Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Periodontitis shares pathogenic mechanisms with rheumatoid arthritis (RA) and may trigger its onset. However, little information is available about inflammatory responses in oral fluids of RA patients.
Results: The 33 patients were typical of RA cohorts (85% female, median age 51) and only one currently smoked. The majority (91%) received regular dental care with cleanings every 6 months. 58% had rheumatoid factor (RF) or anti-citrullinated protein antibody (ACPA).
Conclusion: RA patients had oral inflammation despite lack of smoking and regular dental care. Highly elevated MMP levels and correlation between dental parameters and ACPA support pathogenic connections between the diseases. Pg antibodies may be a marker of periodontitis in RA patients. However, elevation of MMPs in oral sites, regardless of periodontitis status or Pg antibodies, suggests the oral muscosa may be a common, and often unrecognized, site of extra-articular inflammation in RA patients.
To cite this abstract in AMA style:Arvikar S, Hasturk H, Strle K, Bolster M, Collier D, Kantarci A, Steere AC. Elevated Matrix Metalloproteinases Levels in Oral Fluids of Most Rheumatoid Arthritis Patients, Even without Frank Periodontitis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/elevated-matrix-metalloproteinases-levels-in-oral-fluids-of-most-rheumatoid-arthritis-patients-even-without-frank-periodontitis/. Accessed July 31, 2021.
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