ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 0118 • ACR Convergence 2022

    Sex-Based Variations in Emergency Department Utilization by Persons with Inflammatory Arthritis Conditions

    Cheryl Barnabe1, Patrick McLane2, Nadia Luca1, Katie Lin1, Kelsey Chomistek1, Meghan Elliott1, Shanon McQuitty3, Eileen Davidson3, Clare Hildebrandt4, Steven Katz2, Brian Holroyd2 and Claire Barber1, 1University of Calgary, Calgary, AB, Canada, 2University of Alberta, Edmonton, AB, Canada, 3Arthritis Research Canada, Vancouver, BC, Canada, 4Patient and Family Advisors, Alberta Health Services, Calgary, AB, Canada

    Background/Purpose: High quality ambulatory care provision should mitigate avoidable emergency department (ED) visits by persons with inflammatory arthritis (IA) conditions and address the unique realities…
  • Abstract Number: 0241 • ACR Convergence 2022

    Inequity in Disease Impact Between Male and Female Rheumatoid Arthritis Patients

    Gonul Hazal Koc1 and Pascal de Jong2, 1Department of Rheumatology, Erasmus University Medical Centre, Rotterdam, the Netherlands, Rotterdam, Netherlands, 2ErasmusMC, Hendrik Ido Ambacht, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is more common in females than males. Moreover, males and females may have different disease courses and burdens, but data on…
  • Abstract Number: 0257 • ACR Convergence 2022

    High Density Lipoprotein Bound miR-1246 Is Enriched in Patients with Rheumatoid Arthritis and Is Proinflammatory

    Qiong Wu, Quanhu Sheng, Danielle Michell, Kasey Vickers and Michelle Ormseth, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: High density lipoprotein (HDL) is known for its anti-atherogenic cholesterol efflux and antioxidant functions. HDL has additional relevance to rheumatoid arthritis (RA) because of…
  • Abstract Number: 0273 • ACR Convergence 2022

    An Update on the Integrated Safety Analysis of Filgotinib in Patients with Moderately to Severely Active RA

    Kevin Winthrop1, Daniel Aletaha2, Roberto Felice Caporali3, Yoshiya Tanaka4, Tsutomu Takeuchi5, Paul Van Hoek6, Christopher Watson7, Pieter-Jan Stiers6, Vijay Rajendran8, Katrien Van Beneden6, jacques-eric gottenberg9 and Gerd Burmester10, 1Oregon Health & Science University, Portland, OR, 2Medical University Vienna, Wien, Austria, 3University of Milan, Milano, Italy, 4University of Occupational and Environmental Health, Kitakyusyu Fukuoka, Japan, 5Keio University and Saitama Medical University, Tokyo, Japan, 6Galapagos NV, Mechelen, Belgium, 7Galapagos Biotech Ltd, Cambridge, United Kingdom, 8Galapagos NV, Gent, Belgium, 9Strasbourg University Hospital, Strasbourg, France, 10Charité University Medicine Berlin, Berlin, Germany

    Background/Purpose: Filgotinib (FIL) is a second-generation oral Janus kinase 1 preferential inhibitor approved in Europe, Japan, and the UK for treatment of RA.1,2 Over a…
  • Abstract Number: 0291 • ACR Convergence 2022

    Tofacitinib Leads to Significant Weight Gain – A Real Life Experience of 429 Patients

    Naga Prabu1, velammal petchaippan2, Gayathri anand3, Aswathi kumar1 and Saranya Ramachandiran3, 1SAKTHI RHEUMATOLOGY CENTRE PVT LTD, Coimbatore, India, 2PSG INSTTUTE OF MEDICAL SCIENCES AND RESEARCH, Coimbatore, India, 3sakthi rheumatology centre pvt l;td, Coimbatore, India

    Background/Purpose: Tofacitinib(Tofa) an oral Janus kinase inhibitor(JAK) has shown good promise in the management of rheumatoid arthritis and psoriatic arthritis. While being increasingly used in…
  • Abstract Number: 0309 • ACR Convergence 2022

    Long-Term Safety and Efficacy of Olokizumab in Patients with Rheumatoid Arthritis – Results of an Open-Label Extension Study

