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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 1327 • ACR Convergence 2025

    Systematic Review of Mobility in Rheumatoid Arthritis with Digitally Measured Objective Assessment

    Anna fishbein1, Rachel Lawson2, Veleka Allen1, Xiaozhong Zhang3, Laura Chambre4, Stephen Ruhmel1, Sophie Wilhelm1, Fredric Marrache5, Maria Wiekowski1, Markus Kohlmann6 and Jeffrey Curtis7, 1Sanofi, Morristown, NJ, 2Sanofi, Earley, United Kingdom, 3Sanofi, Chengdu, China (People's Republic), 4Sanofi, Cambridge, MA, 5Sanofi, Gentilly, France, 6Sanofi, Frankfurt, Germany, 7University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Patients with rheumatoid arthritis (RA) are less physically active than the general population, and these activity differences can be measured through digital devices. This…
  • Abstract Number: 1310 • ACR Convergence 2025

    Naturalized Language Processing Based Extraction of Rheumatoid Arthritis Disease Activity Measures from the Electronic Health Record

    Elizabeth Park1, Iram Kamdar2, Reid Weisberg1, Andy Nguyen1, Joan Bathon3, Jon Giles4, Chunhua Weng5 and Elana Bernstein1, 1Columbia University Irving Medical Center, New York, NY, 2Columbia University Data Science Institute, New York, NY, 3Columbia University, NEW YORK, NY, 4Cedars-Sinai Medical Center, New York, NY, 5Columbia University Department of Biomedical Informatics, New York, NY

    Background/Purpose: A treat-to-target approach in rheumatoid arthritis (RA) requires intense monitoring of RA disease activity with measures such as the clinical disease activity index (CDAI).…
  • Abstract Number: 1199 • ACR Convergence 2025

    Interstitial Lung Disease in Systemic Autoimmune Rheumatic Diseases (SARDs): Radiologic and Histologic Correlations

    Darya S. Jalaledin1, Aidan pye2, Angela Chang2, Navid Saleh2, Saud AlHajeri3, Beatrice Daviault4, Arusa Shah5, Sabrina Hoa6, Océane Landon-Cardinal7, Alec Yu2, Robert Levy8, Jennifer Wilson9, Charles Poirier4, James Choi2, John Yee2, Hyein Kim2 and Kun Huang10, 1Université de Montréal, Saint-Lambert, QC, Canada, 2University of British Columbia, VANCOUVER, BC, Canada, 3University of British Columbia, Vancouver, Canada, 4University of Montreal, Montreal, QC, Canada, 5University of Montreal, Montreal, BC, Canada, 6University of Montreal, Brossard, QC, Canada, 7Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, 8University of British Columbia, Deerfield, IL, 9UBC, Vancouver, BC, Canada, 10University of British Columbia, Vancouver, Surrey, BC, Canada

    Background/Purpose: Systemic autoimmune rheumatic diseases (SARDs) are a major cause of interstitial lung disease (ILD), with high prevalence in inflammatory idiopathic myopathy (IIM), systemic sclerosis…
  • Abstract Number: 1041 • ACR Convergence 2025

    Associated Factors And Direct Cost Analysis Of Dose Reduction And Discontinuation Of Biological Therapies In Rheumatoid Arthritis And Spondyloarthritis: Findings From A Colombian Cohort Within The Framework Of An Integrated Management Model

    Edwin Jauregui1, Deisy Restrepo2, Belcy Garzon2, Alexis Atuesta2, Nestor Correa2, Jessica Barrera2 and Andrea Rubio2, 1Riesgo de fractura S.A, Bogotá, Colombia, 2Riesgo de fractura S.A, Bogotá, Colombia

    Background/Purpose: Dose reduction of biologic therapy (BT) in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) has been increasingly implemented in recent years, in accordance…
  • Abstract Number: 0988 • ACR Convergence 2025

    Distinct Effects of Inhibitory Receptor Agonism on RA Synovial CD4+ T Cell Functions

    Kazuhiko Higashioka1, John Sowerby1, Kathryne Marks2, Diana Pena-Nunez1, Margaret Chang3, Jonathan Coblyn1, Elena Massarotti1, Brian Jones4, Ling-Yang Hao4, Navin Rao4 and Deepak Rao2, 1Brigham and Women's Hospital, Boston, 2Brigham and Women's Hospital, Boston, MA, 3Boston Children's Hospital, Boston, MA, 4Janssen Research & Development, Spring House

    Background/Purpose: Autoreactive T cells play a crucial role in the autoimmune pathology of rheumatoid arthritis (RA). Activation of inhibitory receptors on T cells is a…
  • Abstract Number: 0872 • ACR Convergence 2025

    Silencing of Schnurri-3 protects from TNF-induced bone loss and is accompanied by upregulation of type I Interferon-Stimulated Genes (ISGs) in osteoblasts.

