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Abstracts tagged "Psoriatic arthritis"

  • Abstract Number: 1710 • ACR Convergence 2025

    Defining sonographic enthesitis in psoriatic arthritis: Developing a data- and expert-driven definition for inflammatory enthesitis at the single enthesis level

    Andre Lucas Ribeiro1, Sibel Aydin2, Gurjit Kaeley3, Fahmeen J. Afgani4, Catherine Bakewell5, Marcos Rosemffet6, Minna Kohler7, Amir Haddad8, Maria S. Stoenoiu9, Ari Polachek10, josefina marin11, Arnon Katz12, Sahil Koppikar13 and Lihi Eder14, 1Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil, 2Department of Medicine, University of Ottawa, The Ottawa Hospital Research Institute, Ottawa, ON, Canada, 3UF COM-J, Ponte Vedra Beach, FL, 4Women's College Hospital, Toronto, Canada, 5Intermountain Healthcare, Salt Lake City, UT, 6Instituto de Rehabilitación Psicofísica, Capital Federal, Argentina, 7Massachusetts General Hospital, Harvard Medical School, Boston, MA, 8Carmel Medical Centre, Haifa, Israel, 9Cliniques Universitaires Saint-Luc, Brussels, Belgium, 10Rheumatology Institute of Beilinson Hospital, Petah Tikva, Israel, 11Hospital Universitario Rey Juan Carlos, Madrid, Spain, 12GRAPPA, Seattle, 13Women's College Hospital & University of Toronto, Markham, ON, Canada, 14University of Toronto, Toronto, ON, Canada

    Background/Purpose: Enthesitis affects 30–40% of PsA patients but remains difficult to diagnose due to overlap with non-specific entheseal pain. While OMERACT has standardized ultrasound (US)…
  • Abstract Number: 1439 • ACR Convergence 2025

    Bimekizumab in Psoriatic Arthritis. A real-world prospective study. Comparison of its efficacy in bDMARD-naive and IL-17A-experienced patients

    Vassiliki Poulia1, Eleni Sampatakaki2, Dimitrios Katsifis-Nezis3, Maria Pappa3, Evangelia Mole4, Sousana Gazi4, Elpida Skouvaklidou5, Nikolaos Kougkas5, Maria Polyzou6, Loukia Koutsogeorgopoulou6, Ioannis Xynogalas7, Anastasios Karamanakos7, Konstantinos D Vassilakis1, Evangelos Papadimitriou8, Charalampos Papagoras8, Gerasimos Evangelatos9, Nafsika Gerolymatou10, Paraskevi V Voulgari10 and George E Fragoulis1, 1First Department of Propedeutic and Internal Medicine, Joint Academic Rheumatology program, National and Kapodistrian University of Athens, Athens, Attiki, Greece, 2Joint Academic Rheumatology Program, Attikon University Hospital, National and Kapodistrian University of Athens, School of Medicine, 4th Department of Internal Medicine, Athens, Greece, Athens, Attiki, Greece, 3Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Athens, Attiki, Greece, 4Rheumatology department, KAT General Hospital of Attica, Athens, Attiki, Greece, 54th Department of Internal Medicine, Aristotle University, Thessaloniki, Thessaloniki, Greece, 6Department of Pathophysiology, Joint Academic Rheumatology program, National and Kapodistrian University of Athens, Athens, Attiki, Greece, 7Department of Rheumatology, Evangelismos General Hospital, Athens, Attiki, Greece, 8First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Evros, Greece, 9Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Attiki, Greece, 10Department of Rheumatology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Ioannina, Greece

    Background/Purpose: Bimekizumab, a dual IL-17 A and F blocker, has recently been added in the therapeutic rheumatologist’s armamentarium of PsA, but real-world evidence is lacking.…
  • Abstract Number: 1241 • ACR Convergence 2025

    Beyond Pain Severity in Psoriatic Arthritis: Pain Catastrophizing Independently Impacts Disease Burden and Quality of Life

