Abstracts tagged "Raynaud’s phenomenon"

Abstract Number: 1863 • 2016 ACR/ARHP Annual Meeting
Non-Invasive Investigation of Perfusion, Microvascular Structure, Erythema, Oxidative Stress and Oxygenation in Healthy Controls and in Patients with Primary and Secondary Raynaud’s Phenomenon
Andrea Murray^1,2, Tonia Moore³, Joanne Manning⁴, Ian Poxon², Graham Dinsdale¹, Michael Berks⁵, Sarah Leggett⁶, Mark Dickinson² and Ariane L. Herrick¹, ¹Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Manchester, United Kingdom, ²Photon Science institute, University of Manchester, Manchester, United Kingdom, ³Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Salford, United Kingdom, ⁴Rheumatology Department, Salford Royal NHS Foundation Trust, Salford, United Kingdom, ⁵Centre for Imaging Sciences, University of Manchester, Institute of Population Health, Manchester, United Kingdom, ⁶Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom
Background/Purpose: It is well established that measurements of cutaneous microvascular dysfunction (measured with laser Doppler imaging [LDI]) and structural abnormality (measured with nailfold capillaroscopy [NC])…
Abstract Number: 1867 • 2016 ACR/ARHP Annual Meeting
An Abnormal Nailfold Capillaroscopy Pattern Is Common in Patients with Connective Tissue Disease and Is Associated with Pulmonary and Oesophageal Involvement, Even in the Absence of Systemic Sclerosis
Anniek M van Roon¹, Cato C Huisman¹, Arie M van Roon¹, Alja J Stel², Andries J Smit¹, Hendrika Bootsma² and Douwe J Mulder¹, ¹Internal Medicine - division Vascular Diseases, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: RP is a common symptom of CTD. Nailfold capillary microscopy (NCM) has previously been shown to be associated with disease severity and internal organ…
Abstract Number: 1874 • 2016 ACR/ARHP Annual Meeting
Low Rate of Progression in Cases of Isolated Raynaud’s Phenomenon Screened By Nailfold Videocapillaroscopy and Antinuclear Antibody Status Supports Negative Predictive Value of These Tests
Louise Parker¹, Kevin Howell², Voon H. Ong³ and Christopher P.Denton⁴, ¹Centre for Rheumatology and Connective Diseases, UCL Medical School and Royal Free Hosp, London, United Kingdom, ²Institute of Immunity and Transplantation, University College London, Royal Free Campus, London, United Kingdom, ³Rheumatology, UCL Division of Medicine, London, United Kingdom, ⁴Centre of Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom
Background/Purpose: Raynaud’s phenomenon is common but can progress to definite connective tissue disease. We have observed long term follow up of an unselected consecutive…
Abstract Number: 2889 • 2016 ACR/ARHP Annual Meeting
Therapeutic Plasma Exchange for the Treatment of Raynaud’s and Digital Ulcers in Systemic Sclerosis: A Systematic Review
Edward S Harris¹, Herbert J Meiselman², Patrick M Moriarty³ and Allan Metzger⁴, ¹Scleroderma Education Project Ltd, Madison, WI, ²Keck School of Medicine, University of Southern California, Los Angeles, CA, ³Clinical Pharmacology, University of Kansas Medical Center, Kansas City, KS, ⁴RDL Reference Laboratory Inc, Los Angeles, CA
Background/Purpose: Raynaud's phenomenon (RP) is an early marker of microvascular damage in systemic sclerosis (SSc) and digital ulcers (DU) are a serious complication of vascular…
Abstract Number: 2909 • 2016 ACR/ARHP Annual Meeting
Attitudes Toward Patient-Reported Outcome Instruments for the Assessment of Raynaud’s Phenomenon in Systemic Sclerosis
John Pauling^1,2, Tracy M. Frech^3,4, Michael Hughes⁵, Jessica K. Gordon⁶, Robyn T. Domsic⁷, Francesca Ingegnoli⁸, Neil J. McHugh^1,9, Sindhu R. Johnson¹⁰, Marie Hudson¹¹, Francesco Boin¹², Voon Ong¹³, Marco Matucci Cerinic¹⁴, Nezam Altorok¹⁵, Marina Scolnik¹⁶, Mandana Nikpour¹⁷, Ankoor Shah¹⁸, Janet E. Pope¹⁹, Dinesh Khanna²⁰ and Ariane L. Herrick²¹, ¹Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ²Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ³Internal Medicine, Salt Lake City VAMC, Salt Lake, UT, ⁴Internal Medicine-Division of Rheumatology, University of Utah School of Medicine, SLC, UT, ⁵Centre for Musculoskeletal Research, The University of Manchester, Manchester, United Kingdom, ⁶Rheumatology, Hospital for Special Surgery, New York, NY, ⁷Medicine - Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh, PA, ⁸Department of Rheumatology, Istituto Gaetano Pini, University of Milano, Italy, Milano, Italy, ⁹Rheumatology, Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, United Kingdom, ¹⁰Medicine, Division of Rheumatology, Toronto Western Hospital, University Health Network Pulmonary Hypertension Programme, Toronto General Hospital, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ¹¹Department of Medicine, McGill University and Jewish General Hospital, Montreal, QC, Canada, ¹²Rheumatology, University California San Francisco, San Francisco, CA, ¹³Rheumatology, University College London Medical School, Royal Free Hospital, London, UK, London, United Kingdom, ¹⁴Department of Medicine, Division of Rheumatology, University of Florence, Italy, Florence, Italy, ¹⁵Rheumatology, University of Toledo Medical Center,, Toledo, OH, ¹⁶Rheumatology Section, Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ¹⁷Department of Medicine (St Vincent's Hospital), The University of Melbourne, Melbourne, Australia, ¹⁸Rheumatology and Immunology, Duke University Medical Center, Durham, NC, ¹⁹Monsignor Roney Bldg/Rheum, University of Western Ontario, St Joseph Health Care, London, ON, Canada, ²⁰Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ²¹Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: The Raynaud’s Condition Score (RCS) diary is a clinician-derived validated patient-reported outcome (PRO) instrument for assessing the frequency, duration and severity of Raynaud's phenomenon…
