Abstracts tagged "pathogenesis"

Abstract Number: 2394 • 2013 ACR/ARHP Annual Meeting
In Rheumatoid Arthritis, Smoking Is Not Primarily Associated With Anti-Citrullinated Protein Antibodies, But With The Presence Of Multiple Autoantibodies
Ammar Muhammad¹, Tineke van Wesemael², Yuta Kochi³, Maria Mjaavatten⁴, Kirsten Wevers-de-Boer¹, Cornelia F. Allaart¹, Leendert A. Trouw¹, Akari Suzuki³, Kazuhiko Yamamoto⁵, Annette H.M. van der Helm-van Mil¹, Tom W.J. Huizinga¹, René E.M. Toes¹ and Diane van der Woude¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ⁴Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁵Department of Allergy and Rhaumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Background/Purpose: Smoking is associated with the presence of several autoantibodies in various autoimmune diseases. In rheumatoid arthritis (RA), smoking has been described to be specifically…
Abstract Number: 1773 • 2013 ACR/ARHP Annual Meeting
The Contribution Of Environmental Factors To Familial Risk Of Rheumatoid Arthritis By Serologic Phenotypes Among Women In a Longitudinal Cohort Study
Jeffrey A. Sparks¹, Chia-Yen Chen², Linda T. Hiraki³, Susan Malspeis⁴, Karen H. Costenbader⁴ and Elizabeth W. Karlson¹, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Epidemiology, Harvard School of Public Health, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, ⁴Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Familial risk of RA is composed of shared genetic and environmental factors. Previous studies exploring familial risk of RA have not incorporated environmental factors…
Abstract Number: 1629 • 2013 ACR/ARHP Annual Meeting
Functional Effect Of NR1H3 (LXRA) Promoter Polymorphisms In Korean Patients With Systemic Lupus Erythematosus
Ja-Young Jeon¹, Hyoun-Ah Kim¹, Ju-Yang Jung¹ and Chang-Hee Suh², ¹Department of Rheumatology, Ajou University School of Medicine, Suwon, South Korea, ²Department of Rheumatology, Ajou University Hospital, Suwon, South Korea
Background/Purpose: Liver X receptor alpha (LXRA, NR1H3) and beta (LXRB, NR1H2) can influence macrophage biology by modulation of lipid metabolism and by effects on innate…
Abstract Number: 1394 • 2013 ACR/ARHP Annual Meeting
Self Reported Dental Symptoms Do Not Predict Periodontal Status In Patients With Rheumatoid Arthritis
Gurpal Buttar¹, Anastasia Zelekis-Cholakis², Robert Schroth², Hani S. El-Gabalawy³, Christine A. Peschken⁴ and Carol A. Hitchon⁵, ¹Department of Periodontics, University of Manitoba, Winnipeg, MB, Canada, ²Dental Diagnostics and Surgical Sciences, University of Manitoba, Winnipeg, MB, Canada, ³Arthritis Centre, University of Manitoba, Winnipeg, MB, Canada, ⁴RR 149G, University of Manitoba, Winnipeg, MB, Canada, ⁵University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Periodontal disease (PD) and inflammatory arthritis (IA) share features of inflammation and bone loss and are linked in epidemiologic studies. Severe PD may be…
Abstract Number: 1152 • 2013 ACR/ARHP Annual Meeting
Ligation Of TLR5 Promotes Myeloid Cell Infiltration and Differentiation Into Mature Osteoclasts In RA Patients and Experimental Arthritis
Seung-jae Kim¹, Zhenlong Chen¹, Nathan D. Chamberlain¹, Michael V. Volin², Suncica Volkov¹, William Swedler³, Shiva Arami⁴, Anjali Mehta⁵, Nadera J. Sweiss⁶ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ³Section of Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁴Medicine - Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁵University of Illinois at Chicago, Chicago, IL, ⁶internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of this study was to examine the importance of TLR5 ligation in the pathogenesis of rheumatoid arthritis (RA) and experimental arthritis. Methods:…
Abstract Number: 943 • 2013 ACR/ARHP Annual Meeting
Synergism Between Granulocyte-Macrophage Colony Stimulating Factor and Interleukin-17 Causes Joint Damage Via The Production Of Interleukin-23, Receptor Activator Of NF-κB Ligand and S100A8
Annemarie E.M. Van Nieuwenhuijze¹, Fons A.J. Van de Loo², Birgitte Walgreen³, Miranda B. Bennink⁴, Monique M. Helsen³, Liduine Van den Bersselaar¹, Ian P. Wicks^5,6, Wim B. Van den Berg⁷ and Marije I. Koenders⁷, ¹Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research and Advanced Therapeutics, