Abstracts tagged "Psoriatic arthritis"

Abstract Number: 1860 • ACR Convergence 2020
An Integrative Approach to Identify Heritable and De Novo Genomic Variations in Psoriatic Arthritis Mutilans and Understand Its Systems Biology
Sara Rahmati¹, Quan Li¹, Dafna Gladman², Proton Rahman³ and Vinod Chandran², ¹University Health Network, Toronto, ON, Canada, ²Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ³Memorial University of Newfoundland, Department of Medicine, St John's, Canada
Background/Purpose: Psoriasis is a chronic autoimmune skin disease that burdens ~3% of North Americans. ~24% of psoriatic patients develop psoriasis arthritis (PsA), an inflammatory disease…
Abstract Number: 0102 • ACR Convergence 2020
Bone Health in Patients with Psoriatic Arthritis in the National Swiss Cohort: A Cross-sectional Study
Diana Camelia Dan¹, Youssef Ibrahimy², Berengere Aubry-Rozier³ and Daniel Aeberli⁴, ¹Lausanne University Hospital, Lausanne, Switzerland, ²University of Lausanne, Lausanne, Switzerland, ³Hôpital orthopédique, Lausanne, Switzerland, ⁴University Hospital of Bern, Bern, Switzerland
Background/Purpose: There is much controversy surrounding the loss of bone mass in patients with psoriasis arthritis (PsA). We wanted to evaluate the prevalence of osteoporosis…
Abstract Number: 0312 • ACR Convergence 2020
Dactylitis Is Associated with Greater Disease Severity, Ultrasound Synovitis, and Erosive Damage, in Very Early DMARD Naïve Psoriatic Arthritis
Sayam Dubash¹, Oras Alabas², Xabier Michelena², Gabriele De Marco³, Leticia Garcia-Montoya², Richard Wakefield², Ai Lyn Tan², Philip Helliwell⁴, Paul Emery⁵, Dennis McGonagle² and Helena Marzo-Ortega², ¹The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, England, United Kingdom, ²The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, ³The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Treviglio, Italy, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom
Background/Purpose: Dactylitis is a hallmark feature of Psoriatic arthritis (PsA), defined as a uniform swelling of a finger or toe (“sausage digit”). It is associated…
Abstract Number: 0328 • ACR Convergence 2020
Healthcare Utilization and Costs Among Patients with Psoriatic Arthritis and Psoriasis in the United States – a Retrospective Study of Claims Data from 2009 to 2020
Joseph Merola¹, Reginald Villacorta², Natalie Dennis³, Soumya Chakravarty⁴, Laura Mesana⁵, Iris Lin², Maud Pacou³, Thomas Baker⁶, Yiting Wang⁷ and Steven Peterson⁸, ¹Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Janssen Immunology Global Commercial Strategy Organization, Horsham, ³Amaris, Paris, France, ⁴Janssen Scientific Affairs, LLC, Horsham, PA, USA and Drexel University College of Medicine, Horsham, PA, ⁵Amaris, New York, ⁶Janssen Global Services, LLC, Raritan, NJ, ⁷Janssen R&D, LLC, Titusville, ⁸Janssen Immunology Global Commercial Strategy Organization, Horsham, PA
Background/Purpose: The costs of psoriasis and psoriatic arthritis (PsA) are substantial for both patients and the United States healthcare system. This study compared healthcare resource…
Abstract Number: 0346 • ACR Convergence 2020
Safety Profiles of Ixekizumab versus Adalimumab: 52-Week Results from a Head-to-Head Comparison in Patients with Active Psoriatic Arthritis
Philip Mease¹, Josef Smolen², Arthur Kavanaugh³, Peter Nash⁴, Gaia Gallo⁵, Soyi Liu-Leage⁵, Christophe Sapin⁵ and Mark Genovese⁶, ¹Seattle Rheumatology Associates, P.L.L.C., Seattle, WA, ²Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria, ³UC San Diego Health System, San Diego, CA, ⁴School of Medicine Griffith University, Brisbane, Queensland, Australia, ⁵Eli Lilly and Company, Indianapolis, IN, ⁶Stanford University Medical Center, Palo Alto, CA
