Abstracts tagged "rheumatoid arthritis (RA) and synovitis"

Abstract Number: 928 • 2018 ACR/ARHP Annual Meeting
Single Cell RNA-Sequencing of Rheumatoid Synovial Fibroblasts Reveals a Disease-Associated Spatial Gradient Modulated By Inductive Notch Signaling
Kevin Wei¹, Ilya Korsunsky², Jennifer Marshall³, Gerald Watts⁴, Anqi Gao⁵, Philip Blazar⁶, Jeffrey Lange⁶, Thomas Thornhill⁶, Chris Buckley⁷, Soumya Raychaudhuri⁸ and Michael Brenner⁹, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁶Orthopaedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁷University of Birmingham, Birmingham, United Kingdom, ⁸Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, ⁹Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: In rheumatoid arthritis (RA), tissue resident fibroblasts orchestrate chronic inflammation and regulate pathologic bone and cartilage remodeling that causes irreversible joint damage. Recently, we…
Abstract Number: 1930 • 2018 ACR/ARHP Annual Meeting
Histologic and Transcriptional Evidence of Subclinical Synovial Inflammation in Rheumatoid Arthritis Patients in Clinical Remission
Dana Orange¹, Phaedra Agius², Edward F. DiCarlo³, Serene Z. Mirza⁴, Cristina Rozo⁵, Tania Pannellini⁵, Mark P. Figgie⁶, William H. Robinson⁷, Jackie Szymonifka⁵, Vivian P. Bykerk⁵, Laura T. Donlin⁸ and Susan M. Goodman⁵, ¹Rockefeller University, New York, NY, ²New York Genome Center, New York, NY, ³Laboratory Medicine, Hospital for Special Surgery, New York, NY, ⁴Rheumatology, Hospital for Special Surgery, New York, NY, ⁵Hospital for Special Surgery, New York, NY, ⁶Surgery, Hospital for Special Surgery, New York, NY, ⁷Stanford University, Palo Alto, CA, ⁸Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Rheumatoid Arthritis (RA) patients in clinical remission may still develop structural damage that has been attributed to ongoing synovial inflammation, sometimes only detectable…
Abstract Number: 2473 • 2018 ACR/ARHP Annual Meeting
The Relation between Inflammatory Joint Activity and Disability Related to the Lower Extremities in Early Rheumatoid Arthritis
Maria Mellblom Bengtsson^1,2, Sofia Hagel³, Lennart Jacobsson⁴ and Carl Turesson^1,2, ¹Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ³Rheumatology, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden, ⁴Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Background/Purpose: Arthritis in the lower extremities has a major impact in many patients in rheumatoid arthritis (RA), but has not been extensively studied. The objective…
Abstract Number: 304 • 2018 ACR/ARHP Annual Meeting
Dynamic MRI in Rheumatoid Arthritis for the Assessment of Synovitis Promoting Cartilage Loss
Philipp Sewerin¹, Anja Mueller-Lutz², Matthias Schneider³, Christoph Schleich⁴, Benedikt Ostendorf¹ and Stefan Vordenbäumen⁵, ¹Department and Hiller-Research-Unit for Rheumatology, Heinrich-Heine University, Düsseldorf, Germany, ²Department for diagnostic and interventional Radiology, Heinrich-Heine University, Düsseldorf, Germany, ³Department and Hiller-Research-Unit for Rheumatology, Heinrich-Heine University, Duesseldorf, Germany, ⁴Department for diagnostic and interventional Radiology, Heinrich-Heine University, Duesseldorf, Germany, ⁵Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany
Background/Purpose: To investigate the local inflammatory activity of the synovium by using dynamic magnetic resonance imaging (MRI) and cartilage biochemical composition of the MCP-joints 2…
Abstract Number: 970 • 2017 ACR/ARHP Annual Meeting
ACPA Activate Challenged Synovial Fibroblasts through a PAD Dependent Mechanism: A Potential Explanation of the “Second Hit Model” in RA
