ACR Meeting Abstracts

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Abstracts tagged "Psoriatic arthritis"

  • Abstract Number: 619 • 2017 ACR/ARHP Annual Meeting

    Integrated Efficacy Analysis of Tofacitinib, an Oral Janus Kinase Inhibitor, in Patients with Active Psoriatic Arthritis

    Peter Nash1, Laura C Coates2, Roy Fleischmann3, Kim Papp4, Juan J. Gomez-Reino5, Keith S Kanik6, Cunshan Wang6, Joseph Wu6, Thijs Hendrikx7 and William C Ports6, 1Department of Medicine, University of Queensland, St Lucia, Brisbane, Australia, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 3Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, 4Probity Medical Research and K. Papp Clinical Research Inc, Waterloo, ON, Canada, 5Fundacion Ramon Dominguez, Hospital Clinico Universitario, Santiago de Compostela, Spain, 6Pfizer Inc, Groton, CT, 7Pfizer Inc, Collegeville, PA

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for treatment of psoriatic arthritis (PsA). We examined tofacitinib efficacy in patients (pts) with active…
  • Abstract Number: 1829 • 2017 ACR/ARHP Annual Meeting

    Patterns and Predictors of Progression of Sacroiliitis in Psoriatic Arthritis and Its Relationship with Human Leukocyte Antigen (HLA) Alleles. Results from the Toronto Cohort

    Musaab Elmamoun1, Justine (Yang) Ye2, Richard J. Cook3, Vinod Chandran4 and Dafna D Gladman5, 1Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, 4Medicine, Krembil Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 5Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) is clinically heterogeneous, with broad phenotypes of musculoskeletal (MSK) involvement including peripheral arthritis, enthesitis, dactylitis, and axial involvement. Sacroiliitis (SI) in…
  • Abstract Number: 620 • 2017 ACR/ARHP Annual Meeting

    Safety and Efficacy of Tofacitinib, an Oral Janus Kinase Inhibitor, up to 36 Months in Patients with Active Psoriatic Arthritis: Data from the Second Interim Analysis of OPAL Balance, an Open‑Label, Long-Term Extension Study

    Peter Nash1, Laura C Coates2, Alan J. Kivitz3, Philip J Mease4, Dafna D Gladman5, Jose A Covarrubias-Cobos6, Dona Fleishaker7, Cunshan Wang7, Elizabeth Kudlacz7, Sujatha Menon7, Thijs Hendrikx8 and Keith S Kanik7, 1Department of Medicine, University of Queensland, St Lucia, Brisbane, Australia, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 3Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA, 4Swedish Medical Center and University of Washington, Seattle, WA, 5Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 6Unidad Reumatologica Las Americas S.C.P, Yucatán, Mexico, 7Pfizer Inc, Groton, CT, 8Pfizer Inc, Collegeville, PA

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for psoriatic arthritis (PsA). Interim data up to January 2017 (database not locked) report the…
  • Abstract Number: 1874 • 2017 ACR/ARHP Annual Meeting

    Development of an Ultrasonographic Enthesitis Score for Psoriatic Arthritis Patients

    Stephanie Tom1,2, Yujie Zhong3, Richard J. Cook4, Sibel Z. Aydin5,6, Gurjit S. Kaeley7 and Lihi Eder8,9, 1Women's College Hospital, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada, 3MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom, 4Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, 5The Ottawa Hospital, Ottawa, ON, Canada, 6University of Ottawa, Ottawa, ON, Canada, 7University of Florida, Ponte Vedra Beach, FL, 8Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada, 9Medicine, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Enthesitis affects approximately a third of patients with psoriatic arthritis (PsA) and is often considered the earliest site of inflammation. The accuracy of clinical…
  • Abstract Number: 623 • 2017 ACR/ARHP Annual Meeting

    Tofacitinib Improves Composite Endpoint Measures of Disease in Patients with Psoriatic Arthritis

