ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 3148 • 2016 ACR/ARHP Annual Meeting

    Peptidylarginine Deiminase 2 Is Required for Tumor Necrosis Factor Alpha Induced Citrullination and Arthritis, but Not Neutrophil Extracellular Trap Formation

    Mandar Bawadekar1, Daeun Shim1, Ryan Rebernick1, Chloe Peyton1, Chad J. Johnson2, Thomas F. Warner3, Dres Damgaard4, Claus Henrik Nielsen5, Anthony P. Nicholas6, Ger JM Pruijn7, Jeniel E. Nett8 and Miriam A. Shelef1,9, 1Department of Medicine, Division of Rheumatology, University of Wisconsin-Madison, Madison, WI, 2Department of Medicine, University of Wisconsin-Madison, Madison, WI, 3Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, 4Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, 5Danish Rheumatologic Biobank and DANBIO registry, Rigshospitalet, Glostrup, Gentofte and Herlev University Hospital, Copenhagen, Denmark, 6Neurology, University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, AL, 7Biomolecular Chemistry, Institute for Molecules and Materials and Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, Netherlands, 8Medicine and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, 9William S. Middleton Memorial Veterans Hospital, Madison, WI

    Background/Purpose: The presence of anti-citrullinated protein antibodies in rheumatoid arthritis points to a potential role for citrullination in disease pathogenesis. Peptidylarginine deiminases (PADs) catalyze the…
  • Abstract Number: 1111 • 2016 ACR/ARHP Annual Meeting

    Huntingtin Interactin Protein 1 (HIP1) Regulates Receptor Tyrosine Kinases Mediated Activity and Cell Invasiness in Fibroblast-like Synoviocytes

    Teresina Laragione, Nasim Azizgolshani, Carolyn Harris, Erjing Gao and Percio Gulko, Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Huntingtin-interacting protein 1 (Hip1) is a new arthritis severity gene recently identified in the Pristane and Collagen-induced arthritis (PIA, CIA) quantitative trait locus Cia25/Pia42…
  • Abstract Number: 1435 • 2016 ACR/ARHP Annual Meeting

    KCa1.1 Potassium Channels Are a Novel Therapeutic Target on Fibroblast-like Synoviocytes in Rheumatoid Arthritis

    Mark Tanner1, Redwan Huq1, Rajeev Tajhya1, Michael Pennington2, Teresina Laragione3, Pércio Gulko4 and Christine Beeton5, 1Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX, 2Peptides International, Louisville, KY, 3Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 4Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 5Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX

    Background/Purpose: Fibroblast-like synoviocytes (FLS) develop a high degree of invasiveness during rheumatoid arthritis (RA), leading to joint degradation. There are currently no therapeutics that specifically…
  • Abstract Number: 1436 • 2016 ACR/ARHP Annual Meeting

    TAS8274, a Highly Selective Janus Kinase 3 Inhibitor, Demonstrates Potent Efficacy in an Animal Model of Rheumatoid Arthritis

    Hiroaki Hayashi, Takafumi Harada, Shunsuke Demizu, Fumito Tatsuzawa, Ken Sato, Morihiro Mitsuya, Kenji Tanaka, Kazuhiko Yonekura, Teruhiro Utsugi, Eiji Sasaki and Yoshikazu Iwasawa, TAIHO PHARMACEUTICAL CO., LTD., Tsukuba, Japan

    Background/Purpose:   The family of Janus kinases (JAKs) plays important roles in signaling pathway mediated by various cytokine receptors. An aberrant activation of JAK-STAT signaling…
  • Abstract Number: 1447 • 2016 ACR/ARHP Annual Meeting

    Therapeutic Blockade of Interleukin-6 Trans-Signalling Restores Vascular Function in Murine Collagen Induced Arthritis

    Ruth Davies1, Jessica O Williams2, Katie Sime2, Ellyn Hughes2, Lauren A. Jordan2, Charlotte Rawlings2, Derek Lang3, Stefan Rose-John4, Simon A. Jones5, Anwen S. Williams2 and Ernest H. Choy6,7, 1CREATE Centre, Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom, 2Institute of Infection and Immunity, Cardiff University, Cardiff, United Kingdom, 3Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom, 4Institute of Biochemistry, Christian Albrechts University, Kiel, Germany, 5Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, Wales, 6Section of Rheumatology, Cardiff University, Cardiff, Great Britain, 7CREATE Center, Division of Infection and Immunity,, Cardiff University, Cardiff, United Kingdom

