Abstracts tagged "regulatory cells and systemic lupus erythematosus (SLE)"

Abstract Number: 2832 • 2018 ACR/ARHP Annual Meeting
Multiple Subpopulations of Peripheral Lymphocytes Were Absolutely Decreased in SLE Patients with Infection and Restored By Low-Dose IL-2
Sheng-Xiao Zhang¹, Xiao-Yan Wu², Jing Luo³, Guang-Ying Liu², Chong Gao⁴, Cai-Hong Wang⁵ and Xiao-Feng Li⁵, ¹The Second Hospital of Shanxi Medical University, Taiyuan, China, ²Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, China, ³the Second Hospital of Shanxi Medical University, Taiyuan, China, ⁴Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA, ⁵The Second Hospital of Shanxi Medical Univerity, Taiyuan, China
Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder characterized by disturbed cellular and humoral immune responses. Dysregulations of intrinsic or adaptive immune system…
Abstract Number: 1733 • 2017 ACR/ARHP Annual Meeting
Increased Differentiation Resistance of Regulatory T Cells to Endoplasmic Reticulum Stress in Systemic Lupus Erythematosus Patients
Yunjung Choi¹, Yu-Mi Lee², Eun-Kyeong Lee³, Ji-Hyeon Jeong³, Myeung Su Lee⁴, Changhoon Lee⁵ and Wan-Hee Yoo², ¹Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Hospital, jeonju, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, Korea, Republic of (South), ³Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea, Republic of (South), ⁴Department of Rheumatology, Wonkwang University Hospital, Iksan, Korea, Republic of (South), ⁵Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South)
Background/Purpose: Defects of regulatory T cell (Tregs) mainly contribute to loss of tolerance to self-antigen which is significantly implicated in the pathogenesis of systemic lupus…
Abstract Number: 2574 • 2017 ACR/ARHP Annual Meeting
Interleukin-33 Ameliorates Murine Lupus Via Induction of Regulatory T Cells and M2 Macrophage Polarisation
Mo Yin Mok¹, Ka Sin Law², Wing Yin Kong¹, Ge Liu¹, Wallace Lau², C Luo², FP Huang³, GC Chan⁴ and Kwok Wah Chan³, ¹Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, Hong Kong, ²Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong, ³Department of Pathology, University of Hong Kong, Hong Kong, Hong Kong, ⁴Department of Paediatrics, University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: The levels of IL-33, a Th2 promoting cytokine, and the soluble form of its receptor ST2 were reported to be elevated in serum of…
Abstract Number: 1840 • 2016 ACR/ARHP Annual Meeting
A Dichotomy of Regulatory Immunome Is Related to Disease Activity in Juvenile Systemic Lupus Erythematosus
Joo Guan Yeo^1,2, Thaschawee Arkachaisri^1,3, Justin Hung Tiong Tan¹, Jing Yao Leong⁴, Lena Das¹, Loshinidevi D/O Thana Bathi², Phyllis Chen² and Salvatore Albani^3,4, ¹Rheumatology and Immunology, KK Women's and Children's Hospital, Singapore, Singapore, ²Singhealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ³Duke-National University of Singapore Medical School, Singapore, Singapore, ⁴SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore
Background/Purpose: The pathogenesis of SLE involves disturbances to the homeostatic balance between the immune effector and regulatory system. The conventional mono-dimensional mechanistic interrogation of one…
Abstract Number: 1118 • 2015 ACR/ARHP Annual Meeting
Role of the Chemokine Receptor CXCR3 in the Function of Regulatory B Cells in Patients with SLE
Shun-ichiro Ota^1,2, Hiroaki Niiro³, Naoko Ueki^2,4, Yuri Hirosaki², Hirofumi Tsuzuki², Siamak Jabbarzadeh-Tabrizi², Tsuyoshi Nakayama², Koji Mishima², Ayako Takaki², Hiroki Mitoma², Mitsuteru Akahoshi², Yojiro Arinobu², Hiroshi Tsukamoto² and Koichi Akashi², ¹Department of Rheumatology, Internal medicine and connective tissue disorders, Shimonoseki City Hospital, Shimonoseki, Japan, ²Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan, ³Clinical Education Center, Kyushu University Hospital, Fukuoka, Japan, ⁴Division of Nephrology and Rheumatology, Fukuoka University, Fukuoka, Japan
