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Abstracts tagged "Randomized Trial"

  • Abstract Number: 1960 • ACR Convergence 2022

    Impact of Delaying Initiation of Methotrexate by One Month on the Outcome of RA at One Year

    Theresa Than1, Emmanuelle Dernis2, Olivier BROCQ3, Bruno Fautrel4, Helena HUGUET5, Liana Euller-Ziegler6, Lindsay BUSTAMENTE-CENCI6, Olivier Vittecoq7, Marie-christine PICOT5, Cédric Lukas8, Claire DAIEN9, Charlotte Hua10, Marlène Genty5, Helene Che5, Anouck REMY-MOULARD11, Frederic LIOTE12, Martin Soubrier13, Cécile GAUJOUX-VIALA14, Arnaud Constantin15, Alain Saraux16, Emilie Ducourau17, Stephanie RIST18, CARINE SALLIOT19, Nada IBRAHIM-NASSER18, Clara qUINTEN18, Vincent Goeb20 and Jacques Morel1, 1University and CHU Montpellier, Montpellier, France, 2LE MANS general hospital, LE MANS, France, 3Centre hospitalier Princesse-Grace, Monaco, France, 4Sorbonne University Paris, France and Pierre Louis Institute of Epidemiology and Public Health, Paris, France, Paris, France, 5CHU Montpellier, Montpellier, France, 6CHRU Nice, Nice, France, 7CHU de Rouen, ROUEN, France, 8University Hospital Centre Montpellier, University of Montpellier, Montpellier, France, 9University Hospital, Saint-Gély-du-Fesc, France, 10La Lettre du Rhumatologue, Paris, France, 11CHU Montpellier, Montpellier, Chad, 12University of Paris, Paris, France, 13Gabriel-Montpied Hospital, Clermont-Ferrand, France, 14CHU Nîmes, Univ Montpellier (IDESP), Nîmes, France, 15Toulouse University Hospital, Toulouse, France, 16CHU Brest, Brest, France, 17CH Orleans, Chambray Les Tours, France, 18CH orleans, Orleans, France, 19CHR orleans, Orleans, France, 20CHU Amiens, Amiens, France

    Background/Purpose: It is recommended that vaccinations should be performed prior to start methotrexate (MTX) knowing that delaying initiation of background therapy may have an impact…
  • Abstract Number: 0173 • ACR Convergence 2022

    Cutaneous Manifestations, Clinical Trials, Safety Efficacy and Safety of Lenabasum in the Phase 3 DeterMine Trial in Dermatomyositis

    Victoria Werth1, Barbara White2, Josef Concha3, Josh Dan1, Nancy Dgetluck2, Kathleen Hally2, Scott Constantine2, Rohit Aggarwal4, David Fiorentino5, Ingrid Lundberg6 and Chester Oddis7, 1Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 2Corbus Pharmaceuticals, Norwood, MA, 3Universiity of Pennsylvania/Dermatology, Philadelphia, PA, 4University of Pittsburgh, Division of Rheumatology, Pittsburgh, PA, 5Stanford university/Department of Dermatology, Palo Alto, CA, 6Karolinska Institute, Stockholm, Sweden, 7University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Safe and effective treatments are of significant unmet need in DM. Lenabasum, a CB2 agonist that activates resolution of inflammation, improved skin disease, patient-reported…
  • Abstract Number: 1007 • ACR Convergence 2022

    Metabolic Disorders and Abnormal Dietary Patterns and Their Association with Psoriatic Arthritis Activity: The Dietary Intervention in PsA (DIPSA) Study

    Lihi Eder1, Charlene Compher2, Helen Emanoilidis3, Ryan F. Quinn2, Dafna Gladman4, Vinod Chandran5, Jose Scher6 and Alexis Ogdie7, 1Women’s College Research Institute, Department of Medicine, University of Toronto, Toronto, ON, Canada, 2University of Pennsylvania, Philadelphia, PA, 3Women's College Hospital, Toronto, ON, Canada, 4Toronto Western Hospital, Schroeder Arthritis Institute, Toronto, ON, Canada, 5Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto/ Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 6New York University School of Medicine, New York, NY, 7Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Psoriatic Arthritis (PsA) is associated with obesity and its related metabolic abnormalities. The role of diet as an adjunct therapy in PsA remains unclear.…
  • Abstract Number: 1985 • ACR Convergence 2022

