Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 131 • 2014 ACR/ARHP Annual Meeting
Detection of Synovitis and Erosions with an Automated Ultrasound System: Data from a Prospective Cohort with Early and Established RA
Matthias Witt¹, Janette Frielinghausen², Jan Leipe², Hendrik Schulze-Koops², Ruediger Mueller³ and Mathias Grunke², ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Division for Rheumatology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany, ³Rheumatology, Kantonspital St. Gallen, St. Gallen, Switzerland
Background/Purpose: Arthrosonography has proven to be a sensitive and reliable, but time-consuming method for the evaluation of arthritis in small joints of patients with RA…
Abstract Number: 2385 • 2014 ACR/ARHP Annual Meeting
Reasons for Non-Vaccination in Rheumatoid Arthritis and Spondyloarthritis Patients
Charlotte Hua¹, Jacques Morel², Bernard Combe¹ and Cédric Lukas^1,3, ¹Immuno-Rhumatologie, Hôpital Lapeyronie, Montpellier, France, ²Department of Rheumatology, Hôpital Lapeyronie, Montpellier, France, ³Immuno-Rhumatologie, Hopital Lapeyronie, Montpellier, France
Background/Purpose: Patients with inflammatory rheumatic diseases are at increased risk of infections when compared to healthy controls. Despite the fact that part of these infections…
Abstract Number: 1491 • 2014 ACR/ARHP Annual Meeting
Discovery and Characterization of COVA322, a Clinical Stage Bispecific TNF/IL-17A Inhibitor for the Treatment of Inflammatory Diseases
Dragan Grabulovski, Michela Silacci, Wibke Lembke, Wenjuan Zha, Richard Woods, Roger Santimaria, Julian Bertschinger and Mathias Locher, Covagen AG, Schlieren, Switzerland
Background/Purpose: Biologics such as TNF inhibitors have revolutionized the treatment of inflammatory diseases including rheumatoid arthritis (RA), psoriasis and psoriatic arthritis. However, recent data suggest that…
Abstract Number: 518 • 2014 ACR/ARHP Annual Meeting
Risk of Infection Associated with Subsequent Biologic Use Following Rituximab—Results from a National RA Patient Registry
Leslie R. Harrold¹, George W. Reed^1,2, Chitra Karki³, Robert Magner¹, Ashwini Shewade⁴, Ani John⁴, Joel M. Kremer⁵ and Jeffrey D. Greenberg^3,6, ¹University of Massachusetts Medical School, Worcester, MA, ²Corrona, LLC., Southborough, MA, ³Corrona, LLC, Southborough, MA, ⁴Genentech, Inc, South San Francisco, CA, ⁵Albany Medical College and The Center for Rheumatology, Albany, NY, ⁶NYU School of Medicine, New York, NY
Background/Purpose: Rituximab is a chimeric monoclonal antibody for the treatment of rheumatoid arthritis (RA). Prolonged B-cell depletion from repeated doses of rituximab may be associated…
Abstract Number: 129 • 2014 ACR/ARHP Annual Meeting
Seven Joints Ultrasound Scoring System May be Useful and Effective in Assessing Disease Activity in Patients with Rheumatoid Arthritis in the State of Remission in Daily Clinical Practice
Petra Hanova¹, Jakub Zavada¹, Jana Hurnakova¹, Martin Klein¹, Olga Sleglova¹, Marta Olejarova¹, Martin Komarc², Ladislav ŠEnolt¹ and Karel Pavelka³, ¹Institute of Rheumatology, Charles University, 1st Medical Faculty, Prague, Czech Republic, ²Institute of Biophysics and Informatics, Prague, Czech Republic, ³Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
Background/Purpose: To evaluate if the 7-joint ultrasound scoring system (US7) is able to find synovitis in patients in remission of RA. Methods: Patients with rheumatoid…
Abstract Number: 2165 • 2014 ACR/ARHP Annual Meeting
Myeloid-Derived Suppressor Cells in Rheumatoid Arthritis: Friend or Foe?
