Abstracts tagged "rheumatoid arthritis (RA) and therapy"

Abstract Number: 2528 • 2018 ACR/ARHP Annual Meeting
A Multicenter Study Assessing the Efficacy and Safety of Repository Corticotropin Injection in Patients with Rheumatoid Arthritis: Preliminary Interim Data from the Open-Label Treatment Period
Roy Fleischmann¹, Daniel E. Furst², Richard Brasington³, Erin Connolly-Strong⁴, Jingyu Liu⁴ and Matthew E. Barton⁴, ¹University of Texas Southwestern Medical Center, Dallas, TX, ²David Geffen School of Medicine at UCLA, Los Angeles, CA, ³Washington University School of Medicine, St. Louis, MO, ⁴Mallinckrodt ARD, Inc., Bedminster, NJ
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disorder associated with chronic inflammation and commonly treated with disease-modifying anti-rheumatic drugs (DMARDs) and corticosteroids. Repository corticotropin injection…
Abstract Number: 2536 • 2018 ACR/ARHP Annual Meeting
Vagus Nerve Stimulation in Patients with Rheumatoid Arthritis: 24 Month Safety and Efficacy
Frieda A. Koopman¹, Anne Musters², Marieke M.J. Backer², Danielle Gerlag², Sanda Miljko³, Simeon Grazio⁴, Sekib Sokolovic⁵, Yaakov Levine⁶, David Chernoff⁶, Niek de Vries⁷ and Paul-Peter Tak², ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³University Clinical Hospital, Mostar, Bosnia, ⁴Vinogradsira 29, Clinical Hospital Center Sestre Milosrdnice, Zagreb, Croatia, ⁵Rheumatology, Sarajevo University Clinical Center, Sarajevo, BA, ⁶SetPoint Medical, Inc., Valencia, CA, ⁷Dept. of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: RA is a debilitating chronic disease with an unmet need for additional therapeutic approaches. Modulating innate neuro-immune reflex pathways by stimulation of the vagus…
Abstract Number: 569 • 2018 ACR/ARHP Annual Meeting
Clinical and Sociodemographic Characteristics of Patients with Rheumatoid Arthritis (RA) Starting Triple Therapy and a Combination of a TNF Inhibitor and Methotrexate from a Large US Registry
Joel Kremer^1,2, J. Lynn Palmer³, George W. Reed⁴, Dimitrios A. Pappas⁵, Leslie R Harrold⁶, Jeffrey Greenberg¹ and Jeffrey R. Curtis⁷, ¹Corrona LLC, Waltham, MA, ²Albany Medical College and The Center for Rheumatology, Albany, NY, ³Corrona Research Foundation, Albany, NY, ⁴UMass Medical School, Worcester, MA, ⁵Columbia University, New York, NY, ⁶University of Massachusetts Medical School, Worcester, MA, ⁷University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The combination of methotrexate (MTX), hydroxychloroquine (HCQ) and sulfasalazine (SSZ) has been called Triple Therapy (Triple) and has been compared with a combination of…
Abstract Number: 1550 • 2018 ACR/ARHP Annual Meeting
Improvement of HbA1c in Patients with Rheumatoid Arthritis and Diabetes Type 2 during Treatment with Tocilizumab
Christof Specker¹, Annette Alberding², Martin Aringer³, Gerd R. Burmester⁴, Jan-Paul Flacke⁵, Michael Hofmann⁶, Peter Kaestner⁷, Herbert Kellner⁸, Frank Moosig⁹, Maren Sieburg¹⁰, Hans-Peter Tony¹¹ and Gerhard Fliedner¹², ¹Rheumatology and Clinical Immunology, Universitätsklinikum Essen, Essen, Germany, ²Internal Rheumatology, Krankenhaus St. Josef, Wuppertal, Germany, ³Medicine III, University Medical Center and Faculty of Medicine TU Dresden, Dresden, Germany, ⁴Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany, ⁵Rheumatology, Roche Pharma AG, Grenzach-Wyhlen, Germany, ⁶Rheumatology, Chugai Pharma Europe Ltd., Frankfurt, Germany, ⁷Rheumatology, Ambulantes Rheumazentrum, Erfurt, Germany, ⁸Ambulantes Rheumazentrum, Erfurt, Germany, ⁹Rheumatology Center Schleswig-Holstein Mitte, Neumuenster, Germany, ¹⁰Rheumatologische Gemeinschaftspraxis, Magdeburg, Germany, ¹¹Rheumatology/Immunology, Medizinische Klinik II, Universitätsklinik, Würzburg, Germany, ¹²Rheumatological Practice, Osnabrueck, Germany
Background/Purpose: Interleukin 6 (IL-6) and C-reactive protein (CRP) are independent risk factors for type 2 diabetes mellitus [1], and IL-6 plays a role in insulin…
Abstract Number: 2432 • 2018 ACR/ARHP Annual Meeting
Peripartum Issues in the Inflammatory Arthritis (IA) Patient: A Survey of the Rapport (Rheumatoid Arthritis Pharmacovigilence Program and Outcomes Research in New Therapies) Registry