    The BEGIN Study: A Double-blind, Multi-center, Two-part, Randomized, Placebo-controlled Study of the Safety, Tolerability, and Efficacy of 4 Weeks of Treatment with AP1189 in Early Rheumatoid Arthritis (RA) Patients with Active Joint Disease

    Thomas Jonassen1, Irene Sandholdt2, Birgitte Telmer2 and Ellen-Margrethe Hauge3, 1SynAct Pharma, Holte, Denmark, 2CroxxMed, Hørsholm, Denmark, 3Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: Melanocortin (MC) type 1 and type 3 receptor stimulation is associated with anti-inflammatory activity and the promotion of inflammatory resolution. AP1189 is novel biased…
  • Abstract Number: 0199 • ACR Convergence 2022

    Izokibep, a Novel IL-17A Inhibitor, Improves Patient-reported Outcomes – 16-Week Results from a Placebo-controlled Phase 2 Study in Patients with Active Psoriatic Arthritis

    Peter Taylor1, Frank Behrens2, Philip J Mease3, Dieter Wetzel4, Paul Peloso5, Nicolai Brun4, Brian Wiens6, Jan Brandt-Juergens7, Edit Drescher8, Eva Dokoupilova9, Anna Rowińska-Osuch10, Nadia Abdel- Kader Martin11 and Kurt de Vlam12, 1University of Oxford, Oxford, United Kingdom, 2Rheumatology University Hospital & Fraunhofer Institute Translational Medicine and Pharmacology, Goethe-University Frankfurt, Frankfurt Am Main, Germany, 3Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, 4Affibody AB, Solna, Sweden, 5ACELYRIN, Naples, FL, 6ACELYRIN, Inc., Los Angeles, CA, 7Rheumatologische Schwerpunktpraxis, Berlin, Germany, 8Veszprem Megyei Csolnoky Ferenc Korhaz, Budapest, Hungary, 9Medical Plus, s.r.o. & Masaryk University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Brno, Prague, Czech Republic, 10ETG Network - Rheumatology, Warsaw, Poland, 11Hospital Infanta Luisa Quiron, Rheumatology, Sevilla, Spain, 12University Hospitals Leuven, Leuven, Belgium

    Background/Purpose: Izokibep is a unique IL-17A inhibitor with high potency and small molecular size designed to overcome the limitations of monoclonal antibodies. IL-17 is a…
  • Abstract Number: 1036 • ACR Convergence 2022

    Efficacy and Safety of Tofacitinib in Patients with Psoriatic Arthritis or Ankylosing Spondylitis by History of Cigarette Smoking

    Alexis Ogdie1, Lars Erik Kristensen2, Enrique R Soriano3, Servet Akar4, Yanhui Sun5, David Gruben6, Lara Fallon7, Cassandra D Kinch8 and Dafna Gladman9, 1Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2The Parker Institute, Copenhagen University Hospital, Copenhagen, Denmark, 3Rheumatology Unit and University Institute, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 4Izmir Katip Celebi University School of Medicine, Izmir, Turkey, 5Pfizer CRDC, Shanghai, China, 6Pfizer Inc, Groton, CT, 7Pfizer Inc, Montréal, QC, Canada, 8Pfizer Canada ULC, Kirkland, Canada, 9Toronto Western Hospital, Schroeder Arthritis Institute, Toronto, ON, Canada

    Background/Purpose: In patients (pts) with PsA and AS, smoking may be associated with an increased comorbidity burden, and greater responses to TNF inhibitors (TNFi) are…
  • Abstract Number: 2002 • ACR Convergence 2022

    Do SMS and Email Reminders Increase the Rate of Seasonal Influenza Vaccination in RA Patients Treated with Biologics: A Nested Randomized Controlled Trial Within the ART Registry?

