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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 0446 • ACR Convergence 2025

    A Balancing Act: The Interplay Between Resilience and Frailty in Rheumatoid Arthritis

    Hannah Brubeck1, Kylie Riggles1, Adrienne Tanus1, Nadine El-ayache2, George Mount2, Elizabeth Wahl2, Courtney Loecker3, Jose Garcia4, Dolores Shoback5, Joshua Baker6, Patti Katz7, Ariela Orkaby8 and Katherine Wysham9, 1VA Puget Sound Health Care System, Seattle, WA, 2VA Puget Sound Health Care System & University of Washington, Seattle, WA, 3University of Nebraska Medical Center, Omaha, 4VA Puget Sound Health Care System, VA GRECC, and University of Washington, Seattle, WA, 5San Francisco VA Medical Center & University of California San Francisco, San Francisco, CA, 6University of Pennsylvania, Philadelphia, PA, 7UCSF, San Rafael, CA, 8VA Boston Healthcare System & Division of Aging, Brigham and Women’s Hospital, Harvard Medical School & VA Geriatrics Research Education and Clinical Center, Boston, MA, 9VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA

    Background/Purpose: Frailty, a state of decreased physiological reserve and heightened vulnerability to stressors, occurs prematurely in rheumatoid arthritis (RA) and is associated with poor health…
  • Abstract Number: 0430 • ACR Convergence 2025

    Retrospective evaluation of the clinical impact of democgraphic , serological , clinical , radiological parameters and treatment modalities in patients with RA-ILD

    fatih ŞAhiner1, Mine Nokay2, funda erbasan2, Veli Yazisiz3 and Ender terzioglu2, 1Akdeniz University, Antalya, 2Akdeniz University, Antalya, Turkey, 3Akdeniz University, Faculty of Medicine, Antalya, Turkey

    Background/Purpose: RA-ILD is significant determinants of morbidity and mortality. This study aims to evaluate the demographic and serological characteristics of RA-ILD patients and investigate the…
  • Abstract Number: 0222 • ACR Convergence 2025

    Evaluating the Barriers and Facilitators for Collecting and Documenting Rheumatoid Arthritis Disease Activity Measures Using a Rheumatology Provider Survey

    Isaac Smith1, Linda Tovar2, Michael Battistone2, Andrea Barker3, Bryant England4, Ankoor Shah5, Joshua Baker6, Katherine Wysham7, Beth Wallace8, Ted Mikuls4, Deanna Lazaro9, Pascale Schwab10, Paul Monach11, Gail Kerr12, Andreas Reimold13, Gary Kunkel2, Liron Caplan14, John Richards15, Aleksander Lenert16, Andrew Jones17, Maria I. ("Maio") Danila18, Brian Sauer19, Jorge Rojas20 and Grant Cannon21, 1Duke University Hospital, Durham, NC, 2Salt Lake City VA, Salt Lake City, UT, 3Salt Lake City VA, Cottonwood Heights, UT, 4University of Nebraska Medical Center, Omaha, NE, 5Duke University, Durham, NC, 6University of Pennsylvania, Philadelphia, PA, 7VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 8Michigan Medicine, VA Ann Arbor Healthcare System, Ann Arbor, MI, 9VA New York Harbor Healthcare System, Brooklyn, NY, 10Oregon Health & Science University, Portland, OR, 11VA Boston Healthcare System, Boston, MA, 12Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 13Dallas VA Medical Center, Dallas, TX, 14University of Colorado, Denver, CO, 15Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, 16Iowa Carver College of Medicine, Iowa City, IA, 17VA Saint Louis and Washington University, Saint Louis, 18University of Alabama at Birmingham (UAB), Birmingham VA Medical Center, Birmingham, AL, 19Salt Lake City VA/University of Utah, Salt Lake City, UT, 20VA Puget Sound Health Care System, Seattle, WA, 21University of Utah and Salt Lake City VA, Salt Lake City, UT

    Background/Purpose: Collection of disease activity measures (DAMs) is a key component of high-quality care for rheumatoid arthritis (RA) patients. This study surveyed rheumatology providers at…
  • Abstract Number: 0155 • ACR Convergence 2025

    Effect Modification of Cigarette Smoking on the Relationship between Post Traumatic Stress Disorder and Rheumatoid Arthritis Risk

    Kelsey Coziahr1, Harlan Sayles1, Tate Johnson1, Joshua Baker2, Punyasha Roul3, Grant Cannon4, Gary Kunkel5, Bryant England1 and Ted Mikuls1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Pennsylvania, Philadelphia, PA, 3UNMC, Omaha, NE, 4University of Utah and Salt Lake City VA, Salt Lake City, UT, 5Salt Lake City VA, Salt Lake City, UT

    Background/Purpose: Post-traumatic stress disorder (PTSD) is associated with increased systemic inflammation that may increase the risk of developing autoimmune disorders such as rheumatoid arthritis (RA).…
  • Abstract Number: 0084 • ACR Convergence 2025

