ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 2566 • 2015 ACR/ARHP Annual Meeting

    Novel Therapeutic Compound Tuftsin-Phosphorylcholine Attenuate Collagen Induced Arthritis

    Tomer Bashi1, Miri Blank1, Jasna Omersel2, Alexander Volkov3, Iris Barshack3 and Yehuda Shoenfeld1, 1Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, 2Faculty of pharmacy, University of Ljublijana, Ljublijana, Slovenia, 3Sheba Medical Center, Institute of Pathology, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel

    Background/Purpose: Treatment with helminthes and ova from helminthes, improved clinical findings of several autoimmune diseases in patients and in animal models. We aimed to decipher…
  • Abstract Number: 1210 • 2015 ACR/ARHP Annual Meeting

    Genetic, Environmental, and Serologic Risk Factors for Inflammatory Joint Signs Among First-Degree Relatives without Rheumatoid Arthritis in a Prospective Cohort

    Jeffrey A. Sparks1, Shun-Chiao Chang2, Kevin D. Deane3, Ryan W. Gan4, Kristen Demoruelle3, Marie L. Feser3, LauraKay Moss3, Jane H. Buckner5, Richard M. Keating6, Karen H. Costenbader7, Peter K. Gregersen8, Michael H. Weisman9, Ted R. Mikuls10, James R. O'Dell10, V. Michael Holers3, Jill M. Norris4 and Elizabeth W. Karlson2, 1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 4Epidemiology, Colorado School of Public Health, Aurora, CO, 5Benaroya Research Institute at Virginia Mason, Seattle, WA, 6Division of Rheumatology, Scripps Health, La Jolla, CA, 7Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 8Feinstein Insititute for Medical Research, Manhasset, NY, 9Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 10Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Family history of RA in a first-degree relative increases RA risk 4-fold. Determining risk factors for inflammatory joint signs (IJS) in this high risk…
  • Abstract Number: 2582 • 2015 ACR/ARHP Annual Meeting

    Increased Morbidity and Mortality in Female Versus Male Tumor Necrosis Factor-Transgenic Mice

    Richard Bell1, Ronald Wood2, Joe Chakkalakal3, Christopher T. Ritchlin4, Edward Schwarz5 and Homaira Rahimi6, 1Pathology, University of Rochester, Rochester, NY, 2University of Rochester, Rochester, NY, 3Orthopaedics, University of Rochester, Rochester, NY, 4Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 5Orthopedeatrics, University of Rochester, Rochester, NY, 6Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic debilitating condition with a 2-3 fold greater prevalence in women than men. Additionally, women have worse disease outcomes…
  • Abstract Number: 1254 • 2015 ACR/ARHP Annual Meeting

    Deciphering the Immunome of Clinically Effective Immune Tolerization in Rheumatoid Arthritis

    Jing Yao Leong1,2, Raymond Ong Jr.3, Juntao Li4, Theodorus van den Broek5, Roberto Spreafico4, Maura Rossetti1 and Salvatore Albani1,2, 1SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, 2Duke-National University of Singapore Graduate Medical School, Singapore, Singapore, 3Singhealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, 4SingHealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, 5Translational Research Unit, Sanford-Burnham Medical Research Institute, La Jolla, CA

    Background/Purpose: We have previously described (Nature Medicine, PNAS, A&R, Nature Rheum, Lancet) how oral treatment with the pro-inflammatory, heat shock protein-derived dnaJP1 peptide induces detectable…
  • Abstract Number: 2704 • 2015 ACR/ARHP Annual Meeting

    Neutrophil-Derived Lactoferrin Regulates the Activity of NFAT5 in Rheumatoid Arthritis Synovial Fibroblasts Via Toll-like Receptor 4

    Kunihiko Umekita, Shunichi Miyauchi, Kazuyoshi Kubo, Hajime Nomura, Kazumi Umeki, Koushou Iwao, Mao Komura and Akihiko Okayama, Department of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Miyazaki, Japan

    Background/Purpose: Damage-associated molecular patterns (DAMPs) are proposed to drive aberrant stimulation of Toll-like receptors (TLRs) in the rheumatoid arthritis (RA) joints resulting in increased expression…
  • Abstract Number: 1586 • 2015 ACR/ARHP Annual Meeting

