Abstracts tagged "Psoriatic arthritis"

Abstract Number: 1854 • ACR Convergence 2020
NGF/TrkA System Regulates Pain and the Pannus Formation: Targeting NGF-TrkA in Psoriatic Arthritis
Siba Raychaudhuri¹ and Smriti Raychaudhuri², ¹UC Davis, School of Medicine, Davis, CA, ²VA Sacramento Medical Center, Davis, CA
Background/Purpose: Function of Nerve Growth Factor (NGF) in the nervous system and its regulatory role in pain is well defined. We have shown earlier that…
Abstract Number: 0075 • ACR Convergence 2020
CD209+/CD14+ Dendritic Cells Characterization in Rheumatoid versus Psoriasis Arthritis Patients
Viviana Marzaioli¹, Achilleas Floudas², Mary Canavan¹, Siobhán Wade³, Kieran Murray⁴, Ronan Mullan⁵, Conor Hurson⁶, Douglas Veale⁷ and Ursula Fearon¹, ¹Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland, ²Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Dublin, Ireland, ³Trinity College Dublin, Dublin, Ireland, ⁴Saint Vincent's University Hospital, Dublin 4, Dublin, Ireland, ⁵Adelaide and Meath Hospital, Dublin, Dublin, Ireland, ⁶St Vincents University Hospital, UCD, Dublin, Dublin, Ireland, ⁷EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland
Background/Purpose: Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells which are at the interface between innate and adaptive immunity. There are different…
Abstract Number: 0310 • ACR Convergence 2020
The Prediction of Psoriatic Arthritis Tool (PRESTO) Study – Interim Report
Lihi Eder¹, Ker-Ai Lee², Vinod Chandran³, Jessica Widdifield⁴, Aaron Drucker⁵, Christopher Ritchlin⁶, Cheryl Rosen⁷, Richard Cook² and Dafna Gladman³, ¹Women’s College Research Institute, University of Toronto, Toronto, ON, Canada, ²University of Waterloo, Waterloo, ON, Canada, ³Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ⁴University of Toronto - Toronto, Toronto, ON, Canada, ⁵University of Toronto, Toronto, Canada, ⁶Department of Medicine, University of Rochester Medical Center, Rochester, NY, ⁷University of Toronto, Toronto, ON, Canada
Background/Purpose: A simple, scalable tool that identifies psoriasis patients at high risk for developing PsA could improve early detection and facilitate early intervention. Our overall…
Abstract Number: 0326 • ACR Convergence 2020
Flares Among Patients with Psoriatic Arthritis (PsA) – Frequency and Impact on Patient Outcomes: Real-world Survey in the US and Europe
Ana-Maria Orbai¹, William Tillett², Suzann Grieb³, James Piercy⁴, Steven Peterson⁵, Elizabeth Holdsworth⁴, Sophie Meakin⁴, Soumya Chakravarty⁶, Nicola Booth⁴ and Laure Gossec⁷, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Royal National Hospital for Rheumatic Diseases, Bath, UK; Department of Pharmacy and Pharmacology, University of Bath, Bath, UK, Bath, United Kingdom, ³John Hopkins University School of Medicine, Baltimore, ⁴Adelphi Real World, Bollington, United Kingdom, ⁵Janssen Immunology Global Commercial Strategy Organization, Horsham, PA, ⁶Janssen Scientific Affairs, LLC, Horsham, PA, USA and Drexel University College of Medicine, Horsham, PA, ⁷Sorbonne University, INSERM; Pitié-Salpêtrière Hospital, Paris, Ile-de-France, France
Background/Purpose: Flares in PsA, presenting as periods of acute disease activity, are thought to negatively impact patients’ lives. This has not been extensively studied in…
Abstract Number: 0344 • ACR Convergence 2020
Use of the BASDAI in Psoriatic Arthritis Patients with and Without Axial Disease
Soumya Reddy¹, M. Elaine Husni², Jose Scher³, Ethan Craig⁴, Alexis Ogdie⁴ and Jessica Walsh⁵, ¹NYU School of Medicine, New York, NY, ²Cleveland Clinic, Cleveland, OH, ³NYU School of Medicine, New York City, ⁴University of Pennsylvania, Philadelphia, PA, ⁵University of Utah School of Medicine, George E. Wahlen Veteran Affairs Medical Center, Salt Lake City, UT
