Abstracts tagged "rheumatoid arthritis"

Abstract Number: 2566 • 2015 ACR/ARHP Annual Meeting
Novel Therapeutic Compound Tuftsin-Phosphorylcholine Attenuate Collagen Induced Arthritis
Tomer Bashi¹, Miri Blank¹, Jasna Omersel², Alexander Volkov³, Iris Barshack³ and Yehuda Shoenfeld¹, ¹Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ²Faculty of pharmacy, University of Ljublijana, Ljublijana, Slovenia, ³Sheba Medical Center, Institute of Pathology, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel
Background/Purpose: Treatment with helminthes and ova from helminthes, improved clinical findings of several autoimmune diseases in patients and in animal models. We aimed to decipher…
Abstract Number: 1210 • 2015 ACR/ARHP Annual Meeting
Genetic, Environmental, and Serologic Risk Factors for Inflammatory Joint Signs Among First-Degree Relatives without Rheumatoid Arthritis in a Prospective Cohort
Jeffrey A. Sparks¹, Shun-Chiao Chang², Kevin D. Deane³, Ryan W. Gan⁴, Kristen Demoruelle³, Marie L. Feser³, LauraKay Moss³, Jane H. Buckner⁵, Richard M. Keating⁶, Karen H. Costenbader⁷, Peter K. Gregersen⁸, Michael H. Weisman⁹, Ted R. Mikuls¹⁰, James R. O'Dell¹⁰, V. Michael Holers³, Jill M. Norris⁴ and Elizabeth W. Karlson², ¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁴Epidemiology, Colorado School of Public Health, Aurora, CO, ⁵Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁶Division of Rheumatology, Scripps Health, La Jolla, CA, ⁷Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁸Feinstein Insititute for Medical Research, Manhasset, NY, ⁹Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹⁰Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Family history of RA in a first-degree relative increases RA risk 4-fold. Determining risk factors for inflammatory joint signs (IJS) in this high risk…
Abstract Number: 2582 • 2015 ACR/ARHP Annual Meeting
Increased Morbidity and Mortality in Female Versus Male Tumor Necrosis Factor-Transgenic Mice
Richard Bell¹, Ronald Wood², Joe Chakkalakal³, Christopher T. Ritchlin⁴, Edward Schwarz⁵ and Homaira Rahimi⁶, ¹Pathology, University of Rochester, Rochester, NY, ²University of Rochester, Rochester, NY, ³Orthopaedics, University of Rochester, Rochester, NY, ⁴Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁵Orthopedeatrics, University of Rochester, Rochester, NY, ⁶Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is a chronic debilitating condition with a 2-3 fold greater prevalence in women than men. Additionally, women have worse disease outcomes…
Abstract Number: 1254 • 2015 ACR/ARHP Annual Meeting
Deciphering the Immunome of Clinically Effective Immune Tolerization in Rheumatoid Arthritis
Jing Yao Leong^1,2, Raymond Ong Jr.³, Juntao Li⁴, Theodorus van den Broek⁵, Roberto Spreafico⁴, Maura Rossetti¹ and Salvatore Albani^1,2, ¹SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ²Duke-National University of Singapore Graduate Medical School, Singapore, Singapore, ³Singhealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, ⁴SingHealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, ⁵Translational Research Unit, Sanford-Burnham Medical Research Institute, La Jolla, CA
Background/Purpose: We have previously described (Nature Medicine, PNAS, A&R, Nature Rheum, Lancet) how oral treatment with the pro-inflammatory, heat shock protein-derived dnaJP1 peptide induces detectable…
Abstract Number: 2704 • 2015 ACR/ARHP Annual Meeting
Neutrophil-Derived Lactoferrin Regulates the Activity of NFAT5 in Rheumatoid Arthritis Synovial Fibroblasts Via Toll-like Receptor 4
Kunihiko Umekita, Shunichi Miyauchi, Kazuyoshi Kubo, Hajime Nomura, Kazumi Umeki, Koushou Iwao, Mao Komura and Akihiko Okayama, Department of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Miyazaki, Japan
Background/Purpose: Damage-associated molecular patterns (DAMPs) are proposed to drive aberrant stimulation of Toll-like receptors (TLRs) in the rheumatoid arthritis (RA) joints resulting in increased expression…
Abstract Number: 1586 • 2015 ACR/ARHP Annual Meeting
