Abstracts tagged "rheumatoid arthritis"

Abstract Number: 1660 • ACR Convergence 2021
Relationship Between Risk of New Onset Diabetes Mellitus and Exposure to Individual Antirheumatic Drugs in Patients with Rheumatoid Arthritis: A Nationwide Population Study
So Hye Nam¹, Min-Ju Kim², Ye-Jee kim², Soo Min Ahn², Seokchan Hong³, Chang-Keun Lee², Bin Yoo³, Ji Seon Oh⁴ and Yong-Gil Kim², ¹Uijeongbu Eulji Medical Center, Uijeongbu, Gyeonggi-do, Republic of Korea, ²Asan Medical Center, Seoul, Republic of Korea, ³Asan Medical Center, Seoul, South Korea, ⁴Asan Medical Center, Ulsan, Republic of Korea
Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disease that affects glucose metabolism, mainly insulin resistance, which can lead to diabetes mellitus (DM). Although there…
Abstract Number: 1676 • ACR Convergence 2021
Safety of Baricitinib in Japanese Patients with Rheumatoid Arthritis (RA): The 2020 Interim Report from All-case Post Marketing Surveillance in Clinical Practice
Takao Fujii¹, Tatsuya Atsumi², Nami Okamoto³, Nobunori Takahashi⁴, Naoto Tamura⁵, Atsuo Nakajima⁶, Ayako Nakajima⁷, Hiroaki Matsuno⁸, Naoto Tsujimoto⁹, Atsushi Nishikawa¹⁰, Taeko Ishii¹⁰, Tsutomu Takeuchi¹¹, Masataka Kuwana¹² and Michiaki Takagi¹³, ¹Department of Rheumatology and Clinical Immunology, Wakayama Medical University, Wakayama, Japan, ²Hokkaido University, Sapporo, Japan, ³Osaka Medical College, Takatsuki-city, Japan, ⁴Nagoya University Graduate School of Medicine, Nagoya, Japan, ⁵Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan, ⁶Ueno Touseki Clinic, Fukuoka, Japan, ⁷Center for Rheumatic Diseases, Mie University Hospital, Mie, Japan, ⁸Matsuno Clinic for Rheumatic Diseases, Toyama, Japan, ⁹Eli Lilly Japan K.K.,, Kobe, Japan, ¹⁰Eli Lilly Japan K.K., Kobe, Japan, ¹¹Div. Rheumatology, Keio University, Tokyo, Japan, ¹²Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ¹³Department of Orthopaedic Surgery, Yamagata University Faculty of Medicine, Yamagata, Japan
Background/Purpose: An all-case post marketing surveillance (PMS) of baricitinib, that started in Sep 2017, collects safety and effectiveness for the first 24 weeks of treatment…
Abstract Number: 1692 • ACR Convergence 2021
Long-Term Efficacy and Safety of Upadacitinib in Patients with Rheumatoid Arthritis: 3-year Results from the SELECT-EARLY Study
Ronald F van Vollenhoven¹, Tsutomu Takeuchi², Jacob Aelion³, Nilmo Chavez⁴, Pablo Mannucci⁵, Atul Singhal⁶, Jerzy Swierkot⁷, Alan Friedman⁸, Nasser Khan⁸, Yihan Li⁹, Xianwei Bu⁹, Justin Klaff⁸ and Vibeke Strand¹⁰, ¹Amsterdam University Medical Centers, Department of Rheumatology and Clinical Immunology, Rheumatology and Immunology Center ARC, Amsterdam, Netherlands, ²Div. Rheumatology, Keio University, Tokyo, Japan, ³Arthritis Clinic and West Tennessee Research Institute, Jackson, TN, ⁴Instituto Guatemalteco de Seguridad Social, Ciudad de Guatemala, Guatemala, ⁵Aprillus Asistencia e Investigación, Buenos Aires, Argentina, ⁶Southwest Rheumatology Research LLC, Dallas, TX, ⁷Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Wroclaw, Poland, ⁸AbbVie Inc., North Chicago, IL, ⁹AbbVie Inc., North Chicago, ¹⁰Stanford University School of Medicine, Portola Valley, CA