Background/Purpose: The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is increasingly being used to assess the activity of axial disease in patients with psoriatic arthritis…
Abstract Number: 0370 • ACR Convergence 2020
Guselkumab-Treated Patients Achieved Clinically Meaningful Improvement in Systemic Symptoms as Measured with PROMIS Instrument: Results from Phase-3 Psoriatic Arthritis Trial DISCOVER 1
Ana-Maria Orbai¹, Laura Coates², Atul Deodhar³, Philip Helliwell⁴, Christopher Ritchlin⁵, Alexa Kollmeier⁶, Elizabeth Hsia⁷, Xie Xu⁸, Shihong Sheng⁹, Bei Zhou⁹ and Chenglong Han⁹, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²University of Oxford, Oxford, United Kingdom, ³Oregon Health & Science University, Portland, OR, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Department of Medicine, University of Rochester Medical Center, Rochester, NY, ⁶Janssen Research & Development, LLC, La Jolla, CA, ⁷Janssen Research & Development, LLC and University of Pennsylvania Medical Center, Spring House, PA, ⁸Janssen Research & Development, LLC, San Marcos, CA, ⁹Janssen Research & Development, LLC, Spring House, PA
Background/Purpose: Patients with psoriatic arthritis (PsA) experience broad systemic symptoms including pain, fatigue, depression, sleep disturbance, poor physical function, and diminished social participation. DISCOVER 1…
Abstract Number: 0506 • ACR Convergence 2020
Efficacy and Safety of Guselkumab, a Monoclonal Antibody Specific to the p19-Subunit of Interleukin-23, Through Week 52 of a Phase 3, Randomized, Double-blind, Placebo-controlled Study Conducted in Biologic-naïve Patients with Active Psoriatic Arthritis
Iain McInnes¹, Proton Rahman², Alice Gottlieb³, Elizabeth Hsia⁴, Alexa Kollmeier⁵, Xie Xu⁶, Ramanand Subramanian⁷, Prasheen Agarwal⁷, Shihong Sheng⁷, Yusang Jiang⁷, Bei Zhou⁷, Désirée van der Heijde⁸ and Philip Mease⁹, ¹Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Memorial University of Newfoundland, Department of Medicine, St John's, Canada, ³Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Janssen Research & Development, LLC and University of Pennsylvania Medical Center, Spring House, PA, ⁵Janssen Research & Development, LLC, La Jolla, CA, ⁶Janssen Research & Development, LLC, San Marcos, CA, ⁷Janssen Research & Development, LLC, Spring House, PA, ⁸Leiden University Medical Center, Leiden, Netherlands, ⁹Seattle Rheumatology Associates, P.L.L.C., Seattle, WA
Background/Purpose: Guselkumab (GUS), a monoclonal antibody that specifically binds to the p19-subunit of IL-23, is approved to treat psoriasis. Through Week24 (W24) of the Ph3,…
Abstract Number: 0895 • ACR Convergence 2020
Effects of Guselkumab, a Monoclonal Antibody That Specifically Binds to the p19-Subunit of Interleukin-23, on Dactylitis and Enthesitis in Patients with Active Psoriatic Arthritis: Pooled Results Through Week 24 from Two Phase 3 Studies
Dennis McGonagle¹, Iain McInnes², Atul Deodhar³, Georg Schett⁴, Philip Mease⁵, May Shawi⁶, Shelly Kafka⁷, Chetan Karyekar⁸, Alexa Kollmeier⁹, Elizabeth Hsia¹⁰, Xie Xu¹¹, Shihong Sheng¹², Prasheen Agarwal¹², Bei Zhou¹², Christopher Ritchlin¹³ and Proton Rahman¹⁴, ¹The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, ²Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom, ³Oregon Health & Science University, Portland, OR, ⁴Friedrich-Alexander-Universität Erlangen- Nuremberg, Erlangen, Germany, ⁵Seattle Rheumatology Associates, P.L.L.C., Seattle, WA, ⁶Janssen Global Services, LLC, Toronto, ON, Canada, ⁷Janssen Scientific Affairs, LLC, Horsham, PA, ⁸Janssen Global Services, LLC, Horsham, PA, ⁹Janssen Research & Development, LLC, La Jolla, CA, ¹⁰Janssen Research & Development, LLC and University of Pennsylvania Medical Center, Spring House, PA, ¹¹Janssen Research & Development, LLC, San Marcos, CA, ¹²Janssen Research & Development, LLC, Spring House, PA, ¹³Department of Medicine, University of Rochester Medical Center, Rochester, NY, ¹⁴Memorial University of Newfoundland, Department of Medicine, St John's, Canada
