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Abstracts tagged "Periodontitis"

  • Abstract Number: 2577 • 2016 ACR/ARHP Annual Meeting

    Elevated Matrix Metalloproteinases Levels in Oral Fluids of Most Rheumatoid Arthritis Patients, Even without Frank Periodontitis

    Sheila Arvikar1, Hatice Hasturk2, Klemen Strle3, Marcy Bolster4, Deborah Collier5, Alpdogan Kantarci2 and Allen C. Steere6, 1Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Charlestown, MA, 2Department of Applied Oral Health Sciences, Forsyth, Cambridge, MA, 3Massachusetts General Hospital, Harvard Medical School, Boston, MA, 4Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, 5Rheumatology, Massachusetts General Hospital, Boston, MA, 6Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose:  Periodontitis shares pathogenic mechanisms with rheumatoid arthritis (RA) and may trigger its onset. However, little information is available about inflammatory responses in oral fluids…
  • Abstract Number: 507 • 2016 ACR/ARHP Annual Meeting

    Comparison of Body Mass Index, Anti-Citrullinated Peptides Antibodies Status and Periodontal Condition in First Degree Relatives Individuals to Rheumatoid Arthritis

    Sonia Unriza-Puin1, Wilson Bautista-Molano2,3, Gloria Lafaurie4, Rafael R. Valle-Oñate5, Phillipe Chalem6, Lorena Chila3, Juan Manuel Bello7 and Consuelo Romero Sanchez3,8, 1Unit of Oral Basic Investigation, School of Dentistry, Universidad El Bosque, Bogota, Colombia, 2Rheumatology Department School of Medicine HMC / UMNG, Bogotá, Colombia, 3Unit of Oral Basic Investigation, School of Dentistry, Universidad El Bosque, Bogotá, Colombia, 4Unit of Oral Basic Investigation-UIBO, School of Dentistry, Universidad El Bosque, Bogotá, Colombia, 5Rheumatology, Rheumatology Department School of Medicine HMC / UMNG, Bogota, Colombia, 6Fundación Instituto de Reumatología Fernando Chalem, Bogotá, Colombia, 7Rheumatology Department School of Medicine HMC / UMNG, Bogota, Colombia, 8Rheumatology, School of Medicine HMC / UMNG, Bogota, Colombia

    Background/Purpose:  Association studies in rheumatoid arthritis (RA) have been focused in the pre-clinical phases of the disease in asymptomatic individuals with higher risk to develop…
  • Abstract Number: 572 • 2016 ACR/ARHP Annual Meeting

    Anti-Periodontal Bacteria Antibody Titers Are Inversely Correlated with ACPA in RA-Free Individuals with Periodontal Disease Compared to Community Controls

    Emma Weeding1, Londyn Robinson2, Jeremy Sokolove3, Julie Marchesan4, Steven Offenbacher4, William H. Robinson3, Ryan Demmer5, Bryan Michalowicz6 and Jerry A. Molitor7, 1Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 2University of Minnesota, Minneapolis, MN, 3Stanford University School of Medicine, Stanford, CA, 4Department of Periodontology, Dental School, University of North Carolina at Chapel Hill, Chapel Hill, NC, 5Epidemiology, Columbia University Mailman School of Public Health, New York, NY, 6Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, 7Rheumatic/Autoimmune Diseases, University of Minnesota, Minneapolis, MN

    Background/Purpose: Rheumatoid arthritis (RA) and periodontal disease (PD) are comorbid conditions that share multiple underlying risk factors and pathophysiological features. A dysbiotic periodontal microbiome might…
  • Abstract Number: 1515 • 2016 ACR/ARHP Annual Meeting

    Could Increase Levels of Dickkopf-1 Protein be Considered As a Potential Biomarker for Bone Resorption in Joint and Periodontal Disease in Patients with Early Rheumatoid Arthritis?

