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Abstracts tagged "Renal"

  • Abstract Number: LB17 • ACR Convergence 2025

    Circulating biomarkers for organ involvement in systemic lupus erythematosus: a series of systematic reviews and meta-analyses

    Sitian Zang1, Ranran Yao1, Yan Wang1, Danxue Zhu1, Jing He1 and Zhanguo Li2, 1Peking University People's Hospital, Beijing, China (People's Republic), 2Peking Univeristy People's Hospital, Beijing, China (People's Republic)

    Background/Purpose: Systemic lupus erythematosus (SLE) features heterogeneous clinical manifestations. The identification of biomarkers that facilitate initial disease recognition is a cornerstone of optimized clinical management.…
  • Abstract Number: 1835 • ACR Convergence 2025

    Serum Zonulin As A Biomarker Of Renal Involvement In Systemic Lupus Erythematosus: Shedding Light On The Gut-Kidney Axis

    Alessandra Milone1, Giulio Forte2, Alessia Salzillo2, Barbara De Marino2, Rosa Giacca2, Francesco Ciccia3 and Daniele Mauro4, 1University of Campania L. Vanvitelli, Naples, 2University of Campania L. Vanvitelli, Naples, Italy, 3Rheumatology Section, University of Campania L. Vanvitelli, Naples, Italy, Naples, Italy, 4University of Campania, Italy, Naples, Italy

    Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease in which lupus nephritis (LN) remains a major cause of morbidity and mortality. Zonulin, a…
  • Abstract Number: 0856 • ACR Convergence 2025

    Integrated Single-Cell and Spatial Transcriptomics Reveal Vascular and Immune Pathogenesis in APS Nephropathy

    Shuyi Yu1, Haoyu Pan1, Jinyi Qian1, Xiaohan Wei2, Yuying Fan1, Zhixia Yang1, Shiyan Gu1, Jianzhou Wu1, Cenyi Wang1, Tiancheng Zhou1 and Hui Shi3, 1Department of Rheumatology and Immunology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, Shanghai, Shanghai, China (People's Republic), 2Shanghai JiaoTong University, Shanghai, China (People's Republic), 3Shanghai Jiaotong University Affiliated Ruijin Hospital, Shanghai, China (People's Republic)

    Background/Purpose: To elucidate the molecular and cellular mechanisms underlying antiphospholipid antibody (aPL) nephropathy using integrated single-cell and spatial transcriptomic (SP) profiling of kidney tissues.Methods: Renal…
  • Abstract Number: 1768 • ACR Convergence 2025

    TREM-1 and TREM-2 Define Inflammatory and Protective Axes in ANCA-Associated Glomerulonephritis

    Lea Dionet1, Alexandre Lanau2, Paul Breillat3, Quentin Delcros4, Federica Pallotti5, Margot Poux6, Pierre Isnard1, Arthur Lavigne4, Xavier Puéchal7, alexandre karras8, Jean-Paul Duong9, Olivia Lenoir10, Pierre-Louis Tharaux11 and Benjamin Terrier12, 1INSERM, Paris, France, 2Institut Curie, Paris, France, 3INSERM, PARIS 17, Ile-de-France, France, 4AP-HP, Paris, France, 5Internal Medicine and Clinical Immunology, Rennes, France, 6Université de Paris, PARIS 04EME, France, 7Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hospital Cochin, and Université Paris Cité, Paris ( 75014 ), Ile-de-France, France, 8HEGP - assistance publique hopitaux de paris, paris, France, 9INSERM, Paris, 10Paris Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France, PARIS, Ile-de-France, France, 11Paris Cardiovascular Research Center, Université Paris Cité, INSERM U970, Paris, France, PARIS, France, 12Cochin Hospital, Paris, France

    Background/Purpose: ANCA-associated vasculitis (AAV) is a small-vessel vasculitis that can lead to life-threatening renal injury. Neutrophils, monocytes and macrophages play a pivotal role not only…
  • Abstract Number: 0838 • ACR Convergence 2025

    Complete Renal Response and Long-Term, Progression-Free Survival in Adult Patients With Lupus Nephritis: A Retrospective Cohort Study in the United States

    Lisa Lindsay1, Shu Wang2, Huong Trinh1, Yunru Huang1, William Pendergraft1 and Brad Rovin3, 1Genentech, Inc., South San Francisco, CA, 2Genesis Research LLC, Hoboken, NJ, 3The Ohio State University, Columbus, OH

