ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 511 • 2014 ACR/ARHP Annual Meeting

    First and Second Line Continuation Rates of Non Anti-TNF-α Biological DMARD for the Treatment of Rheumatoid Arthritis

    Tristan Pascart1, Rene-Marc Flipo2, Xavier Deprez3 and Eric Houvenagel4, 1Rheumatology, Saint-Philibert Hospital, Lille, France, 2Rheumatology, University Hospital Lille, Lille, France, 3Rhumatologie, Ch De Valenciennes, Valenciennes, France, 4Rheumatology, Saint-Philibert Hospital, LOMME, France

    Background/Purpose The 2013 update of the EULAR recommendations for the management of RA with synthetic and biological DMARDs set non-anti-TNF- α as first-line biological treatments.…
  • Abstract Number: 2507 • 2014 ACR/ARHP Annual Meeting

    Is There an Autoinflammatory Component in Rheumatoid Arthritis Associated with Better Response to Anakinra (Kineret®)?

    Barbara Missler-Karger1, Hans-Eckhard Langer2, Mika Leinonen3 and Björn Pilström4, 1Rheumatology consultant, Cologne, Germany, 2RHIO Research Institute, Düsseldorf, Germany, 34Pharma AB, Stockholm, Sweden, 4TA Inflammation, Swedish Orphan Biovitrum AB, Stockholm, Sweden

    Background/Purpose 458 patients with rheumatoid arthritis (RA) and inadequate response to traditional DMARDs alone and/or TNFα blocking agents were treated with the IL-1 receptor antagonist…
  • Abstract Number: 1498 • 2014 ACR/ARHP Annual Meeting

    ALX-0061, an Anti-IL-6R Nanobody® for use in Rheumatoid Arthritis, Demonstrates a Different in Vitro Profile As Compared to Tocilizumab

    Maarten Van Roy1, Ariella Van De Sompel2, Kristi De Smet2, Jasper Jacobs2, Tinneke Denayer2 and Hans Ulrichts3, 1Department of Pharmacology, Ablynx N.V., Zwijnaarde, Belgium, 2Ablynx N.V., Zwijnaarde, Belgium, 3Pharmacology, Ablynx N.V., Zwijnaarde, Belgium

    Background/Purpose Interleukin-6 (IL-6) is a pleiotropic cytokine inducing a wide range of biological activities via its receptor, which can either be soluble (sIL-6R) or membrane-bound…
  • Abstract Number: 515 • 2014 ACR/ARHP Annual Meeting

    Dosing of Intravenous Tocilizumab in a Real-World Setting—Analyses from a US RA Registry

    Dimitrios A. Pappas1, Ani John2, Jeffrey R. Curtis3, George W. Reed4,5, Chitra Karki6, Robert Magner5, Joel M. Kremer7, Ashwini Shewade2 and Jeffrey D. Greenberg6,8, 1Columbia University, New York, NY, 2Genentech, Inc, South San Francisco, CA, 3University of Alabama at Birmingham, Birmingham, AL, 4Corrona, LLC., Southborough, MA, 5University of Massachusetts Medical School, Worcester, MA, 6Corrona, LLC, Southborough, MA, 7Albany Medical College and The Center for Rheumatology, Albany, NY, 8NYU School of Medicine, New York, NY

    Background/Purpose: In the US, the recommended starting dose of intravenous tocilizumab (TCZ) in combination with DMARDs or as monotherapy is 4 mg/kg every 4 weeks…
  • Abstract Number: 2501 • 2014 ACR/ARHP Annual Meeting

    Indirect Comparison of Tocilizumab and Tofacitinib in Patients with Rheumatoid Arthritis

    Stacey Chang1, Laura Sawyer1 and Fred Dejonckheere2, 1Symmetron Limited, London, United Kingdom, 2F. Hoffmann-La Roche, Basel, Switzerland

    Background/Purpose: Tocilizumab (TCZ) is a recombinant, humanized, monoclonal antibody directed against the cytokine interleukin-6 receptor, and tofacitinib (Tofa) is an oral, synthetic, disease-modifying antirheumatic drug…
  • Abstract Number: 1494 • 2014 ACR/ARHP Annual Meeting

