Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 1995 • 2019 ACR/ARP Annual Meeting
Gingival-Derived Mesenchymal Stem Cells Alleviate Cartilage Damage in Collagen-Induced Arthritis via Suppressing Activities of Inflamed Synovial Fibroblast
Ximei Zhang¹, Julie Wang ², Nancy Olsen ³, Wael Jarjour ⁴ and Song Guo Zheng ⁴, ¹Ohio State College of Medicine, Columbus, ²Ohio State University, columbus, ³Penn State University, Hershey, PA, ⁴Ohio State College of Medicine, Columbus, OH
Background/Purpose: Dysfunction of immunology and inflammatory responses is crucial in initiating and promoting bone/cartilage destruction in rheumatic arthritis (RA). Inflamed synovial fibroblast cells (ISFs) are…
Abstract Number: 2107 • 2019 ACR/ARP Annual Meeting
Comparison of the Management and Prognosis of Pneumonia in Patients with and Those Without Rheumatoid Arthritis Using the Japanese Diagnosis Procedure Combination Database
Eishi Uechi¹ and Kiyohide Fushimi ², ¹Tomishiro Central Hospital, Tomigusuku city, Okinawa, Japan, ²Tokyo Medical and Dental University Graduate School, Bunkyo-ku, Tokyo, Japan
Background/Purpose: Pneumonia is a common cause of death not only in the general population but also in patients with rheumatoid arthritis (RA). In particular, patients…
Abstract Number: 2282 • 2019 ACR/ARP Annual Meeting
Reproductive Counseling Documentation Practices for Women Receiving Teratogenic Medications in an Academic Rheumatology Clinic Serving a Medicaid/Medicare Patient Population
Kimberly Showalter¹, Melanie Smith ², Jonathan Cheah ², Nilasha Ghosh ², Elena Gkrouzman ², Sarah Lieber ², Sebastian Sattui ², Noa Schwartz ², Monica Schwartzman ², Jessica Berman ², Lisa Sammaritano ² and Anne Bass ³, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, ³Hospital for Special Surgery/Weill Cornell Medicine, New York, NY
Background/Purpose: Women of reproductive age with rheumatic diseases are often prescribed teratogenic medications; thus, reproductive counseling is important. A prior study demonstrated improvement in counseling…
Abstract Number: 2319 • 2019 ACR/ARP Annual Meeting
Are Vitamin D Metabolite Levels at Time of Diagnosis Associated with Long-term Severe Cardiovascular Events in Early Diagnosed Rheumatoid Arthritis Patients, Aggressively Treated During 10 Year Follow Up? Post-hoc Analyses of Observational Data from the CIMESTRA Cohort
Mette Herly¹, Kristian Stengaard-Pedersen ², Kim Hørslev-Petersen ³, Merete Lund Hetland ⁴, Mikkel Østergaard ⁵, Robin Christensen ⁶, Brian Løgstrup ⁷, Peter Vestergaard ⁸, Peter Junker ⁹ and Torkell Ellingsen ¹⁰, ¹Odense University Hospital, Odense C, Syddanmark, Denmark, ²Department of Rheumatology, Department of Clinical Medicine, Aarhus University Hospital, Aarhus University, Aarhus, Denmark, Aarhus, Denmark, ³Department of Rheumatology, King Christian X’s Hospital for Rheumatic Diseases Graasten, Denmark, Graasten, Denmark, ⁴DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark, ⁵Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, ⁶Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital & Department of Rheumatology, Institute of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark, ⁷Aarhus University Hospital, Skejby, Aarhus, Denmark, ⁸Aalborg University Hospital, Aalborg, Denmark, ⁹Odense University Hospital, Odense, Denmark, ¹⁰Department of Rheumatology, Odense University Hospital, Denmark, Odense, Syddanmark, Denmark
Background/Purpose: Cardiovascular disease is highly prevalent in Rheumatoid Arthritis (RA) and in non-RA subjects with low vitamin D levels. The aim of the present study…
Abstract Number: 2338 • 2019 ACR/ARP Annual Meeting
