Abstracts tagged "phenotypes and systemic lupus erythematosus (SLE)"

Abstract Number: 1692 • 2018 ACR/ARHP Annual Meeting
Using ICD-10-CM Codes to Identify Patients with Systemic Lupus Erythematosus in the Electronic Health Record
April Barnado¹, Robert Carroll², Joshua C. Denny² and Leslie Crofford¹, ¹Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, ²Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: The electronic health record (EHR) serves as a powerful tool to enable researchers to collect a large cohort of patients across the healthcare system. …
Abstract Number: 2837 • 2018 ACR/ARHP Annual Meeting
Diminished STAT-3 Phosphorylation and Associated Cell Pathways Characterize MMF-Treated Systemic Lupus Erythematosus Patients
Samantha Slight-Webb¹, Joel M. Guthridge¹, Eliza Chakravarty¹, Hua Chen¹, Rufei Lu², Krista M. Bean¹, Holden T. Maecker³, Paul J. Utz⁴ and Judith A. James⁵, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Stanford University, Stanford, CA, ⁴Medicine, Stanford University School of Medicine, Stanford, CA, ⁵Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Mycophenolate mofetil (MMF) is a commonly used medication to treat major organ involvement in SLE, specifically in patients with lupus nephritis. The safety and…
Abstract Number: 712 • 2017 ACR/ARHP Annual Meeting
Novel Electronic Health Record Method Reveals That dsDNA Antibody-Negative Systemic Lupus Erythematosus Is Associated with Pain, Sleep, and Mood Disorders
April Barnado¹, Robert Carroll², Carolyn Casey³, Joshua C. Denny² and Leslie Crofford¹, ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, ³Lehigh Valley Health Network, Allentown, PA
Background/Purpose: Systemic lupus is a heterogeneous disease with diverse presentations. Studies have shown that dsDNA antibodies associate with renal disease. However, less is known about…
Abstract Number: 713 • 2017 ACR/ARHP Annual Meeting
Long-Term Outcomes in Prolonged Low Disease Activity Are Comparable to Complete Clinical Remission in Systemic Lupus Erythematosus
Konstantinos Tselios¹, Dafna D Gladman², Zahi Touma³, Jiandong Su⁴, Nicole Anderson² and Murray Urowitz⁵, ¹Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, University of Toronto, Division of Rheumatology, Institute of Health Policy, Management and Evaluation, Toronto, ON, Canada, ⁴University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁵Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Prolonged clinical remission is a desirable, though rare outcome in systemic lupus erythematosus (SLE). We recently showed that low disease activity (LDA) state confers…
Abstract Number: 1591 • 2017 ACR/ARHP Annual Meeting
Monophasic Disease Course Pattern in Systemic Lupus Erythematosus
Konstantinos Tselios¹, Dafna D Gladman², Zahi Touma³, Jiandong Su⁴, Nicole Anderson² and Murray Urowitz⁵, ¹Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, University of Toronto, Division of Rheumatology, Institute of Health Policy, Management and Evaluation, Toronto, ON, Canada, ⁴University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁵Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Disease course in systemic lupus erythematosus (SLE) is believed to follow three distinct patterns over time, namely relapsing-remitting, persistently active and prolonged quiescent. We…
Abstract Number: 1672 • 2017 ACR/ARHP Annual Meeting
Cytokines and Autoantibody Cluster-Interaction in Systemic Lupus Erythematosus. a Systems Medicine Approach
Julian Barahona-Correa, Yovana Pacheco, Diana M. Monsalve, Manuel Rojas, Yhojan Rodríguez, Juliana Saavedra, Mónica Rodríguez-Jiménez, Ruben Mantilla, Carolina Ramírez-Santana, Nicolás Molano-González and Juan-Manuel Anaya, Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia
Background/Purpose: Evidence supports the existence of different sub-phenotypes and the pivotal role of cytokines and autoantibodies in systemic lupus erythematosus (SLE). Cytokines interact in a…
Abstract Number: 2596 • 2017 ACR/ARHP Annual Meeting
Hydroxychloroquine Use Is Associated with Decreased Dendritic Cell Activation and Thrombolytic Factors in SLE Patients
Samantha Slight-Webb¹, Rufei Lu², Hua Chen¹, Holden T. Maecker³, Paul J. Utz⁴, Joel M. Guthridge⁵ and Judith A. James⁶, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Medicine, Stanford University School of Medicine, Stanford, CA, ⁵Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: The antimalarial drug hydroxychloroquine (HCQ) has been used for decades to treat various rheumatic diseases including systemic lupus erythematosus (SLE). The efficacy of HCQ…
Abstract Number: 1391 • 2016 ACR/ARHP Annual Meeting
Novel Electronic Health Record-Based Method Confirms Increased Renal Disease Burden in Pediatric-Onset Vs. Adult-Onset Patients with Systemic Lupus Erythematosus
April Barnado¹, Robert Carroll², Carolyn Casey¹, Joshua C. Denny² and Leslie J. Crofford³, ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, ³Medicine, Vanderbilt University Medical Center, Nasville, TN
Background/Purpose: Children with Systemic Lupus Erythematosus (SLE) are often understudied compared with adults. Using the electronic health record (EHR) can increase sample size and the…
Abstract Number: 1783 • 2016 ACR/ARHP Annual Meeting
Phenome-Wide Association Study Identifies a New Association of Atrial Fibrillation in Males with Systemic Lupus Erythematosus
April Barnado¹, Robert Carroll², Carolyn Casey¹, Joshua C. Denny² and Leslie J. Crofford³, ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, ³Medicine, Vanderbilt University Medical Center, Nasville, TN
Background/Purpose: Systemic lupus erythematosus (SLE) has a female to male ratio of 9:1. While SLE is more prevalent in females, males with SLE may have…
Abstract Number: 793 • 2015 ACR/ARHP Annual Meeting
Mesenchymal Stem Cells Promote the Generation of CD206+ Macrophage and Increase Its Phagocytic Activity in Systemic Lupus Erythematosus
Wei Deng, Weiwei Chen, Zhuoya Zhang, Saisai Huang, Wei Kong, Yue Sun, Xuebing Feng, Xiaojun Tang, Genhong Yao and Lingyun Sun, Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Umbilical cord (UC)-derived mesenchymal stem cells (MSCs) have been confirmed to exert therapeutic effects on systemic lupus erythematosus (SLE). Deficiency in SLE macrophages exhibits…
Abstract Number: 3125 • 2015 ACR/ARHP Annual Meeting
White Matter Magnetization Transfer Ratio Histogram Peak Height Helps Identifying Inflammatory Neuropsychiatric Systemic Lupus Erythematosus
César Magro Checa¹, Ece Ercan², Bart J Emmer³, Ron Wolterbeek⁴, Itamar Ronen², Mark A. Van Buchem², T. W. J. Huizinga⁵ and Gerda M. Steup-Beekman⁵, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, Netherlands, ⁵Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Magnetization transfer ratio (MTR) can be used to detect microstructural cerebral changes in normal-appearing brain tissue of neuropsychiatric systemic lupus erythematosus (NPSLE) patients. Our…

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