    Eugen Feist1, Evgeny Nasonov2, Michael Luggen3, Saeed Fatenejad4, Sergey Grishin5, Mikhail Samsonov6 and Roy Fleischmann7, 1Helios Clinic Vogelsang-Gommern, cooperation partner of the Otto von Guericke University Magdeburg, Magdeburg, Germany, 2V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia, 3University of Cincinnati College of Medicine, Cincinnati, OH, 4SFC Medica, LLC, Charlotte, NC, 5R-Pharm, Moscow, Russia, 6R-Pharm JSC, Moscow, Russia, 7Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: Olokizumab (OKZ), an IL-6 ligand inhibitor, demonstrated significant improvements in signs and symptoms of RA vs placebo (PL) and non-inferiority to adalimumab (ADA).1-2 Patients…
  • Abstract Number: 0531 • ACR Convergence 2022

    Development and Performance of a Diagnostic Precision Biomarker for Seronegative Rheumatoid Arthritis Based on DNA Methylation in Blood

    Espen Riskedal1, Karl Trygve Kalleberg1, Arne Søraas2, Maria Dahl Mjaavatten3, Grethe-Elisabeth Stenvik4, Joe Sexton4, Janis Neumann1, Cathrine Lund Hadley1, Guro Goll4, Silje Watterdal Syversen4, Håkon Bøås5, Jennifer Ruth Harris5, Astanand Jugessur5, Siri Lillegraven4 and Espen Haavardsholm4, 1Age Labs AS, Oslo, Oslo, Norway, 2Age Labs AS, Eiksmarka, Norway, 3Diakonhjemmet Hospital, Haslum, Norway, 4Diakonhjemmet Hospital, Oslo, Norway, 5Norwegian Institute of Public Health, Oslo, Norway

    Background/Purpose: Patients with seronegative rheumatoid arthritis (RA) exhibit no detectable antibodies, often resulting in delayed diagnosis and treatment initiation. A blood-based test, capable of detecting…
  • Abstract Number: 0589 • ACR Convergence 2022

    Restoration of NAD+ Levels in Rheumatoid Arthritis with NAD+ Boosters as a Novel Therapeutic Strategy to Resolve Acute Inflammation

    Carlos Pérez-Sánchez1, Adrián Llamas Urbano2, Tomás Cerdó2, Laura Muñoz-Barrera1, Ismael Sánchez-Pareja2, Luz Marina Sánchez-Mendoza3, Nuria Barbarroja1, María Carmen Ábalos-Aguilera4, Juan Antonio Moreno5, María isabel Burón6, José Antonio González-Reyes5, Pilar Font1, Jerusalem Calvo-Gutierrez2, Marta Rojas-Gimenez1, Eduardo Collantes1, Alejandro Escudero-Contreras2, José Manuel Villalba-Montoro6 and Chary Lopez-Pedrera1, 1IMIBIC/University of Cordoba/Reina Sofia Hospital, Cordoba, Spain, 2IMIBIC/University of Cordoba/Reina Sofia Hospital, Córdoba, Spain, 3Department of Cell Biology, Physiology and Immunology, University of Córdoba, Campus de Excelencia Internacional Agroalimentario, ceiA3, Cordoba, Spain, Córdoba, Spain, 4Imibic/ University of Córdoba/ Reina Sofía Hospital, Córdoba, Spain, 5Department of Cell Biology, Physiology and Immunology, University of Córdoba, Campus de Excelencia Internacional Agroalimentario, ceiA3, Córdoba, Spain, 6Department of Cell Biology, Physiology and Immunology, University of Córdoba, Campus de Excelencia Internacional Agroalimentario, ceiA3, Cordoba, Spain

    Background/Purpose: This study aimed to: 1- Evaluate the levels of NAD+ and gene transcripts involved in its metabolism in Rheumatoid Arthritis (RA) patients. 2- Analyse…
  • Abstract Number: 0605 • ACR Convergence 2022

    Citrullinated Peptide-Specific ACPA Are Present in the Female Genital Tract in Premenopausal Women with and Without RA

    Daniele Marcy1, Heather Rothfuss2, Ashley Visser1, Jill Norris3, V. Michael Holers4, Kevin D Deane5, William Robinson6, Brian Cherrington2 and Kristen Demoruelle1, 1University of Colorado Anschutz Medical Campus, Aurora, CO, 2University of Wyoming, Laramie, 3Colorado School of Public Health, Aurora, CO, 4University of Colorado, Denver, CO, 5University of Colorado Denver Anschutz Medical Campus, Denver, CO, 6Stanford University School of Medicine, Palo Alto, CA

    Background/Purpose: Women develop RA ~3 times more often than men. The etiology of this sex difference remains largely unexplained. Generation of anti-citrullinated protein antibodies (ACPA)…
  • Abstract Number: 0623 • ACR Convergence 2022