Background/Purpose: The emerging application of B-cell directed therapies in autoimmune diseases has led to the discovery of a novel B cell population, referred to as…
Abstract Number: 1952 • 2014 ACR/ARHP Annual Meeting
Elucidation of Molecular Mechanisms of Breg Induction in Autoimmune Diseases
Shun-ichiro Ota, Hiroaki Niiro, Naoko Ueki, Yuri Hirosaki, Hirofumi Tsuzuki, Kumiko Noda, Siamak Jabbarzadeh-Tabrizi, Atsushi Tanaka, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroshi Tsukamoto and Koichi Akashi, Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Background/Purpose The advent of B-cell depletion therapy in autoimmune diseases identifies a novel B cell population, referred to as regulatory B cells (Bregs), that exerts…
Abstract Number: 2506 • 2012 ACR/ARHP Annual Meeting
Expression of Helios Facilitates Distinction Between FoxP3⁺ Treg and FoxP3⁺ Activated T Conventional Cells in Patients with Systemic Lupus Erythematosus
Amit Golding¹, Sarfaraz A. Hasni², Gabor G. Illei³ and Ethan M. Shevach⁴, ¹Medicine/Rheumatology and Clinical Immunology, Baltimore VA and University of Maryland School of Medicine, Baltimore, MD, ²Rheumatology, National Institutes of Health, Bethesda, MD, ³Sjogren's Clinic, NIDCR/ NIH, Bethesda, MD, ⁴Laboratory of Immunology, NIAID/NIH, Bethesda, MD
Background/Purpose: FoxP3 is not a reliable marker for distinguishing regulatory T (Treg) cells in humans due to the fact that FoxP3 may be up-regulated in…
Abstract Number: 2504 • 2012 ACR/ARHP Annual Meeting
SOCS1 Is One of the Key Molecules to Prevent the Plasticity of Regulatory T Cells and the Development of Autoimmunity
Reiko Takahashi¹, Kenji Itoh¹, Fumihiko Kimura¹ and Akihiko Yoshimura², ¹Division of Rheumatology, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan, ²Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Suppression of autoimmunity or inflamation by regulatory T cells (Tregs) is now well established, recently, natural Foxp3+T cells have been shown to be a…
Abstract Number: 2340 • 2012 ACR/ARHP Annual Meeting
A Numeric Expansion of Invariant Natural Killer T Cells Protects Against the Progression of Fatal Autoimmunity in Lupus-Prone Mice
Yuriy Baglaenko¹, Nan-Hua Chang², Evelyn Pau³, Christina Loh⁴ and Joan E. Wither⁵, ¹Immunology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁴Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ⁵1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Previous studies from our lab have shown that the introgression of a NZB chromosome 1 (c1) interval extending from 135 to179 Mb onto the…
Abstract Number: 1744 • 2012 ACR/ARHP Annual Meeting
Regulatory B Cells Supress the Progression of Fatal Autoimmunity in Lupus-Prone Mice
Yuriy Baglaenko¹, Nan-Hua Chang², Evelyn Pau³ and Joan E. Wither⁴, ¹Immunology, University of Toronto, Toronto, ON, Canada, ²Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁴1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex multisystem autoimmune disorder characterized by the production of anti-nuclear antibodies (ANA) which form immune complexes and promote…
Abstract Number: 2682 • 2012 ACR/ARHP Annual Meeting
Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses IL-2 Production and Regulatory T Cell Activity in Systemic Lupus Erythematosus
Tomohiro Koga¹, Kunihiro Ichinose², Masayuki Mizui³, José C. Crispín⁴ and George C. Tsokos⁴, ¹Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Division of Rheumatology, Department of Medicine,, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA
Background/Purpose: T cells from patients with SLE exhibit abnormal signaling upon TCR engagement and have an altered gene expression profile. Accordingly, the regulation of several transcription factors…

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