Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 505 • 2014 ACR/ARHP Annual Meeting
A Structured Approach for Comparative Benefit-Risk Assessment of Rituximab for the Treatment of Rheumatoid Arthritis
Ani John¹, George Quartey¹, Patricia B. Lehane², Nicole Mairon³, Michael Schulte³, Ashwini Shewade¹, Carol Chung¹ and Dominic Borie¹, ¹Genentech, Inc, South San Francisco, CA, ²Roche Products Ltd, Welwyn Garden City, United Kingdom, ³F. Hoffmann-La Roche Ltd, Basel, Switzerland
Background/Purpose: Rituximab in combination with methotrexate (MTX) is indicated for the treatment of adult patients with moderate to severe active rheumatoid arthritis (RA) who have…
Abstract Number: 2936 • 2014 ACR/ARHP Annual Meeting
Is Ankylosing Spondylitis a Risk Factor for Cardiovascular Diseases, and How Does These Risks Compare to Those in Rheumatoid Arthritis?
Johan Askling¹, Lennart Jacobsson² and Jonas Eriksson¹, ¹Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²sahlrenska academy, gothenburg, Sweden
Background/Purpose Patients with RA are at increased risk of cardiovascular (CV) diseases, including acute coronary syndromes (ACS), deep venous thromboembolism (DVT) and pulmonary embolism (PE),…
Abstract Number: 2024 • 2014 ACR/ARHP Annual Meeting
Prevalence of Rheumatoid Arthritis in French West Indies, an African Ancestry Population. the Eppra Study
Michel De Bandt¹, Rishika Banydeen², Lauren Brunier³, Katleen Polomat⁴, Veronique Dehlinger⁵, Serge Arfi⁴, Christophe Deligny⁴, Benedicte Garnery⁶, Helene Cormier⁷, Fabienne Dubreuil⁸, Patrick Numeric⁹, Danielle Dufrenot¹⁰, Sabine Molcard⁷, Loic Brithmer⁷, Olivier Fuhrer⁷, Lucien Louis-Joseph¹¹, Sylvie Merle² and Georges Jean-Baptiste⁵, ¹CHUM de Martinique, Unit of rheumatology, Fort de France, France, ²Hôpital universitaire P Zobda-Quitman, CHU de Martinique,, Unit of epidemiology and biostatistics, Fort de FRance, France, ³CHUM de Martinique,, Unit of rheumatology, CHUM, 97200 Fort de France, France, ⁴CHUM de Martinique,, unit of internal medicine, Fort de France, France, ⁵CHUM de Martinique,, Unit of rheumatology, CHUM, Fort de France, France, ⁶Hôpital universitaire P Zobda-Quitman, CHU de Martinique, Unit of internal medicine, Fort de France, France, ⁷Hôpital universitaire P Zobda-Quitman, CHU de Martinique, Unit of rheumatology, Fort de France, France, ⁸Hôpital universitaire P Zobda-Quitman, CHU de Martinique,, Unit of rheumatology, Fort de FRance, France, ⁹route de Chateauboeuf, 97200; French West Indies, Unit of rheumatology, CHUM, Fort de France, France, ¹⁰Hôpital universitaire P Zobda-Quitman, CHU de Martinique, Unit of rheumatology, Fot de France, France, ¹¹Hôpital universitaire P Zobda-Quitman, CHU de Martinique, Unit of rheumatology, Fort de FRance, France
Background/Purpose Rheumatoid arthritis (RA) is a disabling chronic disease, regarded as the most frequent inflammatory rheumatism in adults, with a prevalence estimated between 0.3 and…
Abstract Number: 1385 • 2014 ACR/ARHP Annual Meeting
What Discriminates Best Flares in Rheumatoid Arthritis (RA)? a Subanalysis of the Strass Treatment Tapering in RA Study
Agnès Danré¹, Bruno Fautrel², Toni Alfaiate³, Thao Pham⁴, Jacques Morel⁵, Emmanuelle Dernis Labous⁶, Philippe Gaudin⁷, Olivier Brocq⁸, Elisabeth Solau-Gervais⁹, Jean-Marie Berthelot¹⁰, Jean Charles Balblanc¹¹, Xavier Mariette¹², Florence Tubach¹³ and Laure Gossec¹⁴, ¹Rheumatology, La Pitié Salpêtrière, Paris, France, ²Rheumatology, Pitie Salpetriere Hospital, Paris, France, ³department of epidemiology, biostatistics and clinical research, APHP, Hospital Bichat, Paris, France, ⁴Rheumatology, Sainte Marguerite Hospital, Marseille, France, ⁵Department of Rheumatology, Hôpital