Abstract Number: 2982 • 2015 ACR/ARHP Annual Meeting
Blood Perfusion in Different Skin Areas of Hands in Primary Raynaud’s Phenomenon and Systemic Sclerosis Patients
Alberto Sulli¹, Barbara Ruaro¹, Amelia Chiara Trombetta¹, Vanessa Smith², Carmen Pizzorni¹, Sabrina Paolino¹ and Maurizio Cutolo¹, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino-IST, University of Genova, Genoa, Italy, Genoa, Italy, ²Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
Background/Purpose: Peripheral blood perfusion is reduced in patients affected by both primary (PRP) or secondary Raynaud’s phenomenon (SRP) (1-2). The objective of this study was…
Abstract Number: 3007 • 2015 ACR/ARHP Annual Meeting
Cold Receptor Expression and Function in Human Dermal Fibroblast: Possible Role in the Pathogenesis of Scleroderma Fibrosis
Yongqing Wang¹, John Sun¹, Shadia Nada², Nezam Altorok³ and Bashar Kahaleh⁴, ¹The University of Toledo, Toledo, OH, ²Internal Medicine, Divison of Rheumatology, The University of Toledo, Toledo, OH, ³Internal Medicine, Division of Rheumatology, The University of Toledo, Toledo, OH, ⁴Medicine/Rheumatology, The University of Toledo, Toledo, OH
Background/Purpose: Enhanced cold sensitivity is an early and consistent phenomenon in scleroderma (SSc). We previously demonstrated increased expression of the transient receptor potential melastatine 8…
Abstract Number: 638 • 2015 ACR/ARHP Annual Meeting
Assessment of Myocardial Abnormalities in Primary Sjögren Syndrome Using a Comprehensive Cardiac Magnetic Resonance Approach
Natsumi Ikumi¹, Hitomi Kobayashi², Yasuyuki Kobayashi³, Hirotake Inomata⁴, Yosuke Nagasawa⁴, Kaita Sugiyama⁴, Hiromi Karasawa¹, Takamasa Nozaki⁴, Hidetaka Shiraiwa⁴, Mitsuhiro Iwata², Noboru Kitamura⁵, Yoshihiro Matsukawa¹ and Masami Takei², ¹Division of Heamatology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ²Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ³Advanced Biomedical Imaging Informatics, St.Marianna University School of Medicine, Kawasaki, Japan, ⁴Nihon University School of Medicine, Tokyo, Japan, ⁵NIhon University School of Medicine, Tokyo, Japan
Background/Purpose: Primary Sjögren syndrome (pSS) shares many clinical, inflammatory, and immunological features with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). SLE and RA are…
Abstract Number: 822 • 2015 ACR/ARHP Annual Meeting
Beneficial Effect of Botulinum Toxin-a on Raynaud’s Phenomenon in Japanese Patients with Systemic Sclerosis: A Prospective, Open-Label Trial
Sei-ichiro Motegi¹, Kazuya Yamada¹, Sayaka Toki¹, Akihiko Uchiyama¹, Tetsuya Nakamura² and Osamu Ishikawa¹, ¹Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan, ²Clinical Investigation and Research Unit, Gunma University Graduate School of Medicine, Gunma, Japan
Background/Purpose: Systemic scleroderma (SSc) is a generalized connective tissue disease characterized by fibrosis of the skin and internal organs, vascular dysfunction and immune disorder. Patients…
Abstract Number: 823 • 2015 ACR/ARHP Annual Meeting
Anti-IFI16 Antibodies in Scleroderma Are Associated with Digital Gangrene
Zsuzsanna McMahan¹, Ami A. Shah², Dhananjay Vaidya³, Fredrick M. Wigley⁴, Antony Rosen⁵ and Livia Casciola-Rosen⁶, ¹Rheumatology, Johns Hopkins University, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Medicine, School of Medicine, Johns Hopkins, Baltimore, MD, ⁴Rheum Div/Mason F Lord, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Mason Lord Bldg Ctr Tower, Johns Hopkins University, School of Medicine, Baltimore, MD, ⁶Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Our aim was to examine and confirm the association between anti-IFI16 antibodies and clinical features of scleroderma. Methods: Sera from a discovery sample…
Abstract Number: 848 • 2015 ACR/ARHP Annual Meeting
Nitroglycerin Patch Application in Systemic Sclerosis: Evaluation By Laser Doppler Imaging
Georgiana Bentea, Aurelien Wauters, Jean-Claude Wautrecht and Elie Cogan, Erasme Hospital, Brussels, Belgium
Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune disease, commonly associated with Raynaud phenomenon (RP). The aim of this study was to characterize the microvascular…
Abstract Number: 1880 • 2015 ACR/ARHP Annual Meeting
Circulating Microparticle Populations May Differentiate Between Connective Tissue Diseases.