Validation of a Claims Algorithm to Identify Interstitial Lung Disease in Patients with Rheumatoid Arthritis
Margaret Guthrie¹, Ankoor Shah ², Leonard Lobo ³, Jim Oates ⁴, Cassie Clinton ¹, Narender Annapureddy ⁵, Fenglong Xie ⁶, Bryant England ⁷ and Jeffrey Curtis ¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²Duke University, Durham, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Division of Rheumatology & Immunology/Medical University of South Carolina, Charleston, SC, ⁵Vanderbilt University, Nashville, TN, ⁶University of Alabama at Birmingham, Birmingham, ⁷VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha
Background/Purpose: Interstitial lung disease (ILD) is an increasingly important problem for patients with Rheumatoid Arthritis (RA). However, current approaches to ILD case finding are suboptimal…
Abstract Number: 2363 • 2019 ACR/ARP Annual Meeting
Influence of the Clinical Characteristics and Different Genetic Polymorphisms Related to MTX, on the Efficacy and Safety in Patients with RA Treated with MTX in Monotherapy
Eugenio Chamizo Carmona¹, Carmen carrasco-Cubero ², Sara María Rojas Herrera ¹, María Eugenia Gonzalez Naranjo ², Juan José Aznar Sanchez ³, Raul Veroz Gonzalez ¹, Pedro Dorado ² and Adrian LLerena Ruiz ², ¹Hospital de Mérida, Mérida, Spain, ²CHU de Badajoz, Badajoz, Spain, ³Hospital de Mérida, Mérida
Background/Purpose: Rheumatoid arthritis (RA) produces joint destruction, functional deterioration, comorbidity and premature death. The best results are achieved with an early start of a treat-to-target…
Abstract Number: 2389 • 2019 ACR/ARP Annual Meeting
Treat to Target by Specific Cytokine Interdiction: Multiple Biomarker Disease Activity Test Deconstructed
L Douglas Graham ¹ and Lee Graham¹, ¹Du Page Medical Group, Westmont, IL
Background/Purpose: Rheumatologists have been encouraged to achieve low disease activity state when treating rheumatoid arthritis (RA). If it cannot be achieved with initial therapy, experts…
Abstract Number: 2770 • 2019 ACR/ARP Annual Meeting
Towards the Lowest Efficacious Dose (ToLEDo): Results of a Multicenter Non-Inferiority Randomized Open-Label Controlled Trial Assessing Tocilizumab or Abatacept Injection Spacing in Rheumatoid Arthritis Patients in Remission
Joanna Kedra¹, Philippe Dieudé ², Hubert Marotte ³, Alexandre Lafourcade ⁴, Emilie Ducourau ⁵, Thierry Schaeverbeke ⁶, Aleth Perdriger ⁷, Martin SOUBRIER ⁸, Jacques Morel ⁹, Arnaud Constantin ¹⁰, Emmanuelle Dernis ¹¹, Valérie Royant ¹², Jean-Hugues Salmon ¹³, Thao Pham ¹⁴, Jacques-Eric Gottenberg ¹⁵, Edouard Pertuiset ¹⁶, Maxime Dougados ¹⁷, Valérie Devauchelle Pensec ¹⁸, Philippe Gaudin ¹⁹, gregoire Cormier ²⁰, Philippe Goupille ²¹, Xavier Mariette ²², Francis Berenbaum ²³, Didier Alcaix ²⁴, Sid-Ahmed Rouidi ²⁵, Jean-Marie Berthelot ²⁶, Agnès Monnier ²⁷, Christine Piroth ²⁸, Frédéric Lioté ²⁹, Vincent Goeb ³⁰, Cécile Gaujoux-Viala ³¹, Isabelle Chary-Valckenaere ³², David Hajage ⁴, Florence Tubach ³³ and Bruno Fautrel ³⁴, ¹Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), UMR S1136, Paris France, Paris, France, ²Rheumatology, Bichat Hospital, APHP, Paris;, Paris, France, ³University Hospital, St Etienne, France, ⁴Biostatistics, Public Health and Medical Information department, Pitié-Salpêtrière Hospital, AP-HP, Paris, France, Paris, France, ⁵Rheumatology Department, CHR Orléans, Orléans, France, ⁶FHU ACRONIM, Department of Rheumatology, Centre Hospitalier Universitaire, Bordeaux, France, Bordeaux, France, ⁷Rheumatology department, Rennes University Hospital, France, Rennes, France, ⁸CHU Gabriel Montpied, Clermont Ferrand, Auvergne, France, ⁹CHU