    Background/Purpose: Complete renal response (CRR) and flare prevention, as early markers of long-term kidney survival, are important outcomes in lupus nephritis (LN) clinical trials.Methods: This…
  • Abstract Number: 1722 • ACR Convergence 2025

    Defining Safe Hydroxychloroquine Blood Levels: Time to Switch to Precision Monitoring for Optimized Lupus Care

    Shivani Garg1, Benoit Blanchet2, Yann Nguyen3, Fauzia Hollnagel4, Ada Clarke5, Michelle Petri6, Murray Urowitz7, John Hanly8, Caroline Gordon9, Sang-Cheol Bae10, Juanita Romero-Diaz11, Jorge Sanchez-Guerrero12, Ann Clarke13, Sasha Bernatsky14, Daniel Wallace15, David A. Isenberg16, Anisur Rahman16, Joan Merrill17, Paul Fortin18, Dafna D. Gladman19, Ian Bruce20, Ellen Ginzler21, Mary Anne Dooley22, Rosalind Ramsey-Goldman23, Susan Manzi24, Andreas Jönsen25, Graciela Alarcón26, Ronald van Vollenhoven27, Cynthia Aranow28, Murat Inanc29, Meghan mackay30, Guillermo Ruiz-Irastorza31, S. Sam Lim32, Murat Inac33, Kenneth Kalunian34, Søren Jacobsen35, Christine Peschken11, Diane Kamen36, Anca Askanase37, Jill Buyon38, Julie Chezel5, Alicja Puszkiel39 and Nathalie Costedoat-Chalumeau40, 1University of Madison, School of Medicine and Public Health, Madison, WI, 2National Referral Centre for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, Paris, France, 3Department of Internal Medicine, Beaujon Hospital, AP-HP Nord, Université Paris Cité, Clichy, France, Clichy, France, 4University of Wisconsin, School of Medicine and Public Health, Madison, Madison, WI, 5Cochin Hospital, Paris, France, 6Johns Hopkins University School of Medicine, Timonium, MD, 7University of Toronto, Toronto, ON, Canada, 8Dalhousie University, Halifax, NS, Canada, Halifax, NS, Canada, 9Department of Inflammation and Ageing, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom, 10Hanyang University Medical Center, Seoul, South Korea, 11University of Manitoba, Winnipeg, MB, Canada, 12Mount Sinai Hospital and University Health Network, Toronto, Canada, 13Division of Rheumatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 14Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 15Cedars Sinai Medical Center, Studio City, CA, 16University College London, London, United Kingdom, 17Oklahoma Medical Research Foundation, Oklahoma, 18Centre ARThrite - CHU de Québec - Université Laval, Quebec, QC, Canada, 19Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Division of Rheumatology, Toronto, ON, Canada, 20Centre for Public Health, Faculty of Medicine, Health and Life Sciences, Queen’s University Belfast, Belfast, United Kingdom, 21SUNY Downstate Health Sciences University, New York, NY, 22UNC physician network, Chapel Hill, NC, 23Northwestern University Feinberg School of Medicine, Chicago, IL, 24Lupus Center of Excellence, Autoimmunity Institute, Allegheny Health Network, Pittsburgh, PA, 25Department of Clinical Sciences, Lund University, Lund, Sweden, 26The University of Alabama at Birmingham, Oakland, CA, 27Department of Rheumatology, Amsterdam University Medical Centre, Amsterdam, Netherlands, 28Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Manhasset, NY, 29Istanbul University, Istanbul, Turkey, 30Feinstein Institutes for Medical Research, Manhasset, NY, 31Biobizkaia Health Research Institute, Barakaldo, Spain, 32Emory University School of Medicine, Atlanta, GA, 33Istanbul University, Istanbul, 34UC San Diego, La Jolla, CA, 35Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, 36Medical University of South Carolina, Johns Island, SC, 37Columbia University Medical Center, New York, NY, 38NYU Grossman School of Medicine, New York, NY, 39Cochin Hospital, Paris, 40Inserm DR Paris 5, Paris, France

    Background/Purpose: Current guidelines recommend using hydroxychloroquine (HCQ) dose ≤5.0 mg/kg for managing SLE. However, 6-fold higher SLE flares, including those requiring hospitalizations, are noted with…
  • Abstract Number: 1707 • ACR Convergence 2025

