Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 2099 • 2012 ACR/ARHP Annual Meeting
Patient Self-Assessments and Selected Patient Reported Outcomes May Reliably Identify Rheumatoid Disease Flare in Early Rheumatoid Arthritis Patients
Vivian P. Bykerk¹, Clifton O. Bingham III², Ernest Choy³, Juan Xiong⁴, Gilles Boire⁵, Carol A. Hitchon⁶, Janet E. Pope⁷, J. Carter Thorne⁸, Boulos Haraoui⁹, Edward Keystone¹⁰ and Susan J. Bartlett¹¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Rheumatology, Johns Hopkins University, Baltimore, MD, ³Section of Rheumatology, Cardiff University School of Medicine, Cardiff, United Kingdom, ⁴Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁵Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶University of Manitoba, Winnipeg, MB, Canada, ⁷Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁸Southlake Regional Health Centre, Newmarket, ON, Canada, ⁹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ¹⁰University of Toronto, Toronto, ON, Canada, ¹¹Clinical Epidemiology, McGill University, Montreal, QC, Canada
Background/Purpose: Significant RA worsening or flare may predict poorer outcomes and signal a need for treatment reassessment. However, there is little agreement about how to…
Abstract Number: 1293 • 2012 ACR/ARHP Annual Meeting
Importance of Steady-State Trough Concentrations After Intravenous Golimumab with Concomitant Methotrexate in Subjects with Active Rheumatoid Arthritis
J. H. Leu¹, Z. Xu¹, C. Hu¹, Alan Mendelsohn¹, J. Ford¹, Hugh M. Davis² and H. Zhou¹, ¹Janssen Research and Development, LLC, Spring House, PA, ²Janssen Research & Development, LLC., Spring House, PA
Background/Purpose: To determine an optimized dosing regimen for IV golimumab in subjects with active RA using population pharmacokinetic (PK) modeling and simulation. Methods: Two Phase…
Abstract Number: 489 • 2012 ACR/ARHP Annual Meeting
The Comparative Effectiveness of Anti-TNF Medications Among Older and Disabled Rheumatoid Arthritis Patients in the U.S. Medicare Population
Huifeng Yun¹, Fenglong Xie², Elizabeth S. Delzell³, Lang Chen⁴, Shuo Yang⁵, Kenneth G. Saag⁶ and Jeffrey R. Curtis⁷, ¹Health Care Organization & Policy, University of Alabama-Birmingham, Birmingham, AL, ²Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, ³Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁴Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Clinical Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁶Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, ⁷Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Evaluating the real world effectiveness of biologic DMARDs in rheumatoid arthritis (RA) patients using administrative claims data has previously not been feasible due to…
Abstract Number: 114 • 2012 ACR/ARHP Annual Meeting
US Examination of Wrists and Hands: A Comparison Between Rheumatoid Arthritis and Psoriatic Arthritis
Andrea Delle Sedie¹, Elisa Cioffi¹, Linda Carli², Elena Sardano³, Stefano Bombardieri¹ and Lucrezia Riente¹, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ³Immunology Unit, University of Pisa, Immunology Unit, University of Pisa, Italy
Background/Purpose: very little is known about the differences in joint and periarticular structure involvement in rheumatoid or psoriatic arthritis (PsA). The main pathological features detected…
Abstract Number: 2074 • 2012 ACR/ARHP Annual Meeting
Combined Effects of a c-Fos/AP-1 Inhibitor T-5224 and Methotrexate On Collagen-Induced Arthritis in Mice
Tomomi Date¹, Yukihiko Aikawa¹, Tetsuya Yamamoto¹, Hirokazu Narita¹, Shuichi Hirono² and Shunichi Shiozawa³, ¹Research Laboratories, Toyama Chemical Co., Ltd, Toyama, Japan, ²Department of Pharmaceutical Sciences, School of Pharmacy, Kitasato University, Tokyo, Japan, ³Department of Medicine & Rheumatology, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: Activator protein-1 (AP-1) is an important transcription factor for cytokine production and joint destruction in rheumatoid arthritis (RA), and a potential target for the…