    Kyra Chen1, Uma Scher2 and Rebecca Haberman3, 1NYU Grossman School of Medicine and NYU Langone Health Psoriatic Arthritis Center, New York, 2NYU School of Medicine, Scarsdale, NY, 3NYU Langone Health, New York, NY

    Background/Purpose: Pain remains a major burden in psoriatic arthritis (PsA), often persisting despite effective control of synovial inflammation. This persistent pain may prevent patients from…
  • Abstract Number: 0576 • ACR Convergence 2025

    Factors impacting progression from oligoarticular to polyarticular PsA: Data from the FOREMOST study

    Laura Coates1, Philip J. Mease2, Joseph Merola3, Lourdes Perez Chada4, Dafna D. Gladman5, Alen Zabotti6, Ulrich Mrowietz7, mitsumasa kishimoto8, Cynthia Deignan9, Siddharth Chaudhari10, Lichen Teng11 and Laure Gossec12, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom, 2Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, 3UT Southwestern Medical Center, Dallas, TX, 4Harvard Medical School, Wayland, MA, 5Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Division of Rheumatology, Toronto, ON, Canada, 6Division of Rheumatology, Department of Medicine (DMED), Academic Hospital "Santa Maria della Misericordia", ASUFC, University of Udine, Udine, Italy, Udine, Italy, 7Department of Dermatology, University Medical Center Schleswig-Holstein, Kiel, Germany, 8Kyorin University School of Medicine, Tokyo, Japan, 9Amgen, Inc., Agoura Hills, CA, 10Amgen Inc., Thousand Oaks, CA, 11Amgen Inc., Thousand Oaks, 12Sorbonne Universite and Pitie-Salpetriere Hospital, Paris, France

    Background/Purpose: FOREMOST (NCT03747939)1 offers novel insights on early oligoarticular (oligo, ≤4 active joints) PsA. Our aim was to analyse progression to polyarticular (poly; >4 active…
  • Abstract Number: 0877 • ACR Convergence 2025

    Therapeutic Approach in Patients with Arthralgia at Risk of Progression to Psoriatic Arthritis.

    Rodrigo García Salinas1, Gisel Reyes-Jara2, Felicia Almada3, Juan Arguello2 and Sebastian Magri4, 1Hospital Italiano La Plata, La Plata, Argentina, 2Hospital Italiano de La Plata, La Plata, Argentina, 3Hospital Italiano de La Plata, La Plara, Argentina, 4Hospital Italiano La Plata, Melchor Romero, Argentina

    Background/Purpose: The transition from psoriasis (Pso) to psoriatic arthritis (PsA) presents an opportunity for early intervention and preventive strategies in high-risk patients with arthralgia. Objectives:…
  • Abstract Number: 0522 • ACR Convergence 2025

    The Incidence Rate and Risk Factors of Arrhythmias in Patients with Psoriatic Arthritis

    Abdulrahman Y Almansouri1, Jiayi Li2, Ali Alhadri3, Keith Colaco4, Paula Harvey5, Shadi Ahktari6, Vinod Chandran7, Dafna D. Gladman8, Richard Cook2 and Lihi Eder7, 1King Faisal Specialist Hospital and Research Centre, University of Toronto and Women's College Hospital, Toronto, Canada, 2University of Waterloo, Waterloo, Canada, 3King Fahad Hospital, University of Toronto and Toronto Western Hospital, Schroeder Arthritis Institute, Toronto, Canada, 4University of Toronto, Toronto, Canada, 5University of Toronto Department of Medicine and Women's College Hospital, Toronto, ON, Canada, 6University of Toronto Department of Medicine and Women's College Hospital, Toronto, Canada, 7University of Toronto, Toronto, ON, Canada, 8Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Division of Rheumatology, Toronto, ON, Canada

    Background/Purpose: Patients with psoriatic arthritis (PsA) are at increased risk of developing cardiovascular diseases, including arrhythmias. Given that traditional cardiovascular disease risk factors are prevalent…
  • Abstract Number: 0107 • ACR Convergence 2025

    Role of Achilles Elastography in Differentiating Patients with Early Psoriatic Arthritis