    Background/Purpose: Mortality is increased in rheumatoid arthritis (RA), mainly due to cardiovascular disease (CVD). While molecular mechanisms underlining this clinical observation are unknown, systemic elevations…
  • Abstract Number: 1451 • 2016 ACR/ARHP Annual Meeting

    Glutamine Metabolism Plays a Crucial Role in the Pathogenesis of Rheumatoid Arthritis

    Soshi Takahashi1, Jun Saegusa2, Ikuko Naka3, Kosaku Tsuda3, Takaichi Okano4, Kengo Akashi3, Sho Sendo2, Yo Ueda3, Akira Onishi5, Yoshinori Kogata2 and Akio Morinobu2, 1Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 3Kobe University Graduate School of Medicine, Kobe, Japan, 4Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 5Rheumaology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Many signaling pathways activated under inflammatory and hypoxic conditions have profound effects on intracellular metabolism to support cell growth and survival. Cancer cells consume…
  • Abstract Number: 1462 • 2016 ACR/ARHP Annual Meeting

    Magnesium Is a New Mediator Arthritis Severity and Joint Damage

    Teresina Laragione, Nasim Azizgolshani, Carolyn Harris, Erjing Gao and Percio Gulko, Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose:  Given the effects of magnesium supplementation in suppressing components of the innate immunity in short-term studies, we examined the effect of dietary magnesium modifications…
  • Abstract Number: 1617 • 2016 ACR/ARHP Annual Meeting

    Treatment with Sirukumab, an Anti-IL6 Cytokine Monoclonal Antibody, Improves Fatigue and Health-Related Physical and Emotional Well Being in Patients with Active Rheumatoid Arthritis Refractory to Conventional or Biologic Therapy: Results of 2 Global, Placebo-Controlled, Phase 3 Trials

    Clifton Bingham III1, Yoshiya Tanaka2, George Karpouzas3, Tsutomu Takeuchi4, Daniel Aletaha5, Carter Thorne6, Shihong Sheng7, Weichun Xu7, Ravi Rao8, Kaiyin Fei7, Benjamin Hsu7, Prasheen Agarwal7, Sharon Popik7, Regina Kurrasch9, Steve Peterson7, Rita Ganguly9, Chenglong Han7 and Kelly McQuarrie7, 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2University of Occupational and Environmental Health, Kitakyushu, Japan, 3Division of Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, 4Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, 5Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 6University of Toronto and Southlake Regional Health Centre, Newmarket, ON, Canada, 7Janssen Research & Development, LLC, Spring House, PA, 8GSK Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom, 9GlaxoSmithKline, Collegeville, PA

    Background/Purpose: Patients (pts) with rheumatoid arthritis (RA) often experience both substantial fatigue and a decline in their health-related physical and emotional well-being. Sirukumab is a…
  • Abstract Number: 1656 • 2015 ACR/ARHP Annual Meeting

    Repeated CD4+ T-Cell Depletion in Patients with Rheumatoid Arthritis over Multiple Cycles of Rituximab Treatment

    Matthieu Lavielle1, Denis Mulleman1, Hsueh Cheng Sung2, Clément Bahuaud2, Philippe Goupille1, Hervé Watier3 and Gilles Thibault3, 1Service de Rhumatologie, CHRU de Tours, Université François-Rabelais de Tours, CNRS 7292, Tours, France, 2Université François-Rabelais de Tours, CNRS 7292, Tours, France, 3Laboratoire d'Immunologie, CHRU de Tours, Université François-Rabelais de Tours, CNRS 7292, Tours, France

    Background/Purpose: CD4+ T-cell depletion after a first cycle of rituximab (RTX) in patients with rheumatoid arthritis (RA) was previously reported by our group (Mélet J…
  • Abstract Number: 3198 • 2015 ACR/ARHP Annual Meeting

    Treatment of Rheumatoid Arthritis with an Anti-Tumor Necrosis Factor Agent or Tocilizumab As First Biologic Therapy in a Global Comparative Observational Study

