Abstracts tagged "pulmonary complications"

Abstract Number: 723 • 2012 ACR/ARHP Annual Meeting
Renal Dysfunction and Disease Severity in Scleroderma-Associated Pulmonary Arterial Hypertension
Stephen C. Mathai¹, Laura K. Hummers² and Virginia D. Steen³, ¹Medicine, Johns Hopkins University, Baltimore, MD, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Rheumatology, Georgetown University Medical Center, Washington, DC
Background/Purpose: Renal disease is a common complication of scleroderma (SSc). Isolated reduction in glomerular filtration rate (GFR), a marker of impaired renal function, can occur…
Abstract Number: 217 • 2012 ACR/ARHP Annual Meeting
Myositis-Associated Usual Interstitial Pneumonia Has Better Survival Than Idiopathic Pulmonary Fibrosis
Christine McBurney¹, Rohit Aggarwal², Kevin Gibson³, Kathleen Lindell⁴, Carl Fuhrman⁵, Diane Koontz⁶, Frank Schneider⁷, Naftali Kaminski⁴ and Chester V. Oddis⁸, ¹Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Medicine, University of Pittsburgh, Pittsburgh, PA, ³Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴University of Pittsburgh Dorothy P. & Richard P. Simmons Center for Lung Disease, Pittsburgh, PA, ⁵Radiology, Division of Thoracic Imaging, University of Pittsburgh, Pittsburgh, PA, ⁶Department of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷Anatomic Pathology Department, Pittsburgh, PA, ⁸Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Usual interstitial pneumonia associated with idiopathic pulmonary fibrosis (IPF-UIP) has a poor prognosis with a median survival of 3 years. It is unknown whether…
Abstract Number: 2568 • 2012 ACR/ARHP Annual Meeting
The Risk of Pulmonary Embolism and Deep Vein Thrombosis in Giant Cell Arteritis: A Population-Based Cohort Study
J. Antonio Avina-Zubieta¹, Diane Lacaille², Eric C. Sayre³, Jacek A. Kopec³ and Hyon Choi⁴, ¹Rheumatology, Arthritis Research Centre of Canada, University of British Columbia, Richmond, BC, Canada, ²Rheumatology, Arthritis Research Centre of Canada/University of British Columbia, Richmond, BC, Canada, ³Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁴Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Arthritis Research Centre of Canada/University of British Columbia, Boston, MA
Background/Purpose: A recent hospital-based study has suggested an 8 fold increased risk of pulmonary embolism (PE) in individuals with polymyalgia rheumatica in the year following…
Abstract Number: 1712 • 2012 ACR/ARHP Annual Meeting
The Submaximal Heart and Pulmonary Evaluation: A Novel Noninvasive Test to Identify Pulmonary Hypertension in Patients with Systemic Sclerosis
Elana J. Bernstein¹, Jessica K. Gordon², Robert F. Spiera², Lisa A. Mandl² and Evelyn M. Horn³, ¹Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Cardiology, New York Presbyterian Hospital/Weill Cornell Medical College, New York, NY
Background/Purpose: Pulmonary hypertension (PH), defined as a mean pulmonary artery pressure (mPAP) ≥ 25 mmHg on right heart catheterization (RHC), is a leading cause of…
Abstract Number: 1507 • 2012 ACR/ARHP Annual Meeting
Propylthiouracil Reduces Fibrosis in Chronic Oxidant Stress Mouse Model of Scleroderma
Gianluca Bagnato¹, Alessandra Bitto², Natasha Irrera², Gabriele Pizzino², Neal Roberts³, Maurizio Cinquegrani⁴, Donatella Sangari¹, Francesco Squadrito², Gianfilippo Bagnato¹ and Antonino Saitta⁴, ¹Rheumatology, University of Messina, Messina, Italy, ²Pharmacology, University of Messina, Messina, Italy, ³Medical College of Virginia, Richmond, VA, ⁴Internal Medicine, University of Messina, Messina, Italy
Background/Purpose: Systemic sclerosis (SSc) is characterized by fibrosis of skin and visceral organs; vascular damage and resultant ischemia; and immunological dysregulation manifested by autoantibodies. Hypothyroidism,…
Abstract Number: 1508 • 2012 ACR/ARHP Annual Meeting
Simvastatin Attenuates Pulmonary Fibrosis in a Murine Model of Systemic Sclerosis
Gianluca Bagnato¹, Alessandra Bitto², Natasha Irrera², Gabriele Pizzino², Donatella Sangari¹, Maurizio Cinquegrani³, Neal Roberts⁴, Gianfilippo Bagnato¹, Francesco Squadrito² and Antonino Saitta³, ¹Rheumatology, University of Messina, Messina, Italy, ²Pharmacology, University of Messina, Messina, Italy, ³Internal Medicine, University of Messina, Messina, Italy, ⁴Medical College of Virginia, Richmond, VA
Background/Purpose: Simvastatin is best known for its antilipidemic action due to its inhibition of 3-hydroxy-3-methylglutaryl CoenzymeA (HMG CoA) reductase. Inhibition of biological precursors in this pathway also…

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