    IRENE MARTIN MARTIN1, CARMEN SAN JOSE MENDEZ2, SONIA JIMENEZ BARRIOS3, ELENA MARTIN FERNANDEZ4, JULIA MIRANDA MANZANO5, DIEGO DIOS SANTOS6, JORGE GONZALEZ MARTIN7, PABLO ZURITA PRADA7, MONICA VAZQUEZ DIAZ8 and CARLOS GUILLEN-ASTETE9, 1HOSPITAL VIRGEN DE LAS NIEVES, GRANADA, 2Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain, 3Hospital Universitario Ramón y Cajal, Madrid, Spain, 4HOSPITAL UNIVERSITARIO RAMON Y CAJAL, MADRID, 5FACULTAD BIOMEDICINA, MADRID, 6HOSPITAL DE VERÍN, OURENSE, 7HOSPITAL UNIVERSITARIO HM SANCHINARRO, MADRID, 8HOSPITAL UNIVERSITARIO HLA MONCLOA, MADRID, 9H.U Ramón y Cajal, Madrid, Spain

    Background/Purpose: Elastography (EL) is an imaging technique that evaluates the biomechanical properties of tissues. Pathological tissues have different elastic properties compared to healthy tissues.In diseases…
  • Abstract Number: 0219 • ACR Convergence 2024

    Differentiation of Nail Psoriasis from Healthy Nails Using Ultrasound: A Cross-Sectional Study with a Novel Nail Matrix Measurement Technique

    Ikwinder Preet Kaur1, Ngun Par2, Thway Myant3 and Gurjit Kaeley4, 1University of Florida College of Medicine, Jacksonville, FL, 2University of Florida Jacksonville Physicians Inc, Jacksonville, 3UF Jacksonville, Mia, FL, 4UF COM-J, Ponte Vedra Beach, FL

    Background/Purpose: Psoriatic arthritis (PsA) develops in roughly one-third of psoriasis patients. The inflammatory process in PsA is thought to originate in the nail unit and…
  • Abstract Number: 0582 • ACR Convergence 2024

    Achievement of Minimal and Very Low Disease Activity Among Patients with Psoriatic Arthritis Initiating Biologic or Targeted Synthetic Disease-Modifying Antirheumatic Drugs in the CorEvitas PsA/SpA Registry

    Alexis Ogdie1, Chao Song2, Nicole Middaugh3, Maya Marchese3, Melissa Eliot3, Robert Low2 and Philip Mease4, 1Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2UCB Pharma, Smyrna, GA, 3CorEvitas, LLC, Waltham, MA, 4Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA

    Background/Purpose: Minimal disease activity (MDA) is associated with clinically meaningful improvements in disease activity and patient (pt)-reported outcomes among pts with PsA.1 However, it is…
  • Abstract Number: 0602 • ACR Convergence 2024

    Bimekizumab Impact on Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) Core Domains for Patients with Psoriatic Arthritis: Results up to 2 Years of Treatment Duration

    Joseph F. Merola1, Philip Mease2, Atul Deodhar3, Alice Gottlieb4, Barbara Ink5, Dirk de Cuyper6, Rajan Bajracharya5, Jérémy Lambert7, Jason Coarse8 and Laura Coates9, 1UT Southwestern Medical Center, Dallas, TX, 2Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA, 3Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, 4Icahn School of Medicine at Mount Sinai, Department of Dermatology, Seattle, WA, 5UCB Pharma, Slough, United Kingdom, 6UCB Pharma, Brussels, Belgium, 7UCB Pharma, Colombes, France, 8UCB Pharma, Morrisville, NC, 9University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom

    Background/Purpose: The Group for Research and Assessment of Psoriasis and PsA (GRAPPA) domain‑based treatment recommendations for PsA focus on six key domains: peripheral arthritis, axial…
  • Abstract Number: 1134 • ACR Convergence 2024

    First-in-Human Evaluation of the Safety, Tolerability and Pharmacokinetics of the T Cell Receptor Signal Modulator AX-158