Background/Purpose: Upadacitinib (UPA), an oral Janus kinase inhibitor, demonstrated significant improvements in signs, symptoms, and structural inhibition as monotherapy (mono) vs methotrexate (MTX) in MTX-naïve…
Abstract Number: 1709 • ACR Convergence 2021
Long-term Safety of a Single Infusion of Human Umbilical Cord Blood-derived Mesenchymal Stem Cell Therapy in Rheumatoid Arthritis: The 5-year Follow-up of the Phase I Clinical Trial
Min Jung Kim¹, Eun Hye Park² and Kichul Shin³, ¹Seoul Metropolitan Government–Seoul National University Boramae Medical Center, Seoul, Republic of Korea, ²Chung-Ang University Hospital, Seoul, Republic of Korea, ³Seoul Metropolitan Government- Seoul National University Boramae Medical Center, Seoul, Republic of Korea
Background/Purpose: Mesenchymal stem cell (MSC) therapy represents a promise for the treatment of autoimmune diseases due to its potent immunomodulatory effect. We investigated the long-term…
Abstract Number: 1924 • ACR Convergence 2021
Patient Clustering Based on Multimorbidity Patterns Predicts Healthcare Utilization and Mortality in Rheumatoid Arthritis Within Independent Real-World Datasets
Bryant England¹, Yangyuna Yang¹, Punyasha Roul¹, Christian Haas², Harlan Sayles¹, Fang Yu¹, Brian Sauer³, Joshua Baker⁴, Kaleb Michaud¹, Jeffrey Curtis⁵ and Ted Mikuls¹, ¹University of Nebraska Medical Center, Omaha, NE, ²University of Nebraska Omaha, Omaha, NE, ³University of Utah, Salt Lake City, UT, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Rheumatoid arthritis (RA) leads to substantial healthcare utilization and premature mortality. Prior work has demonstrated that the overlapping presence of comorbid chronic conditions, termed…
Abstract Number: 0021 • ACR Convergence 2021
Unique Alterations in Circulating T Peripheral Helper Cells Are Found in Different Ethnic Groups of ACPA+ Individuals Both At-risk for and with Classified RA
Hideto Takada¹, Yuko Okamoto², Yasuhiro Katsumata³, Jennifer Seifert⁴, Kristen Demoruelle⁵, Jill Norris⁶, Kevin Deane⁷, Masayoshi Harigai³ and V. Michael Holers⁸, ¹Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Japan, ²Tokyo Women's Medical University Division of Rheumatology, 10-22 Kawada-cho, Shinjyuku-ku, Tokyo, Japan, ³Tokyo Women's Medical University School of Medicine, Tokyo, Japan, ⁴University of Colorado School of Medicine, Littleton, CO, ⁵University of Colorado Anschutz Medical Campus, Aurora, CO, ⁶Colorado School of Public Health, Aurora, CO, ⁷University of Colorado Denver, Denver, CO, ⁸University of Colorado, Denver, CO
Background/Purpose: Production of autoantibodies following pathogenic T and B cell interactions precede the development of RA. T follicular helper (Tfh) cells and T peripheral helper…
Abstract Number: 0038 • ACR Convergence 2021
Arthritis Progression in at Risk Individuals Is Associated with ACPAs Not AMPAs
Alexandra Circiumaru¹, Yogan Kisten², Monika Hansson², Heidi Wähämaa³, Meng Sun³, Vijay Joshua³, Hamed Rezaei⁴, Erik Af Klint⁴, Aleksandra Antovic¹, Anca Catrina³ and Aase Haj Hensvold⁵, ¹Division for Rheumatology, Karolinska Institutet; Center for Rheumatology, Academic Specialist Center, Stockholm Region, Stockholm, Sweden, ²Division for Rheumatology, Karolinska Institutet, Stockholm, Sweden, ³Karolinska Institutet and Karolinska university Hospital, Stockholm, Sweden, ⁴Division for Rheumatology, Karolinska Institutet; Department of Rheumatology, Karolinska University Hospital, Stockholm, Sweden, ⁵Karolinska Institutet, Division for Rheumatology; & Center for Rheumatology, Academic Specialist Center, Stockholm Region, Stockholm, Sweden