    Weight Loss in Obese Rheumatoid Arthritis (RA) Patients Improves Disease Activity without Modifying RA Treatment

    Elisa Gremese1, Maria Rita Gigante1, Barbara Tolusso1, Anna Laura Fedele1, Silvia Canestri1, Barbara Aquilanti2, Clara Di Mario1, Luca Petricca1, Stefano Alivernini1 and Gianfranco Ferraccioli1, 1Division of Rheumatology, Institute of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy, 2Dietology Service, Association Columbus, Catholic University of the Sacred Heart, Rome, Italy

    Background/Purpose: Obesity is recognized as a systemic, low-grade inflammatory state and the adipose tissue as an endocrine organ releasing pro-inflammatory cytokines. On the other hand,…
  • Abstract Number: 2705 • 2015 ACR/ARHP Annual Meeting

    AAA-Atpase p97-HDAC6 Controlled Poly-Ubiquitin Turnover Regulates Apoptotic and Autophagy-Associated Cell Death in Arthritis

    Masaru Kato1, Kerstin Klein2, Caroline Ospelt2, Christoph Kolling3, Michihito Kono1, Shinsuke Yasuda1, Renate E. Gay4, Steffen Gay5 and Tatsuya Atsumi1, 1Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3Schulthess Clinic, Zurich, Switzerland, 4Center of Experimental Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, 5Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland

    Background/Purpose: The AAA-ATPase valosin containing protein (p97) and histone deacetylase 6 (HDAC6) interact with each other and are implicated in the degradation of ubiquitin-labelled proteins.…
  • Abstract Number: 1616 • 2015 ACR/ARHP Annual Meeting

    Identification of Genes Regulating TRAIL-Induced Apoptosis in Rheumatoid Arthritis Fibroblasts-like Synoviocytes (RA FLS)

    Rachel Audo1,2, Bernard Combe3,4, Michael Hahne5 and Jacques Morel6, 1Rheumatology, Teaching Hospital of Lapeyronie, Montpellier, France, 2IGMM, CNRS UMR5535, Montpellier, Montpellier, France, 3Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, 4Montpellier University, Montpellier, France, 5IGMM-CNRS UMR5535, Montpellier, France, 6Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France

    Background/Purpose: We previously described that sensitivity to TRAIL-induced apoptosis varied in rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) from one patient to another, and was inversly correlated…
  • Abstract Number: 2710 • 2015 ACR/ARHP Annual Meeting

    Necrox-7 Inhibits Cell Aggressiveness By Suppressing of NF-Kappa B Activation and Reactive Oxygen Species Generation in Human Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Hyun Jung Yoo1,2, Jin Kyun Park2, Eun Young Lee2, Eun Bong Lee2 and Yeong Wook Song2,3, 1Department of Molecular Medicine and Biopharmaceutical Sciences, BK21 plus Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 3Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Seoul National University, Seoul, South Korea

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key component…
  • Abstract Number: 1618 • 2015 ACR/ARHP Annual Meeting

    The Protective Effect of HLA-DRB1*13 Alleles during Specific Phases in the Development of ACPA-Positive RA

    J. van Heemst1, A.H. Hensvold2, X. Jiang2, H. van Steenbergen1, L. Klareskog2, T. W. J. Huizinga1, A.H.M. van der Helm- van Mil1, A.I. Catrina2, René E. M. Toes1, K. Lundberg2 and Diane van der Woude1, 1Leiden University Medical Center, Leiden, Netherlands, 2Karolinska Institute, Stockholm, Sweden

    Background/Purpose: HLA-DRB1*13 alleles are associated with protection from anti-citrullinated protein antibody (ACPA-)positive rheumatoid arthritis (RA). It is however unknown at which phase of disease development…
  • Abstract Number: 2732 • 2015 ACR/ARHP Annual Meeting

    The Effect of Adrenocorticotropin Gel (HP Acthar Gel) in Combination with MTX in Newly Diagnosed RA Patients from a Clinical and Structural Perspective

    Norman B. Gaylis1, Steven Needell2 and Joanne Sagliani1, 1Arthritis & Rheumatic Disease Specialties, Aventura, FL, 2Boca Radiology Group, Boca Raton, FL

