Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 222 • 2018 ACR/ARHP Annual Meeting
Viral Exposures As a Risk Factor for Rheumatoid Arthritis: Summarizing the Evidence
Fatima Kudaeva¹, Janet E. Pope² and Mark Speechley³, ¹Department of Epidemiology & Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²Department of Medicine, University of Western Ontario, London, ON, Canada, ³Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Canada, London, ON, Canada
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease with a complex etiology. Infections are viewed as environmental triggers of RA. Different viral exposures have been…
Abstract Number: 942 • 2018 ACR/ARHP Annual Meeting
Risk of Serious Infections in Tocilizumab Versus TNF Inhibitor Initiators in Patients with RA: A Multi-Database Cohort Study
Ajinkya Pawar¹, Rishi J. Desai², Daniel Solomon¹, Sara Gale³, Min Bao⁴, Khaled Sarsour³, Sebastian Schneeweiss¹ and Seoyoung C. Kim¹, ¹Brigham and Women's Hospital, Boston, MA, ²Division of Pharmacoepidemiology and Pharmacoeconimics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Genentech, South San Francisco, CA, ⁴Roche Innovation Center, New York, NY
Background/Purpose: While biologics are known to be associated with risk of serious infections, data on head-to-head comparison of different biologic drugs for the risk of…
Abstract Number: 1890 • 2018 ACR/ARHP Annual Meeting
Longitudinal Deep Learning on Electronic Health Record Data to Predict Future Rheumatoid Arthritis Disease Activity
Beau Norgeot¹, Benjamin Glicksberg², Dmytro Lituiev², Laura Trupin³, Milena Gianfrancesco³, Atul Butte⁴, Gabriela Schmajuk⁵ and Jinoos Yazdany⁶, ¹Institute for Computational Health Sciences, University of California San Francisco, San Francisco, CA, ²University of California San Francisco, San Francisco, CA, ³Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁴Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA, ⁵Medicine/Rheumatology, University of California - San Francisco, San Francisco, CA, ⁶University of California, San Francisco, San Francisco, CA
Background/Purpose: Rheumatoid Arthritis (RA) is a complex systemic inflammatory disease with variable course that is difficult to precisely predict. Deep Learning (DL), a branch of…
Abstract Number: 2499 • 2018 ACR/ARHP Annual Meeting
Predictors of Rheumatoid Arthritis Development in Patients with Early Undifferentiated Arthritis: A 2-Years Follow-up Study
Juan Molina¹, Maria Gabriela Gonzalez Álvarez², Victoria Navarro-Compán³, Laura Nuño⁴, Alejandro Villalba², Diana Peiteado², Patricia Bogas² and Alejandro Balsa², ¹Rheumatology, Rheumatology, La Paz University Hospital, Madrid, Spain, ²Hospital Universitario La Paz, Madrid, Spain, ³Immuno-Rheumatology research group, IdiPaz. La Paz University Hospital, Madrid, Spain, ⁴Rheumatology, La Paz University Hospital, Madrid, Spain
Background/Purpose: Early treatment of RA improves longterm outcomes. However, at the beginning of the disease, some patients with RA fall within undifferentiated arthritis (UA) patients.…
Abstract Number: 326 • 2018 ACR/ARHP Annual Meeting
Implementation of a Treat-to-Target Quality Improvement Program for Rheumatoid Arthritis Management Using Real-Time Patient Reported Outcome Measures
Malka Forman¹, Cianna Leatherwood², Chang Xu¹, Eunji Ko¹, Bing Lu³, Maura D. Iversen⁴, Daniel Solomon² and Sonali Desai², ¹Brigham and Women's Hospital, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Changing clinical practice patterns and incorporation patient-reported outcome measures (PROMs) for disease activity assessment into routine workflow is challenging. We sought to integrate a…
Abstract Number: 1069 • 2018 ACR/ARHP Annual Meeting
Non-Receptor Protein Tyrosine Phosphatase 14 (PTPN14) Promotes YAP-Dependent Tgfbeta Signaling in RA FLS
Angel Bottini¹, Dennis J. Wu², Rizi Ai³, Michelle LeRoux⁴, Beatrix Bartok¹, Michele Bombardieri⁵, Vida Zhang⁶, Karen M. Doody⁷, Cristiano Sacchetti¹, Martina Zoccheddu¹, Ana Lonic⁸, David L. Boyle⁹, Deepa Hammaker⁹, Tzu-Ching Meng¹⁰, Maripat Corr³, Stephanie M. Stanford³, Myles J. Lewis¹¹, Wei Wang¹², Gary S. Firestein⁹, Yeesim Khew-Goodall⁸, Costantino Pitzalis¹³ and Nunzio Bottini¹⁴, ¹Rheumatology, University of California San Diego, La Jolla, CA, ²University of California San Diego, San Diego, CA, ³University of California San Diego, La Jolla, CA, ⁴La Jolla Institute for Allergy and Immunology, LA JOLLA, CA, ⁵Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kindgdom, London, United Kingdom, ⁶La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁷Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁸SA Pathology and University of South Australia, Adelaide, Australia, ⁹Medicine, University of California San Diego, La Jolla, CA, ¹⁰Academia Sinica, Taipei, Taiwan, ¹¹Barts Health NHS Trust & Barts and the London School of Medicine & Dentistry, London, United Kingdom, London, United Kingdom, ¹²Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, ¹³Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ¹⁴Medicine/Rheumatology, University of California San Diego, La Jolla, CA
Background/Purpose: Non-Receptor Protein Tyrosine Phosphatase 14 (PTPN14) was identified in a phosphatase expression profile survey to be highly expressed in synovial fibroblasts derived from patients…
Abstract Number: 1905 • 2018 ACR/ARHP Annual Meeting
Lower Education Level Is Associated with Higher Risk of Developing Rheumatoid Arthritis
Paola de Pablo¹, Dora Romaguera², Salvatore Panico³, Amalia Mattiello³, Diana Gavrila⁴, Carmen Navarro⁴, Carlotta Sacerdote⁵, Paolo Vineis⁶, Rosario Tumino⁷, William Ollier⁸, Elio Riboli⁶, Patrick Venables⁹ and Benjamin Fisher¹⁰, ¹University of Birmingham, Birmingham, United Kingdom, ²CIBER-OBN (Fisiopatología de la Obesidad y Nutrición), University Hospital Son Espases, Palma, Spain, ³Federico II University of Naples, Naples, Italy, ⁴Murcia Regional Health Council, Murcia, Spain, ⁵Città della Salute e della Scienza University-Hospital, Turin, Italy, ⁶Imperial College London, London, United Kingdom, ⁷"Civic - M.P.Arezzo" Hospital, Ragusa, Italy, ⁸Division of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁹Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ¹⁰Rheumatology, University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Lower socio-economic status (SES) has been associated with worse clinical outcomes, reduced functional ability and lower quality of life; however, little is known about…
Abstract Number: 2501 • 2018 ACR/ARHP Annual Meeting
Disease Activity Is the Major Discriminator When Defining Refractory Rheumatoid Arthritis
Manuel Bécède¹, Josef S. Smolen² and Daniel Aletaha³, ¹Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Disease Activity is the Major Discriminator When Defining Refractory Rheumatoid ArthritisM Bécède, JS Smolen, D Aletaha.Medical University of Vienna, Vienna, AustriaBackground/Purpose: Rheumatoid arthritis (RA) is…
Abstract Number: 490 • 2018 ACR/ARHP Annual Meeting
Catastrophizing in Rheumatoid Arthritis
Soraya Benamar¹, Charlotte Hua², Jacques Morel³, Françoise Barchechath-Flaisler⁴, Bernard Combe³, Cédric Lukas³ and Cécile Gaujoux-Viala⁵, ¹Rheumatology, Department of Rheumatology, Nîmes University Hospital and Montpellier University EA 2415, Nîmes, France, ²Department of Rheumatology, Nîmes University Hospital and Montpellier University EA 2415, Montpellier, France, ³University Hospital Lapeyronie, Department of Rheumatology, Montpellier, France, ⁴Rheumatology, Department of Rheumatology, Nîmes University Hospital and Montpellier University EA 2415, Nîmes, France, ⁵Department of Rheumatology, Nîmes University Hospital and Montpellier University EA 2415, Nîmes, France
Background/Purpose: Several studies pay a particular attention to catastrophizing. Catastrophizing is a negative cognitive and affective response based on inadequate expression of pain. The objective…
Abstract Number: 1072 • 2018 ACR/ARHP Annual Meeting
Fibrin-Triggered Chondrosynovial Adhesion As a Novel Mechanism of Cartilage Damage in Rheumatoid Arthritis