    Philip S. Helliwell1, Laura C Coates1, Oliver FitzGerald2, Peter Nash3, Enrique R Soriano4, M. Elaine Husni5, Ming-Ann Hsu6, Keith S Kanik6, Thijs Hendrikx7, Joseph Wu6 and Elizabeth Kudlacz6, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2ASRI, Dublin, Ireland, Dublin, Ireland, 3Department of Medicine, University of Queensland, St Lucia, Brisbane, Australia, 4Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 5Cleveland Clinic Lerner Research Institute, Cleveland, OH, 6Pfizer Inc, Groton, CT, 7Pfizer Inc, Collegeville, PA

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for the treatment of psoriatic arthritis (PsA). PsA is a heterogeneous disease and composite endpoints…
  • Abstract Number: 2030 • 2017 ACR/ARHP Annual Meeting

    Patient Motivation in Inflammatory Arthritis: The Use of Ultrasound-Guided Patient Education to Endorse Medication Adherence and Facilitate Cost-Effective Targeted Management

    Yasser M. El Miedany1,2, Maha El Gaafary3, Nadia El Aroussy1, Sally Youssef4 and Deborah Palmer5, 1Rheumatology and Rehabilitation, Ain Shams University, Cairo, Egypt, 2Rheumatology, Darent Valley Hospital, Dartford, United Kingdom, 3Community, Environmental and Occupational Medicine, Ain Shams University, Abbassia, Egypt, 4Rheumatology & Rehabilitation, Ain Shams University, Cairo, Egypt, 5Rheumatology, North Middlesex University Hospital, London, United Kingdom

    Background/Purpose: To assess the value of sharing the real-time ultrasound (US) images of the inflamed joints/ tendons with inflammatory arthritis patients and its impact on:…
  • Abstract Number: 179 • 2017 ACR/ARHP Annual Meeting

    Mass Spectrometry Imaging of Synovium: A Novel Approach to Classify the Rheumatoid and Psoriatic Arthritis Patients

    Beatriz Rocha1,2, Berta Cillero-Pastor3, Gert Eijkel3, Lennart R. Huizing3, Cristina Ruiz-Romero1,4, Andrea Cuervo5,6, Ron M A Heeren3, Juan D. Cañete5,6 and Francisco J Blanco1,6, 1Rheumatology Division, ProteoRed/ISCIII Proteomics Group, INIBIC - Hospital Universitario de A Coruña, A Coruña, Spain, A Coruña, Spain, 2The Maastricht Multimodal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, The Netherlands, Masstricht, Netherlands, 3The Maastricht Multimodal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, The Netherlands, Maastricht, Netherlands, 4CIBER-BBN Instituto de Salud Carlos III, INIBIC-CHUAC, A Coruña, Spain., A Coruña, Spain, 5Arthritis Unit, Rheumatology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain, Barcelona, Spain, 6RIER-RED de Inflamación y Enfermedades Reumáticas, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain

    Background/Purpose: Psoriatic arthritis (PsA) and Rheumatoid arthritis (RA) are immune-mediated chronic inflammatory diseases. Synovial membrane is the initial site of inflammation in PsA and RA…
  • Abstract Number: 627 • 2017 ACR/ARHP Annual Meeting

    Efficacy and Safety of Apremilast through 104 Weeks in Subjects with Moderate to Severe Psoriasis Randomized to Placebo, Apremilast, or Etanercept Who Continued on or Switched to Apremilast after Week 16 in a Phase 3b Study

    Kristian Reich1, Mark Goodfield2, Lawrence Green3, Kristine Nograles4, Rongdean Chen4, Eugenia Levi4 and Richard G.B. Langley5, 1Dermatologikum Hamburg, Hamburg, Germany, 2Leeds General Infirmary, Leeds, United Kingdom, 3George Washington University School of Medicine, Washington, DC, WA, 4Celgene Corporation, Summit, NJ, 5Dalhousie University, Halifax, NS, Canada