    Priyanka Kushwaha1, Albert Tai2, Catherine Manning3, Yeon Suk Yang4, Jae-Hyuck Shim4 and Ellen M. Gravallese5, 1Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Boston, MA, 2Department of Immunology, Tufts University School of Medicine, Boston, MA, 3Brigham and Women's Hospital at Harvard Medical School, Boston, MA, 42Department of Medicine/Division of Rheumatology, University of Massachusetts Chan Medical School, Worcester, MA, 5Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: Schnurri-3 (SHN3) is an adaptor protein and a negative regulator of osteoblast (OB) function. Its inhibition prevents bone loss and joint erosion in models…
  • Abstract Number: 0798 • ACR Convergence 2025

    Inhibition of Wnt Signaling Attenuates Inflammatory Arthritis Severity

    Alisa Mueller1, Angela Zou2, Lucy-Jayne Marsh3, Samuel Kemble3, Saba Nayar3, Gerald Watts4, Cassandra Murphy5, Emily Taylor3, Triin Major3, David Gardner6, Christopher Buckley7, Kevin Wei8, Soumya Raychaudhuri5, ilya Korsunsky5, Andrew Filer9, Adam Croft10 and Michael Brenner11, 1Stanford University and VA Palo Alto Health Care System, Stanford, CA, 2Harvard Medical School, Boston, MA, 3University of Birmingham, Birmingham, United Kingdom, 4Harvard Medical School, Brookline, MA, 5Brigham and Women's Hospital, Boston, MA, 6University of Birmingham, Havelock North, New Zealand, 7University of Oxford, Oxford, United Kingdom, 8Brigham and Women's Hospital at Harvard Medical School, Boston, MA, 9The University of Birmingham, Birmingham, United Kingdom, 10University of Birmingham, Hagley, Stourbridge, United Kingdom, 11Brigham and Women's Hospital, Harvard Medical School, Newton, MA

    Background/Purpose: Fibroblasts are critical in promoting pathogenic synovial inflammation and bone erosion in rheumatoid arthritis (RA). Moreover, recent studies have pointed to their potential contribution…
  • Abstract Number: 0496 • ACR Convergence 2025

    Certolizumab Pegol Shows a Higher Retention Rate Compared to JAK Inhibitors in Patients with Rheumatoid Arthritis, Regardless of Baseline Rheumatoid Factor Levels. A Multicenter Retrospective Study.

    Mitndbaim Parra1, Rafaela Ortega-Castro2, Jerusalén Calvo3, Francisco Jose Cepas4, Montserrat Robustillo-Villarino5, Andres Zuniga-Vera5, Ana Martinez-Feito6, Chamaida Plasencia-Rodríguez7, Ester Costa-Moya8, Delia Taverner-Torrent8, Luis Sainz Comas9, Cesar Diaz-Torne9, Virginia Ruiz-Esquide10, Cynthia Rojas11, Lourdes Martin-de la Sierra Lopez12, Laura Jimenez-Rodriguez12, David Velasco-Sanchez12, Regina Fará Garcia13, Antonio Juan-Mas14, Marina soledad Moreno Garcia15, Ana Valeria Acosta Alfaro16, Santiago Muñoz17, Maria Martín López18, Raquel Zas19, FRANCISCO JAVIER GODOY NAVARRETE20, Isabel Anon Onate21, Fernando Ortiz-Márquez22, Natalia Mena Vázquez23, Paula Estrada-Alarcón24, Lourdes Ladehesa25, Alejandro Escudero Contreras3 and Clementina López Medina26, 11. Rheumatology Department, Reina Sofía University Hospital, Cordoba/IMIBIC/University of Cordoba., Cordoba, Spain, 2Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Andalucia, Spain, 3IMIBIC / Reina Sofia Hospital / University of Cordoba, Córdoba, Spain, 4University of Cordoba, Cordoba, Spain, 5Department of Rheumatology, Hospital Universitario de la Plana, Vila-real, Castellón, Spain, Vila-real, Castellón, Spain, 6Hospital Universitario La Paz, Madrid, Madrid, Spain, 7Hospital Universitario La Paz, MADRID, Spain, 8Hospital Sant Joan Reus, Reus, Spain, 9Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, 10Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain, 11Hospital Clinic, Barcelona, Spain, 12Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, 13Hospital Son Llàtzer, Palma, Spain, 14Son Llazter University Hospital, Madrid, Spain, 15Hospital Universitario Miguel Servet, Zaragoza, Spain, 16Hospital Universitario Infanta Sofia; Universidad Europea de Madrid; FIIB HUIS-HUHEN, Madrid, Spain, 17Hospital Universitario Infanta Sofía;Universidad Europea de Madrid. Faculty of Medicine, Health and Sports. Department of Medicine; FIIB HUIS-HUHEN, Madrid, Spain, 18Hospital 12 de Octubre, Madrid, Spain, 19Hospital Universitario Doce de Octubre, Madrid, Spain, 20Jaen University Hospital, Spain, Jaen, Spain, 21Hospital Universitario de Jaén, Jaén, Spain, 22Department of Rheumatology, Hospital Regional Universitario de Málaga, Málaga, Spain, Malaga, Spain, 23Hospital Regional Universitario de Malaga, Malaga, Spain, Málaga, Spain, 24Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain, 25IMIBIC-Reina Sofia Hospital-University of Cordoba, Cordoba, Spain, Cordoba, Spain, 26Department of Medicine, Hospital Universitario Reina Sofia, University of Cordoba, IMIBIC, Cordoba, Spain

