ACR Meeting Abstracts

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Abstracts tagged "prognostic factors"

  • Abstract Number: 1483 • ACR Convergence 2023

    High Chronicity Index of the Modified NIH (National Institute of Health) Scoring System of Lupus Nephritis Is Associated with Increased Risk of End-stage Kidney Disease: A Retrospective Single-center Study

    Shiori Nakagawa, Yasunori Iwata, Takahiro Yuasa, Keisuke Sako, Keisuke Horikoshi, Taichiro Minami, Megumi Oshima, Tadashi Toyama, Shinji Kitajima, Akinori Hara, Norihiko Sakai, Miho Shimizu and Takashi Wada, Department of Nephrology, Kanazawa University Hospital, Kanazawa, Japan

    Background/Purpose: Lupus nephritis (LN) is a major manifestation which develops in more than 50% of patients with systemic lupus erythematosus (SLE), and is also a…
  • Abstract Number: 2482 • ACR Convergence 2023

    Preinflammatory Mesenchymal (PRIME) Cell Signature Genes Enrichment Predicts Treatment Response and Joint Prognosis in Rheumatoid Arthritis

    Takayuki Fujii1, Dana Orange2, Caryn Hale2, Koichi Murata1, Hideo Onizawa1, Akira Onishi1, Masao Tanaka3, Akio Morinobu4 and Shuichi Matsuda5, 1Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Rockefeller University, New York, NY, 3Graduate School of Medicine, Kyoto University, Kyoto, Japan, 4Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Background/Purpose: This study aimed to determine predictors of treatment response and radiographic progression following the initiation of biological disease-modifying antirheumatic medications (bDMARDs) in patients with…
  • Abstract Number: 0253 • ACR Convergence 2023

    Clinical Phenotypes in Patients with Isolated Anti-Sm/RNP Common Motif Antibody Positivity, Compared to Those with or Without Associated Anti-RNP Antibody Reactivity

    Ruoning Ni1 and Petar Lenert2, 1University of Iowa Hospitals and Clinics, Coralville, IA, 2University of Iowa Hospitals and Clinics, Iowa City, IA

    Background/Purpose: Anti-ribonucleoprotein (RNP) and anti-Sm/RNP common motif antibodies play a critical role in diagnosing patients with systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD)…
  • Abstract Number: 1120 • ACR Convergence 2023

    Target Serum Urate Levels, Recurrent Gout Flare Rates, and Gout-Primary Hospitalizations: Nationwide Prospective Cohort Study of 3,613 Gout Patients

    Natalie McCormick1, Chio Yokose2, Gregory Challener1, Amit Joshi3, Sruthi Tanikella1 and Hyon K. Choi4, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Waltham, MA, 3Channing Division of Network Medicine, Boston, MA, 4Massachusetts General Hospital and Harvard Medical School, Lexington, MA

    Background/Purpose: Despite rheumatology guidelines' emphasis on treat-to-target-serum-urate (SU) levels (<6 or <5 mg/dL, urate crystal sub-saturation points), this pathophysiology-based recommendation is not accepted in primary…
  • Abstract Number: 1554 • ACR Convergence 2023

    Therapeutic Approaches and Predictive Factors of Relapse in Severe Ocular Involvement in Behçet’s Disease: A Multicentre Retrospective Study

