ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis (RA) and treatment"

  • Abstract Number: 1333 • 2017 ACR/ARHP Annual Meeting

    Mortality of Tumor Necrosis Factor Transgenic Arthritic Mice with Interstitial Lung Disease Occurs with Pulmonary Arteriole Thickening and Right Ventricular Hypertrophy but Is Not Associated with Inducible Nitric Oxide Synthase Dependent Inflammatory Cell Infiltration

    Richard Bell1, Emily Wu1,2, Homaira Rahimi3 and Edward Schwarz1,4,5, 1Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 2Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, 3Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY, 4University of Rochester, Rochester, NY, 5Univ of Rochester Med Ctr, University of Rochester School of Medicine and Dentistry, Rochester, NY

    Background/Purpose: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) occurs in up to 15% of RA patients, whose median survival expectancy after diagnosis is only 2.6…
  • Abstract Number: 1349 • 2017 ACR/ARHP Annual Meeting

    Treat to Target: What’s the Target?

    Philip Dunn1, Jonida Cote1, Eric Newman2 and Lester Kirchner1, 1Geisinger Medical Center, Danville, PA, 2Department of Rheumatology, Geisinger Medical Center, Danville, PA

    Background/Purpose: The 2015 ACR RA treatment guidelines focus on measuring disease activity and provide a guideline driven treat to target strategy. We hope to understand…
  • Abstract Number: 1418 • 2017 ACR/ARHP Annual Meeting

    The Value of Adalimumab Trough Levels and Clinical Assessments in Predicting Clinical Response in Patients with Established Rheumatoid Arthritis and an Inadequate Response to Methotrexate

    Josef S. Smolen1, Nael Mostafa2, Xin Huang2, Peter Noertersheuser3, Ben Klünder3, Kun Chen2, Jasmina Kalabic3, Iain Sainsbury2, Ruud Oerlemans4, Stefan Florentinus4 and Gerd R. Burmester5, 1Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, 2AbbVie Inc., North Chicago, IL, 3AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, 4AbbVie, Nederland, Hoofddorp, Netherlands, 5Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany

    Background/Purpose: Low trough levels of the tumor necrosis factor inhibitor, adalimumab (ADL), and anti-ADL antibodies (AAA) were reported to be correlated with lack of response…
  • Abstract Number: 610 • 2016 ACR/ARHP Annual Meeting

    A Systematic Review and Meta-Analysis of Comparative Efficacy of Biologics in Treating Patients with Rheumatoid Arthritis: Assessment of Long-Term Radiographic Progression from Published Clinical Trials

    Erin Murray1, Yekaterina Butylkova1, Alexandra Ellis1, Martha Skup2, Jasmina Kalabic3 and Vishvas Garg4, 1Doctor Evidence, Santa Monica, CA, 2AbbVie Inc., North Chicago, IL, 3AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, 4AbbVie Inc, North Chicago, IL

    Background/Purpose: Previously, several studies have meta-analyzed clinical, functional or structural efficacy of biologics in treating rheumatoid arthritis (RA) patients. However, the comparative efficacy of biologics…
  • Abstract Number: 3094 • 2016 ACR/ARHP Annual Meeting

    Factors Associated with Initial or Subsequent Choice of Biologic Disease Modifying Antirheumatic Drugs for the Treatment of Rheumatoid Arthritis

    Yinzhu Jin1, Rishi J. Desai1, Jun Liu1, Nam-Kyong Choi1 and Seoyoung Kim2,3, 1Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston, MA, 2Division of Pharmacoepidemiology and Pharmocoeconomics, Brigham and Women's Hospital, Boston, MA, 3Brigham and Women’s Hospita and, Harvard Medical School,, Boston, MA

    Background/Purpose:  Treatment with disease-modifying antirheumatic drugs (DMARDs) is considered the standard of care for rheumatoid arthritis (RA). Over the past two decades, major advances have…
  • Abstract Number: 637 • 2016 ACR/ARHP Annual Meeting

    Biologic Initiation Patterns Among Rheumatoid Arthritis Patients in Moderate or High Disease Activity While Using Conventional Disease Modifying Anti-Rheumatic Drugs

