Abstracts tagged "rheumatoid arthritis"

Abstract Number: 0493 • ACR Convergence 2025
Phase I Trial in Participants with Rheumatoid Arthritis and Healthy Volunteers with CIT-013, a First in Class NETosis Inhibitor
Maarten Kraan¹, Salah Hadi², Leonie Middelink³, Renato Chirivi³, Eric meldrum³, Naomi Klarenbeek⁴ and Patrick Round³, ¹Citryll BV, Den Dolder, Netherlands, ²ICON Netherlands BV, Groningen, Netherlands, ³Citryll BV, Oss, Netherlands, ⁴CHDR, Leiden, Netherlands
Background/Purpose: Aberrant Neutrophil Extracellular Trap (NET) production contributes to the pathophysiology of multiple inflammatory and autoimmune diseases including rheumatoid arthritis (RA). We report data of…
Abstract Number: 0477 • ACR Convergence 2025
At the patient level, ultrasound evaluation during the follow up of rheumatoid arthritis does not modify radiographic evolution: a prospective, multicenter, randomized, pragmatic clinical trial (BCD study)
Alexandre GARMENDIA¹, Valerie Devauchelle², Grégoire CORMIER³, LE GOFF Benoit⁴, Aleth Perdriger⁵, Saloua Mammou⁶, Emannuel Hoppe⁷, Emmanuelle Dernis⁸, Jose Le Noach⁹, Carine Salliot¹⁰, florent garrigues¹, Raphael Auffret¹, Ichem Mohtarif¹¹, Mateusz Chodorowsky¹¹, Thierry MARHADOUR¹², Divi Cornec¹³, Dewi Guellec¹, Emmanuelle Courtois Communier¹, Alain SARAUX¹⁴ and sandrine jousse¹², ¹CHU de BREST, Brest, Bretagne, France, ²UBO, Brest, France, ³Centre Hospitalier département de Vendée, La Roche Sur Yon, France, ⁴CHU Nantes, Nantes, France, ⁵Rennes University, Rennes, France, ⁶CHU TOURS, TOURS, France, ⁷CHU ANGERS, Angers, France, ⁸Rheumatology Department, Le Mans Central Hospital, Le Mans, France, LE MANS, France, ⁹Centre Hospitalier de Lorient, Lorient, France, ¹⁰CHR orleans, Orleans, France, ¹¹CHU de Brest, Brest, France, ¹²LBAI, UMR¹²²⁷, University of Brest, CHU Brest, Brest, France, Brest, France, ¹³Departement of Rhumatology, CHU Brest, Université de Brest, INSERM UMR¹²²⁷: LBAI, Brest, France, Brest, France, ¹⁴CHU Brest, Brest, France
Background/Purpose: Previous studies, including TASER and ARTIC (1,2), failed to demonstrate a significant benefit of ultrasound (US) compared to clinical evaluation in achieving clinical remission…
Abstract Number: 0461 • ACR Convergence 2025
Right Diagnoses For the Wrong Reasons: Limitations of Current Large-Language Model based Agentic Frameworks for Screening of Rheumatoid Arthritis
Sarthak Verma¹, Avarna Agarwal¹, Umakanta Maharana², Murari Mandal³, Prasanta Padhan¹, Prakashini Mruthyanjaya⁴ and Sakir Ahmed¹, ¹Department of Clinical Immunology and Rheumatology, Kalinga Institute of Medical Sciences, Bhubaneswar, Orissa, India, ²School of Computer Engineering, KIIT University, Bhubaneswar, India, ³School of Computer Engineering, KIIT University, Bhubaneswar, Orissa, India, ⁴Department of Clinical Immunology and Rheumatology, Kalinga Institute of Medical Sciences, Bhubaneswar, India
Background/Purpose: In India, Rheumatoid arthritis (RA) is often diagnosed late. Artificial Intelligence (AI) driven Large Language models (LLMs) can be deployed via widely available mobile…
Abstract Number: 0444 • ACR Convergence 2025
Low Disease Activity: Good Enough?
