Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 73 • 2012 ACR/ARHP Annual Meeting
Trends in 21^stcentury Health Care Utilization in a Rheumatoid Arthritis Cohort Compared to the General Population
Sofia Hagel¹, Ingemar F. Petersson², Ann B. I. Bremander³, Elisabet Lindqvist⁴, Charlotte Bergknut⁵ and Martin Englund⁶, ¹Department of Clinical Sciences Lund, Section for Rheumatology, Lund, Lund University and Skåne University Hospital, Lund, Sweden, ²Lund University, Lund, Sweden, ³Department of Exercise Physiology, Biomechanics and Health, Halmstad University School of Business and Engineering,, Halmstad, Sweden, ⁴Department of Clinical Sciences, Lund, Section for Rheumatology, Lund, Lund University and Skåne University Hospital, Lund, Sweden, ⁵Department of Orthopedics, Lund University, Lund, Sweden, ⁶Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden
Background/Purpose: To study twenty-first century trends in health care utilization by rheumatoid arthritis (RA) patients compared to the general population. Methods: Observational cohort study; using Swedish…
Abstract Number: 2549 • 2012 ACR/ARHP Annual Meeting
Induction of Remission in Patients with up to 12 Months of Moderate-to-Severe Rheumatoid Arthritis Symptoms Treated with Etanercept Plus Methotrexate Over 52 Weeks
Paul Emery¹, Mohammed Hamoudeh², Oliver FitzGerald³, Bernard Combe⁴, Stefanie Gaylord⁵, Theresa Williams⁵, Jack Bukowski⁶, Ronald Pedersen⁵, Andrew S. Koenig⁷ and Bonnie Vlahos⁵, ¹Department of Rheumatology, Leeds General Infirmary, Leeds, United Kingdom, ²Department of Medicine - Rheumatology, Hamad Medical Corporation, Doha, Qatar, ³Department of Rheumatology, St.Vincent's University Hospital, Dublin, Ireland, ⁴Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, ⁵Department of Specialty Care, Pfizer Inc., Collegeville, PA, ⁶Department of Specialty Care, Pfizer Inc, Collegeville, PA, ⁷Pfizer, Inc., Collegeville, PA
Background/Purpose: In the COMET study, etanercept (ETN) plus methotrexate (MTX) therapy in patients with early rheumatoid arthritis (RA) yielded high clinical remission rates,1 but whether…
Abstract Number: 1834 • 2012 ACR/ARHP Annual Meeting
Utilization and Expected Cost of Rheumatoid Arthritis Patients Treated with Golimumab: A Specialty Pharmacy Perspective
Lorie Ellis¹, Susan Bolge², Heidi Hanna³, Christina White³ and Patricia Rice⁴, ¹Health Economics & Outcomes Research, Janssen Scientific Affairs, LLC, Horsham, PA, ²Janssen Scientific Affairs, LLC, Horsham, PA, ³Diplomat Specialty Pharmacy, Flint, MI, ⁴Statistics, CliniRx Research, Naperville, IL
Background/Purpose: Golimumab is a 50 mg, once-monthly, patient-administered anti-tumor necrosis factor alpha (anti-TNF) therapy indicated for moderate to severe rheumatoid arthritis (RA), active psoriatic arthritis,…
Abstract Number: 1046 • 2012 ACR/ARHP Annual Meeting
Automated Breast Volume Scanner (ABVS), a New Automated Ultrasonic Device, Is Useful to Examine Joint Injury in Patients with Rheumatoid Arthritis
Shin-ya Kawashiri¹, Takahisa Suzuki², Yoshikazu Nakashima¹, Akitomo Okada², Naoki Iwamoto³, Kunihiro Ichinose⁴, Mami Tamai², Kazuhiko Arima², Hideki Nakamura⁵, Tomoki Origuchi⁶, Masataka Uetani⁷, Kiyoshi Aoyagi⁸ and Atsushi Kawakami¹, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁴Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ⁶Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁷Department of Radiology and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁸Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: Automated Breast Volume Scanner (ABVS) is an ultrasonic device to be developed for the automated scanning for mammary glands. We have tried to explore…
Abstract Number: 428 • 2012 ACR/ARHP Annual Meeting
TNFα Modulates the Expression of Circadian Clock Gene, Per2, Via D-Box Motif in the Promoter Region in Rheumatoid Synovial Cells
