Session Title: Imaging of Rheumatic Diseases - Poster II: XR/CT/PET/MRI
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Remission in rheumatoid arthritis (RA) arguably is the ultimate goal of an antirheumatic therapy. With modern therapeutic strategies, this goal can be achieved in the majority of patients with early RA (ERA). It is known, that the number and extend of erosions can increase instead of clinically measurable low disease activity or remission (disease activity score in 28 joints; DAS28). We therefore investigated the value of MRI for the detection of erosive changes in patients with DAS28 improvement and/or remission of the German Remission-plus cohort.
Methods: Data-sets of 80 RA patients from the REMISSION-plus study cohort who fulfilled the following criteria were retrospectively analysed: ACR/EULAR 2010 Criteria for RA according to ACR/EULAR criteria, availability of two consecutive MRI scans (low-field MRI, follow up interval 1 year) of the clinically dominant hand and wrist, and the presence of DAS28 (CRP) scores at both time points. The DAS28 was used to assess disease activity. Changes of disease activity were graded by the following classification criteria: DAS28£ 2.6 = clinical remission, £ 3.2 mild disease activity < 5.2 moderate disease activity and > 5.2 severe disease activity. Therapy response was graded by the following improvement criteria proposed by the EULAR committee DAS28 decrease >1.2 units and endpoint score <3.2 =good response, DAS28 decrease >1.2 units and endpoint score >3.2 or DAS28 decrease 0.6 – 1.2 units and endpoint score <5.1 =moderate response, DAS28 decrease <0.6 or DAS28 decrease 0.6 -1.2 units and endpoint score >5.1 =poor response.
To cite this abstract in AMA style:Sewerin DP, Vordenbäumen PDS, Hoyer A, Brinks R, Buchbender DC, Schleich DC, Kamp S, Antoch PDG, Schneider PDM, Ostendorf PDB. Silent Progression in Patients with Rheumatoid Arthritis: Is DAS28 Remission an Insufficient Goal in RA? Results from the German Remission-PLUS Cohort [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/silent-progression-in-patients-with-rheumatoid-arthritis-is-das28-remission-an-insufficient-goal-in-ra-results-from-the-german-remission-plus-cohort/. Accessed December 3, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/silent-progression-in-patients-with-rheumatoid-arthritis-is-das28-remission-an-insufficient-goal-in-ra-results-from-the-german-remission-plus-cohort/