Emily Thoman¹, Sebastiano Porcu¹ and Martin Bergman², ¹Lankenau Medical Center, Wynnewood, PA, ²Drexel University College of Medicine, Philadelphia
Background/Purpose: Treat-to-target is the guiding principle and therapeutic strategy for rheumatoid arthritis (RA) treatment. Escalation of treatment is based on the regular assessment of disease…
Abstract Number: 0378 • ACR Convergence 2025
Identifying Patterns of Telemedicine Readiness and Digital Health Literacy in Rheumatoid Arthritis Patients: A Latent Class Analysis
Preeti Dhanasekaran¹, Bryant Lim², Qai Ven Yap², Hafizah Ahmad³, Siew Hwa Chong³, Ginny Goh³, Manjari Lahiri⁴, Amelia Santosa⁴, Gim Gee Teng³, Peter Cheung⁴, Siriwan Lim¹ and Margaret Ma⁴, ¹National University of Singapore, Singapore, Singapore, ²National University of Singapore, Singapore, ³National University Hospital, Singapore, ⁴National University Hospital, Singapore, Singapore
Background/Purpose: The COVID-19 pandemic accelerated telemedicine adoption, yet readiness and digital literacy vary widely across patient populations. Understanding these differences is crucial to designing equitable…
Abstract Number: 0214 • ACR Convergence 2025
Systematic Comorbidity Screening in Inflammatory Arthritis: The Experience of a Tertiary-Care Centre
Camille Bourgeois¹, Alexandra Kobza², Olivier Fogel³, Maxime Dougados⁴ and Anna Molto⁵, ¹Hospital general universitario Gregorio Marañon, Madrid, Madrid, Spain, ²University of Calgary, North Vancouver, BC, Canada, ³AP-HP, Paris, France, ⁴Department of Medicine, Hopital Cochin, Universite de Paris, Paris, France, ⁵Assistance Publique Hôpitauxde Paris, Paris, France
Background/Purpose: Patients with inflammatory arthritis (IA), including rheumatoid arthritis (RA) and spondyloarthritis (SpA), are at elevated risk for comorbidities, complicating disease management. Despite rheumatology societies…
Abstract Number: 0148 • ACR Convergence 2025
Air Pollution as a Trigger for Flares in Chronic Inflammatory Rheumatic Diseases: a Prospective Single-Center Study in the South of France
Coralie Cruzel¹, antonio Iannelli², Alexandre Armengaud³, Sonia Oppo³, Marie Charlotte Trojani⁴, Stephanie Ferrero⁴, Veronique Breuil⁴, Eric Fontas⁵, Christian Roux⁴ and Clément Viala⁴, ¹². Department of Clinical Research, Cimiez Hospital, CHU Nice, Université Côte d'Azur, Nice, France, France, France, ²³. Centre Hospitalier Universitaire de Nice-Digestive Surgery and Liver Transplantation Unit, Archet ² Hospital, ⁰⁶²⁰² Nice, France., NIce, France, ³¹. University Cote d’Azur, Rheumatology department, CHU Nice, France, Marseille, France, ⁴¹. University Cote d’Azur, Rheumatology department, CHU Nice, France, NIce, France, ⁵². Department of Clinical Research, Cimiez Hospital, CHU Nice, Université Côte d'Azur, Nice, France, NIce, France
Background/Purpose: Rheumatoid arthritis (RA) and spondyloarthritis (SpA), are chronic inflammatory rheumatic diseases. Despite significant advancements in their management through novel therapies, some patients continue to…
Abstract Number: 0081 • ACR Convergence 2025
Trans-endothelial Trafficking of Fibroblast-like Synoviocytes Amplifies Synovial Inflammation in Rheumatoid Arthritis