    Rheumatoid Synovial Fibroblasts Display Imprinted Memory of Their Synovial Endotype Which Can Be Plastically Modulated by B-cells Crosstalk

    Edoardo Prediletto1, Cankut Cubuk2, Elena Pontarini3, Felice Rivellese2, Alessandra Nerviani2, Davide Lucchesi3, Mattia Caliste1, Elisa Corsiero1, Manzoor Ahmed3, rebecca hands3, Myles Lewis2, Costantino Pitzalis2 and Michele Bombardieri4, 1Wlliam Harvey Research Institute Queen Mary University on London, London, United Kingdom, 2Queen Mary University of London, London, United Kingdom, 3William Harvey Research Institute, London, United Kingdom, 4Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University, London, United Kingdom

    Background/Purpose: Despite advances in the treatment of Rheumatoid Arthritis (RA), synthetics and biologicals drugs are ineffective in ~40% of patients. The origin of this refractoriness…
  • Abstract Number: 0751 • ACR Convergence 2022

    Accessing Telehealth and In-Person Healthcare During the COVID-19 Pandemic: Experiences of Individuals with Rheumatoid Arthritis

    Smruthi Ramachandran1, Jenny Leese2, Stephanie Therrien3, Catherine L. Backman1, Jasmin Ma4, Kelly English5, Eileen Davidson6, Shanon McQuitty7, Alison Hoens5, Cheryl Koehn8, James Gavin9, jo Adams9 and Linda Li1, 1University of British Columbia, Vancouver, BC, Canada, 2University of Ottawa, Ottawa, ON, Canada, 3Arthritis Research Canada, Vancouver, BC, Canada, 4Arthritis Research Canada/University of British Columbia, Richmond, BC, Canada, 5Arthritis Patient Advisory Board of Arthritis Research Canada, Vancouver, BC, Canada, 6Arthritis Patient Advisory Board of Arthritis Research Canada, Burnaby, BC, Canada, 7Arthritis Patient Advisory Board of Arthritis Research Canada, Richmond, BC, Canada, 8Arthritis Consumer Experts, Vancouver, BC, Canada, 9University of Southampton, Southampton, United Kingdom

    Background/Purpose: The COVID-19 pandemic has provided opportunity to increase integration of virtual healthcare with in-person medical practices. Individuals with rheumatoid arthritis (RA) continue to self-manage…
  • Abstract Number: 0807 • ACR Convergence 2022

    High Throughput Analyses for the Study of Synovial Tissue Biopsy from Inflammatory Arthritis Patients

    Viviana Marzaioli1, Achilleas Floudas2, Aine Gorman3, Carl Orr4, Douglas Veale5 and Ursula Fearon6, 1Trinity College Dublin and University College Dublin, Dublin, Ireland, 2Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Ireland, 3St Vincent's University Hospital, Dublin, Ireland, 4Saint Vincent's University Hospital, Dublin, Ireland, 5St. Vincent's University Hospital, Blackrock, Dublin, Ireland, 6Trinity College Dublin, Dublin, Ireland

    Background/Purpose: Inflammatory arthritis (IA) is a chronic systemic autoimmune disease of unknown aetiology, which affects the joints. While studies of immune cell populations in peripheral…
  • Abstract Number: 0895 • ACR Convergence 2022

    COVID-19 Vaccination in Autoimmune Diseases Study: Vaccine Safety in Rheumatoid Arthritis

