Abstracts tagged "rheumatoid arthritis"

Abstract Number: 2270 • ACR Convergence 2025
ACKR1 and Leukopenia in Patients with Rheumatoid Arthritis Treated with Disease Modifying Antirheumatic Drugs
Daniela Chavez de Paz Solis¹, Puran Nepa², Laura Daniel³, Yan Guo⁴, Jonathan Mosley⁵, Michael Stein⁶ and Cecilia Chung⁴, ¹University of Maine, Caribou, ME, ²University of Miami, Research Service, Miami VA Healthcare System, Miami, FL, ³University of Miami, Nashville, TN, ⁴University of Miami, Miami, ⁵UT Southwestern Medical Center, Dallas, ⁶Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Disease-modifying antirheumatic drugs (DMARDs) such as methotrexate, sulfasalazine, and leflunomide arecommonly prescribed for RA treatment but carry the risk of leukopenia. The ACKR1 promoter…
Abstract Number: 2254 • ACR Convergence 2025
Association of disease activity with insomnia, depression, and fatigue in patients with rheumatoid arthritis: a multicenter prospective observational study
Misako Higashida-Konishi¹, Keisuke Izumi², Shuntaro Saito Saito³, Hiroki Tabata⁴, Satoshi Hama⁴, Tatsuhiro Oshige⁴, Yutaka Okano⁴, Hisaji Oshima⁴, Katsuya Suzuki⁴, Jiro Sakamoto⁵, Toshikazu Fukami⁵, Kazumichi Minato⁵, Nobuhiko Kajio⁶, Yasushi Kondo³, Hiroaki Taguchi⁶ and Yuko Kaneko³, ¹NHO Tokyo Medical Center, Tokyo Meguroku, Japan, ²Division of Rheumatology, Department of Medicine, NHO Tokyo Medical Center/Keio University School of Medicine/TechDoctor, Inc., Tokyo, Japan, ³Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ⁴Division of Rheumatology, Department of Medicine, NHO Tokyo Medical Center, Tokyo, Japan, ⁵TechDoctor, Inc., Tokyo, Japan, ⁶Department of Rheumatology, Kawasaki Municipal Hospital, Kanagawa, Japan
Background/Purpose: Patients with rheumatoid arthritis (RA) often experience not only joint-related symptoms but also systemic issues such as insomnia, depression, and fatigue [1–3]. These symptoms…
Abstract Number: 2237 • ACR Convergence 2025
Safety of DMARD therapy in veterans with rheumatoid arthritis following melanoma diagnosis: a survival analysis
Gabriella Girolami¹, Shamey Kassim², Alexander Peterson³, Aaron Baraff³, Alexandra Schmidt³, Shailender Bhatia⁴, Natalie Miller⁴, Jennifer Barton⁵, Jeffrey Curtis⁶, Christopher Li⁴ and Namrata Singh⁷, ¹University of Washington, Seattle, ²University of Washington, Seattle, WA, ³VA Puget Sound Health Care System, Seattle, WA, ⁴Fred Hutch Cancer Center, Seattle, ⁵VA Portland Health Care System/OHSU, Portland, OR, ⁶Foundation for Advancing Science, Technology, Education and Research, Birmingham, AL, ⁷University of Washington, Bellevue, WA
Background/Purpose: While disease-modifying anti-rheumatic drugs (DMARDs) are critical in managing rheumatoid arthritis (RA), their immunosuppressive effects raise concerns about cancer-related outcomes. In patients with RA…
Abstract Number: 2176 • ACR Convergence 2025
Addressing Hesitancy in JAK Inhibitor Use: Outcomes from Continuing Medical Education Reveal Confidence-Knowledge Gaps Among Community Rheumatologists
Carole Drexel¹, Eve Wilson², Vibeke Strand³ and Jon Giles⁴, ¹Medlive, Pasadena, MD, ²Medlive, Needham, MA, ³Stanford University School of Medicine, Palo Alto CA, Portola Valley, CA, ⁴Cedars Sinai Medical Center, Los Angeles, CA
Background/Purpose: Despite supportive real-world evidence, the use of Janus kinase inhibitors (JAKi) for rheumatoid arthritis (RA) remains limited in community settings. Concerns stemming from the…
Abstract Number: 1940 • ACR Convergence 2025
Correlation of Hand and Lymphatic Function Post Exercise Intervention in Rheumatoid Arthritis
Allen Anandarajah¹, Ronald Wood², Edward Schwarz³, Ram Haddas² and Homaira Rahimi², ¹University of Rochester Medical Center, Rochester, NY, ²University of Rochester, ROCHESTER, NY, ³University of Rochester, Rochester, NY, USA, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease which often leads to deformities and loss of function of hands. Despite the availability of…
