Abstracts tagged "rheumatoid arthritis"

Abstract Number: 1242 • ACR Convergence 2021
Sex Differences in Treatment Response to Three Different Biological Treatments and Corticosteroids in Patients with Early Rheumatoid Arthritis
Kristina Lend¹, Ronald F van Vollenhoven², Jon Lampa³, Merete Hetland⁴, Espen Haavardsholm⁵, Dan Nordström⁶, Michael Nurmohamed⁷, Bjorn Gudbjornsson⁸, Anna Rudin⁹, Mikkel Ostergaard¹⁰, Till Uhlig¹¹, Gerdur Grondal⁸, Kim Hørslev-Petersen¹², Marte S Heiberg⁵, Tuulikki Sokka-Isler¹³, Jos Twisk¹⁴ and Irene van der Horst-Bruinsma¹⁵, ¹Department of Medicine, Rheumatology Unit, The Karolinska Institute, Stockholm, Sweden, ²Amsterdam University Medical Centers, Department of Rheumatology and Clinical Immunology, Rheumatology and Immunology Center ARC, Amsterdam, Netherlands, ³Karolinska University Hospital, Department of Medicine, Rheumatology Unit, The Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, ⁴DANBIO and COPECARE, Centre for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ⁵Diakonhjemmet Hospital, Oslo, Norway, ⁶Division of Internal Medicine and Rheumatology, Helsinki University Hospital, Helsinki, Finland, ⁷Amsterdam University Medical Centers, Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, ⁸Landspitali University Hospital, University of Iceland, Reykjavik, Iceland, ⁹Rheumatology Clinic, Sahlgrenska University Hospital, Sahlgrenska Academy of University of Gothenburg, Gothenburg, Sweden, ¹⁰Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, and Department of Clinical Medicine, University of Copenhagen, Glostrup, Denmark, ¹¹Diakonhjemmet Hospital, University of Oslo, Oslo, Norway, ¹²Danish Hospital for Rheumatic Diseases, University of Southern Denmark, Reykjavik, Iceland, Haderslev, Denmark, ¹³University of Eastern Finland, Jyväskylä Central Hospital, Jyväskylä, Finland, ¹⁴Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, Amsterdam, Netherlands, ¹⁵Department of Rheumatology, VU University Medical Centre, Amsterdam, Netherlands
Background/Purpose: To investigate sex differences in clinical response to three different biological treatments in combination with methotrexate (MTX) versus MTX plus corticosteroids (active conventional treatment;…
Abstract Number: 1385 • ACR Convergence 2021
Overall Survival in Patients with Systemic Autoimmune Diseases Following Lung or Heart-Lung Transplantation at a Single High-Volume Academic Transplant Center: A Comparative Cohort Study
Jason Melehani¹, Shufeng Li², Joshua Mooney³ and Lorinda Chung², ¹Stanford University, San Jose, CA, ²Stanford University, Palo Alto, CA, ³Stanford University, Stanford, CA
Background/Purpose: Lung manifestations of systemic autoimmune diseases are a frequent cause of early death. For many patients, current treatments cannot arrest the inexorable progression to…
Abstract Number: 1533 • ACR Convergence 2021
Comparison of Hospitalization and Mortality Rate in Patients with Different Rheumatic Diseases: A Brazilian Registry Cross-Sectional Analysis
