ACR Meeting Abstracts

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Abstracts tagged "Psoriatic arthritis"

  • Abstract Number: 2356 • ACR Convergence 2024

    Baseline Characteristics of Patients with Psoriatic Arthritis Treated with Ixekizumab or Interleukin-23 Inhibitors and Interim Effectiveness Results from an Observational Study in the US

    KURT OELKE1, Emily Edson Heredia2, Sarah Ross2, Jeffrey Lisse2, Jennifer Pustizzi2, Ali Sheikhi Mehrabadi2, Natalia Bello2, Frederick Murphy3, Shikha Singla4 and Siba Raychaudhuri5, 1Rheumatic Disease Center, Glendale, WI, 2Eli Lilly and Company, Indianapolis, IN, 3Altoona Arthritis & Osteoporosis Center, Duncansville, PA, 4Medical College of Wisconsin, Milwaukee, WI, 5UC Davis, School of Medicine/ VA Medical Center, Sacramento, Davis, CA

    Background/Purpose: Ixekizumab (IXE), a high-affinity monoclonal antibody that selectively targets interleukin (IL)-17A, has demonstrated efficacy in treating psoriatic arthritis (PsA) in Phase 3/4 clinical trials…
  • Abstract Number: 2636 • ACR Convergence 2024

    Multi-centre Validation of a Serum Protein Biomarker Signature (RAPsA Dx), Which Discriminates Psoriatic Arthritis (PsA) from Rheumatoid Arthritis (RA)

    Stephen Pennington1, Ruoyi Zhou2, Jonathan Brady2, Bruna Wundervald2, Andrew Parnell3, Ciarán Duffy2, Robert Perryman2, James Waddington4, Neil McHugh5, Deepak Jadon6, David Simon7, Filippo Fagni8, Georg Schett9, Fraser Morton10, Aurelie Najm10, Stefan Siebert11, Laura Coates12 and Oliver FitzGerald13, 1UCD, Dublin, Dublin, Ireland, 2Atturos, DUBLIN, Dublin, Ireland, 3NUIM, Maynooth, Ireland, 4Agilent, Manchester, United Kingdom, 5University of Bath, Bath, United Kingdom, 6Cambridge University, Cambridge, United Kingdom, 7Charité - Universittsmedizin Berlin, Berlin, Germany, 8Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, Deutsches Zentrum für Immuntherapie (DZI), Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, 9Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 10University of Glasgow, Glasgow, United Kingdom, 11School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 12University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, 13UCD, Dublin 6, Dublin, Ireland

    Background/Purpose: In a previous study, we reported the discovery and evaluation of a serum protein (22 peptide) signature (RAPsA Dx) which, when using random forest machine…
  • Abstract Number: 0074 • ACR Convergence 2024

    Tofacitinib Therapy Ameliorates Inflammation in a Mouse Model of Psoriasis and Arthritis by Inducing Type 2 Immunity

    Maria de la Luz Garcia-Hernandez1, Javier Rangel-Moreno1, Ananta Paine2, Angel Rangel-Garcia1, Marissa Krantz3, Delaney Martino1, Marc Nuzzo1 and Christopher Ritchlin4, 1University of Rochester, Rochester, NY, 2ORNA Tx, Southborough, MA, 3University of Rochester, Rochester, NY, 4Department of Medicine, Allergy, Immunology, and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY

    Background/Purpose: Psoriatic arthritis (PsA), a chronic progressive inflammatory arthritis, affects peripheral joints and causes patient disability. PsA patients also have skin plaques initiated by activation…
  • Abstract Number: 0384 • ACR Convergence 2024

    Pharmacokinetics of Ustekinumab in Patients with Juvenile Psoriatic Arthritis in a Real‑World Opportunistic Study

    Corey J. Bishop1, Edwin Lam2, Sophia G. Liva3, Jocelyn H. Leu2, Amy S. Paller4, Lucia Z. Diaz5, Laura Wine Lee6, Cory Rubin7, Ruy Carrasco8, Lisa Imundo9, Azadeh Majlessi10, Katherine Berezny1, Kathleen G. Lomax1, Valerie Smith1, Renping Zhang1 and hermine brunner11, 1Janssen Research & Development, Spring House, PA, 2Janssen Research & Development, LLC, a Johnson & Johnson company, Spring House, PA, PA, 3Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, PA, 4Northwestern University, Feinberg School of Medicine, Chicago, IL, 5Dell Children’s Medical Center; Dell Medical School at the University of Texas at Austin, Austin, TX, 6Medical University of South Carolina, Charleston, SC, 7Michigan Dermatology Institute, Waterford, MI, 8Pediatric Rheumatology Consultants of Austin, Austin, TX, 9Columbia University Medical Center, New York, NY, 10Newport Huntington Medical Group, Huntington Beach, CA, 11Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH

    Background/Purpose: Ustekinumab (UST), an interleukin‑12/23p40 antagonist, is currently approved for juvenile psoriatic arthritis (jPsA) solely in the United States (US). Although a phase 3 study…
  • Abstract Number: 0593 • ACR Convergence 2024

    Value of the Routine Assessment of Patient Index Data 3 in Assessing Disease Severity and Treatment Effect in Patients with Early Oligoarticular Psoriatic Arthritis Treated with Apremilast

    Alvin F. Wells1, Arthur Kavanaugh2, William Tillett3, Philip S. Helliwell4, Marijn Vis5, Yuri Klyachkin6, Cynthia Deignan7, Lichen Teng7, Rebecca Wang7 and Alexis Ogdie8, 1Rheumatology and Immunotherapy Center, Franklin, WI, 2University of California San Diego, La Jolla, CA, 3Royal National Hospital of Rheumatic Diseases; Department of Life Sciences, Centre for Therapeutic Innovation, University of Bath, Bath, United Kingdom, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK, Leeds, United Kingdom, 5Erasmus MC, Rotterdam, Netherlands, 6Amgen, Lexington, KY, 7Amgen Inc., Thousand Oaks, CA, 8Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

    Background/Purpose: The Routine Assessment of Patient Index Data 3 (RAPID3) score is a composite of 3 patient-reported outcomes (PROs): Health Assessment Questionnaire (HAQ), pain visual…
  • Abstract Number: 1019 • ACR Convergence 2024

    The Impact of Race and Ethnicity and Historical Redlining on Psoriatic Disease Burden

    Brittany Banbury1, Sharon Dowell2, Christopher Jenkins3, Emily Holladay4, Fenglong Xie5, Jingyi Zhang5, Grace Wright6, Jeffrey Curtis7 and Gail Kerr8, 1Mount Sinai Beth Israel, Brooklyn, NY, 2NEA Baptist Memorial Hospital, JONESBORO, AR, 3Medstar Georgetown University Hospital, Washington, DC, 4University of Alabama at Birmingham, Edmond, OK, 5University of Alabama at Birmingham, Birmingham, AL, 6Grace C Wright MD PC, New York, NY, 7University of Alabama at Birmingham, Hoover, AL, 8Washington DC VAMC/Georgetown and Howard Universities, Washington, DC

    Background/Purpose: Previous literature has suggested racial and ethnic variations in the clinical expression of psoriatic disease, with Non-White patients having more extensive skin disease, higher…
  • Abstract Number: 1436 • ACR Convergence 2024

    The Association of Cigarette Smoking with Radiographic Progression in Psoriatic Arthritis

    Fadi Kharouf1, Hernan Maldonado Ficco2, Shangyi Gao3, barry J Sheanne4, Daniel Pereira5, Richard Cook6, Vinod Chandran7 and Dafna Gladman8, 1University Health Network and University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, 2Hospital San Antonio de Padua, Cordoba, Argentina, 3Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 4St James' Hospital, Dublin, Ireland, 5University Health Network, Toronto, ON, Canada, 6University of Waterloo, Waterloo, Canada, 7University of Toronto, Toronto, ON, Canada, 8University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: The association between smoking and radiographic damage has been established in axial spondyloarthritis and rheumatoid arthritis, but not in psoriatic arthritis (PsA). We designed…
  • Abstract Number: 1472 • ACR Convergence 2024

    Achievement of Low Disease Activity/Remission in Guselkumab-Treated Patients with Moderately-Highly Active Psoriatic Arthritis Regardless of Baseline Characteristics: Pooled Post-Hoc Analysis of Two Phase 3/Randomized Studies

    Philip Mease1, Alice Gottlieb2, Iain McInnes3, Natalie J. Shiff4, Anthony Todd5, Emmanouil Rampakakis6, Francois Nantel7, Jenna Parrett5, Frederic Lavie8 and Proton Rahman9, 1Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA, 2Icahn School of Medicine at Mount Sinai, Department of Dermatology, Seattle, WA, 3University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom, 4Janssen Scientific Affairs, LLC / University of Saskatchewan, Adjunct, Community Health and Epidemiology, Horsham, PA, 5Janssen Scientific Affairs, LLC, Horsham, PA, 6McGill University, Department of Pediatrics / Scientific Affairs, JSS Medical Research Inc., Montreal, QC, Canada, 7Nantel Medsci Consult, Montreal, QC, Canada, 8Janssen Cilag Global Medical Affairs, Immunology Global Medical Affairs, Issy les Moulineaux, France, 9Memorial University of Newfoundland, Faculty of Medicine, Division of Rheumatology, St. John's, Canada