    Audrey Hermant1, Yann Nguyen2, Fleur Cohen3, Antoine Baudet4, Alban DEROUX5, Vincent Poindron6, Cécile-Audrey Durel7, Nicolas Girszyn8, Noémie Le Gouellec9, Benedicte Rouviere10, Helder Gil11, Francois Maurier12, Nicolas Noel13, Loic Raffray14, Hubert De Boysson15, Benoit Faucher16, Bertrand Godeau17, Pierre Lozach18, Claude Bachmeyer19, Alice Berezne4, Gilles Blaison20, Brice Castel21, Guillaume Gondran22, Matthieu Groh23, Stéphane Giorgiutti24, Jeremy Keraen25, Julie Magnant26, Sebastien Monnier27, Philippe Blanche28, Dominique Monnet29, Antoine Brezin29 and Benjamin Terrier30, 1Hopital Cochin, Paris, France, 2Department of Internal Medicine, Hôpital Beaujon, AP-HP, Clichy, France., Montmorency, France, 3Sorbonne Université, Paris, France, 4CH Annecy, Annecy, France, 5CHU de Grenoble, Grenoble, France, 6Strasbourg, Strasbourg, France, 7CHU Lyon, Lyon, France, 8Rouen, Rouen, France, 9CH Valenciennes, Valenciennes, France, 10CHU Brest, Brest, France, 11CHU Besancon, Besançon, France, 12CH Metz, Metz, France, 13CHU Bicetre, Le Kremlin-Bicêtre, France, 14CHU la Réunion, La Réunion, France, 15CHU Caen, Caen, France, 16CHU Marseille, Marseille, France, 17CHU Henri Mondor, Créteil, France, 18CH Le Mans, Le Mans, France, 19CHU Tenon, Paris, France, 20Hôpital Louis PASTEUR, Colmar, France, 21CH Tarbes, Tarbes, France, 22CHU Limoges, Limoges, France, 23National Referral Center for Hypereosinophilic Syndrome (CEREO), Hôpital Foch, Suresnes, France, 24CHRU Strasbourg, Strasbourg, France, 25CH Quimper, Quimper, France, 26CHU Tours, Tours, France, 27CH Versailles, Versailles, France, 28Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, 29CHU Cochin, Paris, France, 30Department of Internal Medicine, Hôpital Cochin, AP-HP, Paris, France

    Background/Purpose: The management of severe ocular involvement in Behçet's disease (BD) is an important issue with major functional implications due to the risk of blindness.…
  • Abstract Number: 2510 • ACR Convergence 2023

    Autoantibody-positivity Before Treatment Is Associated with Immune-related Adverse Events in Melanoma Patients Treated with anti-PD-1

    Tineke van Wesemael1, Jessica Borgers2, Kyra Gelderman3, Els Verdegaal4, C.M. Korse5, M.J.P. Welters6, Ellen Kapiteijn7, W.J. van Houdt2, Sjoerd van der Burg6, René Toes1, J.V. Thienen2, John Haanen2 and Diane van der Woude1, 1Leiden University Medical Center, Leiden, Netherlands, 2Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands, 3Sanquin Diagnostic Services, Amsterdam, Netherlands, 4Department of Medical Oncology, Oncode Institute, Leiden University Medical Center, Amsterdam, Netherlands, 5Department of Laboratory Medicine, Antoni Van Leeuwenhoek, The Netherlands Cancer Institute, Amsterdam, Netherlands, 6Department of Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, Netherlands, 7Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: PD-1 immune checkpoint inhibitors are able to re-activate restrained anti-tumor T-cell responses in melanoma patients. However, PD-1 inhibition may also activate auto-reactive T-cells leading…
  • Abstract Number: 0300 • ACR Convergence 2023

    Nailfold Videocapillaroscopy in Idiopathic Inflammatory Myopathy Compared with Healthy Controls

    Megan Sullivan1, Maximiliano Diaz-Menindez2, Colleen T. Ball2, Benjamin Wang3 and Florentina Berianu1, 1Mayo Clinic Florida, Jacksonville, FL, 2Mayo Clinic Jacksonville, Jacksonville, FL, 3Mayo Clinic, Jacksonville, FL

    Background/Purpose: Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune disorders that cause inflammation of the muscle. This includes dermatomyositis and polymyositis. Literature has been…
  • Abstract Number: 1142 • ACR Convergence 2023

    A Retrospective Analysis of Radiographic and Serologic Findings in Patients with Scleroderma and Interstitial Lung Disease

    Nikita Jhawar, Claire Wilson, Andy Abril, Li Zhuo and Yaohua Ma, Mayo Clinic, Jacksonville, FL

    Background/Purpose: Connective tissue diseases such as scleroderma are frequently associated with interstitial lung disease (ILD). Detection of autoantibodies is crucial in characterizing disease phenotypes, but…
  • Abstract Number: 1570 • ACR Convergence 2023

    Prognostic Assessment of the 2022 ACR/EULAR Classification Criteria for Takayasu Arteritis: A Multi-centre International Study