Claudia Marques¹, Ana Paula Reis², Adriana Kakehasi³, Edgard Neto⁴, Marcelo Medeiros Pinheiro⁵, Gecilmara Salviato Pileggi⁶, Gilda Ferreira⁷, Licia Maria Henrique Mota⁸, Odirlei Andre Monticielo⁹, Sandra Lúcia Ribeiro¹⁰, Felipe Omura¹¹, Adriana Marinho¹², Francinne Ribeiro¹³, Laurindo Rocha Jr¹⁴, Ana Silvia Martins¹⁵, Michel Yazbek¹⁶, Mariana Souza¹⁷, Nathália Sacilotto¹⁸, Samuel Shinjo¹⁹, Lilian Valadares²⁰, Ana Silva²¹, Danielle Christine de Brito²², Viviane de Souza²³, Carolina Costa²⁴, Samia Studart²⁵, Antônio Ximenes²⁶ and Ricardo Xavier²⁷, ¹Hospital das Clnicas - Universidade Federal de Pernambuco - UFPE, Recife, Brazil, ²Centro Universitrio de Braslia- UniCEUB, Brasilia, Brazil, ³Federal University of Minas Gerais, Belo Horizonte, Brazil, ⁴UNIFESP, São Paulo, Brazil, ⁵Universidade Federal de São Paulo, São Paulo, Brazil, ⁶FACISB, Ribeirao Preto, Brazil, ⁷Federal University of Minas Gerais, Belo Horizonte, Brazil, ⁸Universidade de Brasília, Brasilia, Brazil, ⁹Serviço de Reumatologia do Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ¹⁰Universidade Federal do Amazonas, Amazonas, Brazil, ¹¹Clinica Omura, São Paulo, Brazil, ¹²FUNDHACRE, Rio Branco, Brazil, ¹³UERJ, Rio de Janeiro, Brazil, ¹⁴Instituto de Medicina Integral Professor Fernando Figueira - IMIP, Recife, Brazil, ¹⁵UFU, Uberlandia, MG, Brazil, ¹⁶UNICAMP, Campinas, Brazil, ¹⁷SCBH, Belo Horizonte, Brazil, ¹⁸Instituto de Assistência Médica ao Servidor Público Estadual, São Paulo, Brazil, ¹⁹Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²⁰HOSPITAL GETULIO VARGAS, Recife, Brazil, ²¹UFG, GOIANIA, Goias, Brazil, ²²UFPB, Joao Pessoa, Brazil, ²³UFJF, JUIZ DE FORA, Brazil, ²⁴UFES, Vitoria, Brazil, ²⁵HOSPITAL GERAL DE FORTALEZA, Fortaleza, Brazil, ²⁶CLINICA CIP, Goiania, Brazil, ²⁷Departamento de Reumatologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Background/Purpose: The COVID-19 pandemic has brought uncertainties to the rheumatological practice, and despite the large number of publications to date, many questions remain unanswered. One…
Abstract Number: 1657 • ACR Convergence 2021
Comprehensive Assessment of Multimorbidity Burden in a Population-based Cohort of Patients with Rheumatoid Arthritis
Cynthia Crowson¹, Tina Gunderson², Elena Myasoedova², Elizabeth Atkinson², Vanessa Kronzer², Caitrin Coffey² and John Davis², ¹Mayo Clinic, Eyota, MN, ²Mayo Clinic, Rochester, MN
Background/Purpose: Multimorbidity is common in patients with rheumatoid arthritis (RA), and it is associated with poor outcomes. The literature on multimorbidity suffers from numerous definitions…
Abstract Number: 1673 • ACR Convergence 2021
Riding Multiple Waves of Uncertainty: Real World Canadian RA Patient Outcomes over 1 Year of COVID-19 Restrictions
Orit Schieir¹, Susan Bartlett², Marie-France Valois², Louis Bessette³, Gilles Boire⁴, Glen Hazlewood⁵, Carol Hitchon⁶, Edward Keystone⁷, Janet Pope⁸, Diane Tin⁹, Carter Thorne¹⁰, Vivian Bykerk¹¹ and CATCH Investigators¹², ¹Canadian Early Arthritis Cohort Study, Montréal, QC, Canada, ²McGill University, Montréal, QC, Canada, ³Centre de l'Ostoporose et de Rhumatologie de Qubec, Québec City, QC, Canada, ⁴Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁵University of Calgary, Calgary, AB, Canada, ⁶University of Manitoba, Winnipeg, MB, Canada, ⁷Keystone Consulting Enterprises Inc., Toronto, ON, Canada, ⁸University of Western Ontario, London, ON, Canada, ⁹The Arthritis Program Research Group, Newmarket, ON, Canada, ¹⁰Southlake Regional Health Centre, Newmarket, ON, Canada, ¹¹Hospital for Special Surgery, New York, NY, ¹²Mt Sinai Hospital, Toronto, ON, Canada
Background/Purpose: During the COVID-19 pandemic, Canadians adults with RA faced considerable uncertainty due to greater risk of infection, hospitalization, changing access to RA medications, and…
Abstract Number: 1689 • ACR Convergence 2021
Safety, Tolerability, Pharmacokinetics, Receptor Occupancy, and Suppression of T-cell-Dependent Antibody Response in a Phase 1 Study with KPL-404, an anti-CD40 Monoclonal Antibody
Manoj Samant¹, Alistair Wheeler², Guang-Liang Jiang¹, Moses Njenga¹, Madeline Spiers¹, Arian Pano¹ and John F Paolini¹, ¹Kiniksa Pharmaceuticals Corp., Lexington, MA, ²Kiniksa Pharmaceuticals, Ltd., Hamilton, Bermuda
Background/Purpose: T-cell priming and T-cell-dependent B-cell responses require an intact cluster of differentiation (CD)40/CD40L pathway. CD40 is expressed on the surface of B-cells, dendritic cells,…
Abstract Number: 1706 • ACR Convergence 2021
Twenty-four-week Follow-up of a Randomized Controlled First-in-Human Trial of the Safety and Efficacy of Neurostimulation with a Miniaturized Vagus Nerve Stimulation Device in Patients with Multidrug-Refractory Rheumatoid Arthritis
Norman Gaylis¹, Mark Genovese², David Sikes³, Alan Kivitz⁴, Diane Horowitz⁵, Charles Peterfy⁶, Yaakov Levine⁷ and David Chernoff⁸, ¹Arthritis and Rheumatic Disease Specialties, Aventura, FL, ²Stanford University, Sunnyvale, CA, ³Florida Medical Clinic, Wesley Chapel, FL, ⁴Altoona Center for Clinical Research, Duncansville, PA, ⁵Northwell Health, Jericho, NY, ⁶Spire Sciences, Inc., Boca Raton, FL, ⁷SetPoint Medical, Manhassest, NY, ⁸SetPoint Medical, Sausalito, CA
Background/Purpose: Vagus nerve stimulation (VNS) activates innate neuroimmune reflexes that have been shown to reduce pro-inflammatory cytokines and clinical disease activity in subjects with rheumatoid…
Abstract Number: 1917 • ACR Convergence 2021
Sputum TGF-β1 Is Elevated in Subclinical and Clinically Significant Rheumatoid Arthritis-Associated Interstitial Lung Disease and Correlates with Soluble IL-6R Levels
Timothy Wilson¹, Kevin Deane², Joyce Lee¹, Christopher Collora³, Marie Feser³, Mariana Kaplan⁴, Joshua Solomon⁵ and Kristen Demoruelle⁶, ¹University of Colorado, Denver, CO, ²University of Colorado Denver, Denver, CO, ³University of Colorado Denver, Aurora, CO, ⁴National Institutes of Health, Bethesda, MD, ⁵National Jewish Health, Denver, CO, ⁶University of Colorado Anschutz Medical Campus, Aurora, CO
Background/Purpose: Increased levels of transforming growth factor β1 (TGF-β1) in the lung have been implicated in the pathogenesis of several fibrotic lung diseases, but their…
Abstract Number: 0019 • ACR Convergence 2021
Increased Circulating CD39+FoxP3+CD4+ Treg Cells in Early Rheumatoid Arthritis Facilitate the Antiinflammatory Action of Methotrexate
