ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 1347 • ACR Convergence 2023

    Continuing Biologic DMARDs During Pregnancy in Women with Rheumatic Disease Was Not Associated with Increased Unfavorable Pregnancy Outcomes, Serious Infections, and Adverse Effects of Vaccination

    Hiromi Shimada1, Risa Wakiya2, Shusaku Nakashima2, Taichi Miyagi3, Yusuke Ushio4, Koichi Sugihara5, Rina Mino6, Mao Mizusaki2, Kanako Chujo7, Ryoko Kagawa4, Hayamasa Yamaguchi4, Tomohiro Kameda2 and Hiroaki Dobashi2, 1Kagawa University, Kagawa, Japan, 2Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan, 3Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kidagun, Japan, 4Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Miki-cho, Kita-gun, Japan, 5Kagawa University, Miki-cho, Kita-gun, Japan, 6Kagawa University, Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa, Japan, 7Kagawa University, Miki, Kita District, Kagawa, Japan

    Background/Purpose: It is important to control disease activity during pregnancy in women with rheumatic diseases because its exacerbation is associated with increased adverse pregnancy outcomes.…
  • Abstract Number: 1676 • ACR Convergence 2023

    Tofacitinib Accelerates in Vitro Clot Formation and Delays Clot Lysis in Rheumatoid Arthritis Blood by Enhancement of Macrophage TLR4 Mediated Cytokine Responses- a New Angle on Thrombosis with JAKi in Rheumatology

    Paula David1, Thomas Macleod2, Yu Shi3, Payal Ganguly1, Cedric Duval3, Mark Harland1, Chi Wong1, Benazir Saleem4 and Dennis McGonagle5, 1University of Leeds, Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), Leeds, United Kingdom, 2University of Leeds, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 3Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 4Leeds Teaching Hospitals NHS Trust, Rheumatology, Chapel Allerton Hospital, Leeds, United Kingdom, 5Leeds Biomedical Research Centre, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Rheumatoid Arthritis (RA) patients treated with Janus Kinase inhibitors (JAKi) have reportedly higher venous thromboembolism (VTE) risk and atherosclerotic-related complications including myocardial infarction (1).Although…
  • Abstract Number: 1731 • ACR Convergence 2023

    A Competitive Inhibitor of MOART Showed Potent Therapeutic Effects in a Mouse Model of Collagen-induced Arthritis

    Sujin Park1, DongWoo Kang2, Haein An1, Eunji Hong1, Kwiyeom Yoon2, MinWoo Kim2, Hwajung Kim2 and Seong Jin Kim2, 1GILO Institute, GILO Foundation, Seoul, South Korea, 2Medpacto Inc., Seoul, South Korea

    Background/Purpose: Despite tumor necrosis factor (TNF) inhibitors and Jak kinase inhibitors (JKI) have shown a significant advance in the treatment of rheumatoid arthritis (RA) however,…
  • Abstract Number: 1747 • ACR Convergence 2023

    A Newly Described Cytokine interleukin-40 Is Increased in the Serum of Individuals At-risk of Rheumatoid Arthritis and Induces an Inflammatory Response in Mononuclear Cells

    Adela Navratilova1, Klára Prajzlerová2, Nora Růžičková3, Karel Pavelka4, Jiri Vencovsky5, Ladislav Senolt6, Maria Filkova3 and Lucie Andrés Cerezo3, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Hlavní město Praha, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic, 3Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 4Institut of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Praha, Czech Republic, 5Institute of Rheumatology, Prague, Czech Republic, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 6Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Praha, Czech Republic

    Background/Purpose: Interleukin-40 (IL-40) is a newly described cytokine related to malignancies and immunity function. We have previously shown that IL-40 is up-regulated in early stages…
  • Abstract Number: 1763 • ACR Convergence 2023

    Asthma Severity Is Associated Increased Serum Anti-cyclic Antibody Level at Baseline and in Increase During Longitudinal Follow-up