Tharindri Dissanayake¹, Stephanie Keeling² and Walter P. Maksymowych³, ¹Department of Medicine, University of Alberta, Division of Rheumatology, Edmonton, AB, Canada, ²Department of Medicine, University of Alberta, University of Alberta, Edmonton, AB, Canada, ³CaRE Arthritis, Edmonton, AB, Canada
Background/Purpose: Multiple issues surround the peripartum period for IA patients including medication use, risk of disease flare and potential impact on neonatal outcomes. We aimed…
Abstract Number: 529 • 2017 ACR/ARHP Annual Meeting
Pulmonary Involvement in Our Patients with Rheumatoid Arthritis Under Biological Therapy: A Tertiary Hospital Experience
Edurne Guerrero Basterretxea¹, Maria Luz Garcia Vivar¹, Itziar Calvo Zorrilla¹, Oihane Ibarguengoitia², Eva Galíndez Agirregoikoa², Juan Maria Blanco Madrigal³, Esther Ruíz Lucea¹, Ignacio Torre Salaberri¹, Olaia Begoña Fernandez Berrizbeitia², Clara Eugenia Perez¹, Ana Rosa Intxaurbe Pellejero², Natalia Rivera-García⁴ and Iñigo Gorostiza Hormaetxe⁵, ¹RHEUMATOLOGY, Rheumatology Department; Basurto University Hospital, Bilbao, Spain, ²RHEUMATOLOGY, Rheumatology Department; Basurto University Hospital, BILBAO, Spain, ³Rheumatology Department; Basurto University Hospital, Bilbao, Spain, ⁴RESEARCH, Rheumatology Department; Basurto University Hospital, Bilbao, Spain, ⁵RESEARCH, Research Department. Basurto University Hospital, BILBAO, Spain
Background/Purpose: Use of biological therapy (BT) has dramatically improved Rheumatoid Arthritis (RA) management and outcomes for the last decade. Classic extraarticular manifestations are now uncommon,…
Abstract Number: 2483 • 2017 ACR/ARHP Annual Meeting
Cycling Versus Swapping in Patients with Rheumatoid Arthritis with an Inadequate Response to at Least One Tumor Necrosis Factor Alpha Inhibitor: A Systematic Review and Meta-Analysis of Observational Studies
Maria A. Lopez-Olivo, Aliza Matusevich and Maria Suarez-Almazor, Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX
Background/Purpose: In patients with rheumatoid arthritis (RA) who do not respond or lose response to a tumor necrosis factor inhibitor (TNFi), opinions are divided on…
Abstract Number: 1302 • 2016 ACR/ARHP Annual Meeting
Silent Progression in Patients with Rheumatoid Arthritis: Is DAS28 Remission an Insufficient Goal in RA? Results from the German Remission-PLUS Cohort
Dr. Philipp Sewerin¹, PD Dr. Stefan Vordenbäumen¹, Annika Hoyer², Ralph Brinks¹, Dr. Christian Buchbender³, Dr. Christoph Schleich⁴, Sabine Kamp¹, Prof. Dr. Gerald Antoch³, Prof. Dr. Matthias Schneider¹ and Prof. Dr. Benedikt Ostendorf¹, ¹Department of Rheumatology & Hiller Research Unit, Heinrich-Heine University, Düsseldorf, Germany, ²Institute for Biometry and Epidemiology, German Diabetes Center, Duesseldorf, Germany, ³Diagnostic and Interventional Radiology, Heinrich-Heine-University, Düsseldorf, Germany, ⁴Dep. for diagnostic and interventional Radiology, Heinrich-Heine-University, Duesseldorf, Germany
Background/Purpose: disease activity score in 28 joints; Methods: Data-sets of 80 RA patients from the REMISSION-plus study cohort who fulfilled the following criteria were retrospectively…
Abstract Number: 1306 • 2016 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging Measures of Disease Activity in Rheumatoid Arthritis Patients Treated with Multiple Regimens of DMARD Therapy
Paolo Pace¹, Arthur Lau², Jonathan D. Adachi³, Matthew A. Jessome⁴, George Ioannidis² and Minta Patel⁵, ¹Rheumatology, McMaster Unversity, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³McMaster University, Hamilton, ON, Canada, ⁴Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada, ⁵Cambridge Memorial Hospital, Cambridge, ON, Canada
Background/Purpose: Magnetic resonance imaging ( MRI ) in rheumatoid arthritis ( RA ) has been shown to be more sensitive than clinical and radiological parameters…
Abstract Number: 1418 • 2016 ACR/ARHP Annual Meeting
Rheumatologist: If You Fell Ill with Seropositive Active Rheumatoid Arthritis Yourself, What to Do!