Background/Purpose: Guselkumab (GUS), a novel monoclonal antibody that specifically binds to the p19-subunit of IL-23, demonstrated efficacy in the Ph 3 DISCOVER-1 (D1) & DISCOVER‑2…
Abstract Number: 1226 • ACR Convergence 2020
Outcomes and Efficacy of Selective versus Automatic Switching from Etanercept to a Biosimilar in Inflammatory Arthritis Using Electronic Health Records from UK
Roxanne Cooksey¹, Sinead Brophy¹, Muhammad Azizur¹, Jonathan Kennedy¹ and Ernest Choy², ¹Swansea University, Swansea, Wales, United Kingdom, ²CREATE Centre, Cardiff University, Cardiff, Wales, United Kingdom
Background/Purpose: Biosimilars have been approved for the treatment of inflammatory arthritis and evidence from randomised controlled trials have demonstrated equivalent efficacy to biologics. Etanercept biosimilar,…
Abstract Number: 1348 • ACR Convergence 2020
What Influence Do Clinical Domains Other Than Arthritis Have on Composite Clinical Outcomes in Psoriatic Arthritis?: Comparison of Treatment Effects in the SEAM-PsA Trial
Philip Helliwell¹, Philip Mease², Arthur Kavanaugh³, Laura Coates⁴, Alexis Ogdie⁵, Atul Deodhar⁶, Vibeke Strand⁷, Ervant Maksabedian⁸, Gregory Kricorian⁹, Lyrica Liu⁹, David Collier¹⁰ and Dafna Gladman¹¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Seattle Rheumatology Associates, P.L.L.C., Seattle, WA, ³UC San Diego Health System, San Diego, CA, ⁴University of Oxford, Oxford, United Kingdom, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Oregon Health & Science University, Portland, OR, ⁷Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, ⁸Amgen Inc., LOS ANGELES, CA, ⁹Amgen Inc., Thousand Oaks, CA, ¹⁰Amgen, Thousand Oaks, CA, ¹¹Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis is broadly characterized by clinical domains such as enthesitis, dactylitis, nail manifestations, and psoriasis. How these clinical domains influence the response to…
Abstract Number: 1466 • ACR Convergence 2020
Multimorbidity in Rheumatoid Arthritis, Psoriatic Arthritis, Gout, and Osteoarthritis Within the Rheumatology Informatics System for Effectiveness (RISE) Registry
Bryant England¹, Huifeng Yun², Lang Chen³, Kaleb Michaud¹, Ted Mikuls¹ and Jeffrey R Curtis², ¹University of Nebraska Medical Center, Omaha, NE, ²Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Rheumatic and musculoskeletal diseases (RMDs) often predispose the development of other chronic conditions, resulting in multimorbidity. While multimorbidity is increasingly being recognized and examined…
Abstract Number: 1856 • ACR Convergence 2020
Abnormal DNA Methylation in CD4+T Cells Is Associated with Cardiovascular Risk in Psoriatic Arthritis
Iván Arias de la Rosa¹, Maria Dolores Lopez-Montilla², Carlos Pérez-Sánchez¹, Javier Rodriguez-Ubreva³, Esteban Ballestar³, Carmen Torres-Granados¹, María-Carmen Abalos-Aguilera¹, Ignacio Gómez-García¹, Alejandra Maria Patiño-Trives¹, Maria Luque-Tevar¹, Eduardo Collantes-Estévez⁴, Chary Lopez-Pedrera⁵, Alejandro Escudero-Contreras⁴, Clementina Lopez-Medina⁶ and Nuria Barbarroja¹, ¹Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Cordoba, Spain, ²IMIBIC/University of Cordoba/Reina Sofia Hospital, Cordoba, Spain, ³Josep Carreras Institute (IJC), Badalona, Spain, ⁴Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Córdoba, Spain, ⁵IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁶Rheumatology Department, Cochin Hospital, Paris, Paris, France
Background/Purpose: Cardiovascular risk factors are increased in Psoriatic Arthritis (PsA). Latest studies suggested that inflammatory and metabolic disorders may be under epigenetic control, including DNA…
Abstract Number: 0084 • ACR Convergence 2020
Clinical Characteristics of Patients with Rheumatism of Juvenile Onset and Adult Onset in the BIOBADAGUAY Cohort
Natalia Cabrera¹, Vannia Valinotti², Gabriela Avila-Pedretti¹, Sonia Cabrera², Patricia Melgarejo³, Zoilo Morel⁴, Lourdes Roman², Pedro Babak⁴, Rodrigo Acosta², Romina Glitz⁴, Darwin Cordovilla⁵, Roger Rolon⁴, Magali Zanotti-Cavazzoni¹, Marco Antonio Franco Britos⁶, Marcos Vazquez², Pedro Delgadillo⁴, Isabel Acosta², María del Carmen Martinez⁴, Gabriel Elizaur⁴, María Teresa Romero⁴, Ernesto Paredes⁴, Paloma de Abreu¹ and Leticia Segovia⁷, ¹Sociedad Paraguaya de Reumatología, Asunción, Paraguay, ²Hospital de Clínicas, Asunción, Paraguay, ³Hospital IPS, Villa Rica, Paraguay, ⁴Hospital Central del Instituto de Previsión Social, Asunción, Paraguay, ⁵Instituto Nacional de Reumatología, Montevideo, Uruguay, ⁶Instituto de Previsi�n Social, Asunci�n, Central, Paraguay, ⁷Hospital del IPS, Asunción, Paraguay
Background/Purpose: The Paraguayan-Uruguayan cohort of patients with rheumatic inflammatory diseases (BIOBADAGUAY), collect clinical and epidemiological information on adults and children patients receiving biological therapies (BT).…
Abstract Number: 0311 • ACR Convergence 2020
The Link Between Joints and Entheses in Psoriatic Arthritis: An Ultrasound Study Supporting the Synovio-entheseal Complex Theory
Gizem Ayan¹, Ilaria Tinazzi², Sibel Bakirci³, Ummugulsum Gazel⁴, Dilek Solmaz⁵, Umut Kalyoncu⁶ and Sibel Aydin⁷, ¹University of Ottawa Faculty of Medicine, Rheumatology, Ottawa, ON, CANADA, Ottawa Hospital Research Institute, OTTAWA, ON, Canada, ²Sacro Cuore Don Calabria Hospital, Unit of Rheumatology, Negrar-Verona, VR, ITALY, Verona, Italy, ³Antalya Research and Training Hospital, Antalya, TURKEY; University of Ottawa Faculty of Medicine, Rheumatology, Ottawa, ON, CANADA, Antalya, Turkey, ⁴University of Ottawa Faculty of Medicine, Rheumatology, Ottawa, ON, CANADA; The Ottawa Hospital Research Institute, Ottawa, ON, CANADA, ottawa, Canada, ⁵Izmir Katip Celebi University, Department of Internal Medicine, Division of Rheumatology, Izmir, TURKEY, Izmir, Turkey, ⁶Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, ⁷University of Ottawa Faculty of Medicine, Rheumatology, Ottawa, ON, CANADA; The Ottawa Hospital Research Institute, Ottawa, ON, CANADA, Ottawa, ON, Canada
Background/Purpose: The aim of this study is to explore the link between the severity of the joint and entheses involvement in psoriatic arthritis (PsA) using…
Abstract Number: 0327 • ACR Convergence 2020
Skin Involvement in Psoriatic Arthritis (PsA) – The Incremental Impact of Psoriasis on Quality of Life, Disability and Work Productivity: Real-world Survey in US and Europe
Jessica Walsh¹, Alexis Ogdie², Kaleb Michaud³, Steven Peterson⁴, Elizabeth Holdsworth⁵, Sophie Meakin⁵, Soumya Chakravarty⁶, Nicola Booth⁵, Agata Schubert⁷, James Piercy⁵ and Laure Gossec⁸, ¹University of Utah School of Medicine, George E. Wahlen Veteran Affairs Medical Center, Salt Lake City, UT, ²Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ³University of Nebraska Medical Center, Omaha, NE, ⁴Janssen Immunology Global Commercial Strategy Organization, Horsham, PA, ⁵Adelphi Real World, Bollington, United Kingdom, ⁶Janssen Scientific Affairs, LLC, Horsham, PA, USA and Drexel University College of Medicine, Horsham, PA, ⁷Janssen-Cilag, Janssen-Cilag, Poland, ⁸Sorbonne Université and Hôpital Universitaire Pitié Salpêtrière, Paris, France
Background/Purpose: The degree of joint and skin involvement varies across patients with PsA. Differences in patient outcomes with active joint only vs. joint plus skin…

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