    Natalie Boytsov1, George W. Reed2, Leslie R Harrold2,3, Xiang Zhang1, Carol L Gaich1, Cynthia J Larmore1, Ying Shan2, S Rebello4 and Andre B. Araujo1, 1Eli Lilly and Company, Indianapolis, IN, 2Corrona, LLC, Southborough, MA, 3UMass Medical School, Worcester, MA, 4Epidemiology, Corrona, Southborough, MA

      Background/Purpose: The purpose of this study was to describe biologic initiation patterns over a 1-year follow-up period in rheumatoid arthritis (RA) patients with moderate…
  • Abstract Number: 3212 • 2016 ACR/ARHP Annual Meeting

    Treat-to-Target in RA: Does Early Simplified Disease Activity Index (SDAI) Remission Lead to Better 5-Year Functional Outcomes Than SDAI Low Disease Activity?

    Vibeke Norvang, Elisabeth Lie, Inge C Olsen, Eirik K Kristianslund, Tore K Kvien and Till Uhlig, Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: The management of rheumatoid arthritis (RA) has evolved considerably during the last couple of decades, with current recommended practice being a treat-to-target approach, involving…
  • Abstract Number: 1540 • 2016 ACR/ARHP Annual Meeting

    “I Am Always in Pain Somewhere”: Continuing Unmet Need in Rheumatoid Arthritis

    Peter C. Taylor1, Rieke Alten2, Juan Jesus Gomez-Reino3, Roberto Caporali4, Philippe Bertin5, Laura Grant6, Elaine Brohan6, Jane Wells6, Radu Vasilescu7 and Miriam Tarallo8, 1Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 2Charité University Medicine, Berlin, Germany, 3Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain, 4Università di Pavia, Pavia, Italy, 5Rheumatology, CHU Dupuytren, Limoges, France, 6Adelphi Values, Bollington, United Kingdom, 7Medical Affairs, Pfizer, Brussels, Belgium, 8GHV, Pfizer, Rome, Italy

    Background/Purpose: Despite advances in the RA treatment, substantial humanistic and economic burdens remain. This study of patients with RA, with moderate to severe disease activity…
  • Abstract Number: 1616 • 2016 ACR/ARHP Annual Meeting

    Mavrilimumab, a Fully Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor-α Monoclonal Antibody: Long-Term Safety and Efficacy for up to 158 Weeks of Treatment in Patients with Rheumatoid Arthritis

    GR Burmester1, IB McInnes2, JM Kremer3, P Miranda4, J Vencovský5, A Godwood6, M Albulescu6, D Close^6 and Michael Weinblatt7, 1Charité – University Medicine Berlin, Berlin, Germany, 2University of Glasgow, Glasgow, United Kingdom, 3The Albany Medical College, Albany, NY, 4Centro De Estudios Reumatológicos, Santiago, Chile, 5Charles University, Prague, Czech Republic, 6MedImmune, Cambridge, United Kingdom, 7Brigham and Women’s Hospital, Boston, MA

    Background/Purpose: Inhibition of GM–CSFR-α is a novel approach to treat RA. Mavrilimumab, an investigational human monoclonal antibody targeting GM–CSFR-α, has demonstrated efficacy and an acceptable…
  • Abstract Number: 1618 • 2016 ACR/ARHP Annual Meeting

    Leflunomide, Sulfasalazine and Hydroxychloroquine for Rheumatoid Arthritis: Efficacious but Poorly Tolerated

    Kyle A. Register1, Amy C. Cannella2, Ted R. Mikuls3 and James R. O'Dell4, 1Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, 2Section of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 4Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The combination of methotrexate (MTX), sulfasalazine (SSZ) and hydroxychloroquine (HCQ) (triple therapy) is a highly effective and well-tolerated treatment in rheumatoid arthritis (RA). While…
  • Abstract Number: 1619 • 2016 ACR/ARHP Annual Meeting

    EARTH EXPLORER 2, a Phase IIb Exploratory Study Evaluating Efficacy and Safety of Mavrilimumab, a Fully Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor-Alpha Monoclonal Antibody, and the Tumor Necrosis Factor Antagonist Golimumab in Rheumatoid Arthritis

    Michael Weinblatt1, IB McInnes2, JM Kremer3, P Miranda4, J Vencovský5, A Godwood6, M Albulescu6, D Close^6 and GR Burmester^7, 1Brigham and Women’s Hospital, Boston, MA, 2University of Glasgow, Glasgow, United Kingdom, 3The Albany Medical College, Albany, NY, 4Centro De Estudios Reumatológicos, Santiago, Chile, 5Charles University, Prague, Czech Republic, 6MedImmune, Cambridge, United Kingdom, 7Charité – University Medicine Berlin, Berlin, Germany