    Treatment of Rheumatoid Arthritis Patients with the JAK1-Selective Inhibitor GLPG0634 Reverses an Arthritis-Specific Blood Gene Signature to Healthy State

    Mate Ongenaert1, Sonia Dupont2, Béatrice Vayssière2, Reginald Brys1, Luc Van Rompaey1, Christel Menet1 and René Galien2, 1Galapagos NV, Mechelen, Belgium, 2Galapagos SASU, Romainville, France

    Background/Purpose The 4 Janus kinases (JAK1, JAK2, JAK3 and TYK2) are cytoplasmic tyrosine kinases that mediate intracellular signaling of cytokines (e.g. certain interleukins and interferons)…
  • Abstract Number: 497 • 2014 ACR/ARHP Annual Meeting

    Efficacy and Safety Study of a Sequential Therapy of Tocilizumab and, If Initially Inadequately Responded to Tocilizumab, Followed By Rituximab in Patients with Rheumatoid Arthritis and Inadequate Response to Traditional Disease Modifying Anti-Rheumatic Drugs

    Thomas Dörner1, Hans-Peter Tony2, Gerd Burmester1, Hendrik Schulze-Koops3, Jörg Kaufmann4, Peter Kästner5, Herbert Kellner6, Reiner Kurthen7, Sylke Wagner8, Marvin A. Peters9 and Christoph Iking-Konert10, 1Charité - Universitätsmedizin Berlin, Berlin, Germany, 2University Clinic Wuerzburg, Wuerzburg, Germany, 3University Clinic Munich, Munich, Germany, 4Rheumatology Practice, Ludwigsfelde, Germany, 5MVZ Out-patient Rheumatogy Unit Erfurt, Erfurt, Germany, 6Specialist Practice for Rheumatology and Gastroenterology, Munich, Germany, 7Rheumatology Practice, Aachen, Germany, 8Practice for Internal Medicine specialized in Rheumatology, Halle, Germany, 9Roche Pharma AG, Grenzach-Wyhlen, Germany, 10University Clinic Hamburg-Eppendorf, Hamburg, Germany

    Background/Purpose: The MIRAI study evaluated a sequential exposure to 2 defined biologics under rigorous study conditions within a homogeneous population of biological naïve patients (pts)…
  • Abstract Number: 2489 • 2014 ACR/ARHP Annual Meeting

    Analysis of Early Neutropenia, Clinical Response, and Serious Infection Events in Patients Receiving Tofacitinib for Rheumatoid Arthritis

    V. Strand1, A. Dikranian2, J. Beal3, K. Kwok3, S. Krishnaswami4, S. Wood4 and C. Nduaka4, 1Biopharmaceutical Consultant, Portola Valley, CA, 2San Diego Arthritis Medical Clinic, San Diego, CA, 3Pfizer Inc, New York, NY, 4Pfizer Inc, Groton, CT

    Background/Purpose: Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). Post-baseline (BL) decreases in mean peripheral neutrophil count were…
  • Abstract Number: 1463 • 2014 ACR/ARHP Annual Meeting

    Dickkopf-1 Perpetuated Synovial Fibroblast Activation and Synovial Angiogenesis in Rheumatoid Arthritis

    Li Zheng1, Fanlei Hu2, Yingni Li1, Lianjie Shi2, Xiaoxu Ma1, Xuewu Zhang3 and Zhanguo Li4, 1Peking University People's Hospital, Beijing, China, 2Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 311 South Street, XiZhiMen , We, Peking University People's Hospital, Beijing, China, 4Rheum/Immunology, Peking University People's Hospital, Beijing, China

    Background/Purpose . Dkk-1, a master regulator of joint remodeling, is elevated and leads to bone resorption in patients with RA. This study aimed to investigate…
  • Abstract Number: 493 • 2014 ACR/ARHP Annual Meeting

    Efficacy and Safety of Tofacitinib Following Inadequate Response to Nonbiologic DMARD or Biologic DMARD