Kalle Aaltonen¹, Elena Nikiphorou^2,3, Nasim A. Khan⁴ and Tuulikki Sokka⁵, ¹Helsinki University, Helsinki, Finland, ²Whittington Hospital, London, United Kingdom, ³Jyväskylä Central Hospital, Jyväskylä, Finland, ⁴Rheumatology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, ⁵Jyvaskyla Central Hospital, Jyväskylä, Finland
Background/Purpose: International and national bodies have given evidence-based recommendations for rheumatoid arthritis (RA) treatment. We assessed the general uptake of these recommendations by asking rheumatologists…
Abstract Number: 2512 • 2016 ACR/ARHP Annual Meeting
Secular Trends of Sustained Remission in Rheumatoid Arthritis, a Nationwide Register Study in Sweden
Jon T. Einarsson¹, Minna Willim¹, Sofia Ernestam², Tore Saxne¹, Pierre Geborek¹ and Meliha C. Kapetanovic¹, ¹Lund University, Skane University Hospital, Department of Rheumatology, Lund, Sweden, Lund, Sweden, ²Centre of Rheumatology, Stockholm County Council, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: Remission has become a treatment goal in rheumatoid arthritis (RA) especially after the introduction of biologic treatment in 1999. The Swedish quality registry…
Abstract Number: 3068 • 2016 ACR/ARHP Annual Meeting
Smoking and Excess Weight Attenuate Rate of Improvement over First 3 Years in Early RA
Susan J. Bartlett^1,2, Orit Schieir³, Kathleen Andersen⁴, Gilles Boire⁵, Boulos Haraoui⁶, Carol Hitchon⁷, Edward Keystone⁸, Janet E. Pope⁹, J Carter Thorne¹⁰, Diane Tin¹¹, Vivian P. Bykerk¹² and Canadian Early Arthritis Cohort (CATCH) Investigators, ¹Department of Medicine, Division of ClinEpi, Rheumatology, Respirology, McGill University, Montreal, QC, Canada, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, Hospital for Special Surgery, New York, NY, ⁵Rheumatology Division, CHUS - Sherbrooke University, Sherbrooke, QC, Canada, ⁶1551, Ontario Street East, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montreal, QC, Canada, ⁷University of Manitoba, Winnipeg, MB, Canada, ⁸Mt. Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁹University of Western Ontario, St Joseph's Health Care, London, ON, Canada, ¹⁰Southlake Regional Health Centre, Newmarket, ON, Canada, ¹¹The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ¹²Divison of Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Early, aggressive treatment to achieve remission is the primary goal when treating early RA, and is associated with improved long-term outcomes. We have previously…
Abstract Number: 28 • 2015 ACR/ARHP Annual Meeting
The Decrease over Time of Orthopaedic Surgery in Patients with Rheumatoid Arthritis Is Mainly Due to Reduced Rates Among Those with Rheumatoid Factor Positive Disease – Results from a Well Defined Area
Korosh Hekmat^1,2, Lennart T.H. Jacobsson³, Jan-Åke Nilsson¹, Minna Willim¹, Martin Englund^4,5, Ingemar F Petersson⁴ and Carl Turesson⁶, ¹Department of Rheumatology. Malmö University Hospital, Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Karolinska University Hospital, Department of Medicine, Unit of Rheumatology, Stockholm, Stockholm, Sweden, ³Department of Rheumatology Malmö University Hospital, Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁴Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden, ⁵Clinical Epidemiology Unit, Orthopedics, Dept of Clinical Sciences Lund, Lund University, Lund, Sweden, ⁶Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden
Background/Purpose : Seropositive and seronegative rheumatoid arthritis (RA) differ in course and prognostic feature. The overall incidence of orthopaedic surgery in patients with RA has…
Abstract Number: 449 • 2015 ACR/ARHP Annual Meeting
Change from SC to IV Abatacept and Back in Patients with Rheumatoid Arthritis As Simulation of a Vacation: A Prospective Phase IV, Open Label Trial (A-BREAK)
Ruediger Mueller¹, Michael Gengenbacher², Symi richter³, Jean Dudler⁴, Burkhard Moeller⁵ and Johannes von Kempis⁶, ¹Rheumatology, MD, St. Gallen, Switzerland, ²Bethesdaspital, Basel, Switzerland, ³Bethsdaspital, Basel, Switzerland, ⁴Kantonsspital Fribourg, Fribourg, Switzerland, ⁵Rheumatology, Inselspital-University Hospital, Bern, Switzerland, ⁶Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland
Background/Purpose: Holiday seasons can present a major problem to RA patients treated with weekly subcutaneous biologics, including subcutaneous (SC) abatacept. Therefore an evaluation of the…
Abstract Number: 457 • 2015 ACR/ARHP Annual Meeting
RA Patients with Medicare Only Insurance Have Similar Clinical Outcomes As Patients with Private Insurance Despite Having Less Access to Biologics
Marcia S. Genta¹, Amnon Sonnenberg² and Robert M. Genta³, ¹Dallas Arthritis Center, Dallas, TX, ²Medicine - Gastroenterology, Portland VAMC - Oregon Health & Science University, Portland, OR, ³Laboratory, Dallas Arthritis Center, Dallas, TX
Background/Purpose: We have previously shown that patients with Medicare only coverage without financial assistance from foundations were significantly less likely to receive Biologics than patients…

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