    Background/Purpose: Rheumatoid factor (RF) is an antibody directed against the Fc fragment of IgG that plays a key role in the development of rheumatoid arthritis…
  • Abstract Number: 0479 • ACR Convergence 2025

    Risk of Arrhythmias Following IL-6 Inhibitor Use; A Pharmacosurvellience Study of FDA Adverse Event Reporting System (FAERS)

    Asim Khanfar1, Omar Hamdan2, Shiamak Cooper3, Sanjana Thimmannagari1 and Anthony Ocon4, 1Rochester General Hospital, Rochester, NY, 2University of Jordan, Az-Zarqa, Jordan, 3Rochester General Hospital, Irondequoit, NY, 4Rochester Regional Health, Fairport, NY

    Background/Purpose: Interleukin-6 (IL-6) inhibitors, including tocilizumab and sarilumab, are immunomodulatory agents commonly used in the treatment of rheumatoid arthritis and COVID-19. Prior studies have implicated…
  • Abstract Number: 0464 • ACR Convergence 2025

    Synovial Inflammation is not Associated With Reoperation in Patients With Rheumatoid Arthritis Undergoing Total Hip or Knee Arthroplasty

    Solana Cushing1, Kelsey Gripp2, Edward DiCarlo3, Deanna Jannat-Khah1, Yoshimi Endo3, Jose Rodriguez3, Mark Figgie3, Bella Mehta4 and Susan Goodman3, 1Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, New York, 3Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 4Hospital for Special Surgery, Weill Cornell Medicine, Jersey City, NJ

    Background/Purpose: Reoperations following arthroplasty are a significant burden to patients and surgeons. In patients with RA who receive total hip (THA) or knee (TKA) arthroplasty,…
  • Abstract Number: 0446 • ACR Convergence 2025

    A Balancing Act: The Interplay Between Resilience and Frailty in Rheumatoid Arthritis

    Hannah Brubeck1, Kylie Riggles1, Adrienne Tanus1, Nadine El-ayache2, George Mount2, Elizabeth Wahl2, Courtney Loecker3, Jose Garcia4, Dolores Shoback5, Joshua Baker6, Patti Katz7, Ariela Orkaby8 and Katherine Wysham9, 1VA Puget Sound Health Care System, Seattle, WA, 2VA Puget Sound Health Care System & University of Washington, Seattle, WA, 3University of Nebraska Medical Center, Omaha, 4VA Puget Sound Health Care System, VA GRECC, and University of Washington, Seattle, WA, 5San Francisco VA Medical Center & University of California San Francisco, San Francisco, CA, 6University of Pennsylvania, Philadelphia, PA, 7UCSF, San Rafael, CA, 8VA Boston Healthcare System & Division of Aging, Brigham and Women’s Hospital, Harvard Medical School & VA Geriatrics Research Education and Clinical Center, Boston, MA, 9VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA

    Background/Purpose: Frailty, a state of decreased physiological reserve and heightened vulnerability to stressors, occurs prematurely in rheumatoid arthritis (RA) and is associated with poor health…
  • Abstract Number: 0430 • ACR Convergence 2025