Lapeyronie, Montpellier, France, ⁶Rhumatologie, Ch Du Mans, Le Mans, France, ⁷Rhumatologie, Hopital Sud Grenoble, Echirolles, France, ⁸Rheumatology, Hospital of Princesse Grâce de Monaco, Monaco, France, ⁹Rheumatology, University Hospital of Poitiers, Poitiers, France, ¹⁰Rheumatology, CHU Nantes (Nantes University Hospital), Nantes, France, ¹¹Rhumatologie, Ch de Belfort, Belfort Cedex, France, ¹²Rheumatology, University Hospital, Le Kremlin Bicetre, Paris, France, ¹³INSERM, Universite Paris Diderot, Paris, France, ¹⁴Rheumatology, UPMC GRC08, Paris 06 University, Pitié Salpétrière Hospital, Paris, France
Background/Purpose Flares in rheumatoid arthritis (RA) are a patient-perceived increase of disease activity which might be particularly important to assess in the context of treatment…
Abstract Number: 459 • 2014 ACR/ARHP Annual Meeting
Evaluation of the Effect of Tofacitinib on Measured Glomerular Filtration Rate in Patients with Active Rheumatoid Arthritis
J. Kremer¹, A.J. Kivitz², J.a. Simon Campos³, E.L. Nasonov⁴, H. Tony⁵, B. Vlahos⁶, C. Hammond⁶, J. Bukowski⁶, H. Li⁶, S. Schulman⁶, S. Raber⁷, A. Zuckerman⁸ and J. Isaacs⁹, ¹Albany Medical College and The Center for Rheumatology, Albany, NY, ²Altoona Center for Clinical Research, Duncansville, PA, ³Hospital CEM/BIOCEM, Merida, Mexico, ⁴Nasonova State Institute of Rheumatology, Moscow, Russia, ⁵University Hospital Würzburg, Würzburg, Germany, ⁶Pfizer Inc, Collegeville, PA, ⁷Pfizer Inc, San Diego, CA, ⁸Pfizer Inc, Groton, CT, ⁹National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle, United Kingdom
Background/Purpose: In the clinical development program of the oral Janus kinase inhibitor tofacitinib for the treatment of rheumatoid arthritis (RA), small mean increases in serum…
Abstract Number: 2927 • 2014 ACR/ARHP Annual Meeting
Baseline Serum Interferon Beta/Alpha Ratio Predicts Response to Tumor Necrosis Factor Alpha Inhibition in Rheumatoid Arthritis
Priyanka Vashisht¹, Jessica M. Dorschner², Mark A. Jensen³, Beverly Chrabot⁴, Theresa Wampler Muskardin⁵, Marlena Kern⁶, Tetrad Investigators⁷, ABCoN Consortium⁸, S. Louis Bridges Jr.^9,10, P.K. Gregersen¹¹ and Timothy B. Niewold², ¹Division of Rheumatology and Department of Immunology, University of Nebraska Medical Center, Omaha, NE, ²Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Divsion of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ⁴Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, ⁵Div of Rheumatology, Mayo Clinic, Rochester, MN, ⁶North Shore Univ Hospital, Feinstein Institute for Medical Research, Manhasset, NY, ⁷AL, ⁸NY, ⁹University of Alabama at Birmingham, Birmingham, AL, ¹⁰Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹¹The Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose Response to tumor necrosis factor alpha (TNF-α) inhibition is variable in rheumatoid arthritis (RA). Previous studies have suggested that circulating type I interferon (IFN)…
Abstract Number: 1962 • 2014 ACR/ARHP Annual Meeting
Inflammatory Properties of Inhibitor of DNA Binding 1 As a Unique Fibroblast Derived Nuclear Protein
Gautam Edhayan¹, Christine M. Ha¹, Ray A. Ohara¹, Takeo Isozaki¹, M. Asif Amin¹, Ali Arbab², Pei-Suen Tsou³, Phillip L. Campbell⁴, Elena Schiopu³, Dinesh Khanna³, Rachel Morgan¹, Sean C. Friday¹, David A. Fox¹ and Jeffrey Ruth¹, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Georgia Regents University, Augusta, GA, ³University of Michigan Scleroderma Program, Ann Arbor, MI, ⁴Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and…
Abstract Number: 1368 • 2014 ACR/ARHP Annual Meeting
Are Tender Joints Better Than Synovitis to Predict Structural Damage in Rheumatoid Arthritis?
