Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 1945 • 2013 ACR/ARHP Annual Meeting
Comparison Of Selected Joint Evaluation With Comprehensive Assessment In Musculoskeletal Ultrasonography For Detection Of Synovitis In Rheumatoid Arthritis
Ryusuke Yoshimi¹, Atsushi Ihata¹, Yosuke Kunishita¹, Daiga Kishimoto¹, Reikou Kamiyama¹, Kaoru Minegishi¹, Maasa Hama¹, Yohei Kirino¹, Yukiko Asami¹, Atsuhisa Ueda¹, Mitsuhiro Takeno¹, Ichiro Aoki² and Yoshiaki Ishigatsubo¹, ¹Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: Musculoskeletal ultrasonography (US) is recognized as a useful tool for the diagnosis and monitoring of rheumatoid arthritis (RA), though a standard procedure has not…
Abstract Number: 938 • 2013 ACR/ARHP Annual Meeting
A Disintegrin and Metalloprotease-17 (ADAM-17) Is Expressed In Rheumatoid Arthritis and Mediates Monocyte Migration
Takeo Isozaki¹, Nao Oguro², Shinya Seki¹, Yoko Miura¹, Sho Ishii¹, Hiroyuki Tsukamoto¹, Takahiro Tokunaga¹, Masayu Umemura¹, Hidekazu Furuya¹, Ryo Yanai¹, Sakiko Isojima¹, Kuninobu Wakabayashi¹, Nobuyuki Yajima¹, Yusuke Miwa¹ and Tsuyoshi Kasama¹, ¹Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan, ²Div of Rhemuatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized byinflammation and joint destruction. Migration of monocytes/macrophages into the synovium is important in a variety…
Abstract Number: 2380 • 2013 ACR/ARHP Annual Meeting
Is Isoniazid Treatment For LTBI Safe For RA Patients With TNF Inhibitor Therapy?
Yoon-Kyoung Sung^1,2, Soo-Kyung Cho^1,2, Soyoung Won³, Jeeseon Shim³, Dam Kim⁴, Ji-Young Choi¹, Chan-Nam Son⁵, Chan-Bum Choi⁴, Tae-Hwan Kim⁶, Jae-Bum Jun⁶, Dae-Hyun Yoo⁶ and Sang-Cheol Bae^1,2, ¹Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Department of Rheumatology, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ³Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ⁴Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ⁵Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea, ⁶Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: Isoniazid (INH) is increasingly used in RA patients with evidence of latent tuberculosis infection (LTBI) for whom TNF inhibitor therapy is planned. The potential for…
Abstract Number: 1948 • 2013 ACR/ARHP Annual Meeting
Power Doppler Ultrasound 7-Joint Score Vs. Simplified Disease Activity Index In Rheumatoid Arthritis Associated With Fibromyalgia
Rafael Chakr¹, Marina Behar², José A. Mendonça³, Daniela Cervantes², Nizele Calegaro², Nicole Andrade², Iuri Siqueira², Daniel Zanchet², Andrese Gasparin², Penélope Esther Palominos², Charles Kohem⁴, Odirlei Andre Monticielo⁵, Claiton Brenol⁶, Ricardo M. Xavier² and João Carlos T. Brenol⁷, ¹Rheumatology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ²Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ³Rheumatology, Pontifical Catholic University of Campinas / Institute of Clinical Research – IPECC, Campinas, Brazil, ⁴Brazilian Registry of Spondyloarthritis, São Paulo, Brazil, ⁵Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ⁶Universidade Federal do Rio Grande do Sul, Porto Alegre RS, Brazil, ⁷Rheumatology Division, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Background/Purpose: Fibromyalgia (FM) falsely increases rheumatoid arthritis (RA) disease activity clinical composite scores, such as the simplified disease activity index (SDAI), recently incorporated into ACR/EULAR…
Abstract Number: 915 • 2013 ACR/ARHP Annual Meeting
IL-6R Inhibition Reduces Activation Of Different Peripheral Memory B Cell Subsets In RA
Zafar Mahmood¹, Khalid Muhammad¹, Marc Schmalzing², Petra Roll³, Kathrina Eckert¹, Thomas Dörner⁴ and Hans-Peter Tony⁵, ¹Rheumatology and Clinical Immunology, University of Würzburg, Würzburg, Germany, ²Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, Germany, ³Rheumatology and Clinical immunology, University of Würzburg, Würzburg, Germany, ⁴CC12, Dept. Medicine/Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany, ⁵Rheumatology/Clinical Immunology, University of Würzburg, Würzburg, Germany
Background/Purpose: Enhanced B cell activity has been proposed as part of the pathogenesis of rheumatoid arthritis also based on the clinical experiences obtained by B…
Abstract Number: 2441 • 2012 ACR/ARHP Annual Meeting
Readability and Suitability Assessment of Patient Education Materials in Rheumatic Diseases
Rennie L. Rhee¹, Joan Marie Von Feldt², H. Ralph Schumacher³ and Peter A. Merkel⁴, ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Rheumatology, Univ of Pennsylvania/Philadelphia VAMC, Philadelphia, PA, ³Department of Medicine, University of Pennsylvania and VA Medical Center, Philadelphia, PA, ⁴University of Pennsylvania, Philadelphia, PA
