Abstracts tagged "rheumatoid arthritis"

Abstract Number: 2137 • ACR Convergence 2023
Line of Therapy of Biologics and JAK Inhibitors in RA, PsA and AxSpA: Implications for Design and Uptake of New Drugs and Diagnostics
Jeffrey Curtis¹, Fenglong Xie¹, Yuji Su², Patrick Stewart³ and Amy S. Mudano¹, ¹Illumination Health, Hoover, AL, ²University of Alabama at Birmingham and Illumination Health, Birmingham, AL, ³Illumination Health, Birmingham, AL
Background/Purpose: Patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (AxSpA) have an increasing array of treatment options available, and new blood-based diagnostic…
Abstract Number: 2153 • ACR Convergence 2023
Effects of One-year Tofacitinib Therapy on Angiogenic Biomarkers in Rheumatoid Arthritis
György Kerekes¹, Monika Czókolyová¹, Attila Hamar¹, Anita Pusztai¹, Gábor Tajti¹, Mónika Katkó¹, Edit Végh¹, Zsófia Pethő¹, Nóra Bodnár¹, Ágnes Horváth¹, Boglárka Soós¹, Szilvia Szamosi¹, Zsolt Hascsi¹, Mariann Harangi¹, Katalin Hodosi¹, György Panyi¹, Tamas Seres², Gabriella Szücs¹ and Zoltán Szekanecz¹, ¹University of Debrecen, Faculty of Medicine, Debrecen, Hungary, ²University of Colorado Anschutz Medical Campus, Aurora, CO
Background/Purpose: Cardiovascular (CV) morbidity, mortality and perpetuated synovial angiogenesis have been associated with rheumatoid arthritis (RA). In our study we evaluated angiogenic factors in relation…
Abstract Number: 2170 • ACR Convergence 2023
Systemic Glucocorticoids Are Associated with a Time and Dose-dependent Risk of Major Adverse Cardiovascular Event in Patients with Rheumatoid Arthritis: A Population-based Study
Ho SO¹, Tommy LAM², Huan MENG³, Steven LAM³ and Lai-Shan Tam⁴, ¹The Chinese University of Hong Kong, Hong Kong, China, ²Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, Hong Kong, ³The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁴The Chinese University of Hong Kong, New Territories, China
Background/Purpose: Rheumatoid arthritis (RA) and systemic glucocorticoid (GC) use are associated with increased risk of cardiovascular disease. The latest RA management recommendations from the American…
Abstract Number: 2450 • ACR Convergence 2023
Gene by Respiratory Disease Interactions Associated with Developing Rheumatoid Arthritis
Vanessa Kronzer¹, Keigo Hayashi², Cynthia Crowson¹, John Davis¹, Gregory McDermott², Jing Cui³, Elena Losina³, Pierre-Antoine Juge⁴, James Cerhan¹ and Jeffrey Sparks⁵, ¹Mayo Clinic, Rochester, MN, ²Brigham and Women's Hospital, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Division of Rheumatology, Inflammation, and Immunity Brigham & Women's Hospital, Boston, MA, ⁵Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Cigarette smoking, textile dust, and occupational inhalants all strongly interact with the Human Leukocyte Antigen (HLA) shared epitope for risk of seropositive RA. Recently,…
Abstract Number: 2540 • ACR Convergence 2023
The Molecular Stratification of Rheumatoid Arthritis Using High-throughput Technologies Is Directly Associated with Disease Activity and Clinical Response
Ismael Sanchez-Pareja¹, Daniel Toro-Dominguez², Carlos Perez-Sanchez³, Laura Muñoz-Barrera¹, Tomás Cerdó¹, Rafaela Ortega Castro⁴, Jerusalem Calvo⁵, Marta Rojas⁶, Pilar Font Ugalde¹, Maria del Carmen Abalos-Aguilera⁷, Desiree Ruiz-Vilchez¹, Christian Merlo-Ruiz¹, Ivan Arias de la Rosa⁸, Mª Angeles Aguirre⁹, Eduardo Collantes Estévez¹⁰, Nuria Barbarroja¹¹, Marta Alarcon-Riquelme¹², Alejandro Escudero Contreras⁵ and Chary Lopez-Pedrera¹³, ¹IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ²GENYO, Granada, Spain, ³IMIBIC, Córdoba, Spain, ⁴Hospital Reina Sofía, Cordoba, Spain, ⁵Reina Sofia University Hospital, Córdoba, Spain, ⁶Hospital Universitario Reina Sofía, Cordoba, Spain, ⁷Rheumatology Department, Reina Sofia University Hospital/Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain, ⁸IMIBIC/Reina