    Racial and Ethnic Disparities in Kidney Transplant Outcomes Among Patients With Systemic Lupus Erythematosus (SLE): A 20-Year Analysis Spanning Before and After the 2014 Kidney Allocation System Revision

    Soziema Salia1, Boniface Mensah2, Ufuoma Mamoh1, Gilava Hedayati1, Terrylyna Baffoe-Bonnie3, Joan Morny4 and Christhopher Haas3, 1MedStar Health Georgetown University (Baltimore) Internal Medicine Program, Baltimore, MD, 2MedStar Health Georgetown University (Baltimore) Internal Medicine Program, Baltimore, CA, 3MedStar Health Georgetown University (Baltimore) Internal Medicine Program, Baltimore, 4Piedmont Athens Regional Internal Medicine Residency Program, Athens, GA

    Background/Purpose: Systemic lupus erythematosus (SLE) is a leading cause of end-stage kidney disease (ESKD) in young women, particularly among racial and ethnic minorities. Kidney transplantation…
  • Abstract Number: 1546 • ACR Convergence 2025

    Tacrolimus Versus Voclosporin for Active Lupus Nephritis: A Comparative Meta-analysis of Renal Response

    Urvi Zala1 and Rushi Patel2, 1Loyola MacNeal Hospital, Berwyn, IL, Oak Park, IL, 2Baptist Hospitals of Southeast Texas, Beumont, TX

    Background/Purpose: Lupus nephritis (LN) is seen in approximately 40–60 % of patients with systemic lupus erythematosus (SLE) and contributes significantly to morbidity and mortality in…
  • Abstract Number: PP08 • ACR Convergence 2025

    Living Well Despite the Challenges of Sjögren’s Disease and Systemic Lupus Erythematous: My Perspective as a Health Care Provider and Patient

    Matt Makara, Casey Hogan

    Background/Purpose: Typically, the diagnosis of any autoimmune condition can be challenging and take years. In my case, my diagnosis of Sjögren's disesase (SjD) was established…
  • Abstract Number: 1544 • ACR Convergence 2025

    Voclosporin in Lupus Nephritis: Meta-Analysis of 6-Month and 1-Year Efficacy with 1-Year Safety Outcomes

    Sri Laxmi Priya Sunkara1, Ravi Medarametla2, Megha Kotha3 and Wael Jarjour4, 1White river medical center, batesville, AR, 2Mamata Medical College, Guntur, Andhra Pradesh, India, 3Ohio State University, Columbus, OH, 4The Ohio State University, Columbus, OH

    Background/Purpose: Lupus nephritis (LN), is the most sever organ manifestation of systemic lupus erythematosus (SLE) and it contributes significantly to morbidity and mortality. . Standard…
  • Abstract Number: 2694 • ACR Convergence 2025

    Effect of Deucravacitinib Treatment on Renal Dysfunction–Associated Plasma Biomarkers From a Phase 2 Study in Patients With Systemic Lupus Erythematosus

    Amit Saxena1, Chun Wu2, Brad Rovin3, Zahi Touma4, Xueer Chen5, Ilias Kouris6 and Jinqi Liu5, 1Division of Rheumatology, Department of Medicine, NYU Grossman School of Medicine, New York, NY, 2Bristol Myers Squibb, Princeton, 3The Ohio State University, Columbus, OH, 4University of Toronto, Toronto, ON, Canada, 5Bristol Myers Squibb, Princeton, NJ, 6Bristol Myers Squibb, Boudry, Switzerland

    Background/Purpose: Plasma biomarkers may play a role in understanding kidney health in patients with lupus, particularly in terms of early detection of lupus nephritis (LN),…
  • Abstract Number: 1530 • ACR Convergence 2025

    The Renal Activity Index for Lupus Identifies and Predicts Complete Renal Remission or Absence of Kidney Involvement in Systemic Lupus Erythematosus