    Raphaèle Seror1, Gabriel Baron2, Sylvie Miconnet3, Rakiba Belkhir3, Martin Soubrier4, pascale thevenot5, andre basch6, Marie Truchetet7, Pascal Claudepierre8, Emmanuelle Dernis9, Hubert Marotte10, René-Marc Flipo11, Olivier Brocq12, Jacques Morel13, CARINE SALLIOT14, Bruno Fautrel15, Alain Saraux16, CHARLES LESKE17, Naïma Hamamouche18, Thierry schaeverbeke19, Xavier Mariette20, Adeline Ruyssen-Witrand21 and Philippe Ravaud22, 1University Hospital Paris-Saclay, Le Kremlin Bicêtre, France, 2AP-HP Hôtel Dieu Hospital, Université Paris Descartes, Paris, France, 3Rheumatology departement, Bicêtre, Paris-Saclay university, Le Kremlin Bicêtre, France, 4Gabriel-Montpied Hospital, Clermont-Ferrand, France, 5French Society of rheumatology, Paris, France, 6Infirmerie Protestante de Lyon, Caluire-et-Cuire, France, 7Bordeaux University Hospital, Bordeaux, France, 8Paris Est Creteil University, Creteil, France, 9LE MANS general hospital, LE MANS, France, 10INSERM 1059, Saint-Etienne, France, 11CHU Lille, Boulogne-Billancourt, France, 12Rheumatology- CH Princesse Grace, Monaco, Monaco, 13University and CHU Montpellier, Montpellier, France, 14CHR orleans, Orleans, France, 15Sorbonne University Paris, France and Pierre Louis Institute of Epidemiology and Public Health, Paris, France, Paris, France, 16CHU Brest, Brest, France, 17Hospital, Cholet, France, 18e-health Services Sanoïa, Gémenos, France, 19CHU de Bordeaux, Bordeaux, France, 20Paris-Saclay University, Rueil Malmaison, Ile-de-France, France, 21CHU de Toulouse, Toulouse, France, 22Université Paris Cité, Hôtel-Dieu, Paris, France

    Background/Purpose: In patients treated with biologics, vaccination against influenza is recommended. However, vaccination coverage remains very low. The use of automatic digital reminders is an…
  • Abstract Number: L05 • ACR Convergence 2021

    Phase 2 Study Results from a Randomized, Double-blind, Placebo-controlled, Dose-finding Study to Evaluate Efficacy and Safety of Tigulixostat, a Novel Non-purine Selective Xanthine Oxidase Inhibitor, in Gout Patients with Hyperuricemia

    Robert Terkeltaub1, JuneSik Mune2, Jieun Lee3 and Kenneth Saag4, 1VA/UCSD, San Diego, CA, 2LG Chem, Ltd., Seoul, 3LG Chem, Ltd., Seoul, South Korea, 4The University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Gout can be effectively managed by inhibiting synthesis of uric acid. Tigulixostat is a novel non-purine selective xanthine oxidase inhibitor which lowers production of…
  • Abstract Number: L10 • ACR Convergence 2021

    A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease

    joshua solomon1, Felix Woodhead2, Sonye Danoff3, Shana Haynes-Harp4, Tanvi Naik5, Cathie Spino5, Shelley Hurwitz6, Rie Maurer6, Daniel Chambers7, Martin Kolb8, Hiliary Goldberg6 and Ivan Rosas4, 1National Jewish Health, Denver, CO, 2University of Leicester, Leicester, United Kingdom, 3Johns Hopkins University, Baltimore, MD, 4Baylor College of Medicine, Houston, TX, 5University of Michigan, Ann Arbor, MI, 6Brigham and Womens Hospital, Boston, MA, 7University of Queensland, Brisbane, Australia, 8McMaster University, Hamilton, ON, Canada

    Background/Purpose: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a prevalent and morbid condition leading to premature death in 10% of those affected. The TRAIL1 trial…
  • Abstract Number: L19 • ACR Convergence 2021

    Secukinumab in Giant Cell Arteritis: A Randomized, Parallel-group, Double-blind, Placebo-controlled, Multicenter Phase 2 Trial