    Background/Purpose: Guselkumab (GUS), a fully human IL-23p19-subunit inhibitor, has demonstrated multidomain efficacy (swollen/tender joints, psoriasis, enthesitis and dactylitis) in patients (pts) with active PsA in…
  • Abstract Number: 1935 • ACR Convergence 2024

    Timely Referral of Patients with Inflammatory Rheumatic Diseases to Rheumatology: Validation of a Referral Algorithm with Frontline Physicians

    Nelly Ziade1, Karen Mechleb2, Nizar Ani3, avin maroof4, ASAL ADNAN RIDHA5, Manal El Rakawi6, Chafika Haouichat6, Bassel Elzorkany7, Sherif Gamal8, Mariama Erraoui9, Manal Al-Mashaleh10, Fatima Alnaimat11, Basel masri12, fatemah Baron13, Lina El Kibbi14, Krystel Aouad15 and Ihsane Hmamouchi16, and ARCH - ArLAR, 1Saint-Joseph University, Beirut, Lebanon, 2Saint Joseph University Beirut, Beirut, Lebanon, 3Baghdad College of Medicine, Baghdad, Iraq, 4University of Kurdistan Hawler, Erbil, Iraq, 5Baghdad Teaching Hospital, baghdad, Iraq, 6Djillali Bounaama University Hospital, Algiers, Algeria, 7Private (BZRC), Cairo, Egypt, 8Cairo University, Cairo, Egypt, 9Souss Massa Univeristy, Rabat, Morocco, 10Royal Medical Services, Amman, Jordan, 11University of Jordan, Amman, Jordan, 12Jordan Hospital and Medical Center, Amman, Jordan, 13Al-Jahra Hospital, Ministry of Health, Kuwait, Kuwait, 14Specialized Medical Center, Riyadh, Saudi Arabia, 15Saint George Hospital University Medical Center, Beirut, Lebanon, 16Rheumatology Unit, Lalla Aicha Temara Hospital, Temara, Rabat, Morocco

    Background/Purpose: Early referral of patients with chronic inflammatory rheumatic diseases (CIRDs) to rheumatology is essential to reduce diagnostic delays and improve long-term prognosis. Referral strategies…
  • Abstract Number: 2319 • ACR Convergence 2024

    Investigating the Association of Serum Metabolites with Psoriatic Arthritis Musculoskeletal Disease Patterns

    Sheng Han Li1, Nikita Looby2, Max Kotiyar3, Lihi Eder4, Igor Jurisica5, Vathany Kulasingam6 and vinod Chandran7, 1Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada, 2Psoriatic Arthritis Program Schroeder Arthritis Institute, Toronto, Canada, 3Data Science Discovery Centre for Chronic Dsiease, Krembil Research Institute, Toronto, Canada, 4University of Toronto, Women’s College Hospital and Department of Medicine, Toronto, ON, Canada, 5Data Science Discovery Centre, Krembil Research Institute, Toronto, Canada, 6Laboratory Medicine Program, Unviersity Health Network, Toronto, Canada, 7Toronto Western Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Accurate assessment of disease patterns may be important for appropriate management of psoriatic arthritis (PsA). Ultrasonography (USG) is a highly accurate, sensitive, and non-invasive…
  • Abstract Number: 2336 • ACR Convergence 2024

    Patients with Psoriasis with a Positive Psoriasis Epidemiology Screening Tool (PEST): Similarities and Differences Compared to PsA and Patients with Psoriasis and a Negative PEST

    Alexis Ogdie1, William Song2, Joel Gelfand2, Sarah Lonowski3, Rebecca Schumacher4 and Kaleb Michaud3, 1Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3University of Nebraska Medical Center, Omaha, NE, 4Forward Databank, Witchita, KS

    Background/Purpose: Identifying patients at risk for developing psoriatic arthritis (PsA) may allow for accelerated diagnosis and treatment and improve long term outcomes for these patients.…
  • Abstract Number: 2357 • ACR Convergence 2024

    Longitudinal Evaluation of Neutrophil-to-Lymphocyte Ratio in Guselkumab-Treated Patients with Psoriatic Disease and Levels of Systemic Inflammation Associated with Elevated Cardiovascular Risk: Post-hoc Analysis of 4 Phase 3, Randomized, Controlled Studies

