Abstracts tagged "rheumatoid arthritis"

Abstract Number: 1181 • 2012 ACR/ARHP Annual Meeting
The Role of á-Defensin-1 and Its Signal Transduction Mechanisms in the Production of IL-6, IL-8 and MMPs in Rheumatoid Fibroblast-Like Synoviocytes
Joong Kyong Ahn¹, Bo Huang², Eun-Jung Park², Jiwon Hwang³, Jaejoon Lee², Chan Hong Jeon⁴, Eunmi Koh² and Hoon-Suk Cha⁵, ¹Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³Department of Medicine,Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea, ⁵Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose: Fibroblast-like synoviocytes (FLS) play an essential role in the pathophysiology of rheumatoid arthritis (RA). Also, neutrophils are the most abundant cell type of synovial…
Abstract Number: 419 • 2012 ACR/ARHP Annual Meeting
Epigenome Analysis of Rheumatoid Arthritis Synovial Fibroblasts Revealed TBX-5 As a Novel Transcription Factor in Chemokine Regulation
Emmanuel Karouzakis¹, Michelle Trenkmann², Renate E. Gay¹, Beat A. Michel¹, Steffen Gay¹ and Michel Neidhart¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland
Background/Purpose: Changes in DNA methylation and histone marks have been associated with diseases such as cancer, rheumatoid arthritis (RA) and systemic lupus erythematosus. Previously, we…
Abstract Number: 2343 • 2012 ACR/ARHP Annual Meeting
The Therapeutic Antibody Tregalizumab (BT-061) Induces Activation of Regulatory T Cells by Engaging a Unique CD4 Mediated Signaling That Strongly Differs From Signaling Events Induced by Standard Anti-CD4 Antibodies
Bianca Helling¹, Benjamin Daelken¹, Holger Wallmeier², Silke Aigner¹, Chantal Zuber¹, Martin Koenig¹, Andre Engling¹, Frank Osterroth¹, Niklas Czeloth³ and Christoph Uherek¹, ¹Biotest AG, Dreieich, Germany, ²Condor Scientific Computing & Consulting, Sulzbach, Germany, ³Global Research Immunology, Biotest AG, Dreieich, Germany
Background/Purpose: The humanized CD4 specific monoclonal antibody (mAb) tregalizumab is currently being tested in phase II clinical trials in Rheumatoid Arthritis. In contrast to other…
Abstract Number: 1696 • 2012 ACR/ARHP Annual Meeting
Quantitative Evaluation of Dermal Atrophy by High-Resolution Ultrasonography, Comparing Between Patients Under Long-Term Treatment with Prednisolone or Methylprednisolone
Tim Pottel¹, Christoph Schäfer² and Gernot Keyßer², ¹Universitätsklinikum Kröllwitz, Department of Internal Medicine II, 06114 Halle (Saale), Germany, ²Universitätsklinikum Kröllwitz, Department of Internal Medicine II, 06120 Halle (Saale), Germany
Background/Purpose: The katabolic effects of a systemic treatment with glucocorticoids can lead to a progressive atrophy of the skin. Clinical observation suggests a more pronounced…
Abstract Number: 1187 • 2012 ACR/ARHP Annual Meeting
Smoking Status Is Associated with Inflammatory Cytokine Profile and Disease Activity in Anti-Citrullinated Protein Antibody Positive Rheumatoid Arthritis: Decreased Inflammation and Disease Improvement with Smoking Cessation?
