6, Veena Joy7 and Tyler O'Malley8, 1Exagen, Inc., Los Angeles, CA, 2Exagen, Carlsbad, CA, 3Exagen, Boston, MA, 4Allegheny Health Network, Wexford, PA, 5Allegheny Health Network, Pittsburgh, PA, 6Werfen, San Diego, CA, 7ThermoFisher, Philadelphia, PA, 8Exagen, Vista, CA

    Background/Purpose: Studies have found autoantibodies (Ab) directed against heterogeneous nuclear ribonucleoprotein A2/B1 (anti-RA33), peptidyl arginine deiminase 4 (anti-PAD4) and carbamylated proteins (anti-CarP) each have diagnostic…
  • Abstract Number: 0055 • ACR Convergence 2024

    Activating STAT3 Mutations in CD8+ T Cells Correlate to Serological Positivity in Rheumatoid Arthritis

    Katharine moosic1, Thomas Olson2, Mark Freijat3, samara khalique4, Cait Hamele1, Bryna Shemo1, Jesse Boodoo5, William Baker6, Gitanjali Khurana7, Matthew Schmachtenberg8, Tristin Duffy8, Aakrosh Ratan1, Erika Darrah9, Felipe Andrade10, Marieke Jones8, Kristine Olson2, David Feith1, Thomas Loughran1 and Donald Kimpel1, 1University of Virginia, Charlottesville, VA, 2Virginia Commonwealth University, Richmond, VA, 3Flow Rheumatology, Scottsdale, AZ, 4Carilion Clinic/ VirginiaTech, Salem, VA, 5Sarasota Arthritis Center, Sarasota, FL, 6Atrium Health, Charlotte, NC, 7University of Virginia, CROZET, VA, 8University of Virginia, Charlottesville, 9Johns Hopkins University, Baltimore, MD, 10The Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: Large granular lymphocyte (LGL) leukemia is a rare hematologic malignancy characterized by clonal expansion of cytotoxic T-cells and frequent somatic activating STAT3 mutations. A…
  • Abstract Number: 2250 • ACR Convergence 2024

    Cause Specific Mortality Differs in Rheumatoid Arthritis by Sex and Seropositivity

    Elena Joerns1, Ryan Lennon2, Cynthia Crowson2, Andrea Lopez-ruiz2, Roslin Jose George2, Vanessa Kronzer2, John Davis2 and Elena Myasoedova2, 1Mayo Clinic, Rochester, 2Mayo Clinic, Rochester, MN

    Background/Purpose: Persons with rheumatoid arthritis (RA) have an increased risk of mortality compared to the general population. Seropositivity has been shown to be associated with…
  • Abstract Number: 0059 • ACR Convergence 2024

    Fragment Crystallizable (Fc)-Free Certolizumab Pegol Is Not Bound by Rheumatoid Factors, While Fc Containing Biological DMARDsAre, Driving ImmuneComplex Formation and Cellular Clearance

    Susanna R. Bidgood1, Sophie Hopkin1, Kathryn R. Malpas1, David M. Kallenberg1, Jacqueline O’Neill1, Geofrey Odede1, Bernard Lauwerys2, Baran Ufuktepe3 and David Humphreys1, 1UCB Biopharma UK, Slough, United Kingdom, 2UCB Pharma, Brussels, Belgium, 3UCB Pharma, Istanbul, Turkey

    Background/Purpose: RFs are polyclonal autoantibodies which bind the Fc domain of IgGs. Patients with RA and high RF levels have poorer prognosis, more severe progressive…
  • Abstract Number: 2266 • ACR Convergence 2024

    Immunosuppressive Medications and Common Infections in Patients with Rheumatoid Arthritis

    Michael George1, Kelly Gavigan2, Shilpa Venkatachalam3, David Curtis2, Laura Stradford4, William Benjamin Nowell5, Fenglong Xie6, Joshua Baker1 and Jeffrey Curtis7, 1University of Pennsylvania, Philadelphia, PA, 2Global Healthy Living Foundation, Upper Nyack, NY, 3Global Healthy Living Foundation, New York, NY, 4Global Healthy Living Foundation, Nyack, NY, 5Regeneron, New York, NY, 6University of Alabama at Birmingham, Birmingham, AL, 7University of Alabama at Birmingham, Hoover, AL

    Background/Purpose: Patients with RA are at increased risk of serious infection, but less is known about common, non-serious infections. Our prospective study aimed to assess…
  • Abstract Number: 0158 • ACR Convergence 2024

    Rheumatoid Arthritis Testing Patterns by Physicians and Advanced Practice Providers from a National Commercial Laboratory, 2014 – 2023

    Karis Lee1, Min Kyung Lee2, David Alfego3, Kristen Clark4 and Stanley Naides5, 1Labcorp, Orlando, FL, 2Labcorp, San Diego, CA, 3Labcorp, Carlsbad, CA, 4Labcorp, Raleigh, NC, 5Labcorp, Dana Point, CA

    Background/Purpose: With the commercialization of new diagnostic and monitoring tests for rheumatoid arthritis (RA) and an increasing number of advanced practice providers (APPs) in the…
  • Abstract Number: 2286 • ACR Convergence 2024

    Certolizumab Inhibits Radiographic Progression Even in RA Patients with High Rheumatoid Factor Levels: A Pooled, Post-Hoc Analysis of Two Phase 3 Trials

    Josef Smolen1, Gerd Burmester2, Yoshiya Tanaka3, Tsutomu Takeuchi4, Jeffrey Curtis5, Ted Mikuls6, Clementina López Medina7, Peter C. Taylor8, Nicola Tilt9, Bernard Lauwerys10, Baran Ufuktepe11 and Thomas Huizinga12, 1Medical University of Vienna, Vienna, Austria, 2Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 3Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 4Department of Internal Medicine, Keio University, Tokyo, Tokyo, Japan, 5The University of Alabama at Birmingham, Birmingham, AL, 6University of Nebraska Medical Center, Omaha, NE, 7Reina Sofia University Hospital, Cordoba, Spain, 8University of Oxford, Oxford, United Kingdom, 9UCB Pharma, Slough, United Kingdom, 10UCB Pharma, Brussels, Belgium, 11UCB Pharma, Istanbul, Turkey, 12Department of Rheumatology, Leiden University, Leiden, Netherlands

    Background/Purpose: In patients (pts) with rheumatoid arthritis (RA), including those treated with disease-modifying antirheumatic drugs, high rheumatoid factor (RF) levels are a poor prognostic factor,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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