    C. Charles-Schoeman1, Gerd Burmester2, P. Nash3, C.a.F. Zerbini4, S. Anway5, K. Kwok6, T. Hendrikx7, E. Bananis8 and Roy Fleischmann9, 1University of California, Los Angeles, CA, 2Charité – University Medicine Berlin, Berlin, Germany, 3Rheumatology Research Unit, Nambour Hospital, Sunshine Coast and Department of Medicine, University of Queensland, Queensland, Australia, 4Centro Paulista de Investigação Clinica, Sao Paulo, Brazil, 5Pfizer Inc, Groton, CT, 6Pfizer Inc, New York, NY, 7Pfizer BV, Capelle aan den IJssel, Netherlands, 8Pfizer Inc, Collegeville, PA, 9Metroplex Clinical Research Center, University of Texas Southwestern Medical Center, Department of Medicine, Dallas, TX

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Here we compare the efficacy and safety of tofacitinib 5…
  • Abstract Number: 2488 • 2014 ACR/ARHP Annual Meeting

    Relationship Between Different Clinical Measurements and Patient-Reported Outcomes

    Roy Fleischmann1, V Strand2, B Wilkinson3, K Kwok4 and E Bananis3, 1Metroplex Clinical Research Center, University of Texas Southwestern Medical Center, Department of Medicine, Dallas, TX, 2Biopharmaceutical Consultant, Portola Valley, CA, 3Pfizer Inc, Groton, CT, 4Pfizer Inc, New York, NY

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Here we compare the relationship between clinical measures and patient-reported…
  • Abstract Number: 1478 • 2014 ACR/ARHP Annual Meeting

    Pharmacokinetics, Bioavailability and Safety of a Modified-Release Once-Daily Formulation of Tofacitinib in Healthy Volunteers

    M. Lamba1, R. Wang1, T. Fletcher2, C. Alvey1, A. Hazra1, J. Kushner1, J. Larmann1 and T. Stock2, 1Pfizer Inc, Groton, CT, 2Pfizer Inc, Collegeville, PA

    Background/Purpose: Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The efficacy and safety of an immediate-release (IR) formulation…
  • Abstract Number: 487 • 2014 ACR/ARHP Annual Meeting

    Assessment of Lipid Changes in Patients with Early Rheumatoid Arthritis Treated with Tofacitinib or Methotrexate over 24 Months

    C. Charles-Schoeman1, A. Dikranian2, J. Taylor3, B. Wilkinson4, T. Jones5, K. Kwok6 and C. Nduaka4, 1University of California, Los Angeles, CA, 2San Diego Arthritis Medical Clinic, San Diego, CA, 3Anderson Arthritis and Rheumatology Center, Meridian, MS, 4Pfizer Inc, Groton, CT, 5Pfizer Inc, Collegeville, PA, 6Pfizer Inc, New York, NY

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Post-baseline (BL) increases in mean low-density lipoprotein cholesterol (LDL-C) and…
  • Abstract Number: 2418 • 2013 ACR/ARHP Annual Meeting

    The Transmembrane Protein Tyrosine Phosphatase Kappa Promotes Aggressiveness Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes

    Stephanie M. Stanford1, William B. Kiosses2, Amanda M. Campbell3, Michael F. Maestre3, David L. Boyle4, Gary S. Firestein4 and Nunzio Bottini3, 1Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 2The Scripps Research Institute, La Jolla, CA, 3La Jolla Institute for Allergy and Immunology, La Jolla, CA, 4Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA

    Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). In RA these cells…
  • Abstract Number: 2219 • 2013 ACR/ARHP Annual Meeting

    Active Immunization Against VEGF-Derived Oligopeptides Improves Joint Inflammation and Destruction In Collagen-Induced Arthritis

    Emilie Duvallet1, Laure Foulboeuf1, Luca Semerano2, Nadia Belmellat1, Marc Lecouvey3, Eric Assier1, Sylviane Muller4 and Marie-Christophe Boissier5, 1EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France, 2INSERM UMR U1125, University Paris 13, Sorbonne Paris Cité, Bobigny, France, 3CSPBAT Paris 13 University, Bobigny, France, 4Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg, France, 5INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France

    Background/Purpose: We have demonstrated in experimental models the efficacy of vaccination against cytokines, using a heterocomplex of keyhole limpet hemocyanin (KLH) and human TNF, called…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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