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Abstracts tagged "Raynaud’s phenomenon"

  • Abstract Number: 2697 • 2017 ACR/ARHP Annual Meeting

    Systemic Sclerosis Quality of Life Questionnaire (SScQoL) Captures the Complex Problems Experienced By Patients with Scleroderma

    Matylda Sierakowska1, Stanislaw Sierakowski2, Marzena Olesinska3, Marek Brzosko4, Piotr Leszczynski5, Katarzyna Pawlak-Bus5, Bogdan Batko6, Piotr Wiland7, Maria Majdan8, Malgorzata Bykowska-Sochacka9, Wojciech Romanowski10, Aleksandra Zon-Giebel11, Slawomir Jeka12 and Mwidimi Ndosi13, 1Department of Integrated Medical Care, Medical University of Bialystok, Bialystok, Poland, 2Department of Rheumatology and Internal Diseases, Medical University of Bialystok, Poland, Bialystok, Poland, 3Department of Connective Tissue Disease, National Institute of Geriatrics, Rheumatology and Rehabilitation,, Warsaw, Poland, 4Department of Rheumatology and Internal Diseases, Pomeranian Medical University, Szczecin, Poland, 5Department of Rheumatology and Rehabilitation, Medical University in Poznan, Poznan, Poland, 6Center of Rheumatology, J. Dietl Hospital in Krakow, Krakow, Poland, 7Department and Clinic of Rheumatology and Internal Medicine, Medical University, Wroclaw, Poland, 8Department of Rheumatology and Connective Tissue Diseases, Medical University in Lublin, Lublin, Poland, 9Dr J. Titz-Kosko Regional Hospital for Rheumatic Diseases in Sopot, Sopot, Poland, 10Poznan Centre of Rheumatology in Srem, Srem, Poland, 11Silesian Center of Rheumatology, Rehabilitation and Prevention of Disability, Ustron, Poland, 122nd University Hospital, CM UMK, Department of Rheumatology and Connective Tissue Diseases,, Bydgoszcz, Poland, 13Department of Nursing and Midwifery, University of the West of England, Bristol, United Kingdom

    Background/Purpose: Systemic sclerosis (SSc) is a chronic rheumatic disease that disturbs the patients’ biological, social, emotional spiritual, and physical functioning; resulting in reduced quality of…
  • Abstract Number: 2889 • 2017 ACR/ARHP Annual Meeting

    Aminaphtone Ameliorates Clinical Symptoms and Increases Skin Blood Perfusion in Patients with Both Primary and Secondary Raynaud Phenomenon: A Six-Month Open Study

    Alberto Sulli1, Maurizio Cutolo2, Carmen Pizzorni2, Sabrina Paolino2, Elisa Alessandri2, Emanuele Gotelli2 and Barbara Ruaro2, 1Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino, Genoa, Italy, Genova, Italy, 2Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino, Genoa, Italy, Genoa, Italy

    Background/Purpose: Current treatments for Raynaud's phenomenon (RP) have limited efficacy, which was mainly demonstrated by physician/patient reported outcomes. Aminaphtone is a vasoactive drug recently suggested…
  • Abstract Number: 745 • 2017 ACR/ARHP Annual Meeting

    An International Qualitative Research Study Exploring the Patient Experience of Raynaud’s Phenomenon in Systemic Sclerosis

    John D. Pauling1,2, Robyn T. Domsic3, Lesley Ann Saketkoo4, Celia Almeida5, Tracy M. Frech6, Francesca Ingegnoli7, Jane Withey8, Hilary Jay8, Emma Dures9, Joanna Robson10, Neil J. McHugh11,12, Ariane L. Herrick13,14, Marco Matucci-Cerinic15, Dinesh Khanna16 and Sarah Hewlett17, 1Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, 2Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 3Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 4Tulane, New Orleans, LA, 5HAS - Nursing and Midwifery, University of the West of England, Bristol, United Kingdom, 6Division of Rheumatology, University of Utah, Salt Lake City, UT, 7Dept. of clinical and community science, Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy, 8Patient Research Partner, Bath, United Kingdom, 9Academic Rheumatology, Bristol, University of the West of England, Bristol, Bristol, United Kingdom, 10Rheumatology, University of the West of England (UWE Bristol), Bristol, United Kingdom, 11Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 12Department of Pharmacy and Pharmacology, The University of Bath, Bath, United Kingdom, 13Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Manchester, United Kingdom, 14School of Translational Medicine, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, 15Dept of Medicine/Div of Rheum, University of Florence, Florence, Italy, 16Department of Medicine, University of Michigan Scleroderma Program, Ann Arbor, MI, 17UWE Academic Rheumatology, University of West of England, Bristol, United Kingdom