MONTPELLIER, MONTPELLIER, France, ¹⁰Hôpital Pierre-Paul Riquet, Toulouse, France, ¹¹Rheumatology Department, Le Mans Central Hospital, Le Mans, France, ¹²Rheumatology Department, Chartres Hospital, Chartres, France, ¹³Rheumatology, Reims University Hospital, Reims, Reims, France, ¹⁴Aix-Marseille University, CHU Marseille, department of Rheumatology, 13,000 Marseille, France, Marseille, France, ¹⁵Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ¹⁶Rheumatology Department, Pontoise Hospital, Pontoise, France, Pontoise, France, ¹⁷Cochin Hospital, Paris, France, ¹⁸University Hospital of Brest, Brest, France, ¹⁹Rheumatology Department, CHU Grenoble Alpes Hôpital Sud and GREPI - Université Grenoble Alpes, EA7408, Grenoble - Echirolles, France, ²⁰CHD Vendée, La Roche sur Yon, France, ²¹Tours University-Hospital, Tours, France, Tours, France, ²²Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, ²³Sorbonne Université-Inserm CDR Saint-Antoine, AP-HP, Paris, France, ²⁴Rheumatology Department, Le Havre Hospital, Le Havre, ²⁵Rheumatology Department, Dreux, France, ²⁶University Hospital, Nantes, France, ²⁷Internal Medicine Department, CH Côte Basque, Bayonne, France, ²⁸Rheumatology Department, Dijon Hospital, Dijon, France, ²⁹Rheumatology Department, Lariboisiere Hospital, AP-HP, Paris, France, Paris, France, ³⁰Rheumatology Department, Amiens University Hospital, Amiens, France, ³¹Nîmes University Hospital, Nîmes, France, ³²Centre Hospitalier Universitaire de Nancy, VANDOEUVRE, France, ³³Pitié Salpétrière University-Hospital, Paris, Ile-de-France, France, ³⁴Pitié-Salpêtrière Hospital, Department of Rheumatology, AP-HP, Sorbonne University, UPMC university, Paris, Ile-de-France, France
Background/Purpose: Biologic Disease Modifying Anti-Rheumatic Drugs (bDMARD) tapering is proposed by clinical practice guidelines in rheumatoid arthritis (RA) patients in sustained remission. However, no randomized…
Abstract Number: 2861 • 2019 ACR/ARP Annual Meeting
Lung-Related Factors Are Associated with Transitions from Systemic Anti-CCP Antibody Positivity to Classified RA
Ashley Visser ¹, Marie Feser ², Chelsie Fleischer ³, Laura Lenis-Charry ¹, Justin August ¹, Elizabeth Bemis ⁴, Jill Norris ⁵, V. Michael Holers ⁶, Kevin Deane ² and M. Kristen Demoruelle⁷, ¹University of Colorado Denver, Aurora, ²University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, ³University of Colorado Denver, Division of Rheumatology, Aurora, CO USA, Aurora, ⁴University of Colorado Denver, School of Public Health, Aurora, CO USA, Aurora, ⁵Colorado School of Public Health, Aurora, ⁶University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, ⁷University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora
Background/Purpose: Systemic autoimmunity associated with RA precedes the onset of inflammatory arthritis (IA) by several years. In particular, the presence of systemic anti-cyclic citrullinated peptide…
Abstract Number: 34 • 2019 ACR/ARP Annual Meeting
The Role of NFAT5-p65 Complex Enhanceosome in the Inflammatory Responses of Rheumatoid Arthritis Synovial Fibroblasts via TLR4 Signaling
Kunihiko Umekita¹, Yumi Kariya ¹, Chihiro Iwao ¹, Masatoshi Kimura ¹, Risa Kudo ¹, Yuki Rikitake ¹, Shunichi Miyauchi ² and Akihiko Okayama ¹, ¹University of Miyazaki, Miyazaki, Japan, ²University of Miyazaki, Miyazaki
Background/Purpose: Transcription factors belonging to the family of nuclear factors of activated T cells (NFAT) play an essential role in diverse biological processes, such as…
Abstract Number: 116 • 2019 ACR/ARP Annual Meeting
Defective EZH2 Expression Attenuates Treg Differentiation in Rheumatoid Arthritis