    Nils Venhoff1, Wolfgang Schmidt2, Raoul Bergner3, Jürgen Rech4, Leonore Unger5, Hans-Peter Tony6, Meryl Mendelson7, Christian Sieder8, Meron Maricos8 and Jens Thiel9, 1Department of Rheumatology and Clinical Immunology, Vasculitis Center Freiburg, Medical Center - University of Freiburg, University of Freiburg, Freiburg, Germany, 2Immanuel Krankenhaus Berlin, Medical Center for Rheumatology Berlin-Buch, Lindenberger Weg 19, 13125 Berlin, Germany, Berlin, Germany, 3Medizinische Klinik A, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany, 4Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054,, Erlangen, Germany, 5Medical Department 1, Städtisches Klinikum Dresden, Dresden, Germany, 6Department of Medicine 2, Rheumatology and Clinical Immunology Oberduerrbachertstr. 697080, Wuerzburg, Germany, 7Novartis Pharmaceuticals Corporation, East Hanover, NJ, 8Novartis Pharma GmbH, Nuremberg, Germany, 9Department of Rheumatology and Clinical Immunology, Vasculitis Center Freiburg, Medical Center - University of Freiburg, University of Freiburg, Freiburg, Germany; Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

    Background/Purpose: Little is known about glucocorticoid-sparing agents in giant cell arteritis (GCA) except for IL-6 inhibition. Secukinumab (SEC) has shown significant improvements in the signs…
  • Abstract Number: L21 • ACR Convergence 2021

    Rituximab versus Conventional Therapeutic Strategy for Remission Induction in Eosinophilic Granulomatosis with Polyangiitis: A Double-blind, Randomized, Controlled Trial

    Benjamin Terrier1, Gregory Pugnet2, Claire de Moreuil3, Bernard Bonnotte4, Ygal Benhamou5, Elisabeth Diot6, Dominique Chauveau2, Pierre Duffau7, Nicolas Limal8, Antoine Neel9, Geoffrey Urbanski10, Noemie Jourde-Chiche11, Nicolas Martin-Silva12, Francois Maurier13, Arsene Mekinian14, Nicolas Schleinitz11, Felix Ackermann15, Anne-Laure Fauchais16, Antoine Froissart17, Thomas Le Gallou18, Yurdagul Uzunhan19, Jean-Francois Viallard7, Alice Berezne20, Laurent Chiche21, Bruno Crestani14, Guillaume Direz22, Cecile-Audrey Durel23, Pascal Godmer24, Jean-Emmanuel Kahn25, Marc Lambert26, Thomas Quemeneur27, Jacques Cadranel14, Pierre Charles28, Antoine Dossier14, Lea Jilet29, Loic Guillevin14, Hendy Abdoul29 and Xavier Puechal14, 1Cochin Hospital, Paris, France, 2CHU, Toulouse, France, 3CHU, Brest, France, 4CHU, Dijon, France, 5CHU, Rouen, France, 6CHU, Tours, France, 7CHU, Bordeaux, France, 8CHU, Creteil, France, 9CHU, Nantes, France, 10CHU, Angers, France, 11CHU, Marseille, France, 12CHU, Caen, France, 13CH, Metz, France, 14CHU, Paris, France, 15Hopital Foch, Suresnes, France, 16CHU, Limoges, France, 17CHIC, Creteil, France, 18CHU, Rennes, France, 19CHU, Bobigny, France, 20CH, Annecy, France, 21CH, Marseille, France, 22CH, Le Mans, France, 23CHU, Lyon, France, 24CH, Vannes, France, 25CHU, Boulogne, France, 26CHRU, Lille, France, 27CH, Valenciennes, France, 28CH, Paris, France, 29URC, Paris, France

    Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is an eosinophilic ANCA-associated vasculitis.Glucocorticoids, alone or in combination with cyclophosphamide in severe forms, induce remission in most patients…
  • Abstract Number: 0584 • ACR Convergence 2021

    High Number of Comorbidities and Concomitant Medications at Baseline in the Glucocorticoid Low-dose Outcome in Rheumatoid Arthritis (GLORIA) Study: An Older Population with Rheumatoid Arthritis