Laura Nuño¹, Alejandro Villalba¹, Marta Novella-Navarro², Irene Monjo¹, Diana Peitado¹, Sara Garcia-Carazo¹, Alejandro Balsa² and Maria-Eugenia Miranda-Carus¹, ¹Hospital La Paz - IdiPAZ, Madrid, Spain, ²Immuno-Rheumatology Research Group, Hospital La Paz Institute for Health Research-IdiPAZ, Rheumatology, La Paz University Hospital, Madrid, Spain
Background/Purpose: Inhibition of AICAR transformylase by MTX results in augmented release of adenine nucleotides to the extracellular space; these are rapidly hydrolysed by ectonucleotidases CD39…
Abstract Number: 0036 • ACR Convergence 2021
The NAD+ Metabolism Is Altered in Rheumatoid Arthritis and Its Modulation with NAD+ Boosters Exhibits Key Anti-Inflammatory and Anti-Oxidant Effects
Carlos Pérez-Sánchez¹, Luz Marina Sanchez-Mendoza², Nuria Barbarroja³, M.Carmen Abalos-Aguilera⁴, Maria Luque-Tevar⁵, Alejandra Patiño-Trives⁵, Iván Arias de la Rosa³, Cristobal Román-Rodriguez⁶, Juan Antonio Moreno², Maria Isabel Buron², Jose Antonio Gonzalez-Reyes², Marta Rojas-Gimenez⁴, Eduardo Collantes-Estevez⁶, alejandro Escudero⁶, Jose Manuel Villalba² and Chary lopez-pedrera⁶, ¹IMIBIC, Córdoba, Spain, ²Department of Cell Biology, Physiology and Immunology, University of Córdoba, Campus de Excelencia Internacional Agroalimentario, ceiA3, Cordoba, Spain, ³University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, ⁴Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Córdoba, Cordoba, Spain, ⁵Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, ⁶IMIBIC/Reina Sofia Hospital/University of Córdoba, Córdoba, Spain
Background/Purpose: NAD+ is a key cofactor and second messenger for multiple cellular processes that exhibits antioxidant, anti-apoptotic, and anti-inflammatory properties. Numerous publications and clinical trials…
Abstract Number: 0103 • ACR Convergence 2021
Patients with Inflammatory Rheumatic Diseases Are at Increased Risk of COVID-19 Related Hospitalization: Data from a Prospective Controlled Cohort Study
Laura Boekel¹, Femke Hooijberg¹, Erik Vogelzang², Maureen Leeuw¹, Sadaf Atiqi¹, Ronald van Vollenhoven³, Alexandre Voskuyl², Irene van der Horst-Bruinsma², Willem Lems¹, Taco Kuijpers², Marieke van Ham⁴, Luuk Wieske², Filip Eftimov², Maurice Steenhuis⁴, Sofie Keijzer⁴, Olvi Christianawati⁴, Floris Loeff⁴, Sander Tas⁵, Mike Nurmohamed⁶, Theo Rispens⁴ and Gertjan Wolbink¹, ¹Reade, Amsterdam, Netherlands, ²Amsterdam UMC, Amsterdam, Netherlands, ³Department of Rheumatology and Clinical Immunology, Amsterdam University Medical Center, Amsterdam Rheumatology Center, Amsterdam, Netherlands, ⁴Sanquin, Amsterdam, Netherlands, ⁵Amsterdam UMC, locatie AMC, Utrecht, Netherlands, ⁶Reade; Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands
Background/Purpose: Retrospective studies have suggested that patients with rheumatic diseases may be at increased risk of severe COVID-19 related disease, and that this risk may…
Abstract Number: 0178 • ACR Convergence 2021
Abdominal Obesity May Confound Accuracy of Cardiovascular Risk Prediction in Rheumatoid Arthritis; Can Coronary Atherosclerosis Imaging and Biomarkers Help?