Sonia Nasi¹, Jay Degen², Nathalie Busso³, Alexander So⁴ and Thomas Hügle⁵, ¹1 Service of Rheumatology, DAL, Lausanne University Hospital (CHUV), University of Lausanne, Switzerland., epalinges, Switzerland, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rheumatology, University Hospital Lausanne (CHUV), epalinges, Switzerland, ⁴University of Lausanne, Lausanne, Switzerland, ⁵Rheumatology, University Hospital Lausanne (CHUV), Lausanne, Switzerland
Background/Purpose: Pannus infiltration and inflammatory cytokines are the main responsible factors for cartilage damage in rheumatoid arthritis (RA). Moreover, the crosstalk between inflammation and coagulation…
Abstract Number: 1926 • 2018 ACR/ARHP Annual Meeting
Effects of Social Networking on Chronic Disease Management in Rheumatoid Arthritis
Maria A. Lopez-Olivo¹, Jessica Foreman², Heather Lin³, Cheuk Hong Leung⁴, Tiffany Westrich-Robertson⁵, Catherine Hofstetter⁶, Susan K. Peterson⁷, Anne Lyddiatt⁸, Amye L. Leong⁹, Irmgard U. Willcockson¹⁰ and Maria Suarez-Almazor¹, ¹Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, ²Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA, Houston, TX, ³Biostatistics, Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX, ⁴Department of Biostatistics, Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX, ⁵International Foundation for Autoimmune and Autoinflammatory Arthritis, Saint Louis, Missouri, USA, St Louis, MO, ⁶OMERACT patient research partner group, Ottawa, ON, Canada, ⁷Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston Texas, USA, Houston, TX, ⁸Musculoskeletal Group, Cochrane Collaboration, Hamilton, ON, Canada, ⁹Spokesperson; Strategic Relations, Bone and Joint Decade, Santa Barbara, CA, ¹⁰School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: We evaluated a social networking intervention to help patients with rheumatoid arthritis become active partners in their own care. We developed a closed independent…
Abstract Number: 2503 • 2018 ACR/ARHP Annual Meeting
Impact of Tobacco Smoking on 1-Year Mortality Following Total Hip and Total Knee Arthroplasty Among Rheumatoid Arthritis Patients – a Danish Cohort Study Using Nationwide Health Care Registers
René Cordtz^1,2, Laerke Bech-Illum³, Daniel Prieto-Alhambra⁴, Pil Hoejgaard^3,5, Kristian Zobbe^3,6, Nina Imbæk³ and Lene Dreyer⁷, ¹Center for Rheumatology and Spine Diseases, Gentofte-Rigshospitalet, Hellerup, Denmark, ²The Parker Institute, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Copenhagen, Denmark, ³Center for Rheumatology and Spine Diseases - Gentofte, Rigshospitalet, Hellerup, Denmark, ⁴Internal Medicine and Primary Care, URFOA-IMIM, Parc de Salut Mar; Idiap Jordi Gol i Gurina-Institut Català de la Salut; Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK, Barcelona, Spain, ⁵The Parker Institute, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Denmark, ⁶The Parker Institute, Bispebjerg and Frederiksberg Hospital, Capital Region of Denmark, Copenhagen, Denmark, ⁷Departments of Rheumatology and Clinical Medicine, Aalborg University Hospital and Aalborg University, 9000 Aalborg, Denmark
Background/Purpose: Tobacco smoking and rheumatoid arthritis (RA) are independent risk factors for short-term complications following total hip and total knee arthroplasty (THA/TKA). We aimed to…
Abstract Number: 493 • 2018 ACR/ARHP Annual Meeting
Trends in the Incidence of SOLID Tumors in Patients with Rheumatoid Arthritis in Spain. a National Observational Cohort Study
Virginia Villaverde García¹, Manuel Fernández², Ramon Mazzucchelli³, Cristina Macia-Villa⁴, Gloria Candelas⁵, Javier Quirós³, M Peña³, E Perez-Fernandez³, Natalia Crespí⁶, Alberto Garcia-Vadillo⁷, Carmen Barbadillo⁸, J.L Morell-Hita⁹, Hilda Godoy⁸, Maria Espinosa¹⁰, C Morado-Quiñoa⁵, Cristina Martinez-Prada⁵, María Galindo¹¹, O Guzon-Illescas³ and Angela Herranz¹², ¹Rheumatology, Hospital Universitario de Móstoles, Móstoles, Spain, ²Hospital Universitario de Guadalajara, Guadalajara, Spain, ³H.U.Fundación Alcorcón, Madrid, Spain, ⁴Hospital Universitario Severo Ochoa, Madrid, Spain, ⁵H.U. Clínico San Carlos, Madrid, Spain, ⁶C.S. La Rivota, Madrid, Spain, ⁷Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ⁸H.U. Puerta de Hierro, Madrid, Spain, ⁹H.U.Ramón y Cajal, Madrid, Spain, ¹⁰Rheumatology, H.U. Puerta de Hierro, Madrid, Spain, ¹¹Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, ¹²H.U. del Henares, Madrid, Spain