Eoghan M. McCarthy^1,2, Daniel Moreno-Martinez³, Fiona Wilkinson⁴, Neil J McHugh^5,6, Ian N. Bruce^7,8, Yvonne Alexander³, John D. Pauling^6,9 and Ben Parker^7,8, ¹The University of Manchester, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, Mmanchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospital NHS Foundation Trust, Manchester, United Kingdom, ³Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁴School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom, ⁵Rheumatology, Bath Institute of Rheumatic Diseases, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ⁶Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ⁷Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, ⁸Stopford Building, Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ⁹Upper Borough Walls, Royal National Hospital for Rheumatic Disease, Bath, United Kingdom
Background/Purpose: Microparticles (MPs) are membrane-bound vesicles derived from vascular and intravascular cells such as endothelial cells (EMPs) and platelets (PMPs). Circulating MPs levels are altered…
Abstract Number: 1894 • 2015 ACR/ARHP Annual Meeting
Calcium Channel Blockers Are More Effective in the Treatment of Primary Raynaud’s Phenomenon Compared to Secondary: A Meta-Analyis
Janet E. Pope¹, Fadumo Rirash², Paul Tingey³, Sarah Harding⁴, Lara J. Maxwell⁵, Peter Tugwell⁶, Jordi Pardo⁷, Elizabeth Ghogomu⁸ and George A. Wells⁹, ¹University of Western Ontario, London, ON, Canada, ²Medicine/Rheumatology, University of Western Ontario, London, ON, Canada, ³Faculty of Medicine, University of Queensland, Brisbane, Australia, ⁴ERLanger, ERLanger, KY, ⁵Centre for Global Health, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada, ⁶Center For Global Health, Institute of Population Hlth, Ottawa, ON, Canada, ⁷University of Ottawa, Ottawa, ON, Canada, ⁸University of Ottawa, Cochrane Musculoskeletal Group, Ottawa, ON, Canada, ⁹Cardiovascular Research Reference Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada
Background/Purpose: To assess the benefits and harms of calcium channel blockers (CCBs) versus placebo for the treatment of Raynaud's phenomenon (RP) comparing primary to secondary…
Abstract Number: 1896 • 2015 ACR/ARHP Annual Meeting
Early Signs, Symptoms and Auto-Antibodies to Predict Diffuse Cutaneous or Limited Cutaneous Systemic Sclerosis at First Presentation
WMT van den Hombergh¹, HKA Knaapen-Hans¹, Patricia E. Carreira^2,3, FHJ van den Hoogen¹, Jaap Fransen¹ and MC Vonk¹, ¹Rheumatology, Radboud University Medical Centre, Nijmegen, Netherlands, ²Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ³Rheumatology Unit, Hospital 12 de Octubre, Hospital 12 de Octubre, Madrid, Spain
ABSTRACT Background/Purpose: Diffuse cutaneous systemic sclerosis (dcSSc) is associated with a poorer prognosis compared to limited cutaneous SSc (lcSSc), due to earlier and more severe…
Abstract Number: 1928 • 2015 ACR/ARHP Annual Meeting
Isolation and Initial Characterization of Dermal Vascular Smooth Muscle Cells in Systemic Sclerosis
Shadia Nada¹, Farouk Abu Alhana², Yongqing Wang², Nezam Altorok³ and Bashar Kahaleh⁴, ¹Internal Medicine, Divison of Rheumatology, The University of Toledo, Toledo, OH, ²The University of Toledo, Toledo, OH, ³Internal Medicine, Division of Rheumatology, The University of Toledo, Toledo, OH, ⁴Medicine/Rheumatology, The University of Toledo, Toledo, OH
Background/Purpose: Nearly all patients with Systemic sclerosis (SSc) suffer from vascular dysfunction as illustrated by the uniform presence of Raynaud’s phenomena. The role of vascular…

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