Background/Purpose: Ixekizumab (IXE) was shown to be superior to adalimumab (ADA) in achievement of simultaneous improvement of joint and skin disease (American college of Rheumatology…
Abstract Number: 0374 • ACR Convergence 2020
Neo-epitopes of Type I Collagen Can Be Utilized as Translational Biomarkers for Skin and Joint Turnover in Patients with Psoriasis and Psoriatic Arthritis
Solveig S. Groen¹, Signe Holm Nielsen², Conor Magee³, Anne Sofie Siebuhr⁴, Anne C. Bay-Jensen², Morten A. Karsdal⁴, Stephen Pennington⁵ and Oliver FitzGerald⁶, ¹University of Copenhagen, Copenhagen, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³St Vincent's University Hospital and the UCD Conway Institute, University College Dublin, Dublin, Ireland, ⁴Nordic Bioscience A/S, Herlev, Denmark, ⁵University College Dublin, Dublin, Dublin, Ireland, ⁶Conway Institute for Biomolecular Research, University College Dublin, Dublin, Ireland
Background/Purpose: Psoriasis (PsO) is a chronic immune-mediated skin disease. Around 30% of patients diagnosed with PsO will develop psoriatic arthritis (PsA). Patients with PsA may…
Abstract Number: 0508 • ACR Convergence 2020
Maintenance or Achievement of Minimal Disease Activity Following Therapy Optimization with Adalimumab or Methotrexate in Patients with Psoriatic Arthritis: Results from Part 2 of a Randomized, Open-Label Phase 4 Study
Philip Mease¹, Philip G Conaghan², William Tillett³, Maria Antonietta D'Agostino⁴, Proton Rahman⁵, Frank Behrens⁶, Erin Blondell⁷, Xianwei Bu⁸, Liang Chen⁷, Mudra Kapoor⁸ and Laura Coates⁹, ¹Seattle Rheumatology Associates, P.L.L.C., Seattle, WA, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research Leeds Biomedical Research Centre, Leeds, United Kingdom, ³Royal National Hospital for Rheumatic Diseases, Bath, UK; Department of Pharmacy and Pharmacology, University of Bath, Bath, UK, Bath, United Kingdom, ⁴Paris-Saclay Versailles University, Hôpital Ambroise Paré, Boulogne-Billancourt, France, ⁵Memorial University of Newfoundland, Department of Medicine, St John's, Canada, ⁶CIRI/Rheumatology & Fraunhofer IME, Research Division Translational Medicine and Pharmacology, Goethe University Hospital, Frankfurt, Hessen, Germany, ⁷AbbVie Inc., North Chicago, IL, ⁸AbbVie, North Chicago, IL, ⁹University of Oxford, Oxford, United Kingdom
Background/Purpose: Minimal Disease Activity (MDA) is suggested as an appropriate treat-to-target outcome for patients (pts) with PsA. Results from Part 1 of the CONTROL study…
Abstract Number: 0898 • ACR Convergence 2020
Inadequate Response Among Psoriatic Arthritis Patients Prescribed Advanced Therapy in a Real-world US Commercially Insured Population
Julie Birt¹, Michael Grabner², Keith Isenberg³, Theresa Hunter⁴, Chia-Chen Teng², Mingyang Shan¹, Jeffrey Lisse¹, Jianmin Wu¹, Kirstin Griffing¹ and Jeffrey R Curtis⁵, ¹Eli Lilly and Company, Indianapolis, IN, ²Healthcore, Inc, Wilmington, DE, ³Anthem, Inc, Indianapolis, IN, ⁴Eli Lilly and Company, Indianapolis, ⁵Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The purpose of this analysis was to assess the frequency of inadequate response (IR) over 1 year associated with advanced therapy (AT) initiation among…
Abstract Number: 1311 • ACR Convergence 2020
Identification of Clinical Phenotypes in Patients with Axial Spondyloarthritis, Peripheral Spondyloarthritis and Psoriatic Arthritis According to Peripheral Musculoskeletal Manifestations: A Cluster Analysis in the International ASAS-PerSpA Study