    Emma Rinaldi1, Corrado Campochiaro2, Roberto Padoan3, Chengappa Kavadichanda4, Augustine Jose4, Kritika Singh5, Luca Iorio3, Naomi Viapiana6, Upendra Rathore5, Elena Marina Baldissera6, Vikas Agarwal5, Lorenzo Dagna7, Durga P Misra5 and Alessandro Tomelleri8, 1Vita-Salute San Raffaele University, Milan, Italy, 2IRCCS San Raffaele Hospital, Unit of Immunology, Rheumatology, Allergy and Rare Disease. Vita-Salute San Raffaele University, Milan, Italy, 3Department of Medicine DIMED, University of Padova, Padova, Italy, 4Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India, 5Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India, 6IRCCS San Raffaele Hospital, Milan, Italy, 7Ospedale San Raffaele, Milano, Italy, 8Unit of Immunology, Rheumatology, Allergy and Rare Diseases, San Raffaele Scientific Institute, Milano, Italy

    Background/Purpose: The 2022 ACR/EULAR classification criteria for Takayasu arteritis (TAK) rely on a point-based clinical and imaging scoring system (from 0 to 22). The aim…
  • Abstract Number: 2552 • ACR Convergence 2023

    Inflammatory Fibrosis Precedes Loss of Kidney Function in Lupus Nephritis

    Silvia Malvica1, Paride Fenaroli2, Serena Bagnasco1, Jeff Hodgin3, Peter Izmirly4, H Michael Belmont5, Katie Preisinger4, Jill Buyon6, Larry Magder7, Michelle Petri8, the Accelerating Medicines Partnership in RA/SLE9, Avi Rosenberg1 and Andrea Fava10, 1Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, 2Nephrology and Dialysis Unit, Azienda USL - IRCCS Reggio Emilia, Reggio Emilia, Italy, 3University of Michigan, Ann Arbor, MI, 4New York University School of Medicine, New York, NY, 5NYU School of Medicine, New York, NY, 6Department of Medicine, NYU Grossman School of Medicine, New York, NY, 7University of Maryland, Baltimore, MD, 8Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 9Multiple, Multiple, 10Johns Hopkins University, Baltimore, MD

    Background/Purpose: Interstitial fibrosis in lupus nephritis (LN) is often infiltrated by immune cells. However, this is typically regarded as nonspecific "scar reaction" rather than active…
  • Abstract Number: 0320 • ACR Convergence 2023

    Feasibility and Acceptability of Geniculate Artery Embolization for the Treatment of Painful Knee Osteoarthritis

    Amaya Smole1, Benjamin Swett1, Alison Zhao1, Yvonne Shea1, Sarah Gottesman1, Dongmei Sun1, Geoffrey Westrich1, Michael Alexiades1, Alejandro Gonzalez Della Valle1, Sirish Kishore2 and Lisa Mandl3, 1Hospital for Special Surgery, New York, NY, 2Stanford Medicine, Stanford, CA, 3Hospital for Special Surgery, Weill Cornell Medicine, New York, NY

    Background/Purpose: There are limited non-surgical options for patients with severe pain due to knee osteoarthritis (KOA).Using geniculate artery embolization (GAE) to infarct hypervascular synovium, a…
  • Abstract Number: 1160 • ACR Convergence 2023

    Antibody Predictors of Prognosis in a Large Multi-centre Cohort of Idiopathic Inflammatory Myopathy Associated Interstitial Lung Disease

    Jennifer Hannah1, Alexandra Lawrence2, Jennifer Martinovic2, Marium Naqvi2, Saadia Sasha Ali3, Carmel Stock4, Cara Owens4, Anand Devaraj4, Louise Pollard2, Sangita Agarwal2, Belén Atienza-Mateo5, Amit Patel6, Alex West2, Kate Tinsley2, Hasti Robbie7, Felix Chua4, Boris Lams2, Athol Wells4, Sam Norton7, James Galloway7, Elisabetta Renzoni4 and Patrick Gordon8, 1King's College London, London, United Kingdom, 2Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, 3King's College Hospital, Epsom, United Kingdom, 4Royal Brompton and Harefield Hospitals NHS Trust, London, United Kingdom, 5Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 6King's College Hospital, London, United Kingdom, 7King's College London, London, United Kingdom, 8NHS, London, United Kingdom

    Background/Purpose: IIM-ILD follows a varied clinical course. Serological profile can help predict clinical phenotype, but impact on ILD prognosis is less clear. This multicentre UK…
  • Abstract Number: 1699 • ACR Convergence 2023