    Background/Purpose: Many subjects (sbj) with chronic plaque psoriasis exhibit nail and scalp involvement that can markedly affect quality of life and be difficult to treat.…
  • Abstract Number: 2438 • 2017 ACR/ARHP Annual Meeting

    Open Label Transitioning from Originator Etanercept to Biosimilar SB4 Compared to Continuing Treatment with Originator Etanercept in a Historical Cohort in Rheumatic Diseases in Daily Practice

    L. Tweehuysen1, V.J.B. Huiskes2, B.J.F. Van den Bemt (PharmD, PhD)3, S. Teerenstra4, F.H.J. van den Hoogen5, C.H.M. van den Ende5 and A.A. Den Broeder5, 1Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 2Pharmacy, Sint Maartenskliniek, Nijmegen, Netherlands, 3Pharmacy, Sint Maartenskliniek and Radboudumc, Nijmegen, Netherlands, 4Biostatistics, Radboudumc, Nijmegen, Netherlands, 5Rheumatology, Sint Maartenskliniek and Radboudumc, Nijmegen, Netherlands

    Background/Purpose: Blinded transitioning from originator infliximab (INX) to biosimilar CT-P13 was not inferior to continuing INX treatment.1 Open label mandatory transitioning resulted in a  slightly…
  • Abstract Number: 254 • 2017 ACR/ARHP Annual Meeting

    Psoriatic Arthritis Sonographic Enthesitis Scores – Systematic Review of the Literature

    Ofir Elalouf1, Sibel Bakirci2, Zahi Touma3, Melanie A Anderson4, Gurjit S. Kaeley5, Sibel Z. Aydin6 and Lihi Eder7,8, 1Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 2Fellow in Rheumatology, Antalya, Turkey, 3Rheumatology, University of Toronto, Division of Rheumatology, Institute of Health Policy, Management and Evaluation, Toronto, ON, Canada, 4Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 5University of Florida, Ponte Vedra Beach, FL, 6University of Ottawa, Ottawa, ON, Canada, 7Medicine, University of Toronto, Toronto, ON, Canada, 8Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada

    Background/Purpose: Enthesitis is a prominent feature of spondyloarthropathy (SpA), including psoriatic arthritis (PsA). The evaluation of enthesitis has conventionally been conducted by clinical exam, a…
  • Abstract Number: 629 • 2017 ACR/ARHP Annual Meeting

    Is Earlier Golimumab Treatment Initiation in Psa and As Patients Associated with Improved Outcomes?

    Suneil Kapur1, Proton Rahman2, Michelle Teo3, Jodie Reis4, Rajwinder Dhillon5, Pauline Boulos6, Raman Rai7, Regan Arendse8, Julie Vaillancourt9, Emmanouil Rampakakis9, Allen J Lehman10, Francois Nantel11 and Brendan Osborne11, 1University of Ottawa, 139 Greenbank Rd, Suite 203, ON, Canada, 2Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, 3Balfour Medical Clinic, Penticton, BC, Canada, 4University of Saskatchewan, Saskatoon, SK, Canada, 5Private Practice, Niagara Falls, ON, Canada, 6Private Practice, Dundas, ON, Canada, 7Private Practice, Hamilton, ON, Canada, 8University of Saskatchewan, Saskatoon, ON, Canada, 9JSS Medical Research, Montreal, QC, Canada, 10Janssen Inc., Toronto, ON, Canada, 11Medical Affairs, Janssen Inc., Toronto, ON, Canada

    Background/Purpose: Previous studies have suggested that treating patients earlier with biologics could improve disease outcomes. The aim of this analysis was to assess the impact…
  • Abstract Number: 2503 • 2017 ACR/ARHP Annual Meeting

    Does Maastricht Ankylosing Spondylitis Enthesitis Scores Differ between Ankylosing Spondylitis, Psoriatic Arthritis and Rheumatoid Arthritis Patients?