    Maarten Boers1, Linda Hartman1, Daniela Opris-Belinski2, Reinhard Bos3, Marc Kok4, Jose Pereira da Silva5, Eduard N Griep6, Ruth Klaasen7, Cornelia F. Allaart8, Paul Baudoin9, Hennie Raterman10, Zoltan Szekanecz11, Frank Buttgereit12, Pavol Masaryk13, L. Thomas Klausch1, Sabrina Paolino14, Annemarie Schilder15, Willem Lems16 and Maurizio Cutolo14, 1Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, 2Carol Davila University, Bucharest, Romania, 3Department of Rheumatology, Medical Centre Leeuwarden, Leeuwarden, Netherlands, 4Maasstad Hospital, Rotterdam, Netherlands, 5University of Coimbra | UC · Clínica Universitária de Reumatologia. Faculty of Medicine, Columbia, Portugal, 6Antonius Hospital, Leeuwarden, Netherlands, 7Meander Medical Center, Amersfoort, Netherlands, 8Leiden University Medical Center, Leiden, Netherlands, 9Reumazorg ZWN, Almere, Netherlands, 10Northwest Clinics, Alkmaar, Netherlands, 11Division of Rheumatology, University of Debrecen, Faculty of Medicine, Debrecen, Hungary, 12Charité – Universitätsmedizin Berlin, Berlin, Germany, 13National Institute for the Rheumatic Diseases, Bratislava, Slovakia, 14Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Polyclinic San Martino Hospital, Genoa, Italy, 15Medical Centre Leeuwarden, Leeuwarden, Netherlands, 16VUmc, Amsterdam, Netherlands

    Background/Purpose: Older people are often underrepresented in trials because the generally high number of comorbid conditions (1). The objective of this abstract is to document…
  • Abstract Number: 1692 • ACR Convergence 2021

    Long-Term Efficacy and Safety of Upadacitinib in Patients with Rheumatoid Arthritis: 3-year Results from the SELECT-EARLY Study

    Ronald F van Vollenhoven1, Tsutomu Takeuchi2, Jacob Aelion3, Nilmo Chavez4, Pablo Mannucci5, Atul Singhal6, Jerzy Swierkot7, Alan Friedman8, Nasser Khan8, Yihan Li9, Xianwei Bu9, Justin Klaff8 and Vibeke Strand10, 1Amsterdam University Medical Centers, Department of Rheumatology and Clinical Immunology, Rheumatology and Immunology Center ARC, Amsterdam, Netherlands, 2Div. Rheumatology, Keio University, Tokyo, Japan, 3Arthritis Clinic and West Tennessee Research Institute, Jackson, TN, 4Instituto Guatemalteco de Seguridad Social, Ciudad de Guatemala, Guatemala, 5Aprillus Asistencia e Investigación, Buenos Aires, Argentina, 6Southwest Rheumatology Research LLC, Dallas, TX, 7Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Wroclaw, Poland, 8AbbVie Inc., North Chicago, IL, 9AbbVie Inc., North Chicago, 10Stanford University School of Medicine, Portola Valley, CA

    Background/Purpose: Upadacitinib (UPA), an oral Janus kinase inhibitor, demonstrated significant improvements in signs, symptoms, and structural inhibition as monotherapy (mono) vs methotrexate (MTX) in MTX-naïve…
  • Abstract Number: 0674 • ACR Convergence 2021

    A Behavioral Intervention to Improve Gout Outcomes in African Americans with Gout: A 12-month Multicenter, Randomized Controlled Trial

    Jasvinder Singh1, Kenneth Saag1, Joshua Baker2, Amy Joseph3, Seth Eisen4 and Terence Shaneyfelt1, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Pennsylvania, Philadelphia, PA, 3Washington University / St. Louis VA, St Louis, MO, 4Washington University School of Medicine, St Louis, MO

    Background/Purpose: Gout outcomes and severity are worst in African Americans compared to Caucasians with gout. Racial Disparities in gout are well-described. Few or no data…
  • Abstract Number: 1694 • ACR Convergence 2021

    Sustainability of Response to Upadacitinib Among Patients with Active Rheumatoid Arthritis Refractory to Biological Disease-Modifying Anti-Rheumatic Drugs

    Ronald van Vollenhoven1, Stephen Hall2, Alvin Wells3, Sebastian Meerwein4, Yanna Song5, Jessica Suboticki5 and Roy Fleischmann6, 1Department of Rheumatology and Clinical Immunology, Amsterdam University Medical Center, Amsterdam Rheumatology Center, Amsterdam, Netherlands, 2Emeritus Research and Monash University, Melbourne, Australia, Melbourne, Australia, 3Rheumatology and Immunotherapy Center, Franklin, WI, 4AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, 5AbbVie Inc., North Chicago, IL, 6Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: Sustained clinical remission (REM) is the primary treatment goal for patients with rheumatoid arthritis (RA), with low disease activity (LDA) being an appropriate target…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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