    Immunosuppression with Targeted Therapies Reduces Morbidity and Mortality in Pre-Capillary Pulmonary Hypertension Associated with Systemic Sclerosis: A EUSTAR Analysis

    Cosimo Bruni1, Havard Fretheim2, Lorenzo Tofani3, Yannick Weber1, Eric Hachulla4, Patricia Carreira5, Dilia Giuggioli6, Paolo Airò7, Elise Siegert8, Ulf Müller-Ladner9, marco Matucci Cerinic10, Gabriela Riemekasten11, Carmen Pilar Simeon-Aznar12, Jeska de Vries-Bouwstra13, Lesley Ann Saketkoo14, Joerg Distler15, Alexandra Balbir-Gurman16, Ivan Castellvi17, Elisabetta Zanatta18, Vanessa Smith19, Christopher Denton20, Britta Maurer21, Alessandro Giollo18, Florenzo Iannone22, Lorenzo Dagna23, Marie-Elise Truchetet24, Masataka Kuwana25, Yannick ALLANORE26, Yoshiya Tanaka27, Mickael Martin28, Edoardo Rosato29, Ana Maria Gheorghiu30, Francesco Del Galdo31, Kamal Solanki32, Alessandra Vacca33, CATARINA RESENDE34, SUSANA VIEIRA35, Laszlo Czirjak36, Marko Barisic37, Francesco Paolo Cantatore38, valeria Riccieri39, Kristofer Andréasson40, Lorinda Chung41, Carolina Muller42, Daniela OPRIS-BELINSKI43, Simona Rednic44, Petros Sfikakis45, Yair Levy46, Anna Maria Hoffmann-Vold47, Oliver Distler1, Vivien Hsu48, Stefan Heitmann49, Gianluca Moroncini50, Michele Iudici51, Joerg Henes52, Ellen De Langhe53, Ariane Herrick54 and Carlomaurizio Montecucco55, 1Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 2Oslo University Hospital, Oslo, Norway, 3Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy, 4University of Lille, Lille, France, 5Hospital Universitario 12 de Octubre, Madrid, Spain, 6Scleroderma Unit, Rheumatology Unit, University Hospital of Modena and Reggio Emilia, Modena, Italy, 7Spedali Civili di Brescia, Scleroderma UNIT, UOC Reumatologia ed Immunologia Clinica, Piazzale Spedali Civili 1, 25123, Brescia, Italy, 8Department of Rheumatology, Charité University Hospital, Charité Platz 1, D-10117, Berlin, Germany, 9Justus Liebig University Gießen, Campus Kerckhoff, Bad Nauheim, Germany, 10Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Hospital, Milan, Milan, Italy, 11University Clinic Schleswit-Holstein (UKSH), Lübeck, Germany, 12Department of Internal Medicine, Systemic Autoimmune Diseases Unit, Hospital Universitario Vall d'Hebronh, Barcelona, Spain, 13Leiden University Medical Center, Leiden, Netherlands, 14University Medical Center - Comprehensive Pulmonary Hypertension Center and ILD Clinic Programs // New Orleans Scleroderma and Sarcoidosis Patient Care & Research Centeris, New Orleans, LA, 15Clinic for Rheumatology University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany; Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany, 16Rheumatology Institute, Rambam Health Care Campus and Rappaport Faculty of |Medicine, Technion, Haifa, Israel, 17Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Sant Just Desvern, Spain, 18Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padova, Padua, Italy, 19Ghent University Hospital, Gent, Belgium, 20University College London, London, United Kingdom, 21University Hospital Bern, University Bern, Bern, Switzerland, 22Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", Bari, Italy, 23Ospedale San Raffaele, Milano, Italy, 24Bordeaux University Hospital, Bordeaux, France, 25Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 26Université Paris Cité, Paris, France, 27University of Occupational and Environmental Health, Kitakyushu, Japan, 28Department of Internal Medicine, INSERM U1313, Poitiers University, Poitiers University Hospital, Poitiers, France, 29Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy, 30Department of Internal Medicine and Rheumatology, Ion Cantacuzino Clinical Hospital, Bucharest, Romania, 31University of Leeds - Leeds Institute of Rheumatic and Muskuloskeletal Medicine, Leeds, United Kingdom, 32Department of Rheumatology, Te Whatu Ora Health New Zealand Waikato, Hamilton, New Zealand, 33II Chair of Rheumatology, University of Cagliari-Policlinico Universitario, Monserrato, Italy, 34Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHLN, Lisboa, Portugal, 35Hospital Fernando Fonseca, Lisbon, Portugal, 36Dept. Rheumatol Immunol, Medical School, university of Pecs, Pecs, Hungary, 37Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb, School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia, 38Rheumatology Clinic – Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy, 39Department of Clinical, Internal and Cardiovascular Specialities, Sapienza University of Rome, Roma, Italy, 40Lund University, Lund, Sweden, 41Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Woodside, CA, 42Federal University of Parana, CURITIBA / PR, Brazil, 43Saint Mary Hospital, Bucharest, Romania, 44Prof Dr Simona Rednic, Cluj, Romania, 45National Kapodistrian University of Athens Medical School, Athens, Greece, 46Meir Medical Center, Autoimmune Research Laboratory, Kfar-Saba, Israel, 47Oslo University Hospital, Department of Rheumatology, Oslo, Norway, 48Rutgers-RWJ Medical School, South Plainfield, NJ, 49Department of Rheumatology, Marienhospital Stuttgart, Böheimstrasse 37, D-70199, Stuttgart, Germany, 50Marche Polytechnic University, Ancona, Italy, 51Division of Rheumatology, Department of Internal Medicine Specialties, Geneva University Hospitals, Geneva, Switzerland, 52University Hospital Tuebingen, Tuebingen, Germany, 53Division of Rheumatology, University Hospitals Leuven, Leuven, Belgium, 54University of Manchester, Salford, United Kingdom, 55Unità Operativa e Cattedra di Reumatologia, IRCCS Policlinico S Matteo, Pavia, Italy