    Background/Purpose: Raynaud’s phenomenon (RP) is consistently ranked highest in patient surveys exploring the frequency and impact of disease related manifestations of systemic sclerosis (SSc). SSc-RP…
  • Abstract Number: 1686 • 2017 ACR/ARHP Annual Meeting

    Topical Nitroglycerine (NTG) Vs Matching Vehicle in Secondary Raynaud Phenomenon (RP) – a Double-Blind Crossover Study of Subjective and Physiologic Responses to Controlled Cold Challenge

    Dinesh Khanna1, Lorele Mendez2, Rajaie Namas3, Mary Ellen Csuka4, Paul Caldron5, Jerry A. Molitor6, Alan J. Kivitz7, Philip Waller8, Lee Shapiro9, Sabeen Najam10, Amber Khan11, Virginia D. Steen12, Aneureka Chadha13 and James R Seibold14, 1University of Michigan, Ann Arbor, MI, 2Medical Research Center of Miami, Miami, FL, 3Department of Medicine [Division of Rheumatology], University of Michigan, Ann Arbor, MI, 4Medicine, Medical College of Wisconsin, Milwaukee, WI, 5Arizona Arthritis & Rheumatology Research PLLC, Phoenix, AZ, 6Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, 7Altoona Center for Clinical Research, Duncansville, PA, 8Accurate Clinical Research Inc, Houston, TX, 9Rheumatology, Albany Medical College, Albany, NY, 10Accurate Clinical Management LLC, Baytown, TX, 11Accurate Clinical Management LLC, Houston, TX, 12Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, 13Austin Regional Clinic, Austin, TX, 14Scleroderma Research Consultants LLC, Litchfield, CT

    Background/Purpose: A topical therapy for either prevention or palliation of attacks would offer unique advantages to selected patients with Raynaud phenomenon (RP). This study used…
  • Abstract Number: 1700 • 2017 ACR/ARHP Annual Meeting

    Focusing on Pulmonary Vascular Disease at Early Stage of Systemic Sclerosis: Exercise-Induced Pulmonary Arterial Hypertension and Gene Co-Expression Networks Involved in Its Pathogenesis

    Yoshinobu Koyama1, Soichiro Fuke2, Yoshiharu Sato3 and Toshie Higuchi1, 1Center for Autoimmune Diseases, Division of Rheumatology, Japan Red Cross Okayama Hospital, Okayama, Japan, 2Department of Cardiology, Japan Red Cross Okayama Hospital, Okayama, Japan, 3DNA Chip Research Inc, Yokohama, Japan

    Background/Purpose: Pulmonary arterial hypertension (PAH) is prominent as a vascular involvement in systemic sclerosis (SSc), which remains a leading cause of death in spite of…
  • Abstract Number: 164 • 2016 ACR/ARHP Annual Meeting

    99mtc-Hdp Digital Blood Flow Scintigraphy for Assessment of Raynaud Phenomenon Associated with Hand-Arm Vibration Syndrome

    Kyung-Ann Lee1, Hyun-Woo Jeong2, Sang Heon Lee3 and Hae-Rim Kim4, 1Devision of rheumatology, Department of internal medicine, Konkuk University Medical center, Seoul, Korea, The Republic of, 2Department of Nuclear medicine, Konkuk University Medical center, Seoul, Korea, The Republic of, 3Department of Internal Medicine,Division of Rheumatology., Division of Rheumatology, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea, The Republic of, 4Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea, The Republic of

    Background/Purpose:  This study aimed to analyze the 99mTc-HDP scintigraphic features in hand-arm vibration syndrome (HAVS) and to compare with primary Raynaud’s phenomenon (RP) and secondary…
  • Abstract Number: 842 • 2016 ACR/ARHP Annual Meeting

    Aminaphtone Treatment Increases Skin Blood Perfusion and Related Clinical Symptoms in Patients Affected By Raynaud’s Phenomenon: A Pilot Study Based on Laser Speckle Contrast Analysis

    Barbara Ruaro, Sabrina Paolino, Carmen Pizzorni, Maurizio Cutolo and Alberto Sulli, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genova, Italy