    ANA MARIA HEREDIA PALAU1, SEBASTIAN GIRALDO QUINTERO2,3, JULIETTE DE AVILA1, LORENA CHILA MORENO4, GLORIA LAFAURIE5, CONSTANZA RODRIGUEZ4, WILSON BAUTISTA-MOLANO5,6, PHILLIPE CHALEM CHOUEKA7, JUAN MANUEL BELLO GUALTEROS3,8, RAFAEL VALLE-OÑATE3,8 and CONSUELO ROMERO-SÁNCHEZ4,9,10, 1Unit of Oral Basic Investigation-UIBO, School of Dentistry, Universidad El Bosque, Bogota, Colombia, 2Rheumatology and Immunology Department,Hospital Militar Central, Bogota, Colombia, 3School of Medicine, Universidad Militar Nueva Granada, Bogota, Colombia, 4Unit of Oral Basic Investigation-UIBO, School of Dentistry, Universidad El Bosque, BOGOTA, Colombia, 5Unit of Oral Basic Investigation-UIBO, School of Dentistry, Universidad El Bosque, Bogotá, Colombia, 6School of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia, 7Fundación Instituto de Reumatología Fernando Chalem, Bogotá, Colombia, 8Rheumatology and Immunology, Hospital Militar Central, Bogota, Colombia, 9Rheumatology and Immunology Department,Hospital Militar Central, BOGOTA, Colombia, 10School of Medicine, Universidad Militar Nueva Granada, BOGOTA, Colombia

    Background/Purpose:  Periodontitis and rheumatoid arthritis (RA) are chronic destructive inflammatory diseases with significant worldwide prevalence. They are characterized by inflammatory lesions adjacent to bone destruction…
  • Abstract Number: 1549 • 2016 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis and Periodontal Disease: Salivary ACPA Levels and Clinical Presentation

    Zoltan Szekanecz1, Ildiko Tar2, Eva Csösz3, Eva Veiszenbacher4, Edit Végh5, Kinga Bágyi6, Karin Lundberg7, Nastya Kharlamova8 and Ildiko Márton2, 1Department of Rheumatology, University of Debrecen Faculty of Medicine, Debrecen, HU, 2Department of Periodontology, University of Debrecen Faculty of Dentistry, Debrecen, Hungary, 3Center for Molecular Medicine, University of Debrecen Faculty of Medicine, Debrecen, Hungary, 4Faculty of Dentistry, University of Tirgu Mures, Tirgu Mures, Romania, 5Department of Rheumatology, University of Debrecen Faculty of Medicine, Debrecen, Hungary, 6Department of Restorative Dentistry, University of Debrecen Faculty of Dentistry, Debrecen, Hungary, 7Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 8Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden

    Background/Purpose: We evaluated the periodontal involvement of rheumatoid arthritis (RA) patients, and we correlated with various laboratory biomarkers including lipids, autoantibodies, serum vitamin D levels,…
  • Abstract Number: 518 • 2015 ACR/ARHP Annual Meeting

    Antibody Responses to Citrullinated Porphyromonas Gingivalis Peptidylarginine Deiminase: Associations with Disease Risk Factors and Severity in Rheumatoid Arthritis

    Priyanka Vashisht1, Jeffrey Payne2, Geoffrey M. Thiele3, Harlan Sayles4, Fang Yu5, Michael J. Duryee6, Carlos D. Hunter6, Benjamin Wiese1, Anne-Marie Quirke7, Patrick Venables7 and Ted R. Mikuls8, 1Internal Medicine - Rheumatology, University of Nebraska Medical Center, Omaha, NE, 2College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 3Research Services 151, Omaha VA Medical Center, Omaha, NE, 4University of Nebraska Medical Center, Omaha, NE, 5Public Health, University of Nebraska Medical Center, Omaha, NE, 6Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 7Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 8Medicine, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by autoimmunity to citrullinated proteins. Porphyromonas gingivalis (Pg) has been proposed as an epidemiologic link between RA and periodontitis…
  • Abstract Number: 520 • 2015 ACR/ARHP Annual Meeting

    Antibody to Porphyromonas Gingivalis in Pre-Clinical Rheumatoid Arthritis

    Brian Coburn1, Kevin D. Deane2, Jess D. Edison3, Geoffrey M. Thiele1, Michael J. Duryee4, Carlos D. Hunter4, Jeffrey Payne5, Fang Yu6, Harlan Sayles6, V. Michael Holers2, Jill M. Norris7, William R Gilliland8, Jeremy Sokolove9, WH Robinson9 and Ted R. Mikuls1, 1Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 3Walter Reed National Military Medical Center, Bethesda, MD, 4Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 5College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 6University of Nebraska Medical Center, Omaha, NE, 7Epidemiology, University of Colorado Denver, Aurora, CO, 8Rheumatology Service, Walter Reed National Military Medical Center, Bethesda, MD, 9VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA

    Background/Purpose: Periodontitis (PD) has been implicated as an etiologic risk factor in rheumatoid arthritis (RA), an association that is speculated to be related to the…
  • Abstract Number: 965 • 2015 ACR/ARHP Annual Meeting

    Crystal Structure of Porphyromonas Gingivalis peptidylarginine Deiminase: Implications for Autoimmunity in Rheumatoid Arthritis

    Anna B. Montgomery1, Jolanta Kopec2, Leela Shresha2, Marie-Laetitia Thezenasc3, Nicola A. Burgess-Brown2, Roman Fischer3, Wyatt W. Yue2 and Patrick J. Venables1, 1Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 2Structural Genomics Consortium, University of Oxford, Oxford, United Kingdom, 3Target Discovery Institute, University of Oxford, Oxford, United Kingdom

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are the main autoantibody system in rheumatoid arthritis (RA), and due to high sensitivity and specificity testing using the anti-CCP2…
  • Abstract Number: 1206 • 2015 ACR/ARHP Annual Meeting

    Presence of ACPA in a Large (>40.000) Population Based Cohort from the Netherlands

    Elisabeth Brouwer1, Suzanne Arends2, Hendrika Bootsma1, Caroline Roozendaal3, Pieter C Limburg4, Fiona Maas1, René E. M. Toes5, T. W. J. Huizinga6, LA Trouw7 and Annemirthe Van Zanten1, 1Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 2Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands, 3Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands, 4Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 5Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 6Leiden University Medical Center, Leiden, Netherlands, 7Rheumatology, Leiden University Medical Centre, Leiden, Netherlands

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) status provides important information regarding the diagnosis and prognosis of Rheumatoid Arthritis (RA). By using samples from blood bank donors…
  • Abstract Number: 1577 • 2015 ACR/ARHP Annual Meeting

    Periodontal Evaluation Is Associated with Increased Likelihood of Achieving Low Disease Activity in Rheumatoid Arthritis with Methotrexate

    Melanie Rohr1, James R. O'Dell1, Abhijeet Danve2, Harlan Sayles1, Geoffrey M. Thiele3, Jeffrey Payne4 and Ted R. Mikuls5, 1University of Nebraska Medical Center, Omaha, NE, 2Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3Research Services 151, Omaha VA Medical Center, Omaha, NE, 4College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 5Medicine, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis (RA) outcomes have improved substantially due to the development of new drug therapies, but also due to emphasis on early aggressive MTX…
  • Abstract Number: 2721 • 2015 ACR/ARHP Annual Meeting

    Elevated Subgingival Levels of Periodontal Pathogens in Rheumatoid Arthritis Patients, Particularly Leptotrichia species in New-Onset Disease

    Sheila Arvikar1, Hatice Hasturk2, Daniel Nguyen2, Klemen Strle3, Marcy B. Bolster4, Deborah Collier5, Allen C. Steere6 and Alpdogan Kantarci2, 1Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Department of Applied Oral Health Sciences, Forsyth, Cambridge, MA, 3Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 4Rheumatology, Allergy, Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 5Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 6Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Periodontitis, a polymicrobial infectious and inflammatory disease of tooth-supporting structures, shares pathogenic mechanisms with rheumatoid arthritis (RA) and may trigger its onset. Most studies…
  • Abstract Number: 1393 • 2014 ACR/ARHP Annual Meeting

    Periodontal Disease and Its Impact on Structural Joint Damage in a Rheumatoid Arthritis Peruvian Population

    Rocio V. Gamboa-Cardenas1,2, Manuel F. Ugarte-Gil1,3, José Quiñones4, Francisco Zevallos-Miranda1, Fiorella Lazo4, J. Mariano Cucho-Venegas1, Risto A. Perich-Campos1,2, Jose L. Alfaro-Lozano1, Mariela Medina-Chinchon1, Zoila Rodriguez-Bellido1,2, Hugo Torrealva1 and Cesar A. Pastor-Asurza1,2, 1Rheumatology, Hospital Guillermo Almenara, EsSalud, Lima, Peru, 2Universidad Nacional Mayor de San Marcos, Lima, Peru, 3Universidad Cientifica del Sur, Lima, Peru, 4Odontology, Hospital Guillermo Almenara, EsSalud, Lima, Peru