Weight Loss in Obese Rheumatoid Arthritis (RA) Patients Improves Disease Activity without Modifying RA Treatment
Elisa Gremese¹, Maria Rita Gigante¹, Barbara Tolusso¹, Anna Laura Fedele¹, Silvia Canestri¹, Barbara Aquilanti², Clara Di Mario¹, Luca Petricca¹, Stefano Alivernini¹ and Gianfranco Ferraccioli¹, ¹Division of Rheumatology, Institute of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy, ²Dietology Service, Association Columbus, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: Obesity is recognized as a systemic, low-grade inflammatory state and the adipose tissue as an endocrine organ releasing pro-inflammatory cytokines. On the other hand,…
Abstract Number: 2705 • 2015 ACR/ARHP Annual Meeting
AAA-Atpase p97-HDAC6 Controlled Poly-Ubiquitin Turnover Regulates Apoptotic and Autophagy-Associated Cell Death in Arthritis
Masaru Kato¹, Kerstin Klein², Caroline Ospelt², Christoph Kolling³, Michihito Kono¹, Shinsuke Yasuda¹, Renate E. Gay⁴, Steffen Gay⁵ and Tatsuya Atsumi¹, ¹Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, ²Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Schulthess Clinic, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland
Background/Purpose: The AAA-ATPase valosin containing protein (p97) and histone deacetylase 6 (HDAC6) interact with each other and are implicated in the degradation of ubiquitin-labelled proteins.…
Abstract Number: 1616 • 2015 ACR/ARHP Annual Meeting
Identification of Genes Regulating TRAIL-Induced Apoptosis in Rheumatoid Arthritis Fibroblasts-like Synoviocytes (RA FLS)
Rachel Audo^1,2, Bernard Combe^3,4, Michael Hahne⁵ and Jacques Morel⁶, ¹Rheumatology, Teaching Hospital of Lapeyronie, Montpellier, France, ²IGMM, CNRS UMR5535, Montpellier, Montpellier, France, ³Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, ⁴Montpellier University, Montpellier, France, ⁵IGMM-CNRS UMR5535, Montpellier, France, ⁶Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France
Background/Purpose: We previously described that sensitivity to TRAIL-induced apoptosis varied in rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) from one patient to another, and was inversly correlated…
Abstract Number: 2710 • 2015 ACR/ARHP Annual Meeting
Necrox-7 Inhibits Cell Aggressiveness By Suppressing of NF-Kappa B Activation and Reactive Oxygen Species Generation in Human Rheumatoid Arthritis Fibroblast-like Synoviocytes
Hyun Jung Yoo^1,2, Jin Kyun Park², Eun Young Lee², Eun Bong Lee² and Yeong Wook Song^2,3, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, BK21 plus Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ³Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Seoul National University, Seoul, South Korea
Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key component…
Abstract Number: 2355 • 2014 ACR/ARHP Annual Meeting
Apremilast, a Novel Phosphodiesterase 4 Inhibitor, and Methotrexate Independently Prevent Inflammation in Vivo and in Vitro
Miguel Perez-Aso¹, M. Carmen Montesinos², Aranzazu Mediero³, Peter H. Schafer⁴ and Bruce N. Cronstein⁵, ¹545 1st Ave., New York University, New York City, NY, ²Departament de Farmacologia, Facultat de Farmàcia,, Universitat de València, Valencia, Spain, ³Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ⁴Celgene Corporation, Celgene Corporation, Summit, NJ, ⁵NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Phosphodiesterase 4 (PDE4) inhibitors have clear immunoregulatory effects in laboratory studies, and the clinical application of this class of drug in the field of…
Abstract Number: 1031 • 2014 ACR/ARHP Annual Meeting
Induction of Pro-Apoptotic Noxa Expression By Ursolic Acid Sensitizes Rheumatoid Arthritis Synovial Fibroblasts to Apoptosis: A Role of Mir-181a
Salahuddin Ahmed¹, Laura Walsh², Anil Singh¹, Maria Beamer³, Kuladeep Sudini⁴ and Douglas Leaman⁴, ¹Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, ²Department of Pharmacology, University of Toledo, Toledo, OH, ³Department of Pharmacology, Department of Pharmacology, University of Toledo, Toledo, OH, ⁴Department of Biological Sciences, University of Toledo, Toledo, OH
Background/Purpose: In rheumatoid arthritis (RA), the paucity of pro-apoptotic protein expression may significantly contribute to the resistance of synovial fibroblasts (FLS) to apoptosis. In the…
Abstract Number: 452 • 2014 ACR/ARHP Annual Meeting
The Use of Multiplex Bead Array to Follow the Effect of Rituximab on IgG and IgA Serum Autoantibody Responses to Citrullinated Epitopes in Patients with Rheumatoid Arthritis
Geraldine Cambridge¹, Lauren J. Lahey², Maria J. Leandro¹, William H. Robinson² and Jeremy Sokolove², ¹Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, ²VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA
Background/Purpose The majority of patients with established Rheumatoid arthritis (RA) have autoantibodies against the Fc of IgG (Rheumatoid factors-RhF) and to citrullinated protein antigens (ACPAs).…
Abstract Number: 2356 • 2014 ACR/ARHP Annual Meeting
Toluenesulfonylamido-Chalcone, 4-(p-toluenesulfonylamido)-4-Hydroxychalcone (TSAHC) Suppresses Inflammatory Response and Joint Destruction in an Experimental Arthritic Mice and Fibroblast-like Synoviocytes
Yun-Hong Cheon¹, Wan-Hee Yoo², Young Sun Suh³, Min-Gyu Jeon⁴, Hyun-Ok Kim³ and Sang-Il Lee³, ¹Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Chonbuk National University School of Medicine, Jeonju, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, ⁴Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, South Korea
Background/Purpose TSAHC, a toluenesulfonylamido-chalcone, 4-(p-toluenesulfonylamido)-4-hydroxychalcone is a compound to block proliferation and metastatic potential of cancer cells. Fibroblast-like synoviocytes of rheumatoid arthritis (RA-FLS) have inflammatory…
Abstract Number: 940 • 2014 ACR/ARHP Annual Meeting
Reducing Therapy in Rheumatoid Arthritis Patients in Ongoing Remission
Judith Haschka^1,2, Jürgen Rech³, Matthias Englbrecht¹, Stephanie Finzel¹, Michaela Reiser¹, Axel J. Hueber¹, Arnd Kleyer¹, Hans-Peter Tony⁴, Martin Fleck⁵, Karin Manger⁶, Wolfgang Ochs⁷, Jörg Wendler⁸, Hanns-Martin Lorenz⁹, Hubert Nüßlein¹⁰, Rieke Alten¹¹, Winfried Demary¹² and Georg Schett¹, ¹Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 2, The VINFORCE Study Group, St. Vincent Hospital Vienna, Vienna, Austria, ³Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Internal Medicine 2, University Hospital Würzburg, Würzburg, Germany, ⁵Department of Rheumatology and Clinical Immunology, Asklepios Medical Center Bad Abbach, Bad Abbach, Germany, ⁶Rheumatology Practice Bamberg, Bamberg, Germany, ⁷Rheumatology Practice Bayreuth, Bayreuth, Germany, ⁸Rheumatology Practice Erlangen, Erlangen, Germany, ⁹Department of Internal Medicine 5, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany, ¹⁰Rheumatology Practice Nuremberg, Nuremberg, Germany, ¹¹Schlosspark-Klinik, University Medicine Berlin, Berlin, Germany, ¹²Rheumatolgy Practice Hildesheim, Hildesheim, Germany
Background/Purpose: Due to improved therapeutic management a steadily increasing number of rheumatoid arthritis (RA) patients reach stable remission of disease. Data on withdrawal of medication…
Abstract Number: 347 • 2014 ACR/ARHP Annual Meeting
Salt Aggravates Arthritis By Th17 Polarization
Seung Min Jung¹, Hong Ki Min¹, Jung Hee Koh¹, Jin Young Kang¹, Jennifer Lee¹, Seung-Ki Kwok², Kyung-Su Park³, Hyeok-Jae Ko⁴, Wan-Uk Kim⁵, Ho-Youn Kim¹, Sung-Hwan Park¹ and Ji Hyeon Ju¹, ¹Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, St. Mary’s hospital, The Catholic University of Korea, Seoul, South Korea, ³Internal Medicine, St. Vincent Hospital, SuWon Gyeonggi-do, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Daejeon, South Korea, ⁵Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea
Background/Purpose Sodium chloride (NaCl) recently has been shown to drive autoimmune diseases through the induction of pathogenic interleukin 17-producing T helper (Th17) cells. This study…

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