Fanlei Hu¹, Chunqing Guo², Xiang-Yang Wang² and Zhanguo Li¹, ¹Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ²Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA
Background/Purpose Although myeloid-derived suppressor cells (MDSCs) have been linked to T-cell tolerance, their role in rheumatoid arthritis (RA) remains exclusive. Here, we investigated the potential…
Abstract Number: 1450 • 2014 ACR/ARHP Annual Meeting
Spironolactone As a Novel DMARD in Rheumatoid Arthritis
Inderjeet Verma¹, Pawan Krishan² and Ashit Syngle³, ¹Deptt. of Pharmaceutical Sciences & Drug Resaerch, Punjabi University Patiala, India, Chandigarh, India, ²Deptt. of Pharmaceutical Sciences & Drug Research, Punjabi University Patiala, India, Patiala, India, ³Cardio Rheuma, Healing Touch City Clinic, Fortis Multispeciality Hospital, Chandigarh, India
Background/Purpose: Synthetic disease-modifying antirheumatic drugs (DMARDs) though effective have limitations often requiring use of expensive parenteral biologic DMARDs in Rheumatoid Arthritis (RA). Hence there is…
Abstract Number: 517 • 2014 ACR/ARHP Annual Meeting
Real-World Use of Tocilizumab in Rheumatoid Arthritis Patients in Canada: Interim Results
Boulos Haraoui¹, Shahin Jamal², Vandana Ahluwalia³, Tarang Manchanda⁴ and Majed Khraishi⁵, ¹Department of Medicine, Centre Hospitalier de l’Université de Montréal, Montréal, QC, Canada, ²Department of Rheumatology, University of British Columbia, Vancouver, BC, Canada, ³William Osler Health Center, Brampton, ON, Canada, ⁴Hoffmann-La Roche Canada, Mississauga, ON, Canada, ⁵Nexus Clinical Research, St John's, NF, Canada
Background/Purpose Tocilizumab (TCZ) has been approved for the treatment of adults with rheumatoid arthritis (RA) either as monotherapy or as combination with disease-modifying antirheumatic drugs…
Abstract Number: 126 • 2014 ACR/ARHP Annual Meeting
Asymptomatic Versus Symptomatic Ankle Joints in Rheumatoid Arthritis: A High Resolution B-Mode and Power Doppler Ultrasound Study
Mohammed Alsuwaidi¹, Boris P. Ehrenstein¹, Wolfgang Hartung¹ and Martin Fleck², ¹Rheumatology & Clinical Immunology, Asklepios Clinic Bad Abbach, Bad Abbach, Germany, ²Internal Medicine I, University Medical Center of Regensburg, Regensburg, Germany
Background/Purpose: Despite a crucial role for RA patients’ mobility, the ankle joints are frequently clinically neglected, and omitted in activity scoring systems including DAS 28.…
Abstract Number: 2413 • 2013 ACR/ARHP Annual Meeting
Expression and Function Of a YAP, a Novel Pathway In Fibroblast-Like Synoviocyte In Rheumatoid Arthritis
Beatrix Bartok, Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Modulating molecular pathways that regulate pathogenic behavior fibroblast-like synoviocytes (FLS) could lead to new therapies for rheumatoid arthritis (RA). Targeting transcription factors are especially…
Abstract Number: 1944 • 2013 ACR/ARHP Annual Meeting
Ultrasound Characteristics Of Extensor Tendon Abnormalities and Peritendinous Fluid In Rheumatoid Arthritis
Laurie Ann Ramrattan¹ and Gurjit S. Kaeley², ¹Internal Medicine, University of Florida, Jacksonville, FL, ²College of Medicine, University of Florida, Jacksonville, FL
Background/Purpose: Rheumatoid arthritis (RA) is synonymous for involving synovial lined structures such as joints and tendon sheaths. Alterations in the extensor tendons overlying the metacarpophalangeal…
Abstract Number: 1051 • 2013 ACR/ARHP Annual Meeting
Sociodemographic, Health System, and Community Characteristics Associated With Initiation Of Biological Dmards In RA
Edward H. Yelin¹, Chris Tonner², Seoyoung C. Kim³, Jeffrey N. Katz⁴, John Z. Ayanian⁵ and Daniel H. Solomon⁶, ¹Medicine, UC San Francisco, San Francisco, CA, ²Medicine, University of California, San Francisco, San Francisco, CA, ³Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA, ⁵Brigham and Women's Hospital, Boston, MA, ⁶Division of Pharmacoepidemiology, Harvard Medical School, Brigham and Women's Hospital, Division of Rheumatology, Division of Pharmacoepidemiology, Boston, MA
Background/Purpose: The use of biologic DMARDs for RA has improved outcomes, but it is unknown whether there are disparities in initiation of these agents by…
Abstract Number: 2429 • 2013 ACR/ARHP Annual Meeting
Enhanced Responsiveness To Stimulation and Increased Extrusion Of Extracellular Traps By Rheumatoid Arthritis Neutrophil Granulocytes and of Healthy Control Neutrophils to Serum and Synovial Fluid From Rheumatoid Arthritis Patients