Background/Purpose: Individuals with anti citrullinated protein antibodies (ACPA) and musculoskeletal complaints are at high risk for developing rheumatoid arthritis (RA) and often seek medical attention…
Abstract Number: 0120 • ACR Convergence 2021
Fibromyalgianess and Glucocorticoid Persistence Among Patients with Rheumatoid Arthritis
Beth Wallace¹, Meriah Moore², Andrew Heisler³, Lutfiyya Muhammad⁴, Jing Song⁵, Daniel Clauw², Clifton Bingham⁶, Marcy Bolster⁷, Wendy Marder², Tuhina Neogi⁸, Alyssa Wohlfahrt⁹, Dorothy Dunlop¹⁰ and Yvonne Lee¹⁰, ¹Michigan Medicine, VA Ann Arbor Healthcare System, Ann Arbor, MI, ²University of Michigan, Ann Arbor, MI, ³Bronson Rheumatology Specialists, Kalamazoo, MI, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Northwestern University, Worthington, IL, ⁶Johns Hopkins University, Baltimore, MD, ⁷Massachusetts General Hospital, Boston, MA, ⁸Boston University School of Medicine, Boston, MA, ⁹Tufts University School of Medicine, Boston, MA, ¹⁰Northwestern University, Chicago, IL
Background/Purpose: Over one-third of patients with rheumatoid arthritis (RA) exhibit evidence of fibromyalgianess, a cluster of somatic symptoms associated with increased sensitivity to painful stimuli.…
Abstract Number: 0182 • ACR Convergence 2021
Tenderness and Radiographic Progression in Rheumatoid Arthritis and Psoriatic Arthritis
Irina Gessl¹, Mihaela Popescu², Gabriela Supp¹, Martina Durechova¹, Michael Zauner¹, Josef Smolen¹, Daniel Aletaha³ and Peter Mandl¹, ¹Medical University of Vienna, Vienna, Austria, ²Maisonneuve Rosemont Hospital, Longueuil, QC, Canada, ³Medical University Vienna, Vienna, Austria
Background/Purpose: In rheumatoid arthritis (RA) and psoriatic arthritis (PsA), swelling is regarded as a sign of synovitis and is associated with radiographic progression. However, recent…
Abstract Number: 0277 • ACR Convergence 2021
Best Cardiovascular Risk Algorithm to Predict Abnormalities in Left Ventricular Geometry in Rheumatoid Arthritis Patients
Alejandra Rodriguez-Romero, Jose Azpiri-Lopez, Dionicio Galarza-Delgado, Iris Colunga-Pedraza, Jose A. Davila-Jimenez, Natalia Guajardo-Jauregui, Alejandro Meza-Garza, Julieta Loya-Acosta, Jesus Cardenas-de La Garza, Salvador Lugo-Perez, Alan De Leon-Yañez and Catalina Andrade-Vazquez, Hospital Universitario "Dr Jose E. Gonzalez", Monterrey, Mexico
Background/Purpose: A relationship between rheumatoid arthritis (RA) and the presence of abnormalities in left ventricular (LV) geometry such as eccentric remodeling has recently been determined,…
Abstract Number: 0295 • ACR Convergence 2021
Weight History and Associations with Cardiovascular Risk in Patients with Rheumatoid Arthritis
Lydia Federico¹, Kaleb Michaud², Kristin Wipfler³, Gulsen Ozen⁴ and Joshua Baker¹, ¹University of Pennsylvania, Philadelphia, PA, ²University of Nebraska Medical Center, Omaha, NE, ³FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ⁴University of Nebraska Medical Center, Bellevue, NE