    Guillermo Pons-Estel1, Rosana Quintana1, Romina Nieto1, Hermine Brunner2, Marina Scolnik3, Carmen Funes Soaje4, Paula Alba5, Veronica Saurit6, Mercedes Garcia7, GUILLERMO ARIEL BERBOTTO8, Inés Verónica Bellomio9, Mario Eduardo Kerzberg10, Graciela Gomez11, Cecilia Pisoni12, Vicente Juarez13, Ana Malvar14, Nélzio Silva15, ODIRLEI MONTICIELO16, Henrique Mariz17, Francinne Ribeiro18, Eduardo Borba19, Eloisa Bonfa19, Edgard Torres dos Reis-Neto20, Iris Guerra Herrera21, Maria Loreto Massardo22, Gustavo Aroca-Martínez23, Lorena Gómez Escorcia24, Carlos Alberto Cañas25, Gerardo Quintana-Lopez26, Carlos Toro-Gutierrez27, Mario Moreno Alvarez28, MIGUEL SAAVEDRA29, Margarita Portela Hernández30, Hilda Fragoso-Loyo31, Luis H Silveira32, Ignacio García-De la Torre33, Carlos Abud-Mendoza34, Jorge Antonio Esquivel Valerio35, Maria Isabel Acosta36, Astrid Paats37, Claudia S. Mora-Trujillo38, Manuel Ugarte-Gil39, Armando Calvo40, Roberto Muñoz-Louis41, Martin Rebella42, Alvaro Danza43, Federico Zazzetti44, Ashley Orillion45, Urbano Sbarigia46 and Bernardo A. Pons-Estel47, 1Centro Regional de Enfermedades Autoinmunes y Reumáticas, GO-CREAR, Rosario, Argentina, Rosario, Argentina, 2Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Hospital Italiano de Buenos Aires, Argentina, Buenos Aires, Argentina, 4Hospital Italiano de Córdoba, Córdoba, Argentina, Cordoba, Argentina, 5Hospital Córdoba y Sanatorio Allende, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina, Cordoba, Argentina, 6Hospital Privado Universitario de Cordoba, Córdoba, Argentina, Córdoba, Argentina, 7Hospital Interzonal General de Agudos “General San Martín” de la plata, La Plata, Argentina, 8Sanatorio Británico, Rosario, Argentina, ROSARIO, Argentina, 9Hospital Padilla, Tucumán, Argentina, San Miguel de Tucumán, Argentina, 10Hospital J.M Ramos Mejía, Buenos Aires, Argentina, CABA, Argentina, 11Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina, Buenos Aires, Argentina, 12CEMIC Centro de Educación Médica e Investigaciones Clínicas ‘‘Norberto Quirno”, Buenos Aires, Argentina, Ciudad Autonoma Buenos Aires, Argentina, 13Hospital Señor del Milagro Salta, Salta, Argentina, Salta, Argentina, 14Organización Médica de Investigación, Buenos Aires, Argentina, 15Hospital das Clinicas da Universidade Federal de Goias, Goias, Brazil, Goiânia, Brazil, 16Hospital de Clínicas de Porto Alegre, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil, PORTO ALEGRE, Rio Grande do Sul, Brazil, 17Universidad Federal de Pernambuco, Pernambuco, Brazil, Pernambuco, Brazil, 18Hospital Universitário Pedro Ernesto - Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, Rio De Janeiro, Rio de Janeiro, Brazil, 19Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, São Paulo, Brazil, 20Universidad Federal São Paulo, São Paulo, Brazil, São Paulo, Brazil, 21Hospital del Salvador Santiago de Chile, Santiago, Chile, Santiago, Chile, 22Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile, Santiago, Chile, 23Clínica de la Costa y Universidad Simón Bolívar, Barranquilla, Colombia, barranquilla, Colombia, 24Clínica de la Costa y Universidad Simón Bolívar Barranquilla, Barranquilla, Colombia, Barranquilla, Colombia, 25Fundación Valle del Lili, Universidad Icesi, Cali, Colombia, Cali, Colombia, 26Facultad de Medicina, Universidad Nacional de Colombia; Hospital Universitario Fundación Santa Fe de Bogotá; Hospital Universitario Nacional de Colombia, Bogotá, Colombia, Bogotá, Colombia, 27Pontificia Universidad Javeriana de Cali, Cali, Colombia, Cali, Colombia, 28Universidad de Especialidades Espíritu Santo, Guayaquil, Ecuador, Guayaquil, Ecuador, 29Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico, MEXICO, Mexico, 30Hospital de Especialidades del Centro Médico Nacional SXXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico, Mexico City, Mexico, 31Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Mexico City, Mexico, 32Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico, Mexico City, Mexico, 33Centro de Estudios de Investigación Básica y Clínica, S.C., Guadalajara, Mexico, Guadalajara, Jalisco, Mexico, 34Facultad de Medicina de la Universidad Autónoma de San Luis Potosí y Hospital Central "Dr. Ignacio Morones Prieto", San Luis Potosí, Mexico, San Luis Potosí, Mexico, 35Universidad Autónoma de Nuevo León, Rheumatology Service, Hospital Universitario "Dr. José Eleuterio González", Monterrey, Nuevo León, México., MONTERREY, Mexico, 36Facultad de Ciencias Medicas, Universidad Nacional de Asunción, San Lorenzo, Paraguay, Asuncion, Paraguay, 37Facultad de Ciencias Medicas, Universidad Nacional de Asunción, San Lorenzo, Paraguay, Asunción, Paraguay, 38Hospital Nacional Edgardo Rebagliati Martins-EsSalud, Lima, Peru, Lima, Peru, 39Grupo Peruano de Estudio de Enfermedades Autoinmunes Sistémicas, Universidad Científica del Sur, Lima, Peru; Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Peru, Lima, Peru, 40Hospital Nacional Cayetano Heredia Universidad Peruana Cayetano Heredia, Lima, Peru, Jesús María, Peru, 41Hospital Docente Padre Billini, Santo Domingo, Distrito Nacional, Dominican Republic, 42Hospital de Clínicas, Facultad de Medicina, UDELAR, Montevideo, Uruguay, Montevideo, Uruguay, 43Médica Uruguaya, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay, Montevideo, Uruguay, 44Johnson & Johnson, Horsham, PA, USA, Ambler, PA, 45Johnson & Johnson, Spring House, PA, USA, Spring House, PA, 46Johnson & Johnson, Beerse, Belgium, 47Grupo Oroño - Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina

    Background/Purpose: Effective, non-invasive disease activity and treatment response assessments are needed for patients with systemic lupus erythematosus (SLE), especially if associated with kidney disease, i.e.…
  • Abstract Number: 2660 • ACR Convergence 2025

    Understanding Gout in Women: Longitudinal Changes in Serum Urate Levels from Pre-menopause through Post-menopause

    Shreya Billa1, Sho Fukui1, Misti Paudel2, Takahiro Suzuki3, Ryosuke Imai4, Yuntae Kim5, Takehiro Nakai6, Hiromichi Tamaki6, mitsumasa kishimoto7, Hilde Ørbo1, Sara Tedeschi1, Hyon K. Choi8, Masato Okada9 and Daniel Solomon1, 1Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Division of Rheumatology, Inflammation, and Immunity, Boston, MA, 3Department of Cardiovascular Medicine, St. Luke's International Hospital, Tokyo, Japan, 4Department of Pulmonary Medicine, St. Luke's International Hospital, Tokyo, Japan, 5Department of Gastroenterology, St. Luke's International Hospital, Tokyo, Japan, 6Immuno-Rheumatology Center, St. Luke’s International Hospital, Tokyo, Japan, 7Kyorin University School of Medicine, Tokyo, Japan, 8MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA, 9Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan

    Background/Purpose: Understanding longitudinal changes in serum urate (SU) allows for the development of evidence-based interventions for gout. Post-menopausal women, who are at risk of gout,…
  • Abstract Number: 1516 • ACR Convergence 2025

    The Benefits of SGLT2i on GFR Slope and Proteinuria in SLE Depend on Subgroups of Diabetes Mellitus and Baseline eGFR

    Jennifer Lee1, Andrea Fava2, Daniel Goldman3, Laurence Magder4 and Michelle Petri3, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins University, Baltimore, MD, 3Johns Hopkins University School of Medicine, Timonium, MD, 4University of Maryland, Baltimore, Baltimore, MD

    Background/Purpose: Lupus nephritis (LN) affects over 50% of SLE patients. Twenty percent of LN patients develop end-stage renal disease (ESRD) within 10 years. The 2021…
  • Abstract Number: 2640 • ACR Convergence 2025

    Effectiveness of Biological and Target-Synthetic Treatment in Patients with Rheumatoid Arthritis and Kidney Dysfunction: A Large Prospective Registry Study

    Sho Fukui1, Hilde Ørbo2, Sara Tedeschi1, Hongshu Guan3, Leslie Harrold4, Heather Litman5 and Daniel Solomon1, 1Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, 2Diakonhjemmet Hospital, Oslo, Norway, 3Brigham and Women's Hospital/ Harvard Medical School, Boston, 4CorEvitas, Northborough, MA, 5Corrona, LLC, Waltham, MA

    Background/Purpose: Kidney dysfunction is common in patients with rheumatoid arthritis (RA). However, there has been limited and conflicting evidence on the effectiveness of biologic and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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