    Naveen R1, Ioannis Parodis2, Mrudula Joshi3, Parikshit Sen4, Minchul Kim5, Vishwesh Agarwal6, Sinan Kardes7, James B. Lilleker8, Hector Chinoy9, Oliver Distler10, Ai Lyn Tan11, Samuel Shinjo12, Babur Salim13, Tamer A Gheita14, Nelly Ziade15, Tsvetelina Velikova16, Tulika Chatterjee5, Arvind Nune17, Marcin Milchert18, Abraham Edgar Gracia-Ramos19, Albert Selva O’Callaghan20, Miguel Angel Saavedra Salinas21, Lorenzo Cavagna22, Masataka Kuwana23, Johannes Knitza24, Jessica Day25, Ashima Makol26, John Pauling27, Chris Wincup28, Erick Zamora Tehozol29, Jorge Rojas Serrano30, Ignacio Garcia-De La Torre31, Rohit Aggarwal32, Vikas Agarwal1, Latika Gupta33, Elena Nikiphorou34 and CoVAD Study Group35, 1Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2Karolinska Institutet, Stockholm, Sweden, 3Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, India, 4Maulana Azad Medical College, New Delhi, India, 5University of Illinois College of Medicine Peoria, Peoria, IL, 6Mahatma Gandhi Missions Medical College, Lucknow, India, 7Istanbul University, Istanbul, Turkey, 8The University of Manchester, Manchester, United Kingdom, 9The University of Manchester, Sale, United Kingdom, 10Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 11University of Leeds, Leeds, United Kingdom, 12Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil, 13Fauji foundation hospital Rawalpindi, Rawalpindi, Pakistan, 14Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, 15Saint-Joseph University, Beirut, Lebanon, 16Sofia University St. Kliment Ohridski, Sofia, Bulgaria, 17Southport and Ormskirk Hospital NHS Trust, Southport, United Kingdom, 18Pomeranian Medical University in Szczecin, Szczecin, Poland, 19Instituto Mexicano del Seguro Social, Ciudad de México, Mexico, 20Hospital Universitari Vall d'Hebron, Barcelona, Spain, 21IMSS, Ciudad de México, Mexico, 22Università di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Pavia, Italy, 23Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 24Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie, Friedrich-Alexander-UniversityErlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 25Walter and Eliza Hall Institute, Melbourne, Australia, 26Mayo Clinic, Rochester, MN, Rochester, MN, 27North Bristol NHS Trust, Bristol, United Kingdom, 28Rayne Institute, University College London, London, United Kingdom, 29Centro Medico Pensiones, Merida, Mexico, 30Hospital Angeles Villahermosa, Ciudad de México, Mexico, 31Centro de Est. de Inv. Bas. y Clinica, S.C., Guadalajara, Mexico, 32Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 33Royal Wolverhampton Trust, Wolverhampton/University of Manchester, United Kingdom, 34Leiden University Medical Center & King's College London, London, United Kingdom, 35CoVAD study group, Wolwehampton, United Kingdom

    Background/Purpose: COVID-19 vaccination in autoimmune diseases (COVAD) study is a large-scale real-world data on COVID-19 vaccine safety in autoimmune rheumatic diseases (AIRDs) including rheumatoid arthritis…
  • Abstract Number: 0911 • ACR Convergence 2022

    Peer Coach Intervention to Improve Primary Cardiovascular Disease Screening for Patients with Rheumatoid Arthritis

    Iris Navarro-Millan1, Mackenzie Brown2, Yuliana Domínguez Páez3, Geyanne Lui4, Joan Weiner1, Shelley fritz1, Tien Sydnor-Campbell5, Aberdeen Allen6, Assem Jabri1, Shilpa Venkatachalam7, Kelly Gavigan8, William Benjamin Nowell9, Jeffrey Curtis10, Liana Fraenkel11 and Monika Safford1, 1Weill Cornell Medicine, New York, NY, 2Weill Cornell Medicine, Brooklyn, NY, 3Weill Cornell Medicine, Bronx, NY, 4Albert Einstein College of Medicine, New York, NY, 5Weill Cornell Medicine, Philedelphia, 6Weill Cornell Medicine, Parlin, 7Global Healthy Living Foundation, New York, NY, 8Global Healthy Living Foundation, Upper Nyack, NY, 9Global Healthy Living Foundation, Nyack, NY, 10University of Alabama at Birmingham, Hoover, AL, 11Berkshire Medical Center, Lenox, MA

    Background/Purpose: Only 37% of patients with rheumatoid arthritis (RA) receive screening for cardiovascular disease (CVD) despite their high risk. To improve CVD prevention, we designed…
  • Abstract Number: 0927 • ACR Convergence 2022

    Review of 167,990 Same Day RAPID3, CDAI Scores for 61,312 Patients Receiving DMARD Treatment for Rheumatoid Arthritis; Evaluations of Disease Assessments and Treatment Discontinuation

    Nehad Soloman1, Kent Kwas Huston2, Jasvinder singh3, Simon Helfgott4, Andrew Frick5, Scott Milligan5 and Colin Edgerton6, 1Arizona Arthritis & Rheumatology Associates, P.C., Peoria, AZ, 2Kansas City Physician Partners Center for Rheumatic Disease, Kansas City, MO, 3University of Alabama at Birmingham, Birmingham, AL, 4Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 5Trio Health, Louisville, CO, 6Articularis Healthcare, Sullivans Island, SC

    Background/Purpose: Treatment efficacy for rheumatoid arthritis is often measured through disease assessments containing subjective input from the provider, the patient, or both. Here we compare…
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