    Background/Purpose Periodontal disease (PD) or periodontitis is currently considered an epigenetic determinant of both occurrence  and severity of Rheumatoid Arthritis (RA). Common pathophysiological mechanisms like…
  • Abstract Number: 936 • 2014 ACR/ARHP Annual Meeting

    Active Invasion of Periodontal Bacteria into Synovial Joint Exacerbates Collagen-Induced Arthritis in Disease-Prone B10 Riii Mice

    Sasanka Chukkapalli1, Mercedes Rivera-Kweh1, Irina Velsko1, Indraneel Bhattacharyya2, S. John Calise3, Edward Chan4, Minoru Satoh5 and Lakshmyya Kesavalu1, 1Periodontology, College of Dentistry, University of Florida, Gainesville, FL, 2Oral Diagnostic Sciences, College of Dentistry, University of Florida, Gainesville, FL, 3Oral Biology, University of Florida, Gainesville, FL, 4Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, 5Clinical Nursing, Univ. Occupational and Environmental Health, Kitakyushu, Fukuoka, FL, Japan

    Background/Purpose: Periodontitis (PD) is a chronic immunoinflammatory disease caused by complex subgingival periodontal bacteria. Rheumatoid Arthritis (RA) and PD both are chronic inflammatory disorders characterized…
  • Abstract Number: 453 • 2014 ACR/ARHP Annual Meeting

    In a Periodontal Disease Cohort without RA, Indeterminate or Low-Positive Anti-CCP-2 Antibodies Are Associated with Multiple Distinct ACPA

    Jerry A. Molitor1, Bryan S. Michalowicz2, Ryan T. Demmer3, Jane H. Buckner4, Mark H. Wener5 and William H. Robinson6, 1Rheumatology, University of Minnesota, Minneapolis, MN, 2Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, 3Epidemiology, Columbia Univ. Mailman School of Public Health, New York, NY, 4Benaroya Research Institute at Virginia Mason, Seattle, WA, 5Rheumatology & Lab Med, University of Washington, Seattle, WA, 6Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Periodontal disease (PD) and RA share the risk factors HLA DR B1 shared epitope (SE) and tobacco exposure (TE). PD may represent a risk…
  • Abstract Number: 812 • 2013 ACR/ARHP Annual Meeting

    Alveolar Bone Loss Is Associated With Disease Activity and ACPA Expression In Rheumatoid Arthritis

    Ted R. Mikuls1, Jeffrey Payne2, Fang Yu3, Geoffrey M. Thiele4, Shawneen Gonzalez2, Jeffrey Markt5, Jeremy Sokolove6, William H. Robinson7, Richard J. Reynolds8, Grant W. Cannon9, David McGowan10, Gail S. Kerr11, Robert Redman12, Andreas M. Reimold13, Garth Griffiths14, Mark Beatty2, Marian Schmid2, Paul Johnson2, Debra Bergman15, Bartlett C. Hamilton III16, Alan R. Erickson1 and James R. O'Dell17, 1Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 2College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 3University of Nebraska Medical Center, Omaha, NE, 4Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE, 5Otol-Head and Neck Surgery, University of Nebraska Medical Center, Omaha, NE, 6Stanford University, Palo Alto, CA, 7Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 8Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 9Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 10Dentistry, George E. Wahlen VA Medical Center, Salt Lake City, UT, 11Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, 12Dentistry, Washington DC VA, Georgetown and Howard University, Washington, DC, 13Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, 14Dentistry, Dallas VA and University of Texas Southwestern, Dallas, TX, 15Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 16University of Nebraska Medical Center and Omaha VA Medical Center, Omaha, NE, 17Dept of Internal Medicine, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Periodontitis (PD) has been implicated in rheumatoid arthritis (RA) pathogenesis including the expression of anti-citrullinated protein antibody (ACPA).  ACPA, in turn, have been shown…
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