Sofia Hospital/University of Cordoba. Rheumatology service. Cordoba. Spain, Cordoba, Spain, ⁹Reina Sofía University Hospital/ Rheumatology Department, Córdoba, Spain, ¹⁰Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/University of Cordoba, Cordoba, Spain, ¹¹University of Cordoba, Córdoba, Spain, ¹²Center for Genomics and Oncological Research (GENYO), Granada, Spain, ¹³IMIBIC - Reina Sofia Hospital, Córdoba, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a remarkably heterogeneous autoimmune disease whose clinical outcomes with disease-modifying antirheumatic drugs (DMARDs) remain unpredictable. The aim of this study…
Abstract Number: 0025 • ACR Convergence 2023
Relationship Between Genetic Variants in Cannabinoid Receptor 2 and Self-Reported Effectiveness of Cannabis for Pain Management in Rheumatoid Arthritis
Kristin Wipfler¹, Joanna Zeiger², Adam Cornish¹ and Kaleb Michaud³, ¹FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ²Canna Research Foundation, Boulder, CO, ³University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Cannabinoid receptor 2 (CB2) is a member of the cannabinoid receptor family and is encoded by the CNR2 gene. CB2 receptors are found primarily…
Abstract Number: 0088 • ACR Convergence 2023
SLAMF4 Orchestrates the Pathological Cytotoxic Response of CD4+ T Cells in Rheumatoid Arthritis
Megane Lacaud¹, Houda-Ghozlane Bouzidi¹, Magali breckler¹, Delphine Lemeiter², Luca Semerano³, Marie-Christophe Boissier³, Natacha Bessis⁴ and Jerome Biton², ¹Inserm UMR 1225, Université Sorbonne Paris Nord, Bobigny, France, ²Inserm UMR 1125, Université Sorbonne Paris Nord, Bobigny, France, ³Inserm UMR 1125, Université Sorbonne Paris Nord; Assistance Publique-Hôpitaux de Paris, Rheumatology department, Avicenne Hospital, Bobigny, France, ⁴Inserm UMR 1125, Université Sorbonne Paris Nord, Bobigny, France
Background/Purpose: CD4+ Foxp3- conventional T cells (Tconv) play a key role in the inflammatory process involved in rheumatoid arthritis (RA). Recent studies, aided by a…
Abstract Number: 0223 • ACR Convergence 2023
Severity and Risk Factors of Hospitalization of Omicron in Patients with Rheumatoid Arthritis
Yan Wang¹, mengyao zhang², Sitian Zang¹, liang luo³, Chun Li¹, Jing He¹ and zhanguo li², ¹Peking University People’s Hospital, Beijing, China, ²Peking University People's Hospital, Beijing, China, ³Department of Chinese Medicine, the People's Hospital of Yubei District of Chongqing City, Chongqing, China; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China
Background/Purpose: There is still lack of data on the prognosis of patients with RA who have been infected with SARS-Cov-2 Omicron variant, a new strain…
Abstract Number: 0386 • ACR Convergence 2023
Functional Disability and Disease Activity Are Affected by Social Determinants of Health in Patients with Rheumatoid Arthritis
Mohammad Movahedi¹, Kangping Cui², George Tomilnson³, Angela Cesta³, xiuying Li³ and Claire Bombardier⁴, ¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²Sunnybrook Hospital, Toronto, ON, Canada, ³University Health Network, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada
Background/Purpose: The relationship between social determinants of health (SDH) (e.g. income, education, and employment status) and disease outcomes in the RA population is not well…
Abstract Number: 0402 • ACR Convergence 2023
Automated Detection and Quantification of Hand Joint Swelling in Rheumatoid Arthritis: Computer Vision, Deep Neural Network Models, and a Potential Biomarker for Disease Activity Monitoring
Marc Blanchard¹, Jules Maglione², Cinja Koller³, Patrick Hermann⁴, David Brüschweiler³, Arnd Kleyer⁵ and Thomas Hügle⁶, ¹Dept. of Rheumatology, University Hospital Lausanne (CHUV) and University Lausanne, Lausanne, Switzerland, ²EPFL, Lausanne, Switzerland, ³Lausanne University Hospital, Lausanne, Switzerland, ⁴ATREON SA, Lausanne, Switzerland, ⁵University Hospital Erlangen, Erlangen, Germany, ⁶Dept. of Rheumatology, University Hospital Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland
Background/Purpose: We have previously shown that automated detection and processing of dorsal finger fold patterns from hand photographs can be used as a digital biomarker…
Abstract Number: 0419 • ACR Convergence 2023
No Clinically Relevant Changes in Coagulation Activation Between Patients Initiating TNF-blockers versus JAK-inhibitors
Romy Hansildaar¹, Reinder Raadsen¹, Maaike Heslinga² and Michael Nurmohamed², ¹Reade, Amsterdam, Netherlands, ²Amsterdam University Medical Centers, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is associated with a 2-fold higher risk of venous thromboembolism (VTE) compared with the general population. The immune system and hemostatic…
Abstract Number: 0436 • ACR Convergence 2023
Patients with Difficult-to-treat Rheumatoid Arthritis Have Higher Levels of Inflammation on Ultrasound
Ummugulsum Gazel¹, Seyyid Bilal Acikgoz², Catherine Ivory³, Amin Zahrai³, Ozun Bayindir Tsechelidis⁴, Ricardo Sabido-Sauri¹, Elliot Hepworth¹ and sibel aydin⁵, ¹University of Ottawa, Ottawa, ON, Canada, ²University of Ottawa, Rheumatology, Ottawa, ON, Canada, ³The Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁴Ottawa University, Ottawa, ON, Canada, ⁵University of Ottawa - Ottawa, Ottawa, ON, Canada
Background/Purpose: With increasing numbers of advanced therapies, rheumatologists frequently see Rheumatoid Arthritis (RA) patients who have failed ≥2 advanced therapies with different mechanisms of action.…
Abstract Number: 0453 • ACR Convergence 2023
Risk of Lung Cancer in Veterans with Rheumatoid Arthritis in Relation to Use of Conventional versus Biologic or Targeted Synthetic DMARDs
Namrata Singh¹, Alexander Peterson², Aaron Baraff², K Wysham³, Bryant England⁴, Joshua Baker⁵, Nicholas Smith², Ted R Mikuls⁶ and Noel Weiss⁷, ¹University of Washington, Bellevue, WA, ²VA Puget Sound Seattle, Seattle, WA, ³VA Puget Sound/University of Washington, Seattle, WA, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, ⁷University of Washington, Seattle, WA
Background/Purpose: Rheumatoid arthritis (RA) is associated with an increased risk of lung cancer compared to the general population. While smoking is a shared risk factor,…
Abstract Number: 0730 • ACR Convergence 2023
NF-κB Signaling Is Critically Important for Functional Responses of ACPA-producing B Cell Clones from Patients with Rheumatoid Arthritis
Giulia Frazzei¹, Jan Piet van Hamburg², Ronald van Vollenhoven² and Sander Tas³, ¹Amsterdam University Medical Center, location AMC, Amsterdam, Netherlands, ²Amsterdam University Medical Centers, Amsterdam, Netherlands, ³Amsterdam UMC, locatie AMC, Utrecht, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) play a role in rheumatoid arthritis (RA) pathogenesis, and their presence is associated with disease severity. Consequently, detailed analysis of…
Abstract Number: 0795 • ACR Convergence 2023
The Focal Adhesion Protein Lasp1 Links the Arp2/3 Complex to Cell-to-cell Contact Formation in Arthritic Fibroblast-like Synoviocytes
Denise Beckmann¹, Annika Krause¹, Uwe Hansen², Hans-Peter Kiener³, Joachim Kremerskothen¹, Hermann Pavenstädt¹, Adelheid Korb-Pap¹ and Thomas Pap¹, ¹University Hospital Münster, Münster, Germany, ²University Muenster, Muenster, Germany, ³Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
Background/Purpose: In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) undergo a stable transformation leading to an aggressive phenotype that mediates cartilage damage through increased levels of…

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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