    Drayton Rorah1, Linh Ngo2, Mario Castro2, Kristen Demoruelle3 and Scott Matson4, 1University of Kansas Medical Center, Kansas City, KS, 2University of Kansas School of Medicine, Kansas City, KS, 3University of Colorado Anschutz Medical Campus, Aurora, CO, 4University of Kansas School of Medicine, Kansas City, MO

    Background/Purpose: The lung airways have been implicated in the pathogenesis of RA. RA-associated autoantibodies, including anti-cyclic citrullinated peptide (anti-CCP) antibodies are found to be generated…
  • Abstract Number: 1847 • ACR Convergence 2023

    Influence of Seasonal Changes on Adherence in Rheumatoid Arthritis Patients

    Cody Schmidt, Kunal Patel, Samantha Delgado, Guy Cozzi, Elisea Avalos-Reyes, W. Cliff Rutter, Rashmi Grover, Lucia Feczko, Will Cavers and Kjel Johnson, CVS Health, Woonsocket, RI

    Background/Purpose: Rheumatoid arthritis (RA) symptoms are suspected to be linked with exposure to colder environments. Previous studies on RA and seasonality have focused on RA…
  • Abstract Number: 1911 • ACR Convergence 2023

    Using the Technology Acceptance Model to Assess Physician Perceptions and Experiences Using the Rheumatoid Arthritis-Patient-Reported Outcomes Dashboard: Mixed-Methods Study

    Catherine Nasrallah1, Cherish Wilson2, Alicia Hamblin1, Lindsay Jacobsohn1, Cammie Young3, Cammie Young3, Mary Nakamura4, Andrew Gross1, Judith Ashouri1, Mehrdad Matloubian1, Jinoos Yazdany1 and Gabriela Schmajuk2, 1University of California San Francisco, San Francisco, CA, 2UCSF / SFVA, San Francisco, CA, 3University of California San Francisco, Oakland, CA, 4UCSF/SFVAHCS, San Francisco, CA

    Background/Purpose: Improving shared decision-making using a treat-to-target approach, including the use of patient reported outcomes (PROs), is important to providing high quality care for rheumatoid…
  • Abstract Number: 2100 • ACR Convergence 2023

    Paradoxical Antagonistic Association of Visceral and Subcutaneous Adipose Tissue with Circulating C-Reactive Protein in Rheumatoid Arthritis

    Jon Giles and Joan Bathon, Columbia University, New York, NY

    Background/Purpose: C-reactive protein (CRP) is used as an indicator of disease activity in people with RA.However, adipose tissue also expresses inflammatory cytokines that induce hepatic…
  • Abstract Number: 2117 • ACR Convergence 2023

    Frailty Is Associated with Mortality in Veterans with Rheumatoid Arthritis

    Sayuli Bhide1, Punyasha Roul2, Namrata Singh3, Grant Cannon4, Gary Kunkel5, Ted R Mikuls6, Bryant England2, Dolores Shoback7, Patti Katz8, Jose Garcia9, Ariela Orkaby10, Joshua Baker11 and K Wysham12, 1University of Washington, Seattle, WA, 2University of Nebraska Medical Center, Omaha, NE, 3University of Washington, Bellevue, WA, 4University of Utah and Salt Lake City VA, Salt Lake City, UT, 5University of Utah, Salt Lake City, UT, 6Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, 7San Francisco VA Medical Center, San Francisco, CA, 8University of California San Francisco, San Rafael, CA, 9VA Puget Sound Healthcare System, Seattle, WA, 10Veterans Affairs Boston Healthcare System & Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; VA Geriatric Research Education and Clinical Center, Boston, MA, 11University of Pennsylvania, Philadelphia, PA, 12VA Puget Sound/University of Washington, Seattle, WA

    Background/Purpose: Frailty is established as an important predictor of mortality in the general population.1Rheumatoid arthritis (RA) is associated with higher rates of frailty than the…
  • Abstract Number: 2133 • ACR Convergence 2023

    Cardiovascular Risk Factors Are Associated with Discontinuation of Advanced Therapies Due to Treatment Failure in Rheumatoid Arthritis: Results from the OBRI