Meng Sun¹, Vijay Joshua¹, Akilan Krishnamurthy¹, Aase Hensvold¹, Yanying Liu², Sergiu-Bogdan Catrina³, Caroline Ospelt⁴, Vivianne Malmström¹, Johanna Steen¹, Marianne Engström¹, Heidi Wähämaa¹, Bence Rethi¹ and Anca I. Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Peking University People's Hospital, Beijing, China, ³Molecular Medicine and Surgery, Molecular Medicine and Surgery, Stockholm, Sweden, ⁴Center of Experimental Rheumatology, University Hospital Zürich, Zurich, Switzerland
Background/Purpose: Anti-citrullinated proteins antibodies (ACPAs) injected in mice induce IL-8 dependent bone loss and arthralgia, but no synovial changes. We hypothesized that additional stimulus, sensitizing…
Abstract Number: 1405 • 2017 ACR/ARHP Annual Meeting
Using Flow and Mass Cytometry to Demonstrate Robust Tissue Processing to Query Molecular Heterogeneity in Phase 1 of the Accelerating Medicines Partnership (AMP) – RA Network
Kevin Wei¹, Deepak Rao², Fan Zhang³, Chamith Fonseka³, Kamil Slowikowski³, Joshua Keegan⁴, Laura T. Donlin⁵, Jason Turner⁶, Mandy J. McGeachy⁷, Nida Meednu⁸, David Lieb⁹, Stephen Kelly¹⁰, Susan M. Goodman¹¹, David L. Boyle¹², William H. Robinson¹³, Paul J. Utz¹⁴, Gary S. Firestein¹⁵, Harris Perlman¹⁶, Edward F. DiCarlo¹⁷, Costantino Pitzalis¹⁰, Andrew Filer¹⁸, Brendan Boyce¹⁹, Ellen M. Gravallese²⁰, Chad Nusbaum²¹, James Lederer⁴, Nir Hacohen^22,23,24, Peter Gregersen²⁵, Larry W. Moreland²⁶, Michael Holers²⁷, Vivian P. Bykerk²⁸, Soumya Raychaudhuri³, Michael Brenner²⁹ and Jennifer H. Anolik⁸, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁶Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁷Medicine, University of Pittsburgh, Pittsburgh, PA, ⁸Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁹Broad Institute, Cambridge, MA, ¹⁰Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ¹¹Medicine, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ¹²University of California San Diego, La Jolla, CA, ¹³Stanford University School of Medicine, Stanford, CA, ¹⁴Medicine, Stanford University School of Medicine, Stanford, CA, ¹⁵Medicine, University of California San Diego, La Jolla, CA, ¹⁶Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University Feinberg School of Medicine,, Chicago, IL, ¹⁷Laboratory Medicine, Hospital for Special Surgery, New York, NY, ¹⁸Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, ¹⁹University of Rochester Medical Center, Rochester, NY, ²⁰Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA, ²¹The Broad Institute and Harvard, Cambridge, MA, ²²Harvard Medical School, Boston, MA, ²³Massachusetts General Hospital, Charlestown, MA, ²⁴Broad Institute of MIT and Harvard, Cambridge, MA, ²⁵The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, ²⁶Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²⁷Medicine, Division of Rheumatology, University of Colorado Denver, Aurora, CO, ²⁸Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ²⁹Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Discovery and application of new therapies for rheumatoid arthritis (RA) has been hampered by multiple factors, including disease heterogeneity and the lack of well…
Abstract Number: 1416 • 2017 ACR/ARHP Annual Meeting
Higher Expression of Type 1 Interferon in Synovitis of Patient with Undifferentiated Arthritis before They Met Rheumatoid Arthritis Criteria Compared to Established Rheumatoid Arthritis. a Retrospective Study with 14 Years of Follow-up
Andrea Cuervo¹, Raquel Celis², Julio Ramírez³, Alicia Usategui⁴, Regina Faré⁵, M. Victoria Hernández⁶, Virginia Ruiz-Esquide³, Jose Inciarte-Mundo⁷, Raimon Sanmarti⁸, Jose L. Pablos⁹ and Juan D. Cañete⁷, ¹Arthritis Unit. Rheumatology Dpt, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ²Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ³Rheumatology Service, Hospital Clínic de Barcelona, Barcelona, Spain, ⁴Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ⁵Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ⁶Hospital Clinic. Barcelona. Spain, Barcelona, Spain, ⁷Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona, Barcelona, Spain, ⁸Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona, Barcelona, Spain, ⁹Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain
Background/Purpose: Undifferentiated Arthritis (UA) is defined as an inflammatory oligo/poly arthritis that does not fulfil criteria for a definitive diagnosis.Delay in diagnosis and treatment leads…
Abstract Number: 1898 • 2017 ACR/ARHP Annual Meeting
Overweight/Obesity Affect Histological Features of Synovial Membrane of Rheumatoid Arthritis Patients from Disease Onset to Stable Remission Achievement
Stefano Alivernini¹, Barbara Tolusso¹, Maria Rita Gigante¹, Laura Bui², Clara Di Mario¹, Luca Petricca¹, Gabriele Di Sante¹, Roberta Benvenuto², Anna Laura Fedele¹, Francesco Federico², Gianfranco Ferraccioli³ and Elisa Gremese¹, ¹Institute of Rheumatology, Fondazione Policlinico Universitario A. Gemelli - Catholic University of the Sacred Heart, Rome, Italy, ²Institute of Pathology, Fondazione Policlinico Universitario A. Gemelli - Catholic University of the Sacred Heart, Rome, Italy, ³Institute of Rheumatology, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy
Background/Purpose: Despite animal models, little is known about synovial tissue (ST) composition of overweight/obese Rheumatoid Arthritis patients. The aim of the study was to investigate…
Abstract Number: 2567 • 2016 ACR/ARHP Annual Meeting
The Effect of Fibroblast Growth Factor 4 on the Proliferation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis
Xiaoxue Feng¹, Shangling Zhu¹, Weixiang Peng², Fang Liu³, Baiyu Zhang¹ and Jianlin Huang¹, ¹Department of Internal Medicine, Division of Rheumatology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Internal Medicine, Division of Rheumatology, Zhu Hai People's Hospital, Zhuhai, China, ³Department of Internal Medicine, Division of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Background/Purpose: Fibroblast-like synoviocytes (FLSs) contribute to synovial hyperplasia in rheumatoid arthritis (RA). Fibroblast growth factor 4 (FGF4) is a potent mitogen for tumor cells. The…
Abstract Number: 537 • 2015 ACR/ARHP Annual Meeting
The Course of Bone Marrow Edema in Early Undifferentiated and Rheumatoid Arthritis; A Longitudinal MRI Study on Bone Level
W.P. Nieuwenhuis¹, H.W. van Steenbergen², W. Stomp³, T. Stijnen⁴, T. W. J. Huizinga¹, J.L Bloem³, D. van der Heijde¹, M. Reijnierse³ and A.H.M. van der Helm- van Mil², ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Medical Statistics, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: In rheumatoid arthritis (RA) patients, bone marrow edema (BME)-scores are associated with development of erosions. However, little is known on the course and outcome…
Abstract Number: 1607 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Factor Is Associated with the Distribution of Hand Joint Destruction in a Dose-Dependent Manner
Chikashi Terao¹, Noriyuki Yamakawa², Koichiro Yano³, I.M. Markusse⁴, Katsunori Ikari³, Shinji Yoshida³, Moritoshi Furu⁵, Motomu Hashimoto⁵, Hiromu Ito⁵, Takao Fujii⁶, Koichiro Ohmura⁷, Kosaku Murakami⁷, Meiko Takahashi², Masahide Hamaguchi⁸, Yasuharu Tabara², Atsuo Taniguchi³, Shigeki Momohara³, Soumya Raychaudhuri⁹, Cornelia F. Allaart¹⁰, Hisashi Yamanaka¹¹, Tsuneyo Mimori¹² and Fumihiko Matsuda¹³, ¹Departments of Genetics and Rheumatology, Brigham and Women's Hospital, Boston, MA, ²Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁴LUMC, Leiden, Netherlands, ⁵Department of the Control for Rheumatic Diseases, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁶Dept of Rheum/Clinical Immun, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁷Dept of Rheum & Clinical Immun, Kyoto Univ Grad School of Med, Kyoto, Japan, ⁸Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan, ⁹Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ¹⁰Rheumatology, LUMC, Leiden, Netherlands, ¹¹Tokyo Women's Medical University, Tokyo, Japan, ¹²Dept of Rheum & Clinical Immun, Kyoto Univ Grad Schl of Med, Kyoto, Japan, ¹³Genomic Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction. Although many studies have addressed correlates associated with the speed of joint destruction,…