    Background/Purpose: Mavrilimumab, a fully human monoclonal antibody targeting the granulocyte-macrophage colony-stimulating factor receptor-α, has demonstrated efficacy and safety in disease-modifying antirheumatic drug (DMARD)-inadequate responder (IR)…
  • Abstract Number: 1640 • 2016 ACR/ARHP Annual Meeting

    Effect of BMI on Baricitinib Efficacy: Pooled Analysis from Two Phase 3 Rheumatoid Arthritis Clinical Trials

    Cristiano A.F Zerbini1, David Muram2, Vipin K. Arora2, Jahangir Alam2 and Jeffrey R. Curtis3, 1Centro Paulista de Investigação Clinica, São Paulo, Brazil, 2Eli Lilly and Company, Indianapolis, IN, 3Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose : The efficacy of some rheumatoid arthritis (RA) therapies is reduced among patients with high BMI. This analysis assessed the effects of baseline BMI…
  • Abstract Number: 1676 • 2016 ACR/ARHP Annual Meeting

    Methotrexate and Anti-Tumor Necrosis Treatment Improve Endothelial Function in Patients with Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

    Gia Deyab1, Ingrid Hokstad2, Stefan Agewall3, Torstein Lyberg4, Jon Elling Whist5, Milada Cvancarova Småstuen6, Gunnbjørg Hjeltnes7 and Ivana Hollan8,9,10,11, 1Department of Medical Biochemistry, Innlandet Hospital Trust, Lillehammer, Norway, 2Lillehammer Hospitat for Rheumatic Diseases, Lillehammer, Norway, 3University of Oslo, Oslo, Norway, 4Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway, 5Innlandet Hospital Trust, Lillehammer, Norway, 6Institution of health care - Health science PhD program, Oslo and Akershus University College, Oslo, Norway, 7Medicine, Innlandet Hospital Trust, Lillehammer, Norway, 8Harvard Medical School, Boston, MA, 9Department of Medicine, Brigham and Women's Hospital, Boston, MA, 10Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, 11Innlandet Hospital Trust, Brumunddal, Norway

    Background/Purpose: Inflammatory rheumatic diseases (IRDs) are associated with accelerated atherosclerosis, which progression is related to inflammation (1). One of the first stages in atherogenesis is…
  • Abstract Number: 2240 • 2016 ACR/ARHP Annual Meeting

    A Descriptive Analysis of Real-World Treatment Patterns in a Turkish Rheumatology Population That Continued Innovator Infliximab (Remicade) Therapy or Switched to Biosimilar Infliximab

    Yusuf Yazici1, Lin Xie2, Adesuwa Ogbomo3, Dennis Parenti4, Kavitha Goyal4, Amanda Teeple4, Lorie A. Ellis5 and Ismail Simsek6, 1New York University, Hospital of Joint Diseases, New York, NY, 2Director, Health Economics & Outcomes Research, STATinMED Research, Ann Arbor, MI, 3STATinMED Research Inc., Ann Arbor, MI, 4Janssen Scientific Affairs, LLC, Horsham, PA, 5Health Economics & Outcomes Research, Janssen Scientific Affairs, LLC, Horsham, PA, 6Guven Hospital, Ankara, Turkey

    Background/Purpose: This study examined treatment patterns in a rheumatology patient (pt) population initially prescribed innovator infliximab (IFX) that either switched to biosimilar infliximab (CT-P13) or…
  • Abstract Number: 2479 • 2016 ACR/ARHP Annual Meeting

    Work Productivity in Early Rheumatoid Arthritis Patients Treated before and after Implementation of a Treat-to-Target Strategy

    Siri Lillegraven1, Maria Dahl Mjaavatten1, Nina P. Sundlisater1, Anna-Birgitte Aga1, Inge C Olsen2, Till Uhlig1, Daniel H. Solomon3, Tore K Kvien1, Espen A. Haavardsholm1 and the ARCTIC Study Group, 1Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Division of Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Rheumatoid arthritis (RA) is a known cause of work productivity loss. Participation in work-related activities is defined as part of the primary goal of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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