Abstracts tagged "Pediatric rheumatology and systemic lupus erythematosus (SLE)"

Abstract Number: 2679 • 2013 ACR/ARHP Annual Meeting
Incidence Rates Of Serious Infections and Infection Subtypes Among Pediatric Systemic Lupus Erythematosus Patients Enrolled In Medicaid, According To Medication Use
Linda T. Hiraki¹, Candace H. Feldman², Mary Beth Son³, Jessica M. Franklin⁴, Michael A. Fischer⁴, Daniel H. Solomon⁵, Seoyoung C. Kim⁶, Wolfgang C. Winkelmayer⁷ and Karen H. Costenbader², ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Immunology, Boston Children's Hospital, Boston, MA, ⁴Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, ⁵Division of Pharmacoepidemiology, Harvard Medical School, Brigham and Women's Hospital, Division of Rheumatology, Division of Pharmacoepidemiology, Boston, MA, ⁶Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁷Division of Nephrology, Stanford University School of Medicine, Stanford, CA
Incidence Rates Of Serious Infections and Infection Subtypes Among Pediatric Systemic Lupus Erythematosus Patients Enrolled In Medicaid, According To Medication UseBackground/Purpose: We investigated incidence rates…
Abstract Number: 2282 • 2012 ACR/ARHP Annual Meeting
Low Gene Copy Number for C4, C4A and C4B Is a Strong Risk Factor for Developing Systemic Lupus Erythematosus in Childhood
Luis Eduardo C. Andrade¹, Kaline M.C. Pereira², Atila G. A. Faria³, Bernadete Liphaus⁴, Adriana A. Jesus⁵, Clovis Silva⁶ and Magda Carneiro-Sampaio⁵, ¹Rheumatology Division, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ²Universidade Federal de São Paulo and Fleury Health and Medicine Laboratories, Sao Paulo, Brazil, ³Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ⁴Pediatria, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁵Pediatrics, Instituto da Criança da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil, ⁶Pediatric Rheumatology, MD; PhD, São Paulo-SP, Brazil
Background/Purpose: C4 is an important component of the Complement system and plays an essential role in the activation cascade of the classical Complement pathway. Complete…
Abstract Number: 929 • 2012 ACR/ARHP Annual Meeting
Epidemiology of the US National Burden of Pediatric Lupus Hospitalization From 2000-2009
Andrea Knight¹, Pamela Weiss², Knashawn Morales³ and Ron Keren⁴, ¹Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, PA, ⁴Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Studies indicate that of 11% of adult hospitalizations are related to systemic lupus erythematosus (SLE), with an average charge of $10,000 US per hospitalization…
Abstract Number: 671 • 2012 ACR/ARHP Annual Meeting
Differences in the SLE Clinical Phenotype by Age of Diagnosis
T. Clark Powell¹, Elizabeth E. Brown on behalf of PROFILE², Gerald McGwin Jr.³, Luis M. Vila⁴, Yesenia C. Santiago-Casas⁴, Michelle Petri⁵, Rosalind Ramsey-Goldman⁶, John D. Reveille⁷, Sergio Duran⁸, Sergio M.A. Toloza⁹, Robin L. Brey¹⁰, Agustin Escalante¹¹, Randy Q. Cron¹², Robert P. Kimberly on behalf of PROFILE investigators¹³ and Graciela S. Alarcon¹⁴, ¹Medicine, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, ⁵Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ⁸UIECD, Guadalajara, Mexico, Guadalajara, Mexico, ⁹Medicine, Hospital San Juan Bautista, Catamarca, Argentina, ¹⁰Medicine/Neurology, UTHSCSA, San Antonio, TX, ¹¹Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, ¹²Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹³Clinical Immun & Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ¹⁴Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that is characterized by the presence of antinuclear autoantibodies, complement activation and the formation and…
Abstract Number: 312 • 2012 ACR/ARHP Annual Meeting
Blood-Based Biomarkers of Neurocognitive Dysfunction in Childhood-Onset Systemic Lupus Erythematosus
Hermine Brunner¹, Jessica Hummel², Shannen Nelson³, Erin C. Thomas⁴, Jennifer L. Huggins¹, Megan L. Curran⁵, Jun Ying⁶ and Marisa S. Klein-Gitelman⁷, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ⁴Division of Rheumatology, Anne & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁵Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Medicine-Internal Medicine-General Medicine, University of Cincinnati, Cincinnati, OH, ⁷Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL
Background/Purpose: Several brain-reactive autoantibodies in the blood have been inconsistently associated with Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) in adults but very little is known whether…
Abstract Number: 289 • 2012 ACR/ARHP Annual Meeting
Mycophenolate Mofetil and Abatacept Combination Therapy in Refractory Pediatric Systemic Lupus Erythematosus Nephritis
Rhina Castillo¹, Suhas M. Radhakrishna², Andreas O. Reiff³ and Katherine AB Marzan¹, ¹Division of Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA, ²Pediatric Rheumatology, Kaiser Permananete Medical Group, Oakland, CA, ³Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA
Background/Purpose: Nephritis (LN) in pediatric systemic lupus erythematosus (pSLE) requires treatment (tx) with corticosteroids (CS) and other agents such as mycophenolate mofetil (MMF) or cyclophosphamide…
Abstract Number: 298 • 2012 ACR/ARHP Annual Meeting
Childhood-Onset Predicts Increased Disease Damage and Steroid Toxicity in a Cohort of Adults with Systemic Lupus Erythematosus
