Abstracts tagged "pregnancy and systemic lupus erythematosus (SLE)"

Abstract Number: 1852 • 2018 ACR/ARHP Annual Meeting
Pregnancy in Lupus: 17-Year U.S. Nationwide Trend in Obstetric and Maternal Outcomes
Yiming Luo¹, Jiehui Xu² and Bella Y. Mehta^3,4, ¹Department of Medicine, Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY, ²Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY, ³Hospital for Special Surgery/Weill Cornell Medicine/Mailman School of Public Health, New York, NY, ⁴Patient Oriented Research Program, Columbia University Mailman School of Public Health, New York, NY
Background/Purpose: Pregnancies in systemic lupus erythematosus (SLE) are considered high risk and associated with medical and obstetric complications [1]. Our objective was to study the…
Abstract Number: 1854 • 2018 ACR/ARHP Annual Meeting
SLE Flares during and after Pregnancy Are Mild and Occur at Similar Rates
Julia Davis-Porada¹, Sam Stern², Marta M. Guerra³, Carl Laskin^4,5, Michelle Petri⁶, Michael Lockshin⁷, Lisa R Sammaritano^8,9, David Branch^10,11, Allen D. Sawitzke¹², Joan T. Merrill^13,14, Jill P. Buyon¹⁵, Mimi Kim¹⁶ and Jane E. Salmon^8,9, ¹Research, Hospital for Special Surgery, New York, NY, ²Albert Einstein College of Medicine, New York, NY, ³Department of Medicine and Program in Inflammation and Autoimmunity, Hospital for Special Surgery, New York, NY, ⁴Mount Sinai Hospital Toronto, Toronto, ON, Canada, ⁵Trio Fertility, Toronto, ON, Canada, ⁶Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Barbara Volcker Center, Hospital for Special Surgery, New York, NY, ⁸Hospital for Special Surgery, New York, NY, ⁹Weill Cornell Medicine, New York, NY, ¹⁰Intermountain Healthcare, Salt Lake City, UT, ¹¹Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT, ¹²Rheumatology, University of Utah Health Sciences Center, Salt Lake City, UT, ¹³University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁴Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁵Medicine, New York University School of Medicine, New York, NY, ¹⁶Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Systemic lupus erythematosus (SLE) disproportionally affects women of childbearing age. Low disease activity for 6 months prior to conception leads to the best outcomes;…
Abstract Number: 2417 • 2018 ACR/ARHP Annual Meeting
Pregnancy Outcomes in Systemic Lupus Erythematous and Pre-Systemic Lupus Erythematous: A Population-Based Cohort Study
A. Nicole Wade¹, Mary A. De Vera², Eric C. Sayre³ and J. Antonio Avina-Zubieta⁴, ¹Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada, ²Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Canada, Richmond, BC, Canada, ⁴Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: The adverse effects of systemic lupus erythematosus (SLE) on maternal and fetal outcomes in pregnancy have been explored mainly in clinic-based cohorts. However, data…
Abstract Number: 2423 • 2018 ACR/ARHP Annual Meeting
Births to Women with Systemic Lupus Erythematosus Can be Identified Accurately in the Electronic Health Record
Ashley Blaske¹, Amanda M. Eudy², Jim C. Oates³, Megan E. B. Clowse² and April Barnado⁴, ¹Medicine and Pediatrics, Vanderbilt University Medical Center, Nashville, TN, ²Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC, ³Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁴Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Studying births in women with systemic lupus erythematosus (SLE) is difficult given its rarity and the challenges of randomized trials. While the electronic health…
Abstract Number: 6 • 2017 ACR/ARHP Annual Meeting
Pregnancy Outcomes in a Cohort of Women with Antiphospholipid Syndrome. 25- Years Long-Term Observation
Dana Tegzova¹, Katerina Andelova², Iva Kucerova², Vera Vlasakova³, Stejskal Jan⁴, Putova Ivana⁵, Marta Olejarova⁶ and Ctibor Dostál⁷, ¹Clinical Department, Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic, ²Institute of Mother and Child Care, Prague, Prague, Czech Republic, ³Dept.of Internal Medicine, City Hospital Ceske Budejovice, Ceske Budejovice, Czech Republic, ⁴1st Medical Faculty, Dpt. of Pathology, Charles University, Prague, Czech Republic, ⁵Institute of Rheumatology, Dpt. of Immunology, Prague, Czech Republic, ⁶Clinical, Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic, ⁷Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic
Background/Purpose: The goal of this long-term project was to investigate the course of pregnancy in patients with APS (primary or secondary with SLE) in 1993-2017,…