Background/Purpose: Comprehension of health resources may be challenging for patients particularly those with limited health literacy. The objective of this study was to examine the…
Abstract Number: 1765 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Is Associated with Signaling Alterations in Naturally Occurring Autoreactive B-Lymphocytes
Taras Lyubchenko¹, Ganna Liubchenko², Holly C. Appleberry², Christopher C. Striebich², Karen E. Franklin², Lezlie A. Derber³ and V. Michael Holers⁴, ¹Medicine, University of Colorado Denver, Aurora, CO, ²University of Colorado Denver, Aurora, CO, ³Division of Rheumatology, University of Colorado Denver, Aurora, CO, ⁴Rheumatology Division, University of Colorado Denver, Aurora, CO
Background/Purpose: Alterations in B cell immune tolerance are important in the development of autoimmune rheumatoid arthritis (RA). Recent studies in healthy human subjects have identified…
Abstract Number: 1053 • 2012 ACR/ARHP Annual Meeting
Severe Joint Injury Assessed by Musculoskeletal Ultrasonography (MSKUS) Predicts the Presence of MRI-Proven Osteitis in Patients with Rheumatoid Arthritis
Shin-ya Kawashiri¹, Takahisa Suzuki², Yoshikazu Nakashima¹, Yoshiro Horai³, Naoki Iwamoto³, Kunihiro Ichinose⁴, Kazuhiko Arima³, Mami Tamai², Hideki Nakamura⁵, Tomoki Origuchi⁶, Kiyoshi Aoyagi⁷ and Atsushi Kawakami¹, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁴Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ⁶Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁷Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: MRI-proven osteitis is known as the prognostic factor toward radiographic progression in patients with rheumatoid arthritis (RA). Musculoskeletal ultrasonography (MSKUS) is another high sensitive…
Abstract Number: 401 • 2012 ACR/ARHP Annual Meeting
Can We Improve Outcomes in Early Rheumatoid Arthritis by Determining Best Practices? An Analysis of the Canadian Early Rheumatoid Arthritis Cohort (CATCH)
Jamie Harris¹, Vivian P. Bykerk², Carol A. Hitchon³, Edward Keystone⁴, J. Carter Thorne⁵, Gilles Boire⁶, Boulos Haraoui⁷, Glen S. Hazlewood⁸, Ashley Bonner⁹, Janet E. Pope¹⁰ and CATCH Investigators¹¹, ¹Western University, London, ON, Canada, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³University of Manitoba, Winnipeg, MB, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Southlake Regional Health Centre, Newmarket, ON, Canada, ⁶Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁷Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁸Medicine, University of Toronto, Toronto, ON, Canada, ⁹McMaster University, Hamilton, ON, Canada, ¹⁰Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ¹¹Toronto, ON, Canada
Background/Purpose: The goal of ERA treatment is remission but many patients do not achieve this state due to patient factors and perhaps differences in treating…
Abstract Number: 54 • 2012 ACR/ARHP Annual Meeting
Use of Health Plan Data to Assess Feasibility of Large Pragmatic Clinical Trials in Rheumatoid Arthritis
Jeffrey R. Curtis¹, Lang Chen², Fenglong Xie³, Jie Zhang¹, Kenneth G. Saag⁴, Stacey Cofield⁵, Kevin L. Winthrop⁶, Nicole C. Wright⁷ and Elizabeth S. Delzell⁸, ¹Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, ⁴Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, ⁵School of Public Health, Department of Biostatistics, Univ of Alabama at Birmingham,, Birmingham, AL, ⁶Dept of Infectious Disease, Oregon Health & Science University, Portland, OR, ⁷Epidemiology, The University of Alabama at Birmingham, Birmingham, AL, ⁸Epidemiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Large pragmatic clinical trials (PCTs) are increasingly used to conduct comparative effectiveness research (CER). PCTs typically have simple inclusion/exclusion criteria and hard outcomes (e.g.…
Abstract Number: 2342 • 2012 ACR/ARHP Annual Meeting
Synovial Tissue Analysis in the Pre-Clinical Phase of Arthritis: T-Cell Infiltration Preceding the Development of Arthritis
Maria J. H. de Hair¹, Marleen G. H. van de Sande¹, Tamara H. Ramwadhdoebe², Robert B. M. Landewé³, Christiaan van der Leij⁴, Mario Maas⁵, Dirkjan van Schaardenburg⁶, Danielle Marie Gerlag¹, Lisa G.M. van Baarsen² and Paul P. Tak⁷, ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology , Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands, ⁴Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Department of Radiology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁶Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ⁷Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: We have previously shown in a pilot study that there is no evident synovial inflammation in autoantibody-positive individuals who are at risk of developing…