Background/Purpose: During the last 20 years, the treatment in rheumatoid arthritis (RA) has changed. Considering the increasing use of biological immunomodulators to treat chronic inflammatory…
Abstract Number: 1198 • 2018 ACR/ARHP Annual Meeting
Ultrasound-Detected Joint Erosions in Rheumatoid Arthritis: What Every Sonographer Should Know
York Kiat Tan^1,2,3, HuiHua Li⁴, John Carson Allen Jr⁵ and Julian Thumboo^1,2,3, ¹Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, ²Duke-NUS Medical School, Singapore, Singapore, ³Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, ⁴Health Services Research, Singapore General Hospital, Singapore, Singapore, ⁵Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore
Background/Purpose: Previous work in rheumatoid arthritis (RA) on bone erosion(s) using ultrasound (US) focused mostly on small joints of the fingers and toes. We aim…
Abstract Number: 1966 • 2018 ACR/ARHP Annual Meeting
Transcriptome and Methylome Integrative Molecular Analysis Uncovers a New Systemic Autoimmune Disease Classification
Guillermo Barturen¹, Sepideh Babaei², Francesc Catala-Moll³, Zuzanna Makowska², Antonio García-Gómez³, Anne Buttgereit⁴, Elena Carnero-Montoro¹, Sikander Hayat⁴, Martin Kerick⁵, Thomas Charlon⁶, David C Gemperline⁷, Lucas Le Lann⁸, Rosa Quirantes-PIné⁹, Isabel Borrás-Linares¹⁰, Brian Muchmore¹, Jorge Kageyama⁴, Javier Rodríguez-Ubreva³, Alvaro Fernández-Ochoa⁹, Pedro Carmona Sanz¹¹, Christophe Jamin⁸, Ralf Lesche², Robert J. Benschop⁷, Chris Chamberlain¹², Ernst R. Dow⁷, Tania Gomes¹, Maria Juárez¹³, Laurence Laigle¹⁴, Jacqueline Marovac¹², Fiona MacDonald¹⁵, Jerome Wojcik⁶, Esteban Ballestar¹⁶, Lorenzo Beretta¹⁷, Maria Orietta Borghi¹⁸, Johan Frostegård¹⁹, Maria Luisa Garcia²⁰, Javier Martín⁵, Jacques-Olivier Pers⁸, Yves Renadineau²¹, Antonio Segura Carretero⁹ and Marta Alarcón-Riquelme^1,19, ¹Medical Genomics, Center for Genomics and Oncological Research (GENYO), Granada, Spain, ²Pharmaceuticals Division, Bayer Pharma Aktiengesellschaft, Berlin, Germany, ³Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain, ⁴Bayer Pharma Aktiengesellschaft, Berlin, Germany, ⁵Institute of Parasitology and Biomedicine López Neyra, Spanish National Research Council, Granada, Spain, ⁶QuartzBIO, SA, Geneva, Switzerland, ⁷Eli Lilly and Company, Indianapolis, IN, ⁸U1227, Université de Brest, Inserm, Labex IGO, CHU de Brest, Brest, France, ⁹Department of Analytical Chemistry, University of Granada, Granada, Spain, ¹⁰Analytical Chemistry, University of Granada, Granada, Spain, ¹¹Unit of Bioinformatics, Center for Genomics and Oncological Research (GENYO), Pfizer-University of Granada-Andalusian Regional Government, Health Sciences Technology Park, Granada, Spain, ¹²UCB Pharma, Slough, United Kingdom, ¹³UCB, Slough, United Kingdom, ¹⁴Institut de Recherches Internationales Servier, Suresnes, France, ¹⁵Bayer Pharma G, Berlin, Germany, ¹⁶Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain, ¹⁷Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ¹⁸University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy, ¹⁹Unit for Chronic Inflammatory Diseases, Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²⁰Nano-Imaging, BIONAND. Centro Andaluz de Nanotecnología y Biomedicina, Malaga, Spain, ²¹U1227, Université de Brest, inserm, Labex IGO, CHU de brest, Brest, France
Background/Purpose: Systemic autoimmune diseases (SADs) are chronic inflammatory conditions with autoimmune aetiology and many common clinical features, difficulting diagnosis and adequate treatment decisions. Finding new…

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