Erica F. Lawson¹, Laura Trupin², Jinoos Yazdany³, Aimee Hersh⁴, Emily von Scheven⁵ and Edward H. Yelin⁶, ¹Pediatrics, University of California, San Francisco, San Francisco, CA, ²Medicine, University of California San Francisco, San Francisco, CA, ³Medicine, University of California, San Francisco, San Francisco, CA, ⁴Pediatrics, University of Utah, Salt Lake City, UT, ⁵Pediatric Rheumatology, University of California San Francisco, San Francisco, CA, ⁶Arthritis Research Group, University of California, San Francisco, San Francisco, CA
Background/Purpose: While previous work has shown that adults with childhood-onset systemic lupus erythematosus (cSLE) have increased risk of mortality, renal disease and myocardial infarction as…
Abstract Number: 276 • 2012 ACR/ARHP Annual Meeting
Development of a Longitudinal, Propective Cohort of Young Adults with Childhood-Onset Systemic Lupus Erythematosus
Aimee Hersh¹, Erica F. Lawson², Emily von Scheven³, Edward H. Yelin⁴ and John F. Bohnsack⁵, ¹Pediatrics, University of Utah, Salt Lake City, UT, ²Pediatric Rheumatology, UC San Francisco, San Francisco, CA, ³Pediatric Rheumatology, University of California, San Francisco, San Francisco, CA, ⁴Medicine, UC San Francisco, San Francisco, CA, ⁵Dept of Pediatriacs, University of Utah, Salt Lake City, UT
Background/Purpose: Data on the adult outcomes of childhood-onset systemic lupus erythematosus (cSLE ) are lacking, and a feasible methodology is needed to obtain long-term follow-up…
Abstract Number: 280 • 2012 ACR/ARHP Annual Meeting
Pediatric Automated Neuropsychological Assessment Metrics As a Screening Tool for Neuropsychiatric Childhood-Onset Systemic Lupus Erythematosus
Patricia Vega-Fernandez¹, Eyal Muscal², Natasha M. Ruth³, Frank Zelko⁴, Andrea Vincent⁵, Erin C. Thomas⁶, Marisa S. Klein-Gitelman⁷, Debra Canter⁸, Alison Tian⁹, Lisa Ravindra¹⁰, HaiMei Liu¹¹, Jessica Hummel¹², Deborah M. Levy¹³, Hermine Brunner¹⁴ and Tresa Roebuck-Spencer⁵, ¹Pediatric Rheumatology, Cincinanti Children's Hospital Medical Center, Cincinnati, OH, ²TCH Pediatric Rheum Center, Baylor College of Medicine, Houston, TX, ³Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Pediatric Neuropsychology Service, Children's Memorial Hospital, Chicago, IL, ⁵Cognitive Science Research Center, University of Oklahoma, Norman, OK, ⁶Division of Rheumatology, Anne & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁷Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁸Pediatric Rheumatology, Texas Children's Hospital, Houston, TX, ⁹Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ¹⁰University Hospital, Cincinnati, Cincinnati, OH, ¹¹Children's Hospital of Fundan University, Shanghai, China, ¹²Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹³Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ¹⁴Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Neuropsychiatric involvement appears to be common in childhood-onset systemic lupus erythematosus (cSLE), with neurocognitive dysfunction (NCD) identified in as many as 59%. NCD is…
Abstract Number: 281 • 2012 ACR/ARHP Annual Meeting
The Pediatric Automated Neuropsychological Assessment Metrics – Reproducibility and Responsive to Change in Cognition in Childhood-Onset Lupus
Patricia Vega-Fernandez¹, Marisa S. Klein-Gitelman², Jessica Hummel³, Erin C. Thomas⁴, Jennifer L. Huggins⁵, Frank Zelko⁶, Tresa Roebuck-Spencer⁷, Jun Ying⁸ and Hermine Brunner⁵, ¹Division of Rheumatology, Cincinanti Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ³Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Division of Rheumatology, Anne & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁵Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Pediatric Neuropsychology Service, Children's Memorial Hospital, Chicago, IL, ⁷Center for the Study of Human Operator Performance, University of Oklahoma, Norman, OK, ⁸Medicine-Internal Medicine-General Medicine, University of Cincinnati, Cincinnati, OH
Background/Purpose: The Childhood-onset Systemic Lupus Erythematosus (cSLE) Neuropsychological Battery (AC&R 2010; 62: 1029-33) was introduced to standardize neuropsychological testing (NPT), specifically probing the domains Attention,…
Abstract Number: 283 • 2012 ACR/ARHP Annual Meeting
Hospitalizations for Patients with Chilhood-Onset Systemic Lupus Erythematosus in the Pediatric Health Information System Databse
Aimee O. Hersh¹, Charlie Casper¹, Tellen D. Bennett¹, Susan L. Bratton¹, John F. Bohnsack² and Rajendu Srivastava¹, ¹Pediatrics, University of Utah, Salt Lake City, UT, ²Dept of Pediatriacs, University of Utah, Salt Lake City, UT
Background/Purpose: To describe patient demographics, admission characteristics and clinical care for hospitalized patients with childhood-onset systemic lupus erythematous (SLE). Methods: Retrospective cohort study of the…
Abstract Number: 286 • 2012 ACR/ARHP Annual Meeting
The Association of N-Methyl-D-Aspartate Receptor Antibodies and Neurocognitive Dysfunction in Pediatric Lupus Patients and in the Offspring of Adult Patients with Lupus
Natasha M. Ruth¹, Mary C. Kral², Stephanie Slan³, Tamara K. Nowling⁴, Murray H. Passo¹ and Gary S. Gilkeson³, ¹Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, ²Genetics and Developmental Pediatrics, MUSC, Charleston, SC, ³Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Medical University of South Carolina, Charleston, SC
Background/Purpose: Approximately 1/5 of all systemic lupus erythematosus (SLE) starts in childhood and central nervous system (CNS) dysfunction is more common in childhood-onset SLE. CNS…

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