Abstract Number: 1180 • 2014 ACR/ARHP Annual Meeting
Dynamic Magnetic Resonance Imaging in the Assessment of the Response to Certolizumab Pegol in Rheumatoid Arthritis Patients: Results from a Phase IIIb Randomized Study
Mikkel Østergaard¹, Mette Bjørndal Axelsen², Lennart T.H. Jacobsson³, Christopher Schaufelberger³, Michael Sejer Hansen⁴, Johannes W.J. Bijlsma⁵, Anna Dudek⁶, Maria Rell-Bakalarska⁷, Fabienne Staelens⁸, Robert Haake⁹, Britt Sundman-Engberg¹⁰ and Henning Bliddal¹¹, ¹Center for Rheumatology and Spine Diseases, Glostrup Hospital, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark, ²Center for Rheumatology and Spine Diseases, Glostrup Hospital, Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Glostrup, Denmark, ³Department of Rheumatology and Inflammation Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ⁴Department of Rheumatology, Gentofte Hospital, Copenhagen, Denmark, ⁵Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Medica Pro Familia, Warsaw, Poland, ⁷Rheuma Medicus, Warsaw, Poland, ⁸UCB Pharma, Brussels, Belgium, ⁹UCB Pharma, Raleigh, NC, ¹⁰UCB Pharma, Stockholm, Sweden, ¹¹The Parker Institute, Department of Rheumatology, Frederiksberg, Denmark
Background/Purpose Magnetic resonance imaging (MRI) can detect early joint inflammation with high sensitivity, without use of radiation. The MARVELOUS study (NCT01235598), using the OMERACT RA…
Abstract Number: 1645 • 2013 ACR/ARHP Annual Meeting
Circulating CD4+CD161+ T Lymphocytes Are Increased In Seropositive Arthralgia Patients But Decreased In Patients With Newly Diagnosed Rheumatoid Arthritis
Paulina Chalan¹, Bart-Jan Kroesen², Kornelis S.M. van der Geest¹, Minke G. Huitema¹, Wayel H. Abdulahad³, Elisabeth Brouwer¹ and Annemieke M.H. Boots⁴, ¹Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Dept. of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ⁴Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Improved understanding of the immune events discriminating between seropositive arthralgia and clinical synovitis is of key importance in rheumatology research. Ample evidence suggests a…
Abstract Number: 1392 • 2013 ACR/ARHP Annual Meeting
The Expression Of Proto-Oncogene Survivin Splicing Variant 2B In Synovial Tissues and Blood From Patients With Rheumatoid Arthritis
Sho Mokuda^1,2, Tatsuhiko Miyazaki³, Junya Masumoto³, Masamoto Kanno⁴ and Kiyoshi Takasugi⁵, ¹Department of Immunology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan, ²Department of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, Matsuyama, Japan, ³Department of Pathology, Division of Analyticalpathology, Ehime University Graduate School of Medicine, Toon, Japan, ⁴Department of Immunology, Graduate School of Biomedical Sciences, Hiroshima University, Hirosima, Japan, ⁵Center for Rheumatic Diseases, Dohgo Spa Hospital, Matsuyama, Japan
Background/Purpose: It has been reported that serum survivin level was an independent risk factor for predicting joint destruction in early rheumatoid arthritis (RA). The proto-oncogene…
Abstract Number: 2092 • 2012 ACR/ARHP Annual Meeting
No Significant Effect of Hepatitis B Virus Infection On Disease Activity, Synovitis or Joint Destruction in Rheumatoid Arthritis
Chan Juan Zou, Yan Hua Li, Ying Qian Mo, Lang Jing Zhu, Dong Hui Zheng, Jian Da Ma, Xia Ouyang and Lie Dai, Division of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
Background/Purpose: The prevalence of chronic hepatitis B virus (HBV) infection is high in China. 4% patients with HBV infection can present with polyarthritis and positive…

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