Background/Purpose: Cardiovascular disease (CVD) is the leading cause of mortality in rheumatoid arthritis (RA), but traditional CVD risk factors may not accurately characterize risk. For…
Abstract Number: 0514 • ACR Convergence 2021
Extracellular Sulfatase-2 Mediates TNF-α Inflammatory Signaling in Human Rheumatoid Arthritis Synovial Fibroblasts
Ruby Siegel¹, Anil singh¹, Judy Vinh¹, H. Mark Kenney², Edward Schwarz³, David Fox⁴, Sadik Khuder⁵ and Salah-uddin Ahmed¹, ¹Washington State University, Spokane, WA, ²University of Rochester Medical Center, Rochester, NY, ³University of Rochester, Rochester, NY, ⁴Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ⁵Department of Medicine and Public Health, University of Toledo,, Toledo, OH
Background/Purpose: TNF-α drives RA synovial fibroblast (RASF)-mediated hyperplasia and joint tissue destruction. Extracellular sulfatase-2 (Sulf-2) influences receptor/ligand binding and subsequent signaling of chemokines, cytokines, and…
Abstract Number: 0577 • ACR Convergence 2021
Comorbidity Burden as Scored Using the Rheumatic Disease Comorbidity Index (RDCI) Is Associated with Varying Treatment Patterns in Patients with Inflammatory Arthritis – a Study Using the EHR-Derived Rheumatic and Arthritis Disease Information Registry (RADIR)
Diviya Rajesh, Deanna Jannat-Khah, Huong Do, Jonah Levine, Medha Barbhaiya, Lisa Mandl and Vivian Bykerk, Hospital for Special Surgery, New York, NY
Background/Purpose: Higher comorbidity burden (CB) has been associated with treatment choices in RA, but not assessed in populations including multiple forms of inflammatory arthritis (IA)…
Abstract Number: 0607 • ACR Convergence 2021
Validation Studies of Rheumatoid Arthritis Patient-Reported Outcome Measures in Diverse Populations at Risk for Inequity: A Systematic Review
Cheryl Barnabe¹, Aimee Wattiaux², Jennifer Petkovic³, Dorcas Beaton⁴, Beverley Shea³, Regina Greer-Smith⁵, Jennifer Humphreys⁶, Christie Bartels⁷, Peter Tugwell³ and Valerie Umaefulam¹, ¹University of Calgary, Calgary, AB, Canada, ²University of Wisconsin, Madison, WI, ³University of Ottawa, Ottawa, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Healthcare Research Associates, Hazel Crest, IL, ⁶University of Manchester, Manchester, United Kingdom, ⁷University of Wisconsin School of Medicine and Public Health, Madison, WI
Background/Purpose: Existing patient-reported outcome measures (PROMs) in rheumatoid arthritis (RA) may be limited in their applicability to populations that experience inequities. We conducted a systematic…
Abstract Number: 0787 • ACR Convergence 2021
Association of Hemoglobin Levels and Radiographic Progression in the BRASS Registry
Nancy Shadick¹, Owen Hagino², Amy Praestgaard³, Stefano Fiore², Michael Weinblatt⁴ and Gerd Burmester⁵, ¹Brigham and Women's Hospital, Boston, MA, ²Sanofi, Bridgewater, NJ, ³Sanofi, Cambridge, MA, ⁴Brigham and Women’s Hospital, Boston, MA, ⁵Charité University Medicine Berlin, Berlin, Germany
Background/Purpose: To evaluate baseline hemoglobin (Hb) and radiographic progression over time for patients in the Brigham and Women’s Hospital Rheumatoid Arthritis Sequential Study (BRASS) registry.Methods:…

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