Jaeyeon Kim¹, Sanaz Panahandeh², Hieu Nguyen³, Kainat Mian⁴, Hadijat Makinde⁴, Kyoung Jae Won⁵, Arminja Kettenbach³, Harris R Perlman⁴, Costantino Pitzalis⁶ and Nunzio Bottini⁷, ¹Cedars Sinai Medical Center, Los Angeles, CA, ²Cedars-Sinai Medical Center, Los Angeles, ³Geisel School of Medicine at Dartmouth, Lebanon, NH, ⁴Northwestern University, Chicago, IL, ⁵Cedars-Sinai Medical Center, Los Angeles, CA, ⁶QMUL, Bromley Kent, United Kingdom, ⁷Cedars Sinai Medical Center, Beverly Hills, CA
Background/Purpose: The discovery of circulating fibroblast-like synoviocyte (FLS), known as PRIME cells, in RA patients suggests that synovial FLS may enter the circulation through blood…
Abstract Number: 0061 • ACR Convergence 2025
IL-22 Contributes to Autoantibody-induced Arthritis Via Modulation of Inflammatory Cytokine and Chemokine Expression in the Inflamed Synovium of a Murine Model
Shinjiro Kaieda¹, Suzuna Sugi¹, Takuma Koga², Takashi Kinoshita¹ and Tomoaki Hoshino¹, ¹Kurume university School of Medicine, Kurume, Japan, ²Kurume Universty School of Medicine, Kurume, Japan
Background/Purpose: IL-22 is a key cytokine involved in modulating tissue responses during inflammation and is markedly upregulated in inflammatory diseases, such as psoriasis, inflammatory bowel…
Abstract Number: 2685 • ACR Convergence 2025
Assessing for Racial/Ethnic Variability in U.S.-FRAXTM Performance Among Older Adult Women with Rheumatoid Arthritis in the United States
Rachel Elam¹, Jing Li², Angel Paul³, Emma Kersey⁴, gabriela Schmajuk⁵, William Leslie⁶ and Laura Carbone¹, ¹Augusta University, Augusta, GA, ²University of California, San Francisco, San Francisco, CA, ³University of California San Francisco, Berkeley, CA, ⁴University of California San Francisco, San Francisco, CA, ⁵University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, CA, ⁶University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Women with rheumatoid arthritis (RA) have 1.5- and 2-fold higher risk of major osteoporotic fracture (MOF: first of distal forearm, hip, humerus, or clinical…
Abstract Number: 2616 • ACR Convergence 2025
Real-World Implication of Clinical Disease Activity Index (CDAI) Utilization on Treatment Decisions and Clinical Outcomes in Rheumatoid Arthritis
Ryan Clark¹, Sally Almahdawi¹, Carolina Alvarez², Rumey Ishizawar³ and Thuyvan Phan⁴, ¹UNC Eshelman School of Pharmacy, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Miami, FL, ³UNC Division of Rheumatology, Allergy and Immunology and TARC, Chapel Hill, NC, ⁴UNC Health, Chapel Hill, NC
Background/Purpose: The University of North Carolina (UNC) Hospitals Rheumatology Clinic is utilizing the Clinical Disease Activity Index (CDAI) in patients with rheumatoid arthritis (RA) per…
Abstract Number: 2286 • ACR Convergence 2025
Association of Semaglutide Prescription with Improved Joint Outcomes in Rheumatoid Arthritis Patients
Faissal Stipho¹, Yazin Hindosh², Jonathan Sayegh², Akram Hindosh², Bassam Mitri² and Issa Batarseh¹, ¹Department of Internal Medicine, Banner University Medical Center / University of Arizona, Tucson, Arizona, Tucson, AZ, ²University of Arizona College of Medicine Tucson, Tucson, AZ
Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune disorder that results in immune dysfunction and swelling of major joints, leading to discomfort, pain, stiffness, and loss…