    Background/Purpose: Aminaphtone is an oral vasoactive drug used to treat microvascular impairement since 30 years, and recently suggested to down-regulate endothelin-1 production by endothelial cells,…
  • Abstract Number: 1863 • 2016 ACR/ARHP Annual Meeting

    Non-Invasive Investigation of Perfusion, Microvascular Structure, Erythema, Oxidative Stress and Oxygenation in Healthy Controls and in Patients with Primary and Secondary Raynaud’s Phenomenon

    Andrea Murray1,2, Tonia Moore3, Joanne Manning4, Ian Poxon2, Graham Dinsdale1, Michael Berks5, Sarah Leggett6, Mark Dickinson2 and Ariane L. Herrick1, 1Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Manchester, United Kingdom, 2Photon Science institute, University of Manchester, Manchester, United Kingdom, 3Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Salford, United Kingdom, 4Rheumatology Department, Salford Royal NHS Foundation Trust, Salford, United Kingdom, 5Centre for Imaging Sciences, University of Manchester, Institute of Population Health, Manchester, United Kingdom, 6Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: It is well established that measurements of cutaneous microvascular dysfunction (measured with laser Doppler imaging [LDI]) and structural abnormality (measured with nailfold capillaroscopy [NC])…
  • Abstract Number: 1867 • 2016 ACR/ARHP Annual Meeting

    An Abnormal Nailfold Capillaroscopy Pattern Is Common in Patients with Connective Tissue Disease and Is Associated with Pulmonary and Oesophageal Involvement, Even in the Absence of Systemic Sclerosis

    Anniek M van Roon1, Cato C Huisman1, Arie M van Roon1, Alja J Stel2, Andries J Smit1, Hendrika Bootsma2 and Douwe J Mulder1, 1Internal Medicine - division Vascular Diseases, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: RP is a common symptom of CTD. Nailfold capillary microscopy (NCM) has previously been shown to be associated with disease severity and internal organ…
  • Abstract Number: 1874 • 2016 ACR/ARHP Annual Meeting

    Low Rate of Progression in Cases of Isolated Raynaud’s Phenomenon Screened By Nailfold Videocapillaroscopy and Antinuclear Antibody Status Supports Negative Predictive Value of These Tests

    Louise Parker1, Kevin Howell2, Voon H. Ong3 and Christopher P.Denton4, 1Centre for Rheumatology and Connective Diseases, UCL Medical School and Royal Free Hosp, London, United Kingdom, 2Institute of Immunity and Transplantation, University College London, Royal Free Campus, London, United Kingdom, 3Rheumatology, UCL Division of Medicine, London, United Kingdom, 4Centre of Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom

    Background/Purpose:   Raynaud’s phenomenon is common but can progress to definite connective tissue disease. We have observed long term follow up of an unselected consecutive…
  • Abstract Number: 2889 • 2016 ACR/ARHP Annual Meeting

    Therapeutic Plasma Exchange for the Treatment of Raynaud’s and Digital Ulcers in Systemic Sclerosis: A Systematic Review

    Edward S Harris1, Herbert J Meiselman2, Patrick M Moriarty3 and Allan Metzger4, 1Scleroderma Education Project Ltd, Madison, WI, 2Keck School of Medicine, University of Southern California, Los Angeles, CA, 3Clinical Pharmacology, University of Kansas Medical Center, Kansas City, KS, 4RDL Reference Laboratory Inc, Los Angeles, CA

    Background/Purpose: Raynaud's phenomenon (RP) is an early marker of microvascular damage in systemic sclerosis (SSc) and digital ulcers (DU) are a serious complication of vascular…
  • Abstract Number: 2909 • 2016 ACR/ARHP Annual Meeting

    Attitudes Toward Patient-Reported Outcome Instruments for the Assessment of Raynaud’s Phenomenon in Systemic Sclerosis

