Abstracts tagged "Pediatric rheumatology and systemic lupus erythematosus (SLE)"

Abstract Number: 1257 • 2013 ACR/ARHP Annual Meeting
Feasibility and Clinical Implications Of The Pediatric Automated Neuropsychological Assessment Metrics for Screening Of Childhood-Onset Neuropsychiatric Systemic Lupus Erythematosus
Patricia Vega-Fernandez¹, Natasha M. Ruth², Deborah M. Levy³, Frank Zelko⁴, Eyal Muscal⁵, Marisa S. Klein-Gitelman⁶, HaiMei Liu⁷, Adam Huber⁸, Jiha Lee⁹, Jessica Hummel⁹, Lori B. Tucker¹⁰, Tresa Roebuck-Spencer¹¹ and Hermine Brunner^12,13, ¹Division of Rheumatology, Cincinanti Children's Hospital Medical Center, Cincinnati, OH, ²Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, ³Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ⁴Pediatric Neuropsychology Service, Children's Memorial Hospital, Chicago, IL, ⁵TCH Pediatric Rheum Center, Baylor College of Medicine, Houston, TX, ⁶Division of Rheumatology, Children's Memorial Hospital, Chicago, IL, ⁷Children's Hospital of Fundan University, Shanghai, China, ⁸IWK Health Centre, Halifax, NS, Canada, ⁹Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁰Rheumatology, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, ¹¹Cognitive Science Research Center, University of Oklahoma, Norman, OK, ¹²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹³Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Neuropsychiatric disease is common in childhood-onset Systemic Lupus Erythematosus (cSLE). Signs of cNPSLE can be subtle and difficult to ascertain in daily clinical practice.…
Abstract Number: 2282 • 2012 ACR/ARHP Annual Meeting
Low Gene Copy Number for C4, C4A and C4B Is a Strong Risk Factor for Developing Systemic Lupus Erythematosus in Childhood
Luis Eduardo C. Andrade¹, Kaline M.C. Pereira², Atila G. A. Faria³, Bernadete Liphaus⁴, Adriana A. Jesus⁵, Clovis Silva⁶ and Magda Carneiro-Sampaio⁵, ¹Rheumatology Division, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ²Universidade Federal de São Paulo and Fleury Health and Medicine Laboratories, Sao Paulo, Brazil, ³Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ⁴Pediatria, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁵Pediatrics, Instituto da Criança da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil, ⁶Pediatric Rheumatology, MD; PhD, São Paulo-SP, Brazil
Background/Purpose: C4 is an important component of the Complement system and plays an essential role in the activation cascade of the classical Complement pathway. Complete…
Abstract Number: 929 • 2012 ACR/ARHP Annual Meeting
Epidemiology of the US National Burden of Pediatric Lupus Hospitalization From 2000-2009
Andrea Knight¹, Pamela Weiss², Knashawn Morales³ and Ron Keren⁴, ¹Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, PA, ⁴Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Studies indicate that of 11% of adult hospitalizations are related to systemic lupus erythematosus (SLE), with an average charge of $10,000 US per hospitalization…
Abstract Number: 671 • 2012 ACR/ARHP Annual Meeting
Differences in the SLE Clinical Phenotype by Age of Diagnosis
T. Clark Powell¹, Elizabeth E. Brown on behalf of PROFILE², Gerald McGwin Jr.³, Luis M. Vila⁴, Yesenia C. Santiago-Casas⁴, Michelle Petri⁵, Rosalind Ramsey-Goldman⁶, John D. Reveille⁷, Sergio Duran⁸, Sergio M.A. Toloza⁹, Robin L. Brey¹⁰, Agustin Escalante¹¹, Randy Q. Cron¹², Robert P. Kimberly on behalf of PROFILE investigators¹³ and Graciela S. Alarcon¹⁴, ¹Medicine, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, ⁵Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ⁸UIECD, Guadalajara, Mexico, Guadalajara, Mexico, ⁹Medicine, Hospital San Juan Bautista, Catamarca, Argentina, ¹⁰Medicine/Neurology, UTHSCSA, San Antonio, TX, ¹¹Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, ¹²Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹³Clinical Immun & Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ¹⁴Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that is characterized by the presence of antinuclear autoantibodies, complement activation and the formation and…