Abstract Number: 1219 • 2012 ACR/ARHP Annual Meeting
Periodontal Disease Is Associated with Rheumatoid Arthritis but Its Severity Is Not Correlated with Rheumatoid Arthritis Disease Activity
In Ah Choi¹, Jin-Hee Kim², Kyung Hwa Kim², Hye Won Kim³, Myeong Jae Yoon¹, Bon Seung Ku⁴, Hyejin Oh³, Joo Youn Lee⁵, Eun Young Lee¹, Eun Bong Lee⁶, Yong-Moo Lee² and Young Wook Song⁷, ¹Department of Internal Medicine, School of Medicine, Seoul National University, Seoul, South Korea, ²Department of Periodontology, School of Dentistry, Seoul National University, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Central Hospital, Ulsan, South Korea, ⁵Department of molecular medicine and biophamaceutical sciences,Seoul National University, Seoul, South Korea, ⁶Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁷Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, South Korea
Background/Purpose: The prevalence of periodontal disease is known to be increased in patients with rheumatoid arthritis (RA) compared to the general population. We investigated whether…
Abstract Number: 455 • 2012 ACR/ARHP Annual Meeting
Lack of Additive Benefits of Concomitant Methotrexate Use to Tocilizumab Monotherapy for Rheumatoid Arthritis in Daily Clinical Practice
Keisuke Izumi¹, Yuko Kaneko², Hidekata Yasuoka³, Noriyuki Seta⁴, Hideto Kameda⁵, Masataka Kuwana⁵ and Tsutomu Takeuchi⁶, ¹Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, ²Dept of Internal Medicine, Keio Univ School of Medicine, Shinjuku-ku, Japan, ³Division of Rheumatology, Department of Internal Medicine, Keio Univ School of Medicine, Tokyo, Japan, ⁴Department of Internal Medicine, Keio university, Tokyo, Japan, ⁵Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ⁶Keio University School of Medicine, Tokyo, Japan
Background/Purpose: To explore the benefit of concomitant use of methotrexate (MTX) for the effectiveness of TCZ in rheumatoid arthritis (RA) patients in daily clinical practice.…
Abstract Number: 88 • 2012 ACR/ARHP Annual Meeting
The Effect of Weather On Patient Symptoms in Rheumatoid Arthritis: A Systematic Review of the Literature and Exploration of “weather sensitivity”
Annika Cutinha¹, Frederick Wolfe² and Kaleb Michaud³, ¹Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²National Data Bank for Rheumatic Diseases, Wichita, KS, ³Rheumatology, National Data Bank for Rheumatic Diseases & University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Patients with rheumatoid arthritis (RA) often attribute an exacerbation of their symptoms to changes in the weather. There are several studies examining this relationship.…
Abstract Number: 1990 • 2012 ACR/ARHP Annual Meeting
Risk of Falling Is Equivalent Between Patients with Rheumatoid Arthritis and Healthy Individuals – the Tomorrow Study-
Kenji Mamoto¹, Tatsuya Koike², Tadashi Okano¹, Atsuko Kamiyama², Yuko Sugioka¹, Masahiro Tada¹ and Hiroaki Nakamura¹, ¹Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ²Rheumatosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan
Background/Purpose: Patients with rheumatoid arthritis (RA) who have muscle weakness and stiff or painful joints might be at increased risk of falling. The present study…
Abstract Number: 1223 • 2012 ACR/ARHP Annual Meeting
Frequency of Deep Vein Thromboses and Pulmonary Emboli in Rheumatoid Arthritis
Christian A. Pineau¹, Evelyne Vinet² and Sasha Bernatsky³, ¹Rheumatology, McGill University Health Center, Montreal, QC, Canada, ²McGill University Health Center, Montreal, QC, Canada, ³Clinical Epidemiology, Research Institute of the McGill University Health Ctre, Montreal, QC, Canada
Background/Purpose: There are few data regarding the frequency of deep vein thromboses (DVTs) and pulmonary emboli (PE’s) in patients with rheumatoid arthritis (RA). To determine…
Abstract Number: 413 • 2012 ACR/ARHP Annual Meeting