Clementina Lopez-Medina¹, Sylvie Chevret², Anna Molto¹, Joachim Sieper³, Mehmet Tuncay Duruöz⁴, Uta Kiltz⁵, Bassel El-Zorkany⁶, Najia Hajjaj-Hassouni⁷, Ruben Burgos-Vargas⁸, Jose Maldonado-Cocco⁹, Nelly Ziade¹⁰, Meghna Gavali¹¹, Victoria Navarro-Compán¹², Shue Fen Luo¹³, Alessandro Biglia¹⁴, Tae-Jong Kim¹⁵, Mitsumasa Kishimoto¹⁶, Fernando Pimentel-Santos¹⁷, Jieruo Gu¹⁸, Laura Muntean¹⁹, Floris van Gaalen²⁰, Pál Géher²¹, Marina Magrey²², Sebastian Ibanez²³, Wilson Bautista-Molano²⁴, Walter Maksymowych²⁵, Pedro M Machado²⁶, Robert Landewé²⁷, Désirée van der Heijde²⁸ and Maxime Dougados²⁹, ¹Rheumatology Department, Cochin Hospital, Paris, Paris, France, ²INSERM (U1153): Clinical Epidemiology and Biostatistics, University of Paris, Paris, France, ³Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴Marmara University School of Medicine, PMR Department, Rheumatology Division, Istanbul, Turkey, ⁵Rheumazentrum Ruhrgebiet, Ruhr-University Bochum, Herne, Germany, ⁶Cairo University, Cairo, Egypt, ⁷Health Sciences College, International University of Rabat (UIR), Rabat, Morocco, ⁸Department of Rheumatology, General Hospital of Mexico, Ciudad de Mexico, Mexico, ⁹Buenos Aires School of Medicine, Buenos Aires, Argentina, ¹⁰Saint-Joseph University, Beirut, Lebanon, Beirut, Lebanon, ¹¹Nizam’s Institute of Medical Sciences, Hyderabad, India, ¹²Hospital Universitario La Paz IdiPaz, Madrid, Pais Vasco, Spain, ¹³Chang Gung Memorial Hospital-Linkou, Taoyuan, Taipei, Taiwan (Republic of China), ¹⁴Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy, ¹⁵Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea, ¹⁶Department Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan, ¹⁷3.CEDOC, NOVA Medical School, Faculdade de Ciências Médicas da Universidade NOVA de Lisboa, Lisboa, Portugal; 7.Hospital Egas Moniz (CHLO) (Rheumatology Department), Lisboa, Portugal, Lisbon, Portugal, ¹⁸Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, guangzhou, China (People's Republic), ¹⁹Rheumatology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, ²⁰Leiden University Medical Center (LUMC), Leiden, Netherlands, ²¹Semmelweis University, Budapest, Budapest, Hungary, ²²Case Western Reserve University School of Medicine, Cleveland, OH, ²³Facultad de Medicina Clínica Alemana – Universidad del Desarrollo, Santiago, Region Metropolitana, Chile, ²⁴University Hospital Fundación Santa Fé de Bogotá and Universidad El Bosque, Bogotá, Colombia, ²⁵University of Alberta, Edmonton, AB, Canada, ²⁶University College London, London, United Kingdom, ²⁷Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, ²⁸Leiden University Medical Center, Leiden, Netherlands, ²⁹Department of Rheumatology, Hopital Cochin, Université de Paris, Paris, France
Background/Purpose: Patients with a clinical diagnosis of Spondyloarthritis (SpA) and Psoriatic Arthritis (PsA) may have predominant axial or predominant peripheral symptoms. However, a huge clinical…
Abstract Number: 1350 • ACR Convergence 2020
Safety Profile of Upadacitinib in Psoriatic Arthritis: Integrated Analysis from Two Phase 3 Trials
Gerd Burmester¹, Kevin Winthrop², Peter Nash³, Philippe Goupille⁴, Valderilio F Azevedo⁵, Carlo Salvarani⁶, Reva M McCaskill⁷, John Liu⁷, Bosny J Pierre-Louis⁷, Jaclyn K Anderson⁷ and Eric Ruderman⁸, ¹Charité University Hospital Berlin, Berlin, Germany, ²Oregon Health & Science University, Portland, OR, ³School of Medicine Griffith University, Brisbane, Queensland, Australia, ⁴University Hospital and CIC1415, Tours, France, ⁵Federal University of Paraná, Curitiba, Brazil, ⁶Rheumatology Unit, Azienda USL-IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia, Reggio Emilia, Italy, ⁷AbbVie Inc., North Chicago, IL, ⁸Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Upadacitinib (UPA) has shown efficacy and safety in patients (pts) with active PsA in the Phase 3 SELECT-PsA 1 and SELECT-PsA 2 clinical trials.…