Abstract Number: 312 • 2012 ACR/ARHP Annual Meeting
Blood-Based Biomarkers of Neurocognitive Dysfunction in Childhood-Onset Systemic Lupus Erythematosus
Hermine Brunner¹, Jessica Hummel², Shannen Nelson³, Erin C. Thomas⁴, Jennifer L. Huggins¹, Megan L. Curran⁵, Jun Ying⁶ and Marisa S. Klein-Gitelman⁷, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ⁴Division of Rheumatology, Anne & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁵Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Medicine-Internal Medicine-General Medicine, University of Cincinnati, Cincinnati, OH, ⁷Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL
Background/Purpose: Several brain-reactive autoantibodies in the blood have been inconsistently associated with Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) in adults but very little is known whether…
Abstract Number: 289 • 2012 ACR/ARHP Annual Meeting
Mycophenolate Mofetil and Abatacept Combination Therapy in Refractory Pediatric Systemic Lupus Erythematosus Nephritis
Rhina Castillo¹, Suhas M. Radhakrishna², Andreas O. Reiff³ and Katherine AB Marzan¹, ¹Division of Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA, ²Pediatric Rheumatology, Kaiser Permananete Medical Group, Oakland, CA, ³Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA
Background/Purpose: Nephritis (LN) in pediatric systemic lupus erythematosus (pSLE) requires treatment (tx) with corticosteroids (CS) and other agents such as mycophenolate mofetil (MMF) or cyclophosphamide…
Abstract Number: 298 • 2012 ACR/ARHP Annual Meeting
Childhood-Onset Predicts Increased Disease Damage and Steroid Toxicity in a Cohort of Adults with Systemic Lupus Erythematosus
Erica F. Lawson¹, Laura Trupin², Jinoos Yazdany³, Aimee Hersh⁴, Emily von Scheven⁵ and Edward H. Yelin⁶, ¹Pediatrics, University of California, San Francisco, San Francisco, CA, ²Medicine, University of California San Francisco, San Francisco, CA, ³Medicine, University of California, San Francisco, San Francisco, CA, ⁴Pediatrics, University of Utah, Salt Lake City, UT, ⁵Pediatric Rheumatology, University of California San Francisco, San Francisco, CA, ⁶Arthritis Research Group, University of California, San Francisco, San Francisco, CA
Background/Purpose: While previous work has shown that adults with childhood-onset systemic lupus erythematosus (cSLE) have increased risk of mortality, renal disease and myocardial infarction as…
Abstract Number: 276 • 2012 ACR/ARHP Annual Meeting
Development of a Longitudinal, Propective Cohort of Young Adults with Childhood-Onset Systemic Lupus Erythematosus
Aimee Hersh¹, Erica F. Lawson², Emily von Scheven³, Edward H. Yelin⁴ and John F. Bohnsack⁵, ¹Pediatrics, University of Utah, Salt Lake City, UT, ²Pediatric Rheumatology, UC San Francisco, San Francisco, CA, ³Pediatric Rheumatology, University of California, San Francisco, San Francisco, CA, ⁴Medicine, UC San Francisco, San Francisco, CA, ⁵Dept of Pediatriacs, University of Utah, Salt Lake City, UT
Background/Purpose: Data on the adult outcomes of childhood-onset systemic lupus erythematosus (cSLE ) are lacking, and a feasible methodology is needed to obtain long-term follow-up…
Abstract Number: 280 • 2012 ACR/ARHP Annual Meeting
Pediatric Automated Neuropsychological Assessment Metrics As a Screening Tool for Neuropsychiatric Childhood-Onset Systemic Lupus Erythematosus