α(1,2)-Linked Fucosylated Cytokines Are Upregulated in Rheumatoid Arthritis
Takeo Isozaki¹, Jeffrey H. Ruth², M. Asif Amin¹, Phillip L. Campbell¹, Christine M. Ha² and Alisa E. Koch³, ¹Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ²Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Glycosylation is a common post-translational modification of proteins in eukaryotes. Fucosylated glycans are synthesized by fucosyltransferases (futs). We previously reported that sialyl Lewisx, synthesized…
Abstract Number: 89 • 2012 ACR/ARHP Annual Meeting
Poor to Moderate Performance of Patient Self-Report in Indentifying Periodontitis in Patients with Rheumatoid Arthritis
Ted R. Mikuls¹, Jeffrey Payne², Harlan Sayles³, Shawneen Gonzalez², Jeffrey Markt⁴, Mark Beatty², Grant W. Cannon⁵, David McGowan⁶, Gail S. Kerr⁷, Robert Redman⁸, Andreas M. Reimold⁹ and Garth Griffiths¹⁰, ¹Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ²College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, ³College of Public Health, University of Nebraska Medical Center, Omaha, NE, ⁴Otol-Head and Neck Surgery, University of Nebraska Medical Center, Omaha, NE, ⁵Division of Rheumatology, George E. Wahlen VA Medical Center, Salt Lake City, UT, ⁶Dentistry, George E. Wahlen VA Medical Center, Salt Lake City, UT, ⁷Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, ⁸Dentistry, Washington DC VA, Georgetown and Howard University, Washington, DC, ⁹Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, ¹⁰Dentistry, Dallas VA and University of Texas Southwestern, Dallas, TX
Background/Purpose: Periodontitis (PD) is a putative risk factor for rheumatoid arthritis (RA) risk and progression. PD is defined as inflammation of the supporting tissues of the teeth, progressive attachment and…
Abstract Number: 2637 • 2012 ACR/ARHP Annual Meeting
Cost-Effectiveness and Cost-Utility Analysis of Treat-to-Target Versus Usual Care in Early Rheumatoid Arthritis: Results of the Dutch Rheumatoid Arthritis Monitoring Registry
Marloes Vermeer¹, Wietske Kievit², Ina H. Kuper³, Annemarie Braakman-Jansen⁴, Hein J. Bernelot Moens⁵, Theo R. Zijlstra⁶, Alfons A. den Broeder⁷, Piet L.C.M. van Riel², Jaap Fransen² and Mart A.F.J. van de Laar¹, ¹University of Twente & Medisch Spectrum Twente, Enschede, Netherlands, ²Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Medisch Spectrum Twente, Enschede, Netherlands, ⁴Psychology & Communication, University of Twente, Enschede, Netherlands, ⁵Ziekenhuisgroep Twente, Hengelo, Netherlands, ⁶Isala Klinieken, Zwolle, Netherlands, ⁷Rheumatology, Maartenskliniek, Nijmegen, Netherlands
Cost-Effectiveness and Cost-Utility Analysis of Treat-to-Target Versus Usual Care in Early Rheumatoid Arthritis: Results of the Dutch Rheumatoid Arthritis Monitoring RegistryBackground/Purpose: Treat-to-target (T2T) has proven…
Abstract Number: 1819 • 2012 ACR/ARHP Annual Meeting
Predictors of Pneumococcal Vaccination in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus
Anna Gramling¹, Kaleb Michaud², Harlan Sayles³, Frederick Wolfe⁴ and Michelene Hearth-Holmes⁵, ¹Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Rheumatology, National Data Bank for Rheumatic Diseases & University of Nebraska Medical Center, Omaha, NE, ³Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁴National Data Bank for Rheumatic Diseases, Wichita, KS, ⁵Internal Medicine/Rheumatology Division, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are at high risk for serious infection, including those caused by Streptococcus pneumoniae. Administration…
Abstract Number: 1192 • 2012 ACR/ARHP Annual Meeting
IL-21 Regulates B Cell Proliferation and Differentiation in Rheumatoid Arthritis
Lingyun Sun, Rui Liu and Xia Li, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Interleukin (IL)-21 is a member of type I cytokine family. Recent studies have indicated that IL-21 is an important regulator for human B cell…

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