    John Pauling1,2, Tracy M. Frech3,4, Michael Hughes5, Jessica K. Gordon6, Robyn T. Domsic7, Francesca Ingegnoli8, Neil J. McHugh1,9, Sindhu R. Johnson10, Marie Hudson11, Francesco Boin12, Voon Ong13, Marco Matucci Cerinic14, Nezam Altorok15, Marina Scolnik16, Mandana Nikpour17, Ankoor Shah18, Janet E. Pope19, Dinesh Khanna20 and Ariane L. Herrick21, 1Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, 2Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 3Internal Medicine, Salt Lake City VAMC, Salt Lake, UT, 4Internal Medicine-Division of Rheumatology, University of Utah School of Medicine, SLC, UT, 5Centre for Musculoskeletal Research, The University of Manchester, Manchester, United Kingdom, 6Rheumatology, Hospital for Special Surgery, New York, NY, 7Medicine - Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh, PA, 8Department of Rheumatology, Istituto Gaetano Pini, University of Milano, Italy, Milano, Italy, 9Rheumatology, Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, United Kingdom, 10Medicine, Division of Rheumatology, Toronto Western Hospital, University Health Network Pulmonary Hypertension Programme, Toronto General Hospital, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, 11Department of Medicine, McGill University and Jewish General Hospital, Montreal, QC, Canada, 12Rheumatology, University California San Francisco, San Francisco, CA, 13Rheumatology, University College London Medical School, Royal Free Hospital, London, UK, London, United Kingdom, 14Department of Medicine, Division of Rheumatology, University of Florence, Italy, Florence, Italy, 15Rheumatology, University of Toledo Medical Center,, Toledo, OH, 16Rheumatology Section, Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 17Department of Medicine (St Vincent's Hospital), The University of Melbourne, Melbourne, Australia, 18Rheumatology and Immunology, Duke University Medical Center, Durham, NC, 19Monsignor Roney Bldg/Rheum, University of Western Ontario, St Joseph Health Care, London, ON, Canada, 20Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, 21Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom

    Background/Purpose:  The Raynaud’s Condition Score (RCS) diary is a clinician-derived validated patient-reported outcome (PRO) instrument for assessing the frequency, duration and severity of Raynaud's phenomenon…
  • Abstract Number: 2909 • 2015 ACR/ARHP Annual Meeting

    A Systematic Review and Meta-Analysis of Cutaneous Manifestations in Late Versus Early-Onset Systemic Lupus Erythematosus

    Jennifer Medlin1, Karen E. Hansen2, Sara Fitz3 and Christie M. Bartels4, 1Internal Medicine, University of Wisconsin Hospitals and Clinics, Madison, WI, 2Rheumatology/Medicine, Univ of Wisconsin, Madison, WI, 3Department of Dermatology, Mercy Medical Center, Dubuque, IA, 4Medicine, Rheumatology, University of Wisconsin School of Medicine and Public Health, Madison, WI

    Background/Purpose:   Systemic lupus erythematosus (SLE) is commonly diagnosed in females of reproductive age, with those diagnosed after the age of 50 referred to as…
  • Abstract Number: 2963 • 2015 ACR/ARHP Annual Meeting

    Correlations Between Microvasculature Changes and Angiogenic Factors in Systemic Sclerosis – Data from a Single Center Registry

    Radim Becvar1, Simona Skacelova2, Jiri Stork3, Hana Hulejová4, Ivana Putova5, Michal Tomcik6 and Marie Jachymova7, 1Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, 3Clinic of Dermatology and Venerology, Prague, Czech Republic, 4Institute of Rheumatology, Department of Rheumatology of the First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 5Institute of Rheumatology and Department of Rheumatology of the 1st Faculty of Medicine, Charles University, Prague 2, Czech Republic, 6Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Prague, Czech Republic, 7Second Internal Clinic – Clinic of Cardiology and Angiology, General University Hospital,, Prague, Czech Republic

    Background/Purpose: Histopathological hallmarks of systemic sclerosis (SSc) are perivascular infiltrates and a reduced capillary density, which precede the excessive accumulation of extracellular matrix components in…
  • Abstract Number: 2970 • 2015 ACR/ARHP Annual Meeting

    Primary Care Assessment of Capillaroscopy Abnormalities in Patients with Raynaud’s Phenomenon

    Rebecca Overbury1, Maureen Murtaugh2, Aryeh Fischer3 and Tracy M. Frech4, 1Internal Medicine and Pediatrics, University of Utah, Salt Lake City, UT, 2Internal Medicine-Division of Epidemiology, University of Utah School of Medicine, SLC, UT, 3University of Colorado School of Medicine, Aurora, CO, 4Div of Rheumatology, University of Utah Medical Ctr, Salt Lake City, UT

    Background/Purpose: Raynaud’s phenomenon is a clinical symptom that can commonly present to a primary care provider or generalist. Proper identification of an underlying connective tissue…
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