Xinyue Xiao¹, Yueting Li ², Hua Chen ¹ and Xuan Zhang ², ¹Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College; The Ministry of Education Key Laboratory, Beijing, China, Beijing, Beijing, China (People's Republic), ²Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College; The Ministry of Education Key Laboratory, Beijing, China, Beijing, China (People's Republic)
Background/Purpose: To explore the role of EZH2, a histone methylation regulator, in the pathogenesis of rheumatoid arthritis (RA).Methods: Forty treatment-naïve patients with active disease and…
Abstract Number: 195 • 2019 ACR/ARP Annual Meeting
The Clinical Characteristics of Patients with Inflammatory Arthritis and a Persistently Low Alkaline Phosphatase Level in a Veteran Affairs Rheumatology Clinic
Luke Monteagudo¹, Amy Gravely ², Peter Valen ³ and David Ewart ³, ¹The University of Minnesota, Minneapolis, ²Minneapolis Veteran Affairs Medical Center, Minneapolis, ³University of Minnesota School of Medicine/ Minneapolis Veteran Affairs Medical Center, Minneapolis
Background/Purpose: Background: The biochemical hallmark of hypophosphatasia (HPP) is a low alkaline phosphatase (ALP) level. It is recognized that some forms of HPP present in adulthood…
Abstract Number: 300 • 2019 ACR/ARP Annual Meeting
Proliferative Globular Synovitis, an Ultrasound Pattern Associated with Seropositive Rheumatoid Arthritis
Ana Belén Azuaga-Piñango¹, Beatriz Frade-Sosa ², Roberto Gumucio ³, Katherine Cajiao-Sanchez ², Stanislava Mandelikova ², Virginia Ruiz-Esquide ⁴, Raul Castellanos-Moreira ², Raimon Sanmarti ⁵, Juan Cañete ⁵ and Julio Ramirez ¹, ¹Hospital Clinic, Barcelona, Spain, Barcelona, Spain, ²Hospital Clinic, Barcelona, Spain, Barcelona, Catalonia, Spain, ³Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain, ⁴Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Catalonia, Spain, ⁵Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Spain
Background/Purpose: Rheumatoid Arthritis (RA) has a synovial ultrasound (US) pattern, while soft tissue involvement is more frequently found in Psoriatic Arthritis (PsA). No previous studies…
Abstract Number: 453 • 2019 ACR/ARP Annual Meeting
Including Pain, Fatigue and Functionality Regularly in the Assessment of Patients with Early Rheumatoid Arthritis Separately Adds to the Evaluation of Disease Status
Sofia Pazmino¹, Anikó Lovik ², Annelies Boonen ³, Diederik De Cock ¹, Veerle Stouten ¹, Johan Joly ⁴, Kristien Van der Elst ⁵, Delphine Bertrand ¹, Rene Westhovens ⁶ and Patrick Verschueren ⁵, ¹KU Leuven, Leuven, Belgium, ²Leuven Biostatistics and Statistical Bioinformatics Center, KU Leuven, Leuven, Vlaams-Brabant, Belgium, ³Maastricht University Medical Center, Maastricht, Netherlands, ⁴University Hospitals Leuven, Leuven, Vlaams-Brabant, Belgium, ⁵University Hospital Leuven, Leuven, Belgium, ⁶University Hospitals, Leuven, Belgium
Background/Purpose: Rheumatoid arthritis (RA) level of disease activity, cannot be evaluated by a single clinical or laboratory measurement. Hence, composite indices have been created via…
Abstract Number: 478 • 2019 ACR/ARP Annual Meeting
The Influence of Gender on Composite Disease Activity Indices for Rheumatoid Arthritis
Takahiro NIshino¹, Atsushi Hasimoto ¹, Shigeto Tohma ² and Toshihiro Matsui ¹, ¹National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan, ²National Hospital Organization Tokyo National Hospital, Tokyo, Japan
Background/Purpose: Disease activity of patients with rheumatoid arthritis should be assessed equally independent of gender, age, or disease duration. However, at present, they are not…

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