ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "pulmonary complications"

  • Abstract Number: 721 • 2012 ACR/ARHP Annual Meeting

    Measurement of Pulmonary Arteries by Cardiac Magnetic Resonance Imaging: A Simple and Useful Tool for the Detection of Pulmonary Hypertension in Systemic Sclerosis Patients without Overt Cardiac Microvascular Perfusion Defects or Fibrosis

    Sandra Chartrand1, Lada Miller1, Martial Koenig2, Jean-Richard Goulet1, Eric Rich1, Anne S. Chin3, Yves Provost3, Carl Chartrand-Lefebvre3, Pauline Gou1, Jean-Luc Senécal1 and Tamara Grodzicky1, 1Rheumatology, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, 2Internal Medicine, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, 3Radiology, Hôtel-Dieu de Montréal du CHUM, Montréal, QC, Canada

    Background/Purpose: Pulmonary hypertension (PH) is a major complication of systemic sclerosis (SSc). We observed that a significant proportion of our SSc patients with PH as…
  • Abstract Number: 720 • 2012 ACR/ARHP Annual Meeting

    Left-Heart Disease Is a Frequent Cause of Pulmonary Hypertension in Systemic Sclerosis, Is Associated with Increased Levels of MR-ProANP and MR-ProADM but Is Unrelated to Elevated NT-ProBNP Levels: A Retrospective Cohort Analysis

    Lada Miller1, Sandra Chartrand1, Martial Koenig2, Jean-Richard Goulet3, Eric Rich1, Michal Abrahamowicz4, Jean-Luc Senécal1 and Tamara Grodzicky1, 1Rheumatology, Hôpital Notre-Dame du CHUM, Montreal, QC, Canada, 2Internal Medicine, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, 3Rheumatology, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, 4Centre Universitaire de Santé McGill (CUSM), Montreal, QC, Canada

    Background/Purpose: Pulmonary hypertension (PH) is a significant cause of morbidity and mortality in systemic sclerosis (SSc). Pulmonary arterial hypertension (PAH) is reportedly the most frequent…
  • Abstract Number: 1508 • 2012 ACR/ARHP Annual Meeting

    Simvastatin Attenuates Pulmonary Fibrosis in a Murine Model of Systemic Sclerosis

    Gianluca Bagnato1, Alessandra Bitto2, Natasha Irrera2, Gabriele Pizzino2, Donatella Sangari1, Maurizio Cinquegrani3, Neal Roberts4, Gianfilippo Bagnato1, Francesco Squadrito2 and Antonino Saitta3, 1Rheumatology, University of Messina, Messina, Italy, 2Pharmacology, University of Messina, Messina, Italy, 3Internal Medicine, University of Messina, Messina, Italy, 4Medical College of Virginia, Richmond, VA

    Background/Purpose: Simvastatin is best known for its antilipidemic action due to its inhibition of 3-hydroxy-3-methylglutaryl CoenzymeA (HMG CoA) reductase. Inhibition of biological precursors in this pathway also…
  • Abstract Number: 1507 • 2012 ACR/ARHP Annual Meeting

    Propylthiouracil Reduces Fibrosis in Chronic Oxidant Stress Mouse Model of Scleroderma

    Gianluca Bagnato1, Alessandra Bitto2, Natasha Irrera2, Gabriele Pizzino2, Neal Roberts3, Maurizio Cinquegrani4, Donatella Sangari1, Francesco Squadrito2, Gianfilippo Bagnato1 and Antonino Saitta4, 1Rheumatology, University of Messina, Messina, Italy, 2Pharmacology, University of Messina, Messina, Italy, 3Medical College of Virginia, Richmond, VA, 4Internal Medicine, University of Messina, Messina, Italy

    Background/Purpose: Systemic sclerosis (SSc) is characterized by fibrosis of skin and visceral organs; vascular damage and resultant ischemia; and immunological dysregulation manifested by autoantibodies. Hypothyroidism,…
  • Abstract Number: 1712 • 2012 ACR/ARHP Annual Meeting

    The Submaximal Heart and Pulmonary Evaluation: A Novel Noninvasive Test to Identify Pulmonary Hypertension in Patients with Systemic Sclerosis

    Elana J. Bernstein1, Jessica K. Gordon2, Robert F. Spiera2, Lisa A. Mandl2 and Evelyn M. Horn3, 1Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, 2Rheumatology, Hospital for Special Surgery, New York, NY, 3Cardiology, New York Presbyterian Hospital/Weill Cornell Medical College, New York, NY

    Background/Purpose: Pulmonary hypertension (PH), defined as a mean pulmonary artery pressure (mPAP) ≥ 25 mmHg on right heart catheterization (RHC), is a leading cause of…
  • Abstract Number: 2568 • 2012 ACR/ARHP Annual Meeting

    The Risk of Pulmonary Embolism and Deep Vein Thrombosis in Giant Cell Arteritis: A Population-Based Cohort Study

    J. Antonio Avina-Zubieta1, Diane Lacaille2, Eric C. Sayre3, Jacek A. Kopec3 and Hyon Choi4, 1Rheumatology, Arthritis Research Centre of Canada, University of British Columbia, Richmond, BC, Canada, 2Rheumatology, Arthritis Research Centre of Canada/University of British Columbia, Richmond, BC, Canada, 3Arthritis Research Centre of Canada, Richmond, BC, Canada, 4Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Arthritis Research Centre of Canada/University of British Columbia, Boston, MA

    Background/Purpose: A recent hospital-based study has suggested an 8 fold increased risk of pulmonary embolism (PE) in individuals with polymyalgia rheumatica in the year following…
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