Kohsuke Yoshida¹, Akira Hashiramoto², Takaichi Okano³, Nao Shibanuma⁴ and Shunichi Shiozawa⁵, ¹Hyogo Prefectural Rehabilitation Center at Nishi-harima, Tatsuno, Japan, ²Department of Internal Medicine, Kobe University Graduate School of Medicine / The Center for Rheumatic Diseases, Kobe University Hospital, Kobe, Japan, ³The Center for Rheumatic Diseases,, Kobe University Hospital, Kobe, Japan, ⁴The Center for Rheumatic Diseases, Kobe University Hospital / Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ⁵Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: The mammalian clock genes including Clock (circadian locomotor output cycles kaput), Bmal1 (brain and muscle Arnt-like protein 1), Per (Period) and Cry (Cryptochrome) regulate…
Abstract Number: 81 • 2012 ACR/ARHP Annual Meeting
Transitions Among Disease Activity States: Estimates and Models of Covariate Associations
George W. Reed¹, David H. Collier², Andrew S. Koenig³, Katherine C. Saunders⁴, Joel M. Kremer⁵ and Sameer Kotak⁶, ¹University of Massachusetts Medical School, Worcester, MA, ²Amgen Inc., Thousand Oaks, CA, ³Specialty Care, Pfizer Inc, Collegeville, PA, ⁴Corrona, LLC., Southborough, MA, ⁵Albany Medical College and The Center for Rheumatology, Albany, NY, ⁶Specialty Care, Pfizer Inc., New York, NY
Background/Purpose: Many RA patients have variable disease activity over time due to disease variability, reduction in efficacy of current medications, environmental factors and other…
Abstract Number: 2426 • 2012 ACR/ARHP Annual Meeting
Prevalence and Characteristics of Sleep Problems in Rheumatoid Arthritis: A Systematic Review of the Literature
Cassandra Coleman¹ and Yvonne C. Lee², ¹Rheumatology, Brigham and Women's Hospital, Boston, MA, ²Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) patients commonly complain of sleep problems. Difficulties with sleep may be associated with increased fatigue, greater pain and worse quality of…
Abstract Number: 1792 • 2012 ACR/ARHP Annual Meeting
Identification of the Antimicrobial Peptide LL-37 As a Potential Mediator of Synovial Inflammation in Rheumatoid Arthritis
Petra Neregård¹, Marianne Engström¹, Erik Af Klint¹, Birgitta Agerberth² and Anca Catrina³, ¹Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Department of Medical Biochemistry and Biophysics, Chemistry I, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: LL-37, a member of the cathelicidin family of host defense peptides, has a broad range of antimicrobial and immunomodulatory effects that potentially can have…
Abstract Number: 1049 • 2012 ACR/ARHP Annual Meeting
The Prevalence of the Ultrasonographic Positive Power Doppler Synovitis Is High and Predicts the Risk of Relapse and Structural Progression in Rheumatoid Arthritis in Clinical Remission: A Systematic Literature Review and Meta Analysis
Huong Nguyen¹, Adeline Ruyssen-Witrand¹, Arnaud L. Constantin¹, Violaine Foltz², Frédérique Gandjbakhch³ and Alain G. Cantagrel¹, ¹Rheumatology, Purpan University Hospital, Toulouse, France, ²APHP, Pitié Salpétrière Hospital, Universite Paris 6, Paris, France, ³Department of Rheumatology, APHP, Pitié Salpétrière Hospital, Universite Paris 6, Paris, France
Background/Purpose: Ultrasonography (US) can detect synovitis in patients with rheumatoid arthritis (RA) more sensitively than clinical examination either in active disease or in remission.1, 2…
Abstract Number: 395 • 2012 ACR/ARHP Annual Meeting
Trends in Disease Activity, Response and Remission Rates in Rheumatoid Arthritis During the Last Decade: Results From the NOR-DMARD Register
Anna-Birgitte Aga¹, Elisabeth Lie², Karen M. Fagerli², Till Uhlig², Tore K. Kvien² and Espen A. Haavardsholm³, ¹Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: During the past decade there has been an increasing focus on early, aggressive treatment of patients with rheumatoid arthritis (RA), and combined with the…