    Retrospective evaluation of the clinical impact of democgraphic , serological , clinical , radiological parameters and treatment modalities in patients with RA-ILD

    fatih ŞAhiner1, Mine Nokay2, funda erbasan2, Veli Yazisiz3 and Ender terzioglu2, 1Akdeniz University, Antalya, 2Akdeniz University, Antalya, Turkey, 3Akdeniz University, Faculty of Medicine, Antalya, Turkey

    Background/Purpose: RA-ILD is significant determinants of morbidity and mortality. This study aims to evaluate the demographic and serological characteristics of RA-ILD patients and investigate the…
  • Abstract Number: 0222 • ACR Convergence 2025

    Evaluating the Barriers and Facilitators for Collecting and Documenting Rheumatoid Arthritis Disease Activity Measures Using a Rheumatology Provider Survey

    Isaac Smith1, Linda Tovar2, Michael Battistone2, Andrea Barker3, Bryant England4, Ankoor Shah5, Joshua Baker6, Katherine Wysham7, Beth Wallace8, Ted Mikuls4, Deanna Lazaro9, Pascale Schwab10, Paul Monach11, Gail Kerr12, Andreas Reimold13, Gary Kunkel2, Liron Caplan14, John Richards15, Aleksander Lenert16, Andrew Jones17, Maria I. ("Maio") Danila18, Brian Sauer19, Jorge Rojas20 and Grant Cannon21, 1Duke University Hospital, Durham, NC, 2Salt Lake City VA, Salt Lake City, UT, 3Salt Lake City VA, Cottonwood Heights, UT, 4University of Nebraska Medical Center, Omaha, NE, 5Duke University, Durham, NC, 6University of Pennsylvania, Philadelphia, PA, 7VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 8Michigan Medicine, VA Ann Arbor Healthcare System, Ann Arbor, MI, 9VA New York Harbor Healthcare System, Brooklyn, NY, 10Oregon Health & Science University, Portland, OR, 11VA Boston Healthcare System, Boston, MA, 12Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 13Dallas VA Medical Center, Dallas, TX, 14University of Colorado, Denver, CO, 15Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, 16Iowa Carver College of Medicine, Iowa City, IA, 17VA Saint Louis and Washington University, Saint Louis, 18University of Alabama at Birmingham (UAB), Birmingham VA Medical Center, Birmingham, AL, 19Salt Lake City VA/University of Utah, Salt Lake City, UT, 20VA Puget Sound Health Care System, Seattle, WA, 21University of Utah and Salt Lake City VA, Salt Lake City, UT

    Background/Purpose: Collection of disease activity measures (DAMs) is a key component of high-quality care for rheumatoid arthritis (RA) patients. This study surveyed rheumatology providers at…
  • Abstract Number: 0155 • ACR Convergence 2025

    Effect Modification of Cigarette Smoking on the Relationship between Post Traumatic Stress Disorder and Rheumatoid Arthritis Risk

    Kelsey Coziahr1, Harlan Sayles1, Tate Johnson1, Joshua Baker2, Punyasha Roul3, Grant Cannon4, Gary Kunkel5, Bryant England1 and Ted Mikuls1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Pennsylvania, Philadelphia, PA, 3UNMC, Omaha, NE, 4University of Utah and Salt Lake City VA, Salt Lake City, UT, 5Salt Lake City VA, Salt Lake City, UT

    Background/Purpose: Post-traumatic stress disorder (PTSD) is associated with increased systemic inflammation that may increase the risk of developing autoimmune disorders such as rheumatoid arthritis (RA).…
  • Abstract Number: 0084 • ACR Convergence 2025

    Regulation of the same chemokine gene transcription by different histone lysine methyltransferases, MLL1 and MLL3, in rheumatoid arthritis synovial fibroblasts

    Keita Okamoto1, Yasuto Araki2, Yoshimi Aizaki2, Hiroshi Kajiyama3, Kazuhiro Yokota2, Yu Funakubo2, Yuho Kadono4, Yuji Akiyama5 and Toshihide Mimura6, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Moroyama-chou, Iruma-gun, Saitama, Japan, 2Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 3Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Iruma-gun, Saitama, Japan, 4Department of Orthopaedic Surgery, Saitama Medical University, Moroyama-machi, Iruma-gun, Saitama, Japan, 5Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Moroyama-machi, Iruma-gun, Saitama, Japan, 6Saitama Seikeikai Hospital, Higashimatsuyama, Saitama, Japan

    Background/Purpose: Rheumatoid arthritis synovial fibroblasts (RASFs) produce various matrix metalloproteinases (MMPs), cytokines, and chemokines. Histone lysine methylation has been shown to play an important role…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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