Catriona Cramb¹, Jeremy Sokolove², Geoffrey M. Thiele³, Gail S. Kerr⁴, Grant W. Cannon⁵, Andreas M. Reimold⁶, Ted R. Mikuls⁷ and William H. Robinson⁸, ¹VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, ²Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ³Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE, ⁴Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, ⁵Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁶Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, ⁷Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁸Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Smoking is a major risk factor for rheumatoid arthritis (RA) and has been associated with increased disease severity and lower rates disease remission. We…
Abstract Number: 375 • 2012 ACR/ARHP Annual Meeting
Cell Phone Based Automated Monitoring of Patients with Early Rheumatoid Arthritis
Kari Puolakka¹, Tuulikki Sokka² and Hannu Kautiainen³, ¹Department of Medicine, South Karelia Central Hospital, Lappeenranta, Finland, ²Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland, ³Unit of Primary Health Care, Helsinki University Central Hospital, Helsinki, Finland
Cell phone based automated monitoring of patients with early rheumatoid arthritis Background/Purpose: Frequent monitoring improves patient compliance and outcomes of RA. Limited resources may hinder adherence…
Abstract Number: 2171 • 2012 ACR/ARHP Annual Meeting
Comparative Efficacy of Biologics As Monotherapy and in Combination with Methotrexate in Rheumatoid Arthritis Patients with an Inadequate Response to Conventional Dmards: A Network Meta-Analysis
Felicity Buckley¹, Axel Finckh², Thomas W. Huizinga³, Fred Dejonckheere⁴ and Jeroen P. Jansen¹, ¹MAPI Consultancy, Boston, MA, ²Rhumatology, University Hospital of Geneva, Geneva, Switzerland, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴F. Hoffmann-La Roche Ltd, Basel, Switzerland
Background/Purpose: A number of meta-analyses compare the efficacy of biologics for rheumatoid arthritis (RA). However, systematic reviews comparing the efficacy of biologics as monotherapy versus…
Abstract Number: 1662 • 2012 ACR/ARHP Annual Meeting
Anti-IL-6 Therapy Impairs Intestinal Repair Through Inhibition of Epithelial Proliferation After Injury
Kristine Kuhn¹, Hiroyuki Miyoshi², Nicholas A. Manieri², Nicole P. Malvin², Vinieth Bijanki², Paul Allen² and Thaddeus S. Stappenbeck², ¹Internal Medicine, Washington University School of Medicine, St. Louis, MO, ²Pathology and Immunology, Washington University School of Medicine, St. Louis, MO
Background/Purpose: Inhibition of IL-6 is used for treatment of rheumatoid arthritis and now being investigated as biologic therapy for a wide variety of autoimmune conditions,…
Abstract Number: 1014 • 2012 ACR/ARHP Annual Meeting
Trimmed Analyses, a New Approach to the Analysis of Sharp Score Data in the Assessment of Progression in Patients with Rheumatoid Arthritis
Robert B. M. Landewé¹, Désirée van der Heijde², Carol Connell³, John Bradley⁴, David Gruben³ and Michael Brown³, ¹Academic Medical Center/University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Pfizer Inc., Groton, CT, ⁴Pfizer Inc, Groton, CT
Background/Purpose: Tofacitinib is a novel oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy for RA. In the Phase 3 ORAL…
Abstract Number: 382 • 2012 ACR/ARHP Annual Meeting
Does Biased Risk Perception Explain the Underuse of Disease Modifying Anti-Rheumatic Drugs?
Richard W. Martin¹, Andrew J. Head², James D. Birmingham³ and Aaron T. Eggebeen¹, ¹Medicine, Rheumatology, Michigan State University College of Human Medicine, Grand Rapids, MI, ²Medicine, Rheumatology, College of Human Medicine, Michigan State University, Grand Rapids, MI, ³Medicine & Pediatrics, Rheumatology, Michigan State University College of Human Medicine, Grand Rapids, MI
Background/Purpose: The prescription of a Disease Modifying Anti-rheumatic Drugs (DMARD) for patients with rheumatoid arthritis (RA) is considered a standard of effective care. However a…
Abstract Number: 2145 • 2012 ACR/ARHP Annual Meeting
Age At Onset Determines Severity and choice of Treatment in Early Rheumatoid Arthritis
Lena Innala¹, Bozena Möller², Lotta Ljung³, Torgny Smedby⁴, Anna Södergren⁵, Staffan Magnusson⁶, Ewa H. Berglin⁵, Solbritt M. Rantapää-Dahlqvist⁷ and Solveig Wållberg-Jonsson⁵, ¹Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Rheumatology, Sweden, Umeå, Sweden, ²Department of Rheumatology, Sunderby Hospital, Luleå, Sweden, ³Clinical epidemiology unit, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Rheumatology, Östersund hospital, Östersund, Sweden, ⁵Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Umeå, Sweden, ⁶Department of Internal Medicine, Sundsvall Hospital, Sundsvall, Sweden, ⁷Department for Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden
Background/Purpose: Mortality is increased in rheumatoid arthritis (RA). Contributing factors are disease activity/severity and comorbidity. A relationship between age at onset and pharmacological treatment has…
Abstract Number: 1669 • 2012 ACR/ARHP Annual Meeting
Infection Risk After Orthopaedic Surgery in Patients with Inflammatory Rheumatic Diseases, with Focus On Discontinuation of TNF-Alpha-Inhibitors
Catrina B. Scherrer¹, Anne AF Mannion², Diego Kyburz³, Markus Vogt⁴ and Ines A. Kramers-de Quervain¹, ¹Rheumatology, Schulthess Clinic, Zürich, Switzerland, ²Research Department, Schulthess Clinic, Zürich, Switzerland, ³Department of Rheumatology, University Hospital of Zurich, Zurich, Switzerland, ⁴Infectious Diseases Service, Cantonal Hospital Zug, Baar, Switzerland
Background/Purpose: Infections after orthopaedic surgeries are feared complications, leading to costly treatments and successive interventions. A higher postoperative infection risk is discussed in patients with…
Abstract Number: 901 • 2012 ACR/ARHP Annual Meeting
Colony-Stimulating Factor (CSF) Receptor 1 Blockade Overcomes Overlapping Effects of M-CSF and Interleukin-34 On Myeloid Differentiation and Gene Expression to Reduce Inflammation in Human and Murine Models of Rheumatoid Arthritis
Samuel Garcia¹, Linda M. Hartkamp², Inge E. van Es², Haishan Lin³, Li Long³, Emma L. Masteller³, Brian R. Wong³, Paul P. Tak⁴ and Kris A. Reedquist², ¹Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Five Prime Therapeutics, Inc., South San Francisco, CA, ⁴Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: Disease activity and response to therapy in RA correlates with changes in synovial macrophage numbers and their products. M-CSF or IL-34 stimulation of their…
Abstract Number: 389 • 2012 ACR/ARHP Annual Meeting
Oral Glucocorticoid Sparing Effects of Rituximab in Rheumatoid Arthritis Patients Who Have Switched from an Anti-TNF Therapy – an Administrative Claims Database Analysis
Stephen Johnston¹, Tripthi Kamath², Nianwen Shi³, Robert Fowler³, Bong-Chul Chu³ and William Reiss⁴, ¹Truven Health Analytics, Bethesda, MD, ²Genentech, South San Francisco, CA, ³Truven Health Analytics, Washington, DC, ⁴Genentech Inc., South San Francisco, CA
Background/Purpose: The current treatment paradigm in RA is to attempt to decrease concomitant use of oral glucocorticoids (OGC). This study examined the OGC-sparing effects of…
Abstract Number: 2149 • 2012 ACR/ARHP Annual Meeting
Atsttrin-â, an Engineered Protein Derived From Progranulin Growth Factor, Binds to TNF Receptors and Exhibits Potent Anti-Inflammatory Activity in Mice
Yunpeng Zhao, Qingyun Tian, Haicheng Song, Fanhua Wei and Chuanju Liu, Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY
Background/Purpose: Progranulin (PGRN) is a multifunctional growth factor. Recently, we reported that PGRN and its derived protein Atsttrin-α (referred to as “Atsttrin” in our previous…

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