    Ernest H. Choy1, Corrado Bernasconi2, Maher Aassi2, Jose F. Molina3 and Oscar M. Epis4, 1Cardiff University, Institute of Infection and Immunity, Tenovus Building, University Hospital of Wales, Cardiff, United Kingdom, 2F. Hoffmann-La Roche, Basel, Switzerland, 3Centro Integral de Reumatologia Reumalab, Medellin, Colombia, 4Rheumatology Unit, A.O. Ospedale Niguarda Ca' Granda, Milan, Italy

    Background/Purpose: ACT-iON was a global, multicenter, observational, 52-wk, clinical practice study of the effectiveness of tocilizumab (TCZ) vs anti–tumor necrosis factor (aTNF) agents prescribed as…
  • Abstract Number: 1667 • 2015 ACR/ARHP Annual Meeting

    Clinical Parameters and B Cell Subsets As Biomarkers of Response to Tocilizumab in Rheumatoid Arthritis

    Anna Laura Fedele, Barbara Tolusso, Elisa Gremese, Silvia Canestri, Clara Di Mario, Marcin Nowik and Gianfranco Ferraccioli, Division of Rheumatology, Institute of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy

    Background/Purpose: Tocilizumab (TCZ) is an effective treatment for Rheumatoid Arthritis (RA) and it is a modifier of B cell subsets in vivo, inducing changes in…
  • Abstract Number: 175 • 2015 ACR/ARHP Annual Meeting

    Correlating Semiquantitative Ultrasound Scores with Measured Synovial Thickness

    Ralf G. Thiele1, Darren Tabechian1, Laura C Coates2 and Jennifer H. Anolik1, 1University of Rochester Medical Center, Rochester, NY, 2Medicine, University of Rochester, Rochester, NY

    Background/Purpose: In studies of rheumatoid arthritis using ultrasonography (US), findings of synovial thickening are often reported in semiquantitative scores. For synovial biopsies of small joints,…
  • Abstract Number: 1682 • 2015 ACR/ARHP Annual Meeting

    Suppression of Chronic Arthritis By a Novel Nuclear Factor of Activated T-Cell 5 (NFAT5) Inhibitor

    Wan-Uk Kim1, Eun-Jin Han2, Chong-Hyeon Yoon3, Ki-Jo Kim4, Seung-Ah Yoo5, Bong Ki Hong5 and Saseong Lee5, 1Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, 2Institute of Bone & Joint Disease, The Catholic University of Korea, Seoul, South Korea, 3Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, 4St. Mary's Hospital, Seoul, South Korea, 5Institute of Bone and Joint Diseases, The Catholic University of Korea, Seoul, South Korea

    Background/Purpose: We reported that nuclear factor of activated T-cells 5 (NFAT5), originally identified as an osmo-protective transcription factor, has a critical role in the pathogenesis…
  • Abstract Number: 450 • 2015 ACR/ARHP Annual Meeting

    Use of Tofacitinib in a Real World Setting:  Clinical Features in a Cohort of Patients Using the Database Jointman Compared to a Published Clinical Trial

    Sergio Schwartzman1, Keith Knapp2, Gary Craig3, Karen Ferguson4 and Howard Kenney5, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Arthritis Northwest, Spokane, WA, 3Discus Analytics, Inc., Spokane, WA, 4Arthritis Northwest PLLC., Spokane, WA, 5Rheumatology, Arthritis Northwest, Spokane, WA

    Background/Purpose: It is well accepted that patients studied in pharmaceutically sponsored clinical trials do not always represent the types of patients seen in clinical practice. …
  • Abstract Number: 2012 • 2015 ACR/ARHP Annual Meeting

    TNF Confers Pathogenic Memory in Synovial Fibroblasts Via Chromatin Remodeling, NF-Kb-Dependent Transcription and MAPK-Mediated mRNA Stabilization

    Konstantinos Loupasakis1, Christopher Sohn2, Lionel B. Ivashkiv3 and George D. Kalliolias2, 1Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY, 2Hospital for Special Surgery, New York, NY, 3Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY

    Background/Purpose: We investigated mechanisms driving pathogenic behavior of synovial fibroblasts (FLS) in rheumatoid arthritis (RA). Methods: FLS from RA patients (1987 classification criteria) were extracted.…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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