Abstract Number: 1774 • ACR Convergence 2025
Citrullinated and Malondialdehyde-Acetaldehyde Co-Modified Fibrinogen Activates Macrophages and Induces Pro-Fibrotic shift in Coronary Endothelium Phenotype
Nozima Aripova¹, Wenxian Zhou², Hannah Johnson¹, Michael Duryee¹, Kimberley Sinanan¹, Carlos Hunter¹, Tate Johnson¹, Mabruka Alfaidi¹, Daniel Anderson³, Kishore Bidasee¹, Geoffrey Thiele¹ and Ted Mikuls¹, ¹University of Nebraska Medical Center, Omaha, NE, ²University of Nebraska Medical Center, Bellevue, NE, ^30587964, Durham, NC
Background/Purpose: Rheumatoid arthritis (RA) patients are at increased risk for developing heart failure with preserved ejection fraction (HFpEF), which is characterized by impaired left ventricular…
Abstract Number: 1679 • ACR Convergence 2025
Does First-Line b- or tsDMARDs Choice Influence Progression to Difficult-to-Treat Rhumatoid arthritis? Insights from our longitudinal RA UCLouvain Brussels cohort
Cécile VAN MULLEM¹, Francesco NATALUCCI¹, Stéphanie DIERCKX¹, Aleksandra AVRAMOVSKA¹, Tatiana SOKOLOVA² and Patrick Durez¹, ¹Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCLouvain) – Institut de Recherche Expérimentale et Clinique (IREC), Rheumatology, Brussels, Belgium, ²Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCLouvain) – Institut de Recherche Expérimentale et Clinique (IREC), Rheumatology, Brussels, Brussels Hoofdstedelijk Gewest, Belgium
Background/Purpose: The management of Rheumatoid Arthritis (RA) has markedly advanced, enabling the achievement of disease control and remission. Nevertheless, a proportion of patients remains refractory…
Abstract Number: 1375 • ACR Convergence 2025
86-96% of rheumatoid arthritis (RA) patients with RA who have 0 or 1 swollen joint or tender joint but are classified as moderate/high on RA indices have 1-9 comorbidities recognized on a multidimensional health assessment questionnaire (MDHAQ)
Theodore Pincus¹, Juan Schmukler¹ and Tengfei Li², ¹Rush University Medical Center, Chicago, IL, ²Rush, chicago, IL
Background/Purpose: Rheumatoid arthritis (RA) guidelines suggest management according to “treat-to-target,” with escalation of treatment in patients with moderate/high (M/H) DAS28 (disease activity score 28) or…
Abstract Number: 1358 • ACR Convergence 2025
Real-World Evidence for the Superiority of Subcutaneous Methotrexate in RA: A Comparative Observational Study with Ultrasonographic Assessment
Masatsugu Komagamine¹, Sari Taguchi², Masataka Komagamine², Tetsuji Naka¹ and Minoru Fujimoto¹, ¹Division of Allergy and Rheumatology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan, ²Komagamine Rheumatology and Orthopedic Clinic, Morioka, Japan
Background/Purpose: Methotrexate (MTX) is a foundational agent in the management of rheumatoid arthritis (RA). While oral MTX is widely prescribed, its subcutaneous (SC) formulation may…
Abstract Number: 1341 • ACR Convergence 2025
Physical Function Across Age in Patients With Rheumatoid Arthritis and Population Controls: A Cross-Sectional Study of Four Performance Measures
Saskia Truijen¹, Annelies Boonen¹, Sofia Ramiro² and Marloes van Onna¹, ¹Maastricht University Medical Centre+ & Maastricht University, Maastricht, Limburg, Netherlands, ²Leiden University Medical Center, Bunde, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) may accelerate age-related functional decline compared to the general population. This study aimed to examine whether four performance measures of physical…
Abstract Number: 1324 • ACR Convergence 2025
Similar Negative Effects of Fatigue on Physical Activity in Persons with Rheumatoid Arthritis and Healthy Controls: A Patient-Control Study