Peter Cheung¹, Karine Mari², Valerie Devauchelle³, Jacques Bentin⁴, Sandrine Jousse-Joulin⁵, Maria-Antonietta d'Agostino⁶, Gérard Chales⁷, Isabelle Chary-Valckenaere⁸, Fabien Etchepare⁹, Philippe Gaudin¹⁰, Xavier Mariette¹¹, Alain Saraux¹² and Maxime Dougados¹³, ¹Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, ²RCT, Lyon, France, ³Rheumatology, Brest university medical school, EA 2216, Lab Ex, INSERM, IGO,UBO and CHU de la Cavale Blanche,, Brest, France, ⁴Rheumatology, CHU-Brugmann, Brussels, Belgium, ⁵Rheumatology, CHU Brest, Brest, France, ⁶Rheumatology, Versailles-Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ⁷Dept of Rheumatology, CHR - Hopital Sud, Rennes, France, ⁸Rheumatology, Nancy University Hospital, Nancy, France, ⁹AP-HP, La Pitié-Salpétrière Hospital, Rheumatology Department, Paris-VI University, Paris, France, ¹⁰Rhumatologie, Hopital Sud Grenoble, Echirolles, France, ¹¹Paris-Sud University, Paris, France, ¹²Rhumatologie, CHU Brest and EA 2216, UBO, Brest, France, ¹³Université Paris René Descartes and Hôpital Cochin, Paris, France
Background/Purpose: Longitudinal studies indicate that synovitis can predict subsequent structural damage in rheumatoid arthritis (RA) but the clinical relevance of tenderness is unclear. The aim…
Abstract Number: 469 • 2014 ACR/ARHP Annual Meeting
Safety of Rituximab in Patients with Chronic Inflammatory Arthritis. Seven-Year Follow-up Observational Study
Andrea Cuervo¹, M. Victoria Hernández¹, Sonia Cabrera¹, Jose Inciarte-Mundo¹, Julio Ramirez¹, Virginia Ruiz-Esquide¹, Juan D. Cañete² and Raimon Sanmarti¹, ¹Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ²Rheumatology, Hospital Clinic, Barcelona, Spain
Background/Purpose: Rituximab (RTX) is a biologic therapy approved for the treatment of active rheumatoid arthritis (RA) refractory to tumour necrosis factor antagonists. It causes B…
Abstract Number: 1888 • 2013 ACR/ARHP Annual Meeting
Transcriptional Regulation Of Peptidylarginine Deiminase Type IV: Implications For Rheumatoid Arthritis
Ali Abbas¹, Kevin Le¹, Virginia Pimmett¹, David A. Bell², Ewa Cairns² and Rodney P. DeKoter¹, ¹Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
Background/Purpose: High titers of anti-citrullinated protein/peptide antibodies (ACPA) have been detected in sera of rheumatoid arthritis (RA) patients, implicating citrullinating enzymes in the pathogenesis of…
Abstract Number: 877 • 2013 ACR/ARHP Annual Meeting
Results From The RATE-RA Study: A Multicenter, Single-Arm Study To Evaluate The Safety Of Administering Rituximab At a More Rapid Infusion Rate In Patients With Rheumatoid Arthritis