    Background/Purpose: Although adrenocorticotropin (ACTH) gel was approved by the FDA for the treatment of RA in 1952, data on its clinical and structural benefits for…
  • Abstract Number: 1622 • 2015 ACR/ARHP Annual Meeting

    Genome-Wide Association Analysis and Whole Genome Sequencing Identify Variants Associated with Radiographic Severity of Rheumatoid Arthritis in African Americans

    Vincent A. Laufer1, Richard J. Reynolds2, Maria I. Danila3, R. Curtis Hendrickson4, Elliot J. Lefkowitz5, Devin Absher6, Robert P. Kimberly7 and S. Louis Bridges Jr.8, 1Division of Clinical Rheumatology and Immunology, University of Alabama at Birmingham, Birmingham, AL, 2Medicine, University of Alabama at Birmingham, Birmingham, AL, 3AL, 4University of Alabama at Birmingham, Birmingham, AL, 5Microbiology, University of Alabama at Birmingham, Birmingham, AL, 6Hudson Alpha Institute for Biotechnology, Huntsville, AL, 7Medicine, Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 8Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Joint damage manifested by bony erosions and joint space narrowing is a major contributor to the morbidity and mortality of RA. Reports in Caucasians…
  • Abstract Number: 3098 • 2015 ACR/ARHP Annual Meeting

    Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease at 12 Months: Results from the Pathobiology of Early Arthritis Cohort

    Maria DiCicco1, Frances Humby1, Stephen Kelly2, Rebecca Hands1, nora ng3, Arti Mahto3, Illias Lazarou3, Vidalba Rocher1, Lu Zou3, Michele Bombardieri4, Christopher Buckley5, A.H.M. van der Helm- van Mil6, Robert B.M. Landewé7, Désirée van der Heijde8, Iain B. McInnes9, Peter C. Taylor10 and Costantino Pitzalis11, 1Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, 2William Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, 3William Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, London, United Kingdom, 4Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, 5University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom, 6Leiden University Medical Center, Leiden, Netherlands, 7University of Amsterdam and Atrium Medical Center, Amsterdam, Netherlands, 8Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 9Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 10Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford Botnar Research Centre, Oxford, United Kingdom, 11Centre for Experimental Medicine & Rheumatology, Queen Mary's School of Medicine and Dentistry, London, United Kingdom

    Background/Purpose: The inflammatory cell infiltrate in RA synovium has been recognised to organise into lymphocytic aggregates (Ags) with data to suggest that these structures are…
  • Abstract Number: 1646 • 2015 ACR/ARHP Annual Meeting

    Which Factors Influence the Prescription of Tocilizumab Alone or in Combination with Dmards in Rheumatoid Arthritis Patients in a Real Life Setting? the ACT-Solo Study: An Analysis of Efficacy and Safety at 12 Months

    Jacques Tebib1, Isabelle Idier2, Mathieu Coudert3, David Pau4, Jean-Francis Maillefert5 and Rene-Marc Flipo6, 1Rheumatology, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France, 2Chugai Pharma, La Defense, France, 3Statistics, Experis IT, Nanterre, France, 4Statistics, Roche, Boulogne-Billancourt, France, 5Rheumatology, University Hospital, Dijon, France, 6Rheumatology, University Hospital, Lille, France

    Background/Purpose: Baseline factors influencing the use of tocilizumab (TCZ) in monotherapy (Mono) instead of combination with DMARDs (Combo) in real-life practice in RA patients (pts)…
  • Abstract Number: 3136 • 2015 ACR/ARHP Annual Meeting

    Impact of Prokinetic Agents on Systemic Sclerosis-Associated Gastrointestinal Disease: A Systematic Review

    Annaliese Tisseverasinghe1, Ahmad Kadhim2, Ambica Parmar2, Louis Liu2 and Sindhu R. Johnson1, 1Toronto Scleroderma Program, Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital, Institue of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, 2Division of Gastroenterology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: More than 90% of patients with Systemic Sclerosis (SSc) have gastroinstestinal (GI) involvement, commonly dysmotility causing complications such as gastroesophageal reflux and constipation. Treatment…
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