    Joseph Merola1, Alexis Ogdie2, Arthur Kavanaugh3, Evan Leibowitz4, Emmanouil Rampakakis5, Ryan Funk6, Francois Nantel7, Frederic Lavie8, Katelyn Rowland9 and Enrique R. Soriano10, 1UT Southwestern Medical Center, Newton, MA, 2Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 3University of California San Diego, La Jolla, CA, 4Janssen Scientific Affairs, LLC, Fair Lawn, NJ, 5McGill University, Department of Pediatrics / Scientific Affairs, JSS Medical Research Inc., Montreal, QC, Canada, 6Johnson & Johnson Innovative Medicine, Long Grove, IL, 7Nantel MedSci Consult, Montreal, QC, Canada, 8Janssen Cilag Global Medical Affairs, Immunology Global Medical Affairs, Issy les Moulineaux, France, 9Janssen Pharmaceuticals, Horsham, PA, 10Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: Psoriatic disease (PsD) is associated with an increased risk of cardiovascular (CV) disease. Neutrophil-to-lymphocyte ratio (NLR) is a biomarker of systemic inflammation; NLR ≥2.5…
  • Abstract Number: 2638 • ACR Convergence 2024

    Defining Sonographic Enthesitis in Psoriatic Arthritis: Developing a Data- and Expert-driven Diagnostic Criteria for Inflammatory Enthesitis at the Single Enthesis Level

    Andre Lucas Ribeiro1, Sibel Aydin2, Gurjit Kaeley3, Fahmeen Afgani4, Catherine Bakewell5, Marcos Rosemffet6, Minna Kohler7, Amir Haddad8, Maria S. Stoenoiu9, Ari Polachek10, josefina marin11, Arnon Katz12 and Lihi Eder13, 1Women's College Hospital & University of Toronto, Porto Alegre, Rio Grande do Sul, Brazil, 2University of Ottawa - Ottawa, Ottawa, ON, Canada, 3UF COM-J, Ponte Vedra Beach, FL, 4Women's College Hospital, Toronto, Canada, 5Intermountain Healthcare, Salt Lake City, UT, 6Instituto de Rehabilitación Psicofísica, Capital Federal, Argentina, 7Massachusetts General Hospital, Boston, MA, 8Carmel Medical Centre, Haifa, Israel, 9Cliniques Universitaires Saint-Luc, Brussels, Belgium, 10Tel-Aviv Medical Center, Tel-Aviv, Israel, Petah-Tikva, Israel, 11Hospital Italiano de Buenos Aires, buenos aires, Argentina, 12GRAPPA - Patient Research Partner, Haifa, Israel, 13University of Toronto, Women’s College Hospital and Department of Medicine, Toronto, ON, Canada

    Background/Purpose: Clinical enthesitis occurs in 30-40% of psoriatic arthritis (PsA) patients, but its clinical diagnosis is challenging due to similarities to non-specific entheseal pain. Despite…
  • Abstract Number: 0075 • ACR Convergence 2024

    Micro-RNAs as Biomarkers for Methotrexate Treatment Response in Patients with Psoriatic Arthritis

    Darshini Ganatra1, Omar Cruz Correa1, Ameth Garrido2, Starlee Lively3, Rohan Apurva Machhar4, Remy Pollock5, Mohit Kapoor6 and Dafna Gladman7, 1University Health Network, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada, 3UHN, Toronto, Canada, 4Novartis, Mississauga, ON, Canada, 5Pfizer, Toronto, ON, Canada, 6Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada, 7University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) is a form of inflammatory arthritis linked to psoriasis, a chronic skin and nail disease. PsA is a progressive joint disease…
  • Abstract Number: 0421 • ACR Convergence 2024

    The Effect of Biologic Treatment for Psoriatic Arthritis and Axial Spondyloarthritis on Semen Parameters – a Longitudinal Study

    Katya Meridor1, Shimi Barda2, sara Pel3, sharon Nevo2, Julia Berman2, daphna paran4, Ori Elkayam5 and Ari Polachek6, 1Tel Aviv Medical Center, Kfar Saba, Israel, 2Tel-Aviv Medical Center, Tel-Aviv, Israel, 3Tel-Aviv Medical Center, Petah-Tikva, Israel, 4Tel-Aviv Medical Center, EVEN-YEHUDA, Israel, 5Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 6Tel-Aviv Medical Center, Tel-Aviv, Israel, Petah-Tikva, Israel

    Background/Purpose:  Psoriatic arthritis (PsA) and axial spondyloarthritis (AxSpA) are commonly diagnosed in young males in their reproductive years. However, only a few studies have investigated…
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