Abstract Number: 53 • 2012 ACR/ARHP Annual Meeting
Comparison of Decision Rules for Identifying Patients with Rheumatoid Arthritis (RA) in Administrative Healthcare Databases
John G. Hanly, Kara Thompson and Chris Skedgel, Division of Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada
Background/Purpose: Identification of RA cases in administrative healthcare databases is used to estimate disease frequency, healthcare utilization and cost for RA. However, the optimal methodology…
Abstract Number: 2441 • 2012 ACR/ARHP Annual Meeting
Readability and Suitability Assessment of Patient Education Materials in Rheumatic Diseases
Rennie L. Rhee¹, Joan Marie Von Feldt², H. Ralph Schumacher³ and Peter A. Merkel⁴, ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Rheumatology, Univ of Pennsylvania/Philadelphia VAMC, Philadelphia, PA, ³Department of Medicine, University of Pennsylvania and VA Medical Center, Philadelphia, PA, ⁴University of Pennsylvania, Philadelphia, PA
Background/Purpose: Comprehension of health resources may be challenging for patients particularly those with limited health literacy. The objective of this study was to examine the…
Abstract Number: 1765 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Is Associated with Signaling Alterations in Naturally Occurring Autoreactive B-Lymphocytes
Taras Lyubchenko¹, Ganna Liubchenko², Holly C. Appleberry², Christopher C. Striebich², Karen E. Franklin², Lezlie A. Derber³ and V. Michael Holers⁴, ¹Medicine, University of Colorado Denver, Aurora, CO, ²University of Colorado Denver, Aurora, CO, ³Division of Rheumatology, University of Colorado Denver, Aurora, CO, ⁴Rheumatology Division, University of Colorado Denver, Aurora, CO
Background/Purpose: Alterations in B cell immune tolerance are important in the development of autoimmune rheumatoid arthritis (RA). Recent studies in healthy human subjects have identified…
Abstract Number: 1053 • 2012 ACR/ARHP Annual Meeting
Severe Joint Injury Assessed by Musculoskeletal Ultrasonography (MSKUS) Predicts the Presence of MRI-Proven Osteitis in Patients with Rheumatoid Arthritis
Shin-ya Kawashiri¹, Takahisa Suzuki², Yoshikazu Nakashima¹, Yoshiro Horai³, Naoki Iwamoto³, Kunihiro Ichinose⁴, Kazuhiko Arima³, Mami Tamai², Hideki Nakamura⁵, Tomoki Origuchi⁶, Kiyoshi Aoyagi⁷ and Atsushi Kawakami¹, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁴Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ⁶Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁷Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: MRI-proven osteitis is known as the prognostic factor toward radiographic progression in patients with rheumatoid arthritis (RA). Musculoskeletal ultrasonography (MSKUS) is another high sensitive…
Abstract Number: 401 • 2012 ACR/ARHP Annual Meeting
Can We Improve Outcomes in Early Rheumatoid Arthritis by Determining Best Practices? An Analysis of the Canadian Early Rheumatoid Arthritis Cohort (CATCH)
Jamie Harris¹, Vivian P. Bykerk², Carol A. Hitchon³, Edward Keystone⁴, J. Carter Thorne⁵, Gilles Boire⁶, Boulos Haraoui⁷, Glen S. Hazlewood⁸, Ashley Bonner⁹, Janet E. Pope¹⁰ and CATCH Investigators¹¹, ¹Western University, London, ON, Canada, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³University of Manitoba, Winnipeg, MB, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Southlake Regional Health Centre, Newmarket, ON, Canada, ⁶Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁷Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁸Medicine, University of Toronto, Toronto, ON, Canada, ⁹McMaster University, Hamilton, ON, Canada, ¹⁰Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ¹¹Toronto, ON, Canada
Background/Purpose: The goal of ERA treatment is remission but many patients do not achieve this state due to patient factors and perhaps differences in treating…

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