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Abstracts tagged "pediatric rheumatology and rituximab"

  • Abstract Number: L04 • ACR/ARHP Annual Meeting 2018

    Pediatric Open-Label Clinical Study of Rituximab for the Treatment of Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA)

    Paul Brogan1, Gavin Cleary2, Aimee O. Hersh3, Ozgur Kasapcopur4, Satyapal Rangaraj5, Rae S.M. Yeung6, Andrew Zeft7, Simone Melega8, Paul Brunetta9, Jennifer Cooper10, Pooneh Pordeli11 and Patricia B. Lehane12, 1Infection Inflammation and Rheumatology, UCL GOL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, 2Alder Hey Children's Hospital, Liverpool, United Kingdom, 3Pediatrics/Rheumatology, University of Utah, Salt Lake City, UT, 4Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey, 5Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, 6Paediatrics, Immunology and Medical Science, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, 7Center for Pediatric Rheumatology & Immunology, The Cleveland Clinic Foundation, Cleveland, OH, 8F. Hoffmann-La Roche, Basel, Switzerland, 9Genentech, Inc., South San Francisco, CA, 10Pediatric Rheumatology, Univ. of California San Francisco, San Francisco, CA, 11Hoffmann-La Roche Ltd., Mississauga, ON, Canada, 12Roche Products Ltd., Welwyn Garden City, United Kingdom

    Background/Purpose: PePRS is a Phase IIa international, multicenter, open-label single arm study of rituximab in pediatric patients with newly diagnosed or relapsing GPA or MPA.…
  • Abstract Number: 1319 • ACR/ARHP Annual Meeting 2014

    Safety of Rituximab in Treating Pediatric Rheumatologic Disease

    Arunima Agarwal1, Anusha Ramanathan2 and Rhina Castillo3, 1Pediatric Rheumatology, Children's Hospital of Los Angeles, Los Angeles, CA, 2Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA, 3Pediatric Rheumatology, Childrens Hospital Los Angeles, Los Angeles, CA

    Background/Purpose Rituximab is a chimeric human/murine monoclonal antibody directed against the B cell specific antigen CD20. There is growing evidence that suggests Rituximab may also…
  • Abstract Number: 1297 • ACR/ARHP Annual Meeting 2014

    Safety and Efficacy of Rituximab in Pediatric Lupus and Other Rheumatic Diseases

    Ajay Tambralli1, Timothy Beukelman2, Randy Q. Cron2 and Matthew L. Stoll2, 1Medicine, University of Rochester, Rochester, NY, 2Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose:  Rituximab (RTX) is a chimeric monoclonal antibody that specifically targets CD20 positive B cells and is used successfully for a variety of pediatric rheumatologic…

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