    Steffan Robstad Nilssen1, Jintana B: Andersen1, Hanne K. Vestaby1, Glenn Haugeberg2 and Brigitte Michelsen3, 1Dept. of Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 2Martina Hansens Hospital, Bærum, Norway, 3Dept. of Rheumatology, Hospital of Southern Norway Trust, kristiansand, Norway

    Background/Purpose: The Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) is an enthesitis index developed and validated as an outcome measure in ankylosing spondylitis (AS), but is…
  • Abstract Number: 342 • 2017 ACR/ARHP Annual Meeting

    Health Related Quality of Life Is Comparable in Psoriatic Arthritis and Rheumatoid Arthritis Patients in Spite of Different Disease Activity. SF-36 Data from a Large Prospective Observational Multicentre Study

    Brigitte Michelsen1,2, Till Uhlig1, Eirik K Kristianslund1, Joseph Sexton1, Elisabeth Lie1, Karen M Fagerli3, Hilde B Hammer4, Glenn Haugeberg5,6 and Tore K Kvien7, 1Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Dept. of Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 3Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Martina Hansens Hospital, Bærum, Norway, 6NTNU, Norwegian University of Science and Technology, Trondheim, Norway, 7Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: It is well established that RA patients have lower health related quality of life (HRQoL) across several domains compared with the general population, whereas…
  • Abstract Number: 631 • 2017 ACR/ARHP Annual Meeting

    Predictors of Long-Term Retention of Methotrexate and Other Dmards with Golimumab in Rheumatoid Arthritis and Psoriatic Arthritis: An Analysis from a Prospective, Observational Registry

    Derek Haaland1, Anna Jaroszynska2, B Haraoui3, Suneil Kapur4, Jacqueline Stewart5, Wojciech Olsynzynski6, Keltie Anderson7, Raman Rai8, Michael Starr9, Alexander Tsoukas10, Eliofotisti Psaradellis11, Emmanouil Rampakakis11, Cathy Tkaczyk12, Allen J Lehman13, Francois Nantel12 and Brendan Osborne12, 1Rheumatology, Clinical Immunology & Allergy, McMaster University, Barrie, ON, Canada, 2Private practice, Burlington, ON, Canada, 3Institut de Recherche en Rhumatologie de Montréal (IRRM), Montreal, QC, Canada, 4University of Ottawa, 139 Greenbank Rd, Suite 203, ON, Canada, 5Penticton Regional Hospital, Penticton, BC, Canada, 6University of Saskatchewan, Saskatoon, ON, Canada, 7University of Saskatchewan, Saskatoon, SK, Canada, 8Private Practice, Hamilton, ON, Canada, 9Rheumatology, McGill University, Pointe-Claire,, QC, Canada, 10McGill University, Montreal, QC, Canada, 11JSS Medical Research, Montreal, QC, Canada, 12Medical Affairs, Janssen Inc., Toronto, ON, Canada, 13Janssen Inc., Toronto, ON, Canada

    Background/Purpose: Previous studies have suggested that concomitant methotrexate therapy may increase the efficacy of biologic treatments. A scarcity of data exists on the benefits of…
  • Abstract Number: 2526 • 2017 ACR/ARHP Annual Meeting

    Baseline Data from the Recent-Onset Psoriatic Arthritis Registry of the Spanish Society of Rheumatology

    Rubén Queiro1, Ana Laiz2, Carlos Alberto Montilla-Morales3, Eva Galindez-Agirregoikoa4, Juan J. Bethencourt5 and Daniel Seoane6, 1Rheumatology Department. Hospital Universitario Central de Asturias, Oviedo, Spain, 2Rheumatology, HU. Santa Creu i San Pau, Barcelona, Spain, 3Hospital Clínico Universitario de Salamanca, Salamanca, Spain, 4Rheumatology Division, Hospital Universitario de Basurto, Bilbao, Spain, 5Rheumatology, HU. Canarias, Sta. Cruz de Tenerife, Spain, 6Research Unit, Spanish Foundation of Rheumatology, Madrid, Spain

    Background/Purpose: The natural history of psoriatic arthritis (PsA) is hardly known and the information regarding PsA prospective cohorts is very scarce worldwide. The information obtained…
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