Abstract Number: 1297 • 2017 ACR/ARHP Annual Meeting
Hydroxychloroquine in Lupus Pregnancy: A Meta-Analysis of Individual Participant Data
Amanda M. Eudy¹, Michelle Petri², Rebecca Fischer-Betz³, Abeer Mokbel⁴, Cecilia Nalli⁵, Laura Andreoli⁵, Angela Tincani⁶, Yair Molad⁷, Stephen Balevic⁸ and Megan E. B. Clowse¹, ¹Rheumatology, Duke University Medical Center, Durham, NC, ²Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Rheumatology and Hiller Research Unit, University Hospital Duesseldorf, Duesseldorf, Germany, ⁴Department of Rheumatology and Rehabilitation, Cairo University Hospital, Cairo, Egypt, ⁵Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ⁶Spedali Civili and University of Brescia, Brescia, Italy, ⁷Rheumatology Unit, Rabin Medical Center, Beilinson Hospital, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁸Rheumatology, Adult and Pediatric, Duke University Medical Center, Durham, NC
Background/Purpose: Our current knowledge about how to treat lupus in pregnancy derives from small prospective or retrospective cohorts, and how best to manage lupus nephritis…
Abstract Number: 2438 • 2016 ACR/ARHP Annual Meeting
Increased Risk of Postpartum Depression in SLE Pregnancies
Evelyne Vinet¹, Susan Scott², Debbie Ehrmann Feldman³, Christian A. Pineau⁴ and Sasha Bernatsky², ¹Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ²Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ³School of Rehabilitation, Université de Montréal, Montreal, QC, Canada, ⁴McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Chronic diseases have been shown to be a strong risk factor for postpartum depression. Although there is a 2-fold increased risk of major depression…
Abstract Number: 2044 • 2016 ACR/ARHP Annual Meeting
Effect of Pregnancy on Disease Flares in Patients with Systemic Lupus Erythematosus
Amanda M. Eudy^1,2, Anna Maria Siega-Riz², Stephanie Engel², Nora Franceschini², Annie Green Howard³, Megan E. B. Clowse¹ and Michelle Petri⁴, ¹Rheumatology, Duke University Medical Center, Durham, NC, ²Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: There are conflicting results about the effect pregnancy has on the health of systemic lupus erythematosus (SLE) women. The objective of the current analysis…
Abstract Number: 2433 • 2016 ACR/ARHP Annual Meeting
Trends in Use of Hydroxychloroquine during Pregnancy in SLE Patients from 2001 to 2012
Bonnie L. Bermas¹, Seoyoung Kim^2,3, Krista Huybrechts⁴, Sonia Hernandez-diaz⁵, Brian T. Bateman⁶ and Rishi J. Desai⁷, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ³Division of Pharmacoepidemiology and Pharmocoeconomics, Brigham and Women's Hospital, Boston, MA, ⁴Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston, MA, ⁵Harvard School of Public Health, Boston, MA, ⁶Division of Pharmacoepidemiology and Pharocoeconomics, Brigham and Women's Hospital, Boston, MA, ⁷PharmacoEpidemiology & PharmacoEconomics, Brigham & Women's Hospital, Boston, MA
Background/Purpose : Data suggest that hydroxychloroquine (HCQ) use during systemic lupus erythematosus (SLE) pregnancies improves outcomes. In the past decade, single-center studies report that a…
Abstract Number: 1996 • 2015 ACR/ARHP Annual Meeting
Complement Activation Predicts Adverse Pregnancy Outcome in Patients with SLE and/or aPL Antibodies
Jane E. Salmon^1,2, Mimi Kim³, Marta Guerra⁴, Elianna Kaplowitz¹, Carl Laskin⁵, Michelle Petri⁶, Ware D. Branch^7,8, Michael Lockshin⁹, Lisa R. Sammaritano², Joan T. Merrill¹⁰, Mary D. Stephenson¹¹, Munther Khamashta¹², Alan M. Peaceman¹³, Anne Lynch¹⁴ and Jill P. Buyon¹⁵, ¹Hospital for Special Surgery, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Biostatistics and Research Design Resource, Albert Einstein Coll Med, Bronx, NY, ⁴Rheumatology 3rd Fl Rsrch, Hospital for Special Surgery, New York, NY, ⁵Medicine, Rheumatology and Obstetrics and Gynecology, University of Toronto and LifeQuest Centre for Reproductive Medicine, Toronto, ON, Canada, ⁶Johns Hopkins University School of Medicine, Baltimore, MD, ⁷University of Utah, Salt Lake City, UT, ⁸Intermountain Healthcare, Salt Lake City, UT, ⁹Barbara Volcker Center for Women & Rheumatic Disease, Hospital for Special Surgery, New York, NY, ¹⁰Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹¹University of Illinois College of Medicine, Chicago, IL, ¹²Graham Hughes Lupus Research Laboratory, The Rayne Institute, St Thomas' Hospital, London, United Kingdom, ¹³Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁴Colorado School of Public Health, Aurora, CO, ¹⁵NYU School of Medicine, New York, NY
