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Abstracts tagged "RCT"

  • Abstract Number: 3183 • 2016 ACR/ARHP Annual Meeting

    Tocilizumab for the Treatment of Giant Cell Arteritis – MR-Angiography Results from the First Randomized Placebo-Controlled Trial 

    Stephan Reichenbach1,2, Sabine Adler3, Jennifer Cullmann4, Harald Bonel4, Stefan Kuchen5, Felix Wermelinger1, Diana Dan1, Michael Seitz1 and Peter M. Villiger1, 1Department of Rheumatology, Immunology and Allergology, University Hospital Bern, Bern, Switzerland, 2Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland, 3Rheumatology, Immunology, Allergology, University Hospital Bern, Bern, Switzerland, 4Department of Diagnostic, Interventional and Pediatric Radiology, University Hospital Bern, Bern, Switzerland, 5Rheumatology, Immunology, and Allergology, University of Bern, Bern, MD, Switzerland

    Background/Purpose:  As published in The Lancet online, March 4, 2016, the first randomized, placebo-controlled trial (RCT) of tocilizumab (TCZ) in giant cell arteritis (GCA) showed…
  • Abstract Number: 3210 • 2016 ACR/ARHP Annual Meeting

    10+ Years’ Follow-up of a Danish 2-Year Treat-to-Target RCT in Patients with Early Rheumatoid Arthritis: Baseline Predictors of Functional and Radiographic Outcomes

    Merete Lund Hetland1, Kristian Stengaard-Pedersen2, Peter Junker1, Hanne Lindegaard1, Torkell Ellingsen1, Jan Pødenphant2, Henrik Skjødt1, Aage Vestergaard2, Bo Jannik Ejbjerg1, Søren Jacobsen1, Niels Steen Krogh1, Mikkel Ostergaard1 and Kim Hørslev-Petersen2, 1Rigshospitalet (Glostrup and Blegdamsvej), Århus University Hospital, Odense University Hospital, Herlev/Gentofte Hospital, Slagelse Sygehus, Chr X hospital (University of South Denmark) and Zitelab Aps, DANBIO Registry and Departments of Rheumatology, Glostrup, Denmark, 2Rigshospitalet (Glostrup and Blegdamsvej), Århus University Hospital, Odense University Hospital, Herlev/Gentofte Hospital, Slagelse Sygehus, Chr X hospital (University of South Denmark) and Zitelab Aps, DANBIO Registry and Departments of Rheumatology, Copenhagen, Denmark

    Background/Purpose:  Few RCTs have investigated long-term (10+ years) outcomes of goal-directed synovitis suppression in early rheumatoid arthritis (RA). The CIMESTRA trial was a 2-year double-blinded…
  • Abstract Number: 214 • 2016 ACR/ARHP Annual Meeting

    Anakinra Compared to Prednisone on the Treatment of Acute CPPD Crystal Arthritis, a Randomized, Controlled, Double-Blind Study

    Alexandre Dumusc1, Borbala Pazar Maldonado1, Charles Benaim2, Isabelle Fabreguet1, Pascal Zufferey1, Bérengère Aubry-Rozier1 and Alexander So1, 1Rheumatology Department, Lausanne University Hospital, Switzerland, Lausanne, Switzerland, 2Physical Medicine and Rehabilitation Department, Lausanne University Hospital, Switzerland, Lausanne, Switzerland

    Background/Purpose:   Calcium pyrophosphate crystal-induced arthritis (CPPD) is an acute crystal arthritis, frequently involving the wrist or the knee. Monosodium urate in gout or CPPD…
  • Abstract Number: 311 • 2016 ACR/ARHP Annual Meeting

    Comparative Effectiveness of Ayurveda and Conventional Care in Knee Osteoarthritis – a Randomized Controlled Trial

    Christian Kessler1,2, Kartar Dhiman3, Abhimanyu Kumar4, Thomas Ostermann5, Shivenarain Gupta6,7, Antonio Morandi8, Martin Mittwede7,9, Elmar Stapelfeldt2, Michaela Spoo2, Katja Icke1, Andreas Michalsen1,2 and Claudia Witt1,10, 1Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany, 2Department for Complementary Medicine, Immanuel Hospital Berlin, Berlin, Germany, 3Central Council for Research in Ayurvedic Sciences (CCRAS), New Delhi, India, New Delhi, India, 4All India Institute of Ayurveda, New Delhi, India, 5Department of Psychology and Psychotherapy, University of Witten Herdeckey, Witten, Germany, 6Department of Kaya Cikitsa, J.S. Ayurveda College & P.D. Patel Ayurveda Hospital, Nadiad, India, 7European Academy of Ayurveda, Birstein, Germany, 8Ayurvedic Point, School of Ayurvedic Medicine, Milan, Italy, 9Department of Theology and Religious Sciences, University of Frankfurt, Frankfurt, Germany, 10Institute of Complementary and Integrative Medicine, University Hospital and University of Zurich, Zürich, Switzerland

    Background/Purpose:  Ayurveda is used to treat knee osteoarthritis (OA) despite limited evidence. We aimed to evaluate the effectiveness of complex multimodality Ayurvedic treatment in comparison…
  • Abstract Number: 1144 • 2016 ACR/ARHP Annual Meeting

    Impact of Decision-Making Role Preferences in the Efficacy of a Multimedia Patient Education Tool for Patients with Common Rheumatologic Conditions

    Andrea Barbo1, Maria Suarez-Almazor2 and Maria A. Lopez-Olivo3, 1Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, 2Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Houston, TX, 3Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine,The University of Texas MD Anderson Cancer Center, Houston, Texas, USA,, Houston, TX

    Background/Purpose:  A preference for shared decision-making among patients with chronic conditions has been associated with better health outcomes. We compared the impact of a multimedia…
  • Abstract Number: 2315 • 2015 ACR/ARHP Annual Meeting

    Six-Month Effects of a Multimedia Patient Education Tool in Patients with Rheumatoid Arthritis. a Randomized Controlled Trial

    Maria A. Lopez-Olivo1, Andrea Barbo2, Tara Rizvi3, Robert Volk4, Heather Lin5 and Maria E. Suarez-Almazor6, 1Department of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, 2Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, 3Rheumatology, Baylor College of Medicine, Houston, TX, 4Health Services Research, The University of Texas, MD Anderson Cancer Center, Houston, TX, 5Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, 6General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX

    Background/Purpose: We conducted a multi-centered, open-label, parallel, randomized controlled trial to evaluate the efficacy of a multimedia-patient education tool (MM-PtET) for patients with rheumatoid arthritis…
  • Abstract Number: 2313 • 2015 ACR/ARHP Annual Meeting

    Responder Rates and Numbers Needed to Treat Based on Clinically Meaningful Improvements in Patient Reported Outcomes (PROs) Including Health-Related Quality of Life (HRQoL) after Sarilumab Treatment during a Phase III Randomized Controlled Trial (RCT)

    Vibeke Strand1, Regina Rendas-Baum2, George J. Joseph3, Chieh-I Chen4, Hubert van Hoogstraten5, T. W. J. Huizinga6 and Mark C. Genovese7, 1Biopharmaceutical Consultant, Portola Valley, CA, 2QualityMetric Inc, Lincoln, RI, 3Global Health Economics & Outcomes Research (HEOR), Sanofi, Bridgewater, NJ, 4Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 5Sanofi, Bridgewater, NJ, 6Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 7Division of Rheumatology, Stanford University Medical Center, Palo Alto, CA

    Background/Purpose: Sarilumab is a human monoclonal antibody (mAb) directed against the soluble IL-6 receptor (sIL-6R), administered subcutaneously (SC) every 2 weeks (q2w).  In the phase…
  • Abstract Number: 2219 • 2015 ACR/ARHP Annual Meeting

    Improving Outcomes with a Multimedia Patient Education Tool in Patients with Osteoporosis after 6 Months. a Randomized Controlled Trial

    Maria A. Lopez-Olivo1, Andrea Barbo2, Tara Rizvi3, Robert Volk4, Heather Lin5 and Maria E. Suarez-Almazor1, 1General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, 2Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, 3Rheumatology, Baylor College of Medicine, Houston, TX, 4General Internal Medicine, UT MD Anderson Cancer Center, Houston, TX, 5Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX

    Background/Purpose: We conducted a 6-month multi-centered, open-label, parallel, randomized control trial to compare a multimedia-patient education tool (MM-PtET) including storylines and narratives with a written…
  • Abstract Number: 2218 • 2015 ACR/ARHP Annual Meeting

    A Randomized Controlled Trial to Evaluate a Multimedia Patient Education Tool in Patients with Knee Osteoarthritis. Six-Month Results

    Maria A. Lopez-Olivo1, Andrea Barbo2, Tara Rizvi3, Robert Volk4, Heather Lin5 and Maria E. Suarez-Almazor1, 1General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, 2Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, 3Rheumatology, Baylor College of Medicine, Houston, TX, 4General Internal Medicine, UT MD Anderson Cancer Center, Houston, TX, 5Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX

    Background/Purpose: Video modelling is often used in patient education to improve patient outcomes. We conducted a multi-centered, open-label, parallel, randomized controlled trial that evaluated the…
  • Abstract Number: 2126 • 2015 ACR/ARHP Annual Meeting

    Trial of Atorvastatin for the Primary Prevention of Cardiovascular Events in Patients with Rheumatoid Arthritis