    Background/Purpose: Systemic sclerosis (SSc) associated pre-capillary pulmonary hypertension (precapPH) is a severe condition that requires prompt treatment. Although immunosuppressants (IMS) are standard of care for…
  • Abstract Number: 2554 • ACR Convergence 2023

    Validation of a Flare Risk Index Informed by Select Immune Mediators in Systemic Lupus Erythematosus in a Confirmatory Cohort

    Melissa Munroe1, Derek Blankenship2, Daniele DeFreese2, Adrian Holloway2, Mohan Purushothaman2, Wade DeJager3, Susan Macwana3, Joel Guthridge3, Stan Kamp3, Nancy Redinger3, Teresa Aberle3, Eliza Chakravarty3, Cristina Arriens4, Yanfeng Li5, Hu Zeng5, Stephanie Dezzutti6, Peter Izmirly7, Uma Thanarajasingam5, Diane L. Kamen6, Jill Buyon8, Judith James3 and Eldon Jupe2, 1Oklahoma Medical Research Foundation; Progentec Diagnostics, Inc., Oklahoma City, OK, 2Progentec Diagnostics, Inc., Oklahoma City, OK, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Oklahoma Medical Research Foundation and University of Oklahoma Health Sciences Center, Department of Arthritis & Clinical Immunology, Oklahoma City, OK, 5Mayo Clinic, Rochester, MN, 6Medical University of South Carolina, Charleston, SC, 7New York University School of Medicine, New York, NY, 8NYU Grossman School of Medicine, New York, NY

    Background/Purpose: SLE is marked by immune dysregulation linked to varied clinical disease activity. Using a unique confirmatory cohort of SLE patients, this study seeks to…
  • Abstract Number: 036 • 2023 Pediatric Rheumatology Symposium

    Predictive Factors of Long-lasting Remission Following Anakinra Withdrawal in Patients with Systemic Juvenile Idiopathic Arthritis After Achievement of Clinical Inactive Disease

    Germana Nardini1, Claudia Bracaglia2, Denise Pires Marafon1, Emanuela Sacco3, Arianna De Matteis1, Ivan Caiello1, Giusi Prencipe1, Fabrizio De Benedetti2 and Manuela Pardeo2, 1Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesu', Roma, Italy, 2Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, 3Fondazione Casa Sollievo della Sofferenza, Pediatria, San Giovanni Rotondo, Italy

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a rare autoinflammatory disease of unknown etiology. Several uncontrolled studies showed that early treatment with anakinra is associated…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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