Background/Purpose: Women with SLE and/or aPL antibodies (SLE/APL) are at increased risk for adverse pregnancy outcomes (APO) yet identification of those destined for complications remains…
Abstract Number: 2120 • 2015 ACR/ARHP Annual Meeting
Alterations in Complement C3 and iC3b in SLE Pregnancies
Marta M. Guerra¹, Martin Schmidt², Elianna Kaplowitz³, Vibeke Strand⁴ and Jane E. Salmon⁵, ¹Rheumatology 3rd Fl Rsrch, Hospital for Special Surgery, New York, NY, ²Kypha, Inc., St. Louis, MO, ³Hospital for Special Surgery, New York, NY, ⁴Division of Immunology/Rheumatology, Stanford University School of Medicine, Portola Valley, CA, ⁵Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY
Background/Purpose: Pregnancy in patients with SLE is associated with increased risk of maternal and fetal complications. Studies in experimental models and humans suggest that complement…
Abstract Number: 2121 • 2015 ACR/ARHP Annual Meeting
Placentas of Lupus Pregnancies Are Characterized By Marked Inflammatory Changes Despite Good Disease Control
Wendy Marder¹, Jason S. Knight², Mariana J. Kaplan³, Emily C. Somers⁴, Xu Zhang⁴, Alexander A. O'Dell⁵, Vasantha Padmanabhan⁴ and Richard W. Lieberman⁴, ¹Div of Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴University of Michigan, Ann Arbor, MI, ⁵Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus (SLE) is associated with increased risk of adverse pregnancy outcomes (APO), including preeclampsia and intrauterine growth restriction. While significant placental…
Abstract Number: 2200 • 2015 ACR/ARHP Annual Meeting
Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking Clinical Database and Repository Cluster Analysis: Identification of Different Clinical Phenotypes Among Antiphospholipid Antibody-Positive Female Patients
Stephane Zuily¹, Cecilia B. Chighizola², DENIS WAHL¹, Pier Luigi Meroni³ and Doruk Erkan⁴, ¹CHU de Nancy, Vascular Medicine Division and Regional Competence Centre For Rare Vascular And Systemic Autoimmune Diseases; and UMR_S U1116 Research Unit, France, Nancy, France, ²Department of Clinical Sciences and Community Health, University of Milan, Istituto Auxologico Italiano, Cusano Milanino, Italy, ³University of Milan, Department of Clinical Sciences and Community Health, Division of Rheumatology, Gaetano Pini Institute, Milan, Italy, ⁴Barbara Volcker Center for Women & Rheumatic Disease, Hospital for Special Surgery, New York, NY
Background/Purpose: APS ACTION International Clinical Database and Repository was created to study the natural course of persistently antiphospholipid antibodies (aPL)-positive patients ± autoimmune disorders over…
Abstract Number: 2533 • 2015 ACR/ARHP Annual Meeting
A Comparison of Pregnancy Outcomes before and after Lupus Diagnosis
Megan E. B. Clowse¹, Maria Dall'Era², Jennifer M. Grossman^3,4, Diane L. Kamen⁵, Jerry McGwin⁶, Robert Roubey⁷ and Jill P. Buyon⁸, ¹Rheumatology & Immunology, Duke University, Durham, NC, ²University of California San Francisco School of Medicine, San Francisco, CA, ³Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ⁴Rheumatology, UCLA, Los Angeles, CA, ⁵Medicine, Medical University of South Carolina, Charleston, SC, ⁶Deparment of Epidemiology, University Of Alabama at Birmingham, School of Public Health, Birmingham, AL, ⁷University of North Carolina, Chapel Hill, NC, ⁸Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: The frequency of pregnancy complications, including miscarriage, stillbirth, preeclampsia, and preterm birth varies between lupus cohorts. This analysis compares pregnancy outcomes that occurred before…
Abstract Number: 2535 • 2015 ACR/ARHP Annual Meeting
Increased Direct Healthcare Costs in SLE Pregnancies
Cristiano Moura¹, Sasha Bernatsky², Yvan St. Pierre³, Susan Scott³, Christian A. Pineau⁴, Ann E. Clarke⁵ and Evelyne Vinet⁴, ¹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ³Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁴Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ⁵Division of Rheumatology, University of Calgary, Calgary, AB, Canada
Background/Purpose: Although adverse obstetrical complications are more frequent in SLE women, no one has evaluated healthcare costs during SLE pregnancies. Thus, we aimed to evaluate…

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