Maartje Cox¹, Kyra Theunissen², Kenneth Meijer², Annick Timmermans³, Sofia Ramiro⁴, Annelies Boonen⁵ and Guy Plasqui², ¹Australian National Phenome Centre - Murdoch University, Booragoon, Western Australia, Australia, ²Maastricht University, Maastricht, Netherlands, ³Universiteit Hasselt, Hasselt, ⁴Leiden University Medical Center, Bunde, Netherlands, ⁵Maastricht University Medical Centre+ & Maastricht University, Maastricht, Limburg, Netherlands
Background/Purpose: People with rheumatoid arthritis (pwRA) are prone to fall short of the World Health Organization’s physical activity (PA) recommendations due to perceived fatigue and…
Abstract Number: 1308 • ACR Convergence 2025
Predictors of Interstitial Lung Disease Progression in Patients with Rheumatoid Arthritis
Bryant England¹, Austin Wheeler¹, Halie Frideres², Scott Matson³, Geoffrey Thiele¹, Katherine Wysham⁴, Grant Cannon⁵, Gary Kunkel⁶, Gail Kerr⁷, Andreas Reimold⁸, John Richards⁹, Dana Ascherman¹⁰, Paul Monach¹¹, Joshua Baker¹² and Ted Mikuls¹, ¹University of Nebraska Medical Center, Omaha, NE, ²UNMC Department of Rheumatology, Omaha, NE, ³University of Kansas, Kansas City, MO, ⁴VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, ⁵University of Utah and Salt Lake City VA, Salt Lake City, UT, ⁶University of Utah and George E Wahlen VAMC, Salt Lake City, UT, ⁷Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, ⁸Dallas VA Medical Center, Dallas, TX, ⁹Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, ¹⁰University of Pittsburgh, Pittsburgh, PA, ¹¹VA Boston Healthcare System, Boston, MA, ¹²University of Pennsylvania, Philadelphia, PA
Background/Purpose: Interstitial lung disease (ILD) is a frequent extra-articular manifestation of RA predisposing to poor health outcomes. The disease course in RA-ILD is variable, with…
Abstract Number: 1110 • ACR Convergence 2025
Tumor outcomes and arthritis flares in patients with pre-existing rheumatoid arthritis receiving immune checkpoint inhibitor therapy
Madalyn Walsh¹, Jeremy Zhang², Bashar Abuqayas¹, Sanchay Jain³, Yosef Zakharia⁴, Aleksander Lenert⁵ and Jennifer Strouse⁶, ¹University of Iowa Hospitals & Clinics, Iowa City, IA, ²Rush University, Chicago, IL, ³University of Iowa, Iowa City, IA, ⁴Mayo Clinic, Rochester, MN, ⁵Iowa Carver College of Medicine, Iowa City, IA, ⁶University of Iowa, Iowa City
Background/Purpose: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of an increasing number of malignancies. Because patients with pre-existing autoimmune disease have been excluded from…
Abstract Number: 1033 • ACR Convergence 2025
Rethinking ANA in Rheumatoid Arthritis: ICAP Pattern Insights from a Large-Scale Taiwanese Cohort
Tien-Ming Chan, Chang Gung Memorial Hospital, Taoyuan, Taiwan (Republic of China)
Background/Purpose: ANA prevalence and patterns vary in RA. Using ICAP nomenclature, this study aimed to determine the prevalence of RA across different ANA patterns and…
Abstract Number: 0930 • ACR Convergence 2025
Potent and Selective Oral IRF5 Degrader, KT-579, Blocks Pro-Inflammatory Cytokines and Reduces Joint Swelling in a Mouse Model of Rheumatoid Arthritis
Ryan Camire¹, Yi Zhang², Virginia Massa², Jordan Leedberg², Erik Corcoran², Emily Lurier², Chris Carroll², Chris Ho², Dapeng Chen², Bradley Enerson², Revonda Mehovic², Ziyan Zhao², Lincoln Howarth², Susanne Breitkopf², Sarah Martinez², Melissa Ford², Xue Fei², Murugappan Sathappa², Juliet Williams³, Matthew Weiss³, Arsalan Shabbir³, Nello Mainolfi⁴ and Veronica Campbell², ¹Kymera Therapeutics, Watertown, MA ⁰²⁴⁷², MA, ²Kymera Therapeutics, Watertown, MA ⁰²⁴⁷², ³Kymera Therapeutics, Watertown, ⁴Kymera Therapeutics, Watertown, MA
Background/Purpose: IRF5, an undrugged transcription factor, is an autoimmune susceptibility gene that has been linked to RA and other autoimmune diseases including SLE, Sjögren’s, and…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].