Charles H. Pritchard¹, Maria W. Greenwald², Joel M. Kremer³, Norman B. Gaylis⁴, William Rigby⁵, Steve Zlotnick⁶, Carol Chung⁷, Birgit Jaber⁸ and William Reiss⁹, ¹Rheumatology, Drexel University College of Medicine, Willow Grove, PA, ²Desert Medical Advances, Palm Desert, CA, ³Center for Rheumatology, Albany Medical College, Albany, NY, ⁴Arthritis & Rheumatic Disease Specialties, Aventura, FL, ⁵Department of Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH, ⁶Genentech, Inc., a Member of the Roche Group, South San Francisco, CA, ⁷Genentech Inc., South San Francisco, CA, ⁸F. Hoffmann-La Roche Ltd., Basel, Switzerland, ⁹Genentech, South San Francisco, CA
Background/Purpose: The FDA-approved dose of rituximab (RTX) in rheumatoid arthritis (RA) is 2 × 1000 mg IV infusions given 2 weeks apart (1 course), with…
Abstract Number: 2383 • 2013 ACR/ARHP Annual Meeting
A Useful Mathematical Model Able To Predict The Early Response To Tocilizumab In Rheumatoid Arthritis
Chiara Stagnaro¹, Claudia Ferrari², Rosaria Talarico³, Camillo Giacomelli¹, Stefano Bombardieri¹ and Laura Bazzichi¹, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Rheumatology Unit, University of Pisa, Pisa, Italy, ³Rheumatology Unit, Pisa, Italy
Background/Purpose: In the last few year the introduction of biological agents has radically changed the clinical outcome of patients with Rheumatoid Arthritis (RA). However, no…
Abstract Number: 1833 • 2013 ACR/ARHP Annual Meeting
Combination Of TNF and IL-6 Induces Osteoclast-Like Cells With Bone-Resorption Activity Both In Vitro and In Vivo
Kazuhiro Yokota, Kojiro Sato and Toshihide Mimura, Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: Although TNF inhibitors suppress bone destruction in patients with rheumatoid arthritis (RA), TNFα stimulation alone does not directly induce osteoclasts, bone-resorbing cells. With the…
Abstract Number: 772 • 2013 ACR/ARHP Annual Meeting
Neovascularization and CD15s Influence Long Distance Migration Of Synovial Fibroblasts From Patients With Rheumatoid Arthritis
Birgit Zimmermann¹, Sina Köppert¹, Stephanie Lefèvre¹, Stefan Rehart², Ulf Müller-Ladner¹ and Elena Neumann³, ¹Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ³Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany
Background/Purpose: Rheumatoid arthritis (RA) synovial fibroblasts (SF) are central cells of cartilage destruction and neoangiogenesis. RASF show an increased migratory potential in the synovium towards…
Abstract Number: 2335 • 2013 ACR/ARHP Annual Meeting
Epstein-Barr Virus In Peripheral Blood Of Rheumatoid Arthritis Patients Predicts Response To Rituximab Therapy
Heikki Valleala¹, Markku Korpela², Markku J. Kauppi³ and Yrjo T. Konttinen⁴, ¹Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland, ²Department of Internal Medicine, Centre for Rheumatic Diseases, Tampere University Hospital, Tampere, Finland, ³Department of Internal Medicine, Päijät-Häme Central Hospital, Lahti, Finland, ⁴Dept of Medicine, Helsinki Univ Central Hospital, Helsinki, Finland
Background/Purpose: Autoreactive B-cells infected by Epstein-Barr virus (EBV) are suspected to be involved in the aetiology of various human chronic autoimmune diseases. The aim of…

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