    Christopher VanDeusen1, Andres Gagete1, Annelize Koch2 and D Scott Batty Jr1, 1Artax Biopharma, Inc, Cambridge, MA, 2Simbec-Orion, Merthyr Tydfil, Wales, United Kingdom

    Background/Purpose: Nck is a cytosolic protein that binds a domain of the T cell receptor (TCR) following TCR interaction to amplify responses from low affinity…
  • Abstract Number: 1458 • ACR Convergence 2024

    Synovial Transcriptomic Sex-Specific Differences in the Response to Biologics in Psoriatic Arthritis Patients

    Pauline KRUG1, angela De Sousa Leite2, Frédéric Lecouvet1, Maria Simona stoenoiu1 and Adrien Nzeusseu Toukap3, 1Cliniques universitaires St-Luc, Brussel, Belgium, 2Cliniques universitaires St-Luc, Brussels, Belgium, 3Cliniques universitaires Saint-Luc,, St.-Lambrechts-Woluwe, Belgium

    Background/Purpose: Psoriatic arthritis (PsA) is a highly heterogeneous disease. The response to therapy is variable among patients (ref.). Therefore, we need a tailored approach. Biologic…
  • Abstract Number: 1671 • ACR Convergence 2024

    Are Patient-reported Outcomes for Dactylitis, Uveitis, Psoriatic Skin and Nail Disease Valid in Patients with Psoriatic Arthritis?

    Louise Nielung1, Merete Hetland2, Lone Skov3, Hans Albert Frandsen4, Lene Dreyer5 and Bente Glintborg6, 1Rigshospitalet Glostrup and University of Copenhagen, Glostrup, Denmark, 2DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark, Glostrup, Denmark, 3Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte, Gentofte, Denmark, 4Patient Partner, Frederiksberg, Denmark, 5Department of Rheumatology, Aalborg UnIversity Hospital, København, Denmark, 6DANBIO, Rigshospitalet Glostrup and University of Copenhagen, Virum, Denmark

    Background/Purpose: In routine care, Danish patients with psoriatic arthritis (PsA) are monitored in DANBIO, a nationwide clinical registry1. Patients enter patient-reported outcomes (PROs) online before…
  • Abstract Number: 2278 • ACR Convergence 2024

    Similar Etanercept Adherence in Individuals with Rheumatic Disease Initiating Originator and Biosimilar: A Population-Based Study

    Olga Tsyruk1, Marina Birck2, Sasha Bernatsky2, Luck Lukusa3, Denis Choquette4, Gilles Boire5 and Walter Maksymowych6, 1McGill University, Montreal, QC, Canada, 2Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 3The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 4Rhumadata™, Montreal, QC, Canada, 5Retired, Sherbrooke, QC, Canada, 6University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Treatment adherence is crucial to optimizing outcomes in rheumatic diseases. Suboptimal adherence is common with inflammatory and chronic diseases, often treated with biologics, including…
  • Abstract Number: 2327 • ACR Convergence 2024

    Differential Quantitative Profile of Myeloid Derived Suppressor Cells and Monocyte Subsets Relate to Clinical Phenotype and Disease Activity in Psoriatic Arthritis Patients

    Jennifer Balderas Miranda1, Jiram Torres Ruiz2, Guillermo Guaracha Basañez3, Virginia Pascual Ramos4, Beatriz Alcalá-Carmona5, Yatzil Reyna-Juárez5, María José Ostos-prado5, Nancy R Mejía-Domínguez5, Guillermo Juarez-Vega6 and Diana Gomez-martin7, 1Universidad Nacional Autónoma de México, Ciudad de México, Mexico, 2INCMNSZ, Mexico, Federal District, Mexico, 3Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirón", Mexico City, Mexico, 4Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Federal District, Mexico, 5Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Distrito Federal, Mexico, 6Red de Apoyo a la Investigación, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Universidad Nacional Autónoma de México, Mexico City, Distrito Federal, Mexico, 7INCMNSZ, Mexico City, Federal District, Mexico

    Background/Purpose: The innate immune system not only participates in PsA pathogenesis but may also counteract with immunomodulatory elements. Proinflammatory and repairing roles according to monocyte…
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