George Karpouzas¹, sarah ormseth², Elizabeth Hernandez² and Matthew Budoff³, ¹Harbor-UCLA Medical Center, Torrance, CA, ²The Lundquist Institute, Harbor-UCLA Medical Center, Torrance, CA, ³Division of Cardiology, and the Lundquist Institute ay Harbor-UCLA Medical Center, Torrance, CA
Background/Purpose: Accurate cardiovascular risk stratification is essential in rheumatoid arthritis (RA) care. Previous studies evaluated the impact of obesity (defined as body mass index) on…
Abstract Number: 0275 • ACR Convergence 2021
Impact of Disease Activity on Left Ventricular Diastolic Dysfunction in Rheumatoid Arthritis Patients
Natalia Guajardo-Jauregui, Dionicio Galarza-Delgado, Iris Colunga-Pedraza, Jose Azpiri-Lopez, Alejandra Rodriguez-Romero, Alejandro Meza-Garza, Julieta Loya-Acosta, Jesus Cardenas-de La Garza, Salvador Lugo-Perez, Catalina Andrade-Vazquez and Alan De Leon-Yañez, Hospital Universitario "Dr Jose E. Gonzalez", Monterrey, Mexico
Background/Purpose: Cardiovascular disease (CVD) is the main cause of mortality in patients with rheumatoid arthritis (RA) reflected by a higher prevalence of cardiovascular risk factors…
Abstract Number: 0293 • ACR Convergence 2021
Increased Prevalence of Scleroderma Specific Autoantibodies in Seropositive Rheumatoid Arthritis with Lung Involvement
Vasiliki Koulouri¹, Kyriaki Tavernaraki², Mayra Giannelou³ and Clio Mavragani¹, ¹National and Kapodistrian University of Athens, Athens, Greece, ²Imaging and Interventional Radiology, Sotiria General and Chest Diseases Hospital, Athens, Greece, ³Department of Rheumatology, General Hospital of Athens "G. Gennimatas", Athens, Greece
Background/Purpose: To evaluate the prevalence of scleroderma (SSc) specific and anti-Ro52 autoantibodies in seropositive rheumatoid arthritis (RA) patients with lung involvement.Methods: Sera from 67 seropositive…
Abstract Number: 0494 • ACR Convergence 2021
The Distribution of Social Deprivation, Distance to Care and Disease Burden in Rheumatoid Arthritis Patients in the United States
Sharon Dowell¹, Huifeng Yun², Jeffrey Curtis³, Lang Chen⁴, Manuela Pedra-Nobre⁵, Dianne Wollaston⁶, SAWSAN NAJMEY⁷, Cynthia Lawrence-Elliott⁸, Theresa Lawrence-Ford⁹, Heather North¹⁰, Robin Dore¹¹, Soha Dolatabadi¹², Thaila Ramanujam¹³, Anne Winkler¹⁴, Stacy Kennedy¹⁵, Stephanie Ott¹⁶, Stephanie Ledbetter¹⁷, Grace Wright¹⁸ and Gail Kerr¹⁹, ¹Howard University College of Medicine, Washington, DC, ²University of Alabama Birmingham, Birmingham, AL, ³Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁴University of Alabama, Birmingham, AL, ⁵North Jersey Rheum. Center, Westfield, NJ, ⁶Memorial Advanced Rheumatology, Houston, TX, ⁷Midstate Rheumatology Center, PA, Freehold, NJ, ⁸North Georgia Rheum Group, Atlanta, GA, ⁹North Georgia Rheum Group, Atlanta, MD, ¹⁰Pardee UNC, Hendersonville, NC, ¹¹Robin K. Dore, MD Inc, Tustin, CA, ¹²Soha Dolatabadi, MD, Los Angeles, CA, ¹³Santa Cruz Rheumatology, Inc., Santa Cruz, CA, ¹⁴Winkler Medical Practice, Springfield, MO, ¹⁵Rowan Diagnostic Clinic, Concord, NC, ¹⁶Fairfield Medical Center, Carroll, OH, ¹⁷University of Alabama at Birmingham, Birmingham, AL, ¹⁸Grace C Wright MD PC, and Association of Women in Rheumatology, New York, NY, ¹⁹Washington D.C., Veterans Affairs Medical Center (VAMC)/Georgetown and Howard Universities, Washington, DC
Background/Purpose: The overall success of RA therapy is dependent on access to specialty care, insurance coverage and effective management of associated comorbidities. Whether RA disease…

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