    Regulation of the same chemokine gene transcription by different histone lysine methyltransferases, MLL1 and MLL3, in rheumatoid arthritis synovial fibroblasts

    Keita Okamoto1, Yasuto Araki2, Yoshimi Aizaki2, Hiroshi Kajiyama3, Kazuhiro Yokota2, Yu Funakubo2, Yuho Kadono4, Yuji Akiyama5 and Toshihide Mimura6, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Moroyama-chou, Iruma-gun, Saitama, Japan, 2Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 3Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Iruma-gun, Saitama, Japan, 4Department of Orthopaedic Surgery, Saitama Medical University, Moroyama-machi, Iruma-gun, Saitama, Japan, 5Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Moroyama-machi, Iruma-gun, Saitama, Japan, 6Saitama Seikeikai Hospital, Higashimatsuyama, Saitama, Japan

    Background/Purpose: Rheumatoid arthritis synovial fibroblasts (RASFs) produce various matrix metalloproteinases (MMPs), cytokines, and chemokines. Histone lysine methylation has been shown to play an important role…
  • Abstract Number: 0066 • ACR Convergence 2025

    RA-required synovial tissue-resident monocyte lineage cells are comprised of three distinct subpopulations.

    Yidan Wang1, Samuel Dowling2, Jessica Maciuch2, Vanessa Manada De Lobos2, Meghan Mayer2, Kainat Mian1, Tyler Therron3, Hadijat Makinde1, Carla Marie Cuda1, Deborah Rachelle Winter4 and Harris R Perlman1, 1Northwestern University, Chicago, IL, 2Northwestern University, Chicago, 3Northwestern Feinberg School of Medicine, Chicago, IL, 4Northwestern University, Skokie, IL

    Background/Purpose: Tissue-resident monocyte-lineage cell (TRMC) are an extravascular population distinct from circulating monocytes and synovial macrophages and are critical for the development of inflammatory arthritis.…
  • Abstract Number: 0013 • ACR Convergence 2025

    Discovery and Characterization of SIM0710, a Novel B and T Lymphocyte Attenuator (BTLA) Agonistic Antibody for Autoimmune/Inflammatory Diseases

    Xiaofeng Zhao1, Xiaoqing Liu1, Yuxi Yan2, Tiezheng Liu3, Yong Fu3, Yulan Hu2, Kangmin Zhou2, Minyun Zhou4, Yingying Hu2 and Shunwei Zhu2, 1State Key Laboratory of Neurology and oncolog Drug Development, Simcere Pharmaceutical Group, Nanjing, China (People's Republic), 2State Key Laboratory of Neurology and Oncology Drug Development, Simcere Pharmaceutical Group, Shanghai, China (People's Republic), 3State Key Laboratory of Neurology and Oncology Drug Development, Simcere Pharmaceutical Group, Nanjing, China (People's Republic), 4State Key Laboratory of Neurology and Oncology Drug Development, Simcere Pharmaceutical group, Nanjing

    Background/Purpose: B and T lymphocyte attenuator (BTLA) is an immune checkpoint molecule that contributes to the regulation of T cell, B cell and dendritic cell…
  • Abstract Number: 2639 • ACR Convergence 2025

    Gut Microbiome Signatures Forecast Clinical Response to Methotrexate in Treatment-Naïve Early Rheumatoid Arthritis

    VINOD GUPTA1, Adam Koller1, Benjamin Hur1, Marissa Bailey1, Kara Delger2, Elena myasoedova1, Vanessa Kronzer1, John Davis1 and Jaeyun Sung1, 1Mayo Clinic, ROCHESTER, MN, 2Mayo Clinic, St Charles, MN

    Background/Purpose: Oral methotrexate (MTX) is the cornerstone treatment for newly diagnosed rheumatoid arthritis (RA), yet up to 50% of patients do not respond adequately. Early…
  • Abstract Number: 2288 • ACR Convergence 2025

    Efficacy of Ivarmacitinib in Patients with Moderate-to-severe Rheumatoid Arthritis Stratified by Baseline Characteristics: A Post-hoc Study of a Phase III Clinical Trial

    Yuan Xue, Bo Wei, Xiaojing Huang and Rui Ding, Zhongshan Hospital Xiamen University, Xiamen, China (People's Republic)

    Background/Purpose: Ivarmacitinib (SHR0302), a selective Janus kinase 1 inhibitor, has demonstrated efficacy in patients with moderate-to-severe rheumatoid arthritis (RA). This post-hoc study aimed to evaluate…
  • Abstract Number: 2272 • ACR Convergence 2025

    Combination Therapy with TNF Inhibitors and JAK Inhibitors in Multi-Drug-Resistant Rheumatoid Arthritis: A Case Series from the RA UCLouvain Brussels Cohort