Stavros Giaglis^1,2, Chanchal Sur Chowdhury³, Ulrich A. Walker⁴, Andreas Buser⁵, Sinuhe Hahn⁶ and Paul Hasler¹, ¹Dept. of Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, ²Dept. of Biomedicine, Laboratory of Prenatal Madicine, University Hospital Basel, Basel, Switzerland, ³Dept. of Biomedicine, Laboratory of Prenatal Diagnostics, University Hospital Basel, Basel, Switzerland, ⁴Department of Rheumatology, University Hospital Basel, Basel, Switzerland, Basel, Switzerland, ⁵Division of Hematology; Swiss Red Cross Blood Transfusion Centre, University Hospital Basel, Basel, Switzerland, ⁶Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland
Background/Purpose: Polymorphonuclear granulocytes (PMNs) are the most abundant immune cell population in the synovial fluid in the joints of patients with rheumatoid arthritis (RA) and…
Abstract Number: 1943 • 2013 ACR/ARHP Annual Meeting
Results of a Reliability Exercise for the Grading of Tendon Rupture in Patients With Rheumatoid Arthritis, using a Consensus-Based Ultrasound Score
George A. W. Bruyn¹, Petra Hanova², Annamaria Iagnocco³, Maria-Antonietta d'Agostino⁴, Lene Terslev⁵, I. Moller⁶, Peter V. Balint⁷, E. Filippucci⁸, Carlos Pineda⁹, Marina Backhaus¹⁰, Richard van Vugt¹¹, Richard J. Wakefield¹², Paul Baudoin¹³, Kei Ikeda¹⁴, Artur Bachta¹⁵, Helen I. Keen¹⁶, Levent Oczakar¹⁷, Sibel Z. Aydin¹⁸, Marwin Gutierrez¹⁹, Peter Mandl²⁰ and Esperanza Naredo²¹, ¹Dept of Rheumatology, MC Groep hospitals, Lelystad, Netherlands, ²Institute of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ³Sapienza University of Rome, Rome, Italy, ⁴Rheumatology, Versailles-Saint Quentin en Yvelines University- APHP, Ambroise-Paré Hospital, Boulogne-Billancourt, France, ⁵The Parker Institute, Copenhagen, Denmark, ⁶Instituto Poal, Barcelona, Spain, ⁷Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, ⁸University Politecnica delle Marche, Ancona, Italy, ⁹Biomedical Research, Instituto Nacional de Rehabilitacion, Mexico City, Mexico, ¹⁰Rheumatology/Immunology, Charite University Hospital, Berlin, Germany, ¹¹VU Medisch Centrum, Amsterdam, Netherlands, ¹²Division of Rheumatic and Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ¹³MC Groep hospitals, Lelystad, Netherlands, ¹⁴Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, ¹⁵Military Medical Institute, Warsaw, Poland, ¹⁶School of Medicine and Pharmacology, The University of Western Australia, Crawley, Australia, ¹⁷Hacettepe University Medical School, Ankara, Turkey, ¹⁸Unit of Rheumatology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey, ¹⁹Università Politecnica delle Marche, Jesi, Italy, ²⁰Medical University of Vienna, Vienna, Austria, ²¹Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain
Background/Purpose: To develop the first ultrasound (US) scoring system of tendon rupture in rheumatoid arthritis (RA) and assess its intra- and inter-observer reliability. Methods: We…
Abstract Number: 984 • 2013 ACR/ARHP Annual Meeting
Development and Usability Testing Of The Arthritis Health Journal: An Online Tool To Promote Self-Monitoring In People With Rheumatoid Arthritis
Erin Carruthers¹, Paul M Adam², Hilary Horlock³, Linda C. Li^4,5, Anne F. Townsend⁶, Charles H Goldsmith^7,8, Beverly Mitchell⁹ and Diane Lacaille^10,11, ¹Arthritis Research Centre of Canada, Richmond, BC, Canada, ²Rheumatology Liaison, Mary Pack Arthritis Centre, Vancouver, BC, Canada, ³Information Management / Information Technology Services, Provincial Health Services Authority, Vancouver, BC, Canada, ⁴Physical Therapy, University of British Columbia, Vancouver, BC, Canada, ⁵Physical Therapy, Arthritis Centre of Canada, Richmond, BC, Canada, ⁶Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁷Health Sciences, Simon Fraser University, Burnaby, BC, Canada, ⁸Biostatistics, Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁹Business Solutions and Collaboration, Provincial Health Services Authority, Vancouver, BC, Canada, ¹⁰Rheumatology, Arthritis Research Centre of Canada, University of British Columbia, Richmond, BC, Canada, ¹¹Medicine, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Patient passports have been used in chronic diseases to promote the active involvement of patients in their care, and have led to better treatment…

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