Abstract Number: 1718 • 2012 ACR/ARHP Annual Meeting
Cost Effectiveness of Nurse-Led Care for People with Rheumatoid Arthritis: A Multicentre RCT
Mwidimi Ndosi¹, Martyn Lewis², Claire Hale³, Howard Bird⁴, Sarah Ryan², Helen Quinn⁴, Elizabeth McIvor⁵, Julia Taylor⁶, Gail Burbage⁷, Deborah Bond⁸, Jo White⁹, Debbie Chagadama¹⁰, Sandra Green¹¹, Lesley Kay¹², Adrian V. Pace¹³, Victoria Bejarano¹⁴, Paul Emery¹⁵ and Jackie Hill¹⁶, ¹Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, ²Keele University, Staffordshire, United Kingdom, ³School of Healthcare, University of Leeds, Leeds, United Kingdom, ⁴University of Leeds, Leeds, United Kingdom, ⁵Stobhill Hospital, Glasgow, UK, Glasgow, United Kingdom, ⁶Rheumatology Centre, Poole Hospital NHS Trust, Poole, United Kingdom, ⁷King's Mill Hospital, Mansfield, United Kingdom, ⁸Queen Elizabeth Hospital King's Lynn, King's Lynn, United Kingdom, ⁹Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ¹⁰Rheumatology, Royal London Hospital, London, United Kingdom, ¹¹Rheumatology, Weston General Hospital, Weston-Super-Mare, United Kingdom, ¹²Department of Rheumatology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ¹³Rheumatology, Russells Hall Hospital, Dudley, United Kingdom, ¹⁴Rheumatology, Barnsley Hospital, Barnsley, United Kingdom, ¹⁵Medicine, Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ¹⁶Acumen, University of Leeds, Leeds, United Kingdom
Background/Purpose: Despite the establishment of the innovative rheumatology nurse-led clinics (NLC) in the UK, the evidence of their cost-effectiveness is unknown. This study aimed at…
Abstract Number: 975 • 2012 ACR/ARHP Annual Meeting
Dense Genotyping of Risk Loci in Black South Africans with Rheumatoid Arthritis: An Association Study
Nimmisha Govind¹, Ananyo Choudhury², Bridget Hodkinson¹, Claudia Ickinger¹, Jacqueline Frost³, Annette T. Lee⁴, Peter K. Gregersen⁵, Richard J. Reynolds⁶, S. Louis Bridges Jr.⁷, Scott Hazelhurst², Michèle Ramsay³ and Mohammed Tikly¹, ¹Rheumatology, Division of Rheumatology, University of the Witwatersrand, Johannesburg, South Africa, ²Wits Bioinformatics Department, Wits Bioinformatics Department, University of the Witwatersrand, Johannesburg, South Africa, ³Division of Human Genetics, National Health Laboratory Service, Division of Human Genetics, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa, ⁴Genomics & Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁵Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁶Clinical Immunology and Rheumatology, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Genome wide association studies (GWAS) have identified numerous rheumatoid arthritis (RA) risk loci in patients of European and Asian ancestry but the causal variants…
Abstract Number: 381 • 2012 ACR/ARHP Annual Meeting
DAS Does Not Predict Increasing Treatment in Early Rheumatoid Arthritis: Results From the CATCH Study
Lonnie Pyne¹, Vivian P. Bykerk², Carol A. Hitchon³, Edward Keystone⁴, J. Carter Thorne⁵, Boulos Haraoui⁶, Ashley Bonner⁷, Janet E. Pope⁸ and CATCH Investigators⁹, ¹Western University, London, ON, Canada, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³University of Manitoba, Winnipeg, MB, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Southlake Regional Health Centre, Newmarket, ON, Canada, ⁶Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁷McMaster University, Hamilton, ON, Canada, ⁸Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁹Toronto, ON, Canada
Background/Purpose: The disease activity score (DAS) was developed in RA to guide therapy. Its utility in practice for early rheumatoid arthritis (ERA) has not been…
Abstract Number: 56 • 2012 ACR/ARHP Annual Meeting
A Validated Mathematical Model Using Electronic Health Records to Identify Rheumatoid Arthritis Patients for Observational Studies
Aarat M. Patel¹, Ilinca D. Metes², Larry W. Moreland³, Melissa Saul⁴, Stephen R. Wisniewski⁵ and Marc C. Levesque⁶, ¹Rheumatology & Clinical Immun / Pediatric Rheumatology, Univ of Pittsburgh Med Ctr / Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Biomedical Informatics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, ⁵Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ⁶Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: To develop and validate a search algorithm with a high specificity and sensitivity to identify rheumatoid arthritis (RA) patients in a large health care…

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