Abstract Number: 2269 • ACR Convergence 2025
Key factors in optimizing the dose of Baricitinib in rheumatoid arthritis: a study based on routine clinical practice and its therapeutic implications
Daniel Campos-Martin¹, Nerea Alcorta-Lorenzo², César Antonio Egües Dubuc², Luis Maria Lopez-Dominguez³, Lucia Otero⁴, Fernando Sánchez-Alonso⁵ and Joaquin Maria Belzunegui-Otano⁶, ¹Rheumatology Department, Donostia University Hospital, San Sebastian-Donostia, Pais Vasco, Spain, ²Rheumatology Department, Donostia University Hospital., San Sebastian, Spain, ³Rheumatology Department, Donostia University Hospital., San Sebastián, Pais Vasco, Spain, ⁴Spanish Society of Rheumatology, Madrid, Spain, ⁵Sociedad Española de Reumatología, Madrid, Spain, ⁶Rheumatology Department, Donostia University Hospital., San Sebastian-Donostia, Spain
Background/Purpose: Baricitinib, a selective JAK1/JAK2 inhibitor, has demonstrated efficacy in rheumatoid arthritis (RA). In patients with stable disease control for at least six months, reducing…
Abstract Number: 2253 • ACR Convergence 2025
Wrist-worn Wearable Device Data Can Be a New Digital Biomarker For Disease Activity In Rheumatoid Arthritis: a Multicenter Single-arm Prospective Study
Misako Higashida-Konishi¹, Keisuke Izumi², Shuntaro Saito Saito³, Hiroki Tabata⁴, Satoshi Hama⁴, Tatsuhiro Oshige⁴, Yutaka Okano⁴, Hisaji Oshima⁴, Katsuya Suzuki⁴, Jiro Sakamoto⁵, Toshikazu Fukami⁵, Kazumichi Minato⁵, Nobuhiko Kajio⁶, Yasushi Kondo³, Hiroaki Taguchi⁶ and Yuko Kaneko³, ¹NHO Tokyo Medical Center, Tokyo Meguroku, Japan, ²Division of Rheumatology, Department of Medicine, NHO Tokyo Medical Center/Keio University School of Medicine/TechDoctor, Inc., Tokyo, Japan, ³Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ⁴Division of Rheumatology, Department of Medicine, NHO Tokyo Medical Center, Tokyo, Japan, ⁵TechDoctor, Inc., Tokyo, Japan, ⁶Department of Rheumatology, Kawasaki Municipal Hospital, Kanagawa, Japan
Background/Purpose: Previous studies have estimated physical and mental states using wearable device data such as from smartwatches [1–3]. This study aimed to identify digital biomarkers…
Abstract Number: 2236 • ACR Convergence 2025
Treatment-induced autoantibodies in Rheumatoid Arthritis patients receiving anti-TNF inhibitors or JAK inhibitors
EVRIPIDIS KALTSONOUDIS¹, Nikolaos Kougkas², Panagiota Karagianni³, Tereza Memi⁴, Nikolaos Koletsos⁵ and Eleftherios Pelechas⁶, ¹Rheumatology Clinic, University of Ioannina, IOANNINA, Ioannina, Greece, ²⁴th Department of Internal Medicine, Aristotle University, Thessaloniki, Thessaloniki, Greece, ³BioAcuHealth.gr, Ioannina, Ioannina, Greece, ⁴University Hospital of Ioannina, Ioannina, Ioannina, Greece, ⁵School of Health Sciences, Faculty of Medicine, University of Ioannina, Department of Rheumatology, Ioannina, Greece, Ioannina, Ioannina, Greece, ⁶Hatzikosta General Hospital of Ioannina, Ioannina, Ioannina, Greece
Background/Purpose: Rheumatoid arthritis (RA) can coexist with other autoimmune disorders such as Sjögren’s syndrome and systemic lupus erythematosus (SLE). In these cases, the terms secondary…

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