    Samar Aboulenain1, Xiuying Li2, Mohammad Movahedi3, Claire Bombardier1 and Bindee Kuriya1, 1University of Toronto, Toronto, ON, Canada, 2Toronto General Hospital, Toronto, ON, Canada, 3Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada

    Background/Purpose: Cardiovascular (CVD) comorbidity can impact overall RA care. We demonstrated that CVD risk factors were associated with higher disease activity and disability. Here, we…
  • Abstract Number: 2149 • ACR Convergence 2023

    Biologic IRL201805 Drives Differential Cell-contact and Metabolism Transcriptional Profiles in Monocytes from RA Patients Compared to Healthy Donors

    Yuriko Yamamura1, Kieran Woolcock2, Valerie Corrigall3, Lara Ravanetti4, Jorge De Alba4, Roly Foulkes5, Paul Eggleton6 and Carl Goodyear2, 1School of Infection & Immunity, University of Glasgow, Glasgow, United Kingdom, 2University of Glasgow, Glasgow, United Kingdom, 3Revolo Biotherapeutics, Tadworth, United Kingdom, 4Revolo Biotherapeutics, London, United Kingdom, 5Revolo Biotherapeutics, Slough, United Kingdom, 6Revolo Biotherapeutics, Exeter, United Kingdom

    Background/Purpose: IRL201805 is a novel biologic derived from Binding Immunoglobulin Protein (BiP) that has been developed for the treatment of Rheumatoid arthritis (RA) (P Eggleton,…
  • Abstract Number: 2166 • ACR Convergence 2023

    Long-Term Effects of Abatacept on Arthritis and Atherosclerosis in Older vs Younger Patients with Rheumatoid Arthritis: 3-year Results of a Prospective, Multicenter, Observational Study

    Zento Yamada1, Sei Muraoka1, Mai Kawazoe2, Wataru Hirose3, Hajime Kono4, Shinsuke Yasuda5, Takahiko Sugihara6 and Toshihiro Nanki2, 1Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan, 2Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Ota-ku, Japan, 3Hirose Clinic of Rheumatology, Saitama, Japan, 4Teikyo University School of Medicine, Tokyo, Japan, 5Department of Rheumatology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 6Toho University, Tokyo, Japan

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at an increased risk of cardiovascular disease secondary to atherosclerosis. Although it has been reported that TNF inhibitor…
  • Abstract Number: 2434 • ACR Convergence 2023

    Acetylated Bacterial Proteins as Potent Antigens Inducing an Anti-modified Protein Antibody Response

    Mikhail Volkov, Arieke Kampstra, Karin van Schie, Joanneke Kwekkeboom, Arnoud de Ru, Peter van Veelen, Thomas Huizinga, René Toes and Diane van der Woude, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Gut-residing bacteria, such as E.coli, can acetylate their proteome under conditions of amine starvation. It is postulated that the (gut) microbiome is involved in…
  • Abstract Number: 2507 • ACR Convergence 2023

    ZCCHC6 Modulates the Global Phosphorylation Landscape in TNF-a-induced Rheumatoid Arthritis Synovial Fibroblasts

    Anil Singh, Farheen Sultan Shaikh and Salahuddin Ahmed, Washington State university, Spokane, WA

    Background/Purpose: ZCCHC6, also known as TUT7 or TENT2, plays a crucial role in RNA processing and metabolism through its uridylyl transferase function. This function involves…
  • Abstract Number: 2592 • ACR Convergence 2023

    Trends, Sociodemographic and Clinical Factors Associated with Avascular Necrosis and Related Arthroplasties in Hospitalized Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis

    Rashmi Dhital1, Neha Singh2, Brian Pedersen2 and Christie M. Bartels3, 1UC San Diego, San Diego, CA, 2University of California San Diego, San Diego, CA, 3University of Wisconsin, School of Medicine and Public Health, Madison, WI

    Background/Purpose: Avascular necrosis (AVN) can be a debilitating complication of autoimmune diseases and steroid treatment, with a higher prevalence in systemic lupus erythematosus (SLE) (0.8-33%)…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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