    George D. Kitas1, Peter Nightingale2, Jane Armitage3, Naveed Sattar4, Jill Belch5, Deborah P.M. Symmons6 and TRACE RA Consortium, 1Dudley Group NHS Foundation Trust, Dudley, and Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, United Kingdom, 2Wolfson Computer Laboratory, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, 3Clinical Trial Service Unit and Epidemiology Unit, University of Oxford, Oxford, United Kingdom, 4University of Glasgow, BHF Glasgow Cardiovascular Research Centre, Glasgow, United Kingdom, 5Division of Cardiovascular and Diabetes Medicine, University of Dundee, Dundee, United Kingdom, 6NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk for cardiovascular disease (CVD) compared to the general population, both due to classical and novel…
  • Abstract Number: 1812 • 2015 ACR/ARHP Annual Meeting

    The First Randomized Control Trial to Evaluate the Effectiveness of Bortezomib for Refractory Systemic Lupus Erythematosus

    Tomonori Ishii1, Yoshiya Tanaka2, Atsushi Kawakami3, Kazuyoshi Saito2, Kunihiro Ichinose4, Yuko Shirota5, Hiroshi Fujii5, Yoko Fujita6, Yukiko Kamogawa5, Tomoaki Machiyama5, Kanae Akita5 and Hideo Harigae5, 1Department of Clinical Trial Implementation, Tohoku University Hospital, Clinical Research, Innovation and Education Center, Sendai, Japan, 2The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, 3Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, 4Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 5Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan, 6Department of Hematolgy and Rheumatolgy, Tohoku University Graduate School of Medicine, Sendai, Japan

    Background/Purpose: Systemic lupus erythematosus (SLE) is a disease characterized by production and deposition of anti-dsDNA antibody. In recent years, treatment methods targeting antibody-producing B cell…
  • Abstract Number: 1783 • 2015 ACR/ARHP Annual Meeting

    Dietary Fish Oil Supplementation Raises Serum Essential Fatty Acid Concentrations in Patients with Systemic Lupus Erythematosus and Correlates with Improvements in Inflammation and Pain

    Cristina Arriens1, Carlos Rodriguez-Navas2, David R. Karp1, Jeffrey McDonald2 and Chandra Mohan3, 1Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 2Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, 3Biomedical Engineering, University of Houston, Houston, TX

    Background/Purpose: A comprehensive metabolomic screen comparing sera from patients with systemic lupus erythematosus (SLE) to healthy controls (HC) indicated a relative deficiency in omega-3 fatty…
  • Abstract Number: 1495 • 2015 ACR/ARHP Annual Meeting

    Person-Centred Care Can Help Patients to Become More Effective Consumers in the Use of Health Information Than Regular Care – an RCT in Patients with Arthritis Undergoing Biological Therapy

    Ingrid Larsson1,2, Stefan Bergman2,3,4 and Ann Bremander2,3,5, 1School of Health and Welfare, Halmstad University, Halmstad, Sweden, 2FoU Spenshult, Halmstad, Sweden, 3Department of Clinical Sciences, Lund, Section of Rheumatology, Lund University, Lund, Sweden, 4Primary Health Care Unit, Department of Public Health and Community Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 5School of Business, Engineering and Science, Halmstad University, Halmstad, Sweden

    Background/Purpose: Person-centred care (PCC) is a holistic approach with respectful and individualized care allowing negotiation of care where persons with health problems are empowered to…
  • Abstract Number: 2896 • 2014 ACR/ARHP Annual Meeting

    a Multi-Center Double-Blind, Randomized, Controlled Trial (db-RCT) to Evaluate the Effectiveness and Safety of Co-Administered Traumeel® (Tr14) and Zeel® (Ze14) Intra‑articular (IA) Injections Versus IA Placebo in Patients with Moderate-to-Severe Pain Associated with OA of the Knee

    Carlos Lozada1, Eve del Rio2, Donald Reitberg2, Robert Smith2, Charles Kahn3 and Roland W. Moskowitz4, 1Rheumatology, University of Miami Miller School of Medicine, Miami, FL, Miami, FL, 2Clinical Research, Rio Pharmaceutical Services, LLC, Bridgewater, NJ, 3South Florida Rheumatology, Hollywood, FL, 4Div of Rheum/Dept of Medicine, University Hospitals Case Medical Center, Cleveland, OH

    Background/Purpose: Tr14 & Ze14 is a combination of dilute biological and mineral extracts administered IA for painful knee OA.  In response to clinician impressions of…
  • Abstract Number: 673 • 2014 ACR/ARHP Annual Meeting

    A Comparison of Rheumatoid Arthritis and Systemic Lupus Erythematosus Trial Design: Ways to Improve Positive Trials in Systemic Lupus Erythematosus

    Amy Miles1 and Janet E. Pope2, 1Medicine, University of Western Ontario and U of Toronto, London, ON, Canada, 2St Joseph Health Care, London, ON, Canada

    Background/Purpose: Recent SLE RCTs were examined and compared to rheumatoid arthritis (RA) RCT to suggest modifications to SLE RCTs that could improve the future success…
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