    Francesco NATALUCCI1, Cécile VAN MULLEM1, Aleksandra AVRAMOVSKA1, Tatiana SOKOLOVA2 and Patrick Durez1, 1Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCLouvain) – Institut de Recherche Expérimentale et Clinique (IREC), Rheumatology, Brussels, Belgium, 2Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCLouvain) – Institut de Recherche Expérimentale et Clinique (IREC), Rheumatology, Brussels, Brussels Hoofdstedelijk Gewest, Belgium

    Background/Purpose: Rheumatoid Arthritis (RA) is a chronic autoimmune disease with persistent synovial inflammation. Several bDMARDs and tsDMARDs target different key players in the immune-regulatory pathways,…
  • Abstract Number: 2256 • ACR Convergence 2025

    Improved Outcomes of Acute Myocardial Infarction Among Patients with Rheumatoid Arthritis: A Propensity Matched National Study

    Qurat Ul Ain1 and MIrza faris Ali Baig2, 1Medstar Georgetown University Hospital, Arlington, VA, 2Medstar Health, Arlington, VA

    Background/Purpose: The increased risk of cardiovascular morbidity and mortality with rheumatoid arthritis has been increasingly acknowledged over the past decades. Cardiovascular disease risk management for…
  • Abstract Number: 2240 • ACR Convergence 2025

    Diabetes Significantly Amplifies Risk of Cardiac Arrhythmias in Rheumatoid Arthritis Patients: Results from a Multi-Center Electronic Health Record Study

    Godbless Ajenaghughrure1, Sila Mateo Faxas2, Gurjot Singh3, Nirys Mateo Faxas4, Kim Nguyen3, Nicole Tejeda5 and Kimberly Ramirez Bonetti6, 1Trihealth Good Samaritan Hospital, Cincinnati, OH, 2Good Samaritan Hospital, Cincinnati, OH, 3Trihealth Good Samaritan Hospital, Cincinnati, 4Independent Author, Santo Domingo, Dominican Republic, 5Independent Author, Cincinnati, 6Independent Author, cincinnati, OH

    Background/Purpose: Both rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM) are independently associated with increased cardiovascular risk. However, the impact of T2DM on cardiac…
  • Abstract Number: 2197 • ACR Convergence 2025

    Mechanisms of Fetal Growth Restriction in Rheumatologic Autoimmune Diseases: Insights into Placental Pathology and Immune Dysregulation

    Larabe Farrukh1, Ananya Venkatesh2, Mana Parast2 and Chelsey Smith3, 1University of California San Diego, San Diego, CA, 2University of California San Diego, San Diego, 3University of California San Diego, LA JOLLA, CA

    Background/Purpose: Fetal growth restriction (FGR) significantly contributes to adverse pregnancy outcomes (APOs) in women with rheumatologic diseases. Understanding the immunopathologic mechanisms underlying FGR is critical…
  • Abstract Number: 1947 • ACR Convergence 2025

    Coronary computed tomography incidental findings in rheumatoid arthritis.

    Emmanuel Tapia López1, Jessica Roldan Ortega2, Evelyn Aranda Cano3, Itzel Palafox Sosa4, Luz Viruel5, Luis H Silveira6, Laura Aline Martinez-Martinez7 and Francisco Castillo-Castellon8, 1Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico, Naucalpan de Juarez, Estado de México, Mexico, 2INSTITUTO NACIONAL DE CARDIOLOGIA, Ciudad de México, Federal District, Mexico, 3Departament of rheumatology Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de Mexico, Federal District, Mexico, 4Escuela Superior de Medicina-Instituto Politècnico Nacional, ciudad de mexico, Federal District, Mexico, 5Universidad Autónoma del Estado de Hidalgo, Tula de Allende, Hidalgo, Mexico, 6Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico, Mexico City, Mexico, 7Rheumatology Department at National Institute of Cardiology Ignacio Chávez, Mexico City, Federal District, Mexico, 8Instituto Nacional de Cardiología Ignacio Chavez, Mexico

    Background/Purpose: Patients with rheumatoid arthritis (RA) have a greater cardiovascular risk than does the general population. The coronary calcium score is a measure used to…
  • Abstract Number: 1880 • ACR Convergence 2025

    Rheumatoid Arthritis Mortality in the U.S. (1999–2020): A Decline in Rates, But Not in Disparities

    Aziz-ur-Rahman Khalid1, Ghassan Makhoul2, Hasan Munshi2, Islam Rajab2, Emmanuel Olumuyide3, MD Walid Akram Hussain2, Aqsa Sorathia2, Elvira Assaf2, Amer Al Badawy2, John Salama2 and Robert Lahita4, 1St. Joseph's University Medical Center, wayne, 2St. Josephs University Medical Center, Paterson, 3Advocate Illinois Masonic Medical Center, Chicago, 4St. Josephs University Medical Center, Wayne, NJ

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease associated with increased morbidity and mortality. While treatments have evolved, national trends and sociodemographic disparities in…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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