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Abstracts tagged "pregnancy and systemic lupus erythematosus (SLE)"

  • Abstract Number: 1852 • 2018 ACR/ARHP Annual Meeting

    Pregnancy in Lupus: 17-Year U.S. Nationwide Trend in Obstetric and Maternal Outcomes

    Yiming Luo1, Jiehui Xu2 and Bella Y. Mehta3,4, 1Department of Medicine, Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY, 2Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY, 3Hospital for Special Surgery/Weill Cornell Medicine/Mailman School of Public Health, New York, NY, 4Patient Oriented Research Program, Columbia University Mailman School of Public Health, New York, NY

    Background/Purpose: Pregnancies in systemic lupus erythematosus (SLE) are considered high risk and associated with medical and obstetric complications [1]. Our objective was to study the…
  • Abstract Number: 1854 • 2018 ACR/ARHP Annual Meeting

    SLE Flares during and after Pregnancy Are Mild and Occur at Similar Rates

    Julia Davis-Porada1, Sam Stern2, Marta M. Guerra3, Carl Laskin4,5, Michelle Petri6, Michael Lockshin7, Lisa R Sammaritano8,9, David Branch10,11, Allen D. Sawitzke12, Joan T. Merrill13,14, Jill P. Buyon15, Mimi Kim16 and Jane E. Salmon8,9, 1Research, Hospital for Special Surgery, New York, NY, 2Albert Einstein College of Medicine, New York, NY, 3Department of Medicine and Program in Inflammation and Autoimmunity, Hospital for Special Surgery, New York, NY, 4Mount Sinai Hospital Toronto, Toronto, ON, Canada, 5Trio Fertility, Toronto, ON, Canada, 6Johns Hopkins University School of Medicine, Baltimore, MD, 7Barbara Volcker Center, Hospital for Special Surgery, New York, NY, 8Hospital for Special Surgery, New York, NY, 9Weill Cornell Medicine, New York, NY, 10Intermountain Healthcare, Salt Lake City, UT, 11Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT, 12Rheumatology, University of Utah Health Sciences Center, Salt Lake City, UT, 13University of Oklahoma Health Sciences Center, Oklahoma City, OK, 14Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 15Medicine, New York University School of Medicine, New York, NY, 16Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Systemic lupus erythematosus (SLE) disproportionally affects women of childbearing age. Low disease activity for 6 months prior to conception leads to the best outcomes;…
  • Abstract Number: 2417 • 2018 ACR/ARHP Annual Meeting

    Pregnancy Outcomes in Systemic Lupus Erythematous and Pre-Systemic Lupus Erythematous: A Population-Based Cohort Study

    A. Nicole Wade1, Mary A. De Vera2, Eric C. Sayre3 and J. Antonio Avina-Zubieta4, 1Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada, 2Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, 3Arthritis Research Canada, Richmond, BC, Canada, 4Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada

    Background/Purpose: The adverse effects of systemic lupus erythematosus (SLE) on maternal and fetal outcomes in pregnancy have been explored mainly in clinic-based cohorts. However, data…
  • Abstract Number: 2423 • 2018 ACR/ARHP Annual Meeting

    Births to Women with Systemic Lupus Erythematosus Can be Identified Accurately in the Electronic Health Record

    Ashley Blaske1, Amanda M. Eudy2, Jim C. Oates3, Megan E. B. Clowse2 and April Barnado4, 1Medicine and Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 2Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC, 3Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 4Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN

     Background/Purpose: Studying births in women with systemic lupus erythematosus (SLE) is difficult given its rarity and the challenges of randomized trials. While the electronic health…
  • Abstract Number: 6 • 2017 ACR/ARHP Annual Meeting

    Pregnancy  Outcomes in a Cohort of Women with Antiphospholipid Syndrome. 25- Years  Long-Term Observation 

    Dana Tegzova1, Katerina Andelova2, Iva Kucerova2, Vera Vlasakova3, Stejskal Jan4, Putova Ivana5, Marta Olejarova6 and Ctibor Dostál7, 1Clinical Department, Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic, 2Institute of Mother and Child Care, Prague, Prague, Czech Republic, 3Dept.of Internal Medicine, City Hospital Ceske Budejovice, Ceske Budejovice, Czech Republic, 41st Medical Faculty, Dpt. of Pathology, Charles University, Prague, Czech Republic, 5Institute of Rheumatology, Dpt. of Immunology, Prague, Czech Republic, 6Clinical, Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic, 7Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic

    Background/Purpose: The goal of this long-term project was to investigate the course of pregnancy in patients with APS (primary or secondary with SLE) in 1993-2017,…
  • Abstract Number: 1297 • 2017 ACR/ARHP Annual Meeting

    Hydroxychloroquine in Lupus Pregnancy: A Meta-Analysis of Individual Participant Data

    Amanda M. Eudy1, Michelle Petri2, Rebecca Fischer-Betz3, Abeer Mokbel4, Cecilia Nalli5, Laura Andreoli5, Angela Tincani6, Yair Molad7, Stephen Balevic8 and Megan E. B. Clowse1, 1Rheumatology, Duke University Medical Center, Durham, NC, 2Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, 3Department of Rheumatology and Hiller Research Unit, University Hospital Duesseldorf, Duesseldorf, Germany, 4Department of Rheumatology and Rehabilitation, Cairo University Hospital, Cairo, Egypt, 5Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, 6Spedali Civili and University of Brescia, Brescia, Italy, 7Rheumatology Unit, Rabin Medical Center, Beilinson Hospital, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 8Rheumatology, Adult and Pediatric, Duke University Medical Center, Durham, NC

    Background/Purpose: Our current knowledge about how to treat lupus in pregnancy derives from small prospective or retrospective cohorts, and how best to manage lupus nephritis…
  • Abstract Number: 2044 • 2016 ACR/ARHP Annual Meeting

    Effect of Pregnancy on Disease Flares in Patients with Systemic Lupus Erythematosus

    Amanda M. Eudy1,2, Anna Maria Siega-Riz2, Stephanie Engel2, Nora Franceschini2, Annie Green Howard3, Megan E. B. Clowse1 and Michelle Petri4, 1Rheumatology, Duke University Medical Center, Durham, NC, 2Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 3Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 4Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: There are conflicting results about the effect pregnancy has on the health of systemic lupus erythematosus (SLE) women. The objective of the current analysis…
  • Abstract Number: 2433 • 2016 ACR/ARHP Annual Meeting

    Trends  in Use of Hydroxychloroquine during Pregnancy in SLE Patients from 2001 to 2012

    Bonnie L. Bermas1, Seoyoung Kim2,3, Krista Huybrechts4, Sonia Hernandez-diaz5, Brian T. Bateman6 and Rishi J. Desai7, 1Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 3Division of Pharmacoepidemiology and Pharmocoeconomics, Brigham and Women's Hospital, Boston, MA, 4Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston, MA, 5Harvard School of Public Health, Boston, MA, 6Division of Pharmacoepidemiology and Pharocoeconomics, Brigham and Women's Hospital, Boston, MA, 7PharmacoEpidemiology & PharmacoEconomics, Brigham & Women's Hospital, Boston, MA

    Background/Purpose : Data suggest that hydroxychloroquine (HCQ) use during systemic lupus erythematosus (SLE) pregnancies improves outcomes. In the past decade, single-center studies report that a…
  • Abstract Number: 2438 • 2016 ACR/ARHP Annual Meeting

    Increased Risk of Postpartum Depression in SLE Pregnancies

    Evelyne Vinet1, Susan Scott2, Debbie Ehrmann Feldman3, Christian A. Pineau4 and Sasha Bernatsky2, 1Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, 2Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 3School of Rehabilitation, Université de Montréal, Montreal, QC, Canada, 4McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: Chronic diseases have been shown to be a strong risk factor for postpartum depression. Although there is a 2-fold increased risk of major depression…
  • Abstract Number: 2121 • 2015 ACR/ARHP Annual Meeting

    Placentas of Lupus Pregnancies Are Characterized By Marked Inflammatory Changes Despite Good Disease Control

    Wendy Marder1, Jason S. Knight2, Mariana J. Kaplan3, Emily C. Somers4, Xu Zhang4, Alexander A. O'Dell5, Vasantha Padmanabhan4 and Richard W. Lieberman4, 1Div of Rheumatology, University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, University of Michigan, Ann Arbor, MI, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4University of Michigan, Ann Arbor, MI, 5Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose:   Systemic lupus erythematosus (SLE) is associated with increased risk of adverse pregnancy outcomes (APO), including preeclampsia and intrauterine growth restriction.  While significant placental…
  • Abstract Number: 2200 • 2015 ACR/ARHP Annual Meeting

    Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking Clinical Database and Repository Cluster Analysis: Identification of Different Clinical Phenotypes Among Antiphospholipid Antibody-Positive Female Patients

    Stephane Zuily1, Cecilia B. Chighizola2, DENIS WAHL1, Pier Luigi Meroni3 and Doruk Erkan4, 1CHU de Nancy, Vascular Medicine Division and Regional Competence Centre For Rare Vascular And Systemic Autoimmune Diseases; and UMR_S U1116 Research Unit, France, Nancy, France, 2Department of Clinical Sciences and Community Health, University of Milan, Istituto Auxologico Italiano, Cusano Milanino, Italy, 3University of Milan, Department of Clinical Sciences and Community Health, Division of Rheumatology, Gaetano Pini Institute, Milan, Italy, 4Barbara Volcker Center for Women & Rheumatic Disease, Hospital for Special Surgery, New York, NY

    Background/Purpose: APS ACTION International Clinical Database and Repository was created to study the natural course of persistently antiphospholipid antibodies (aPL)-positive patients ± autoimmune disorders over…
  • Abstract Number: 2533 • 2015 ACR/ARHP Annual Meeting

    A Comparison of Pregnancy Outcomes before and after Lupus Diagnosis

    Megan E. B. Clowse1, Maria Dall'Era2, Jennifer M. Grossman3,4, Diane L. Kamen5, Jerry McGwin6, Robert Roubey7 and Jill P. Buyon8, 1Rheumatology & Immunology, Duke University, Durham, NC, 2University of California San Francisco School of Medicine, San Francisco, CA, 3Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, 4Rheumatology, UCLA, Los Angeles, CA, 5Medicine, Medical University of South Carolina, Charleston, SC, 6Deparment of Epidemiology, University Of Alabama at Birmingham, School of Public Health, Birmingham, AL, 7University of North Carolina, Chapel Hill, NC, 8Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY

    Background/Purpose: The frequency of pregnancy complications, including miscarriage, stillbirth, preeclampsia, and preterm birth varies between lupus cohorts.  This analysis compares pregnancy outcomes that occurred before…
  • Abstract Number: 2535 • 2015 ACR/ARHP Annual Meeting

    Increased Direct Healthcare Costs in SLE Pregnancies

    Cristiano Moura1, Sasha Bernatsky2, Yvan St. Pierre3, Susan Scott3, Christian A. Pineau4, Ann E. Clarke5 and Evelyne Vinet4, 1Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 2Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 3Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 4Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, 5Division of Rheumatology, University of Calgary, Calgary, AB, Canada

    Background/Purpose: Although adverse obstetrical complications are more frequent in SLE women, no one has evaluated healthcare costs during SLE pregnancies. Thus, we aimed to evaluate…
  • Abstract Number: 2537 • 2015 ACR/ARHP Annual Meeting

    Prescription Medication Use in Sweden Among Pregnant Women with Systemic Lupus Erythematosus and General Population Comparators

    Kristin Palmsten1, Julia F Simard2,3, Christina D Chambers1,4 and Elizabeth V Arkema5, 1Department of Pediatrics, University of California, San Diego, La Jolla, CA, 2Division of Epidemiology, Health Research and Policy Department, and Division of Immunology & Rheumatology, Department of Medicine, Stanford School of Medicine, Stanford, CA, 3Clinical Epidemiology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 4Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, 5Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: There is limited information regarding medication use patterns among pregnant women with systemic lupus erythematosus (SLE). We aimed to characterize trends of medications used…
  • Abstract Number: 2538 • 2015 ACR/ARHP Annual Meeting

    A Population-Based Assessment of Induced Abortions in Women with Systemic Lupus Erythematosus

    Evelyne Vinet1, Emily McDonald2, Susan Scott3, Christian A. Pineau1 and Sasha Bernatsky4, 1Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, 2McGill University, Montreal, QC, Canada, 3Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 4Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: SLE women with unplanned pregnancies might be at increased risk of both disease and pregnancy complications. Until now, there has been no population-based estimate…
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