Abstract Number: 1477 • ACR Convergence 2020
Adherence in Patients with Chronic Rheumatic Diseases Treated with Biological and Synthetic Targeted Therapies During COVID-19 Pandemic
Patricia Castro Pérez¹, Alberto Onteniente González¹, Angel Aragón Díez¹, Angel Gallegos Cid¹, Jesús Garcia-Arroba Muñoz¹ and Jose Manuel Rodriguez heredia¹, ¹Hospital de Getafe, Madrid, Spain
Background/Purpose: Adherence to treatments for chronic rheumatic diseases is influenced by many factors, including the patient's belief in the development of adverse effects such as…
Abstract Number: 1861 • ACR Convergence 2020
T Cells with IL-17A+ Signature in Psoriatic Arthritis Are of Different Subpopulations and Are Polyfuntional
Siba Raychaudhuri¹ and Smriti Raychaudhuri², ¹Division of Rheumatology, Allergy & Clinical Immunology, University of California School of Medicine, Davis, and VA Medical Center Sacramento, Sacramento, CA, ²VA Sacramento Medical Center, Davis, CA
Background/Purpose: A variety of T cells such as Th1, Th2, Th9, Th17, NKT, MAIT, etc have been attributed to multiple autoimmune diseases. In psoriatic arthritis…
Abstract Number: 0148 • ACR Convergence 2020
Perspectives on Treatment Burden for Methotrexate and TNF-inhibitors Among Psoriatic Arthritis and Rheumatoid Arthritis Patients: A Qualitative Study
Alexis Ogdie¹, Yomei Shaw², Michele Almonte³, Ervant Maksabedian⁴ and Kaleb Michaud⁵, ¹Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ²Forward, The National Databank for Rheumatic Diseases, East Lansing, MI, ³University of Pennsylvania, Philadelphia, PA, ⁴Amgen Inc., LOS ANGELES, CA, ⁵University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Physicians often consider adverse events when choosing therapies for PsA and RA but may give less attention to other ways in which treatments affect…
Abstract Number: 0313 • ACR Convergence 2020
Swollen Joints but Not Tender Joints Are Associated with Ultrasound Power Doppler Synovitis in Very Early DMARD Naive Psoriatic Arthritis
Sayam Dubash¹, Oras Alabas¹, Xabier Michelena¹, Leticia Garcia-Montoya¹, Gabriele De Marco², Mira Merashli³, Richard Wakefield¹, Philip Helliwell⁴, Ai Lyn Tan¹, Dennis McGonagle¹, Paul Emery⁵ and Helena Marzo-Ortega¹, ¹The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, ²The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Treviglio, Italy, ³The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Beirut, Lebanon, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom
Background/Purpose: Clinical tender and swollen joint counts are used for biologic drug eligibility and clinical trial inclusion criteria. Ultrasonography (US) adds to clinical examination as…
Abstract Number: 0329 • ACR Convergence 2020
Healthcare Utilization and Costs Associated with Functional Status in Patients with Psoriatic Arthritis
Alexis Ogdie¹, Mark Hwang², Phani Veeranki³, Alexandria Portelli³, Steven Sison³, Jason Shafrin³, Sofia Pedro⁴, Peter Hur⁵, Nina Kim⁶ and Kaleb Michaud⁷, ¹Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ²McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, ³PRECISIONheor, Los Angeles, ⁴FORWARD-The National Data Bank for Rheumatic Diseases, Wichita, ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁶The University of Texas at Austin; Baylor Scott and White Health, Austin, TX, ⁷FORWARD-The National Data Bank for Rheumatic Diseases; University of Nebraska Medical Center, Wichita
Background/Purpose: The Health Assessment Questionnaire Disability Index (HAQ-DI) has been validated and widely used in psoriatic arthritis (PsA) clinical trials for the assessment of patient…

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