Patricia Vega-Fernandez¹, Eyal Muscal², Natasha M. Ruth³, Frank Zelko⁴, Andrea Vincent⁵, Erin C. Thomas⁶, Marisa S. Klein-Gitelman⁷, Debra Canter⁸, Alison Tian⁹, Lisa Ravindra¹⁰, HaiMei Liu¹¹, Jessica Hummel¹², Deborah M. Levy¹³, Hermine Brunner¹⁴ and Tresa Roebuck-Spencer⁵, ¹Pediatric Rheumatology, Cincinanti Children's Hospital Medical Center, Cincinnati, OH, ²TCH Pediatric Rheum Center, Baylor College of Medicine, Houston, TX, ³Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Pediatric Neuropsychology Service, Children's Memorial Hospital, Chicago, IL, ⁵Cognitive Science Research Center, University of Oklahoma, Norman, OK, ⁶Division of Rheumatology, Anne & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁷Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁸Pediatric Rheumatology, Texas Children's Hospital, Houston, TX, ⁹Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ¹⁰University Hospital, Cincinnati, Cincinnati, OH, ¹¹Children's Hospital of Fundan University, Shanghai, China, ¹²Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹³Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ¹⁴Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Neuropsychiatric involvement appears to be common in childhood-onset systemic lupus erythematosus (cSLE), with neurocognitive dysfunction (NCD) identified in as many as 59%. NCD is…
Abstract Number: 281 • 2012 ACR/ARHP Annual Meeting
The Pediatric Automated Neuropsychological Assessment Metrics – Reproducibility and Responsive to Change in Cognition in Childhood-Onset Lupus
Patricia Vega-Fernandez¹, Marisa S. Klein-Gitelman², Jessica Hummel³, Erin C. Thomas⁴, Jennifer L. Huggins⁵, Frank Zelko⁶, Tresa Roebuck-Spencer⁷, Jun Ying⁸ and Hermine Brunner⁵, ¹Division of Rheumatology, Cincinanti Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ³Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Division of Rheumatology, Anne & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁵Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Pediatric Neuropsychology Service, Children's Memorial Hospital, Chicago, IL, ⁷Center for the Study of Human Operator Performance, University of Oklahoma, Norman, OK, ⁸Medicine-Internal Medicine-General Medicine, University of Cincinnati, Cincinnati, OH
Background/Purpose: The Childhood-onset Systemic Lupus Erythematosus (cSLE) Neuropsychological Battery (AC&R 2010; 62: 1029-33) was introduced to standardize neuropsychological testing (NPT), specifically probing the domains Attention,…
Abstract Number: 283 • 2012 ACR/ARHP Annual Meeting
Hospitalizations for Patients with Chilhood-Onset Systemic Lupus Erythematosus in the Pediatric Health Information System Databse
Aimee O. Hersh¹, Charlie Casper¹, Tellen D. Bennett¹, Susan L. Bratton¹, John F. Bohnsack² and Rajendu Srivastava¹, ¹Pediatrics, University of Utah, Salt Lake City, UT, ²Dept of Pediatriacs, University of Utah, Salt Lake City, UT
Background/Purpose: To describe patient demographics, admission characteristics and clinical care for hospitalized patients with childhood-onset systemic lupus erythematous (SLE). Methods: Retrospective cohort study of the…
Abstract Number: 286 • 2012 ACR/ARHP Annual Meeting
The Association of N-Methyl-D-Aspartate Receptor Antibodies and Neurocognitive Dysfunction in Pediatric Lupus Patients and in the Offspring of Adult Patients with Lupus
Natasha M. Ruth¹, Mary C. Kral², Stephanie Slan³, Tamara K. Nowling⁴, Murray H. Passo¹ and Gary S. Gilkeson³, ¹Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, ²Genetics and Developmental Pediatrics, MUSC, Charleston, SC, ³Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Medical University of South Carolina, Charleston, SC
Background/Purpose: Approximately 1/5 of all systemic lupus erythematosus (SLE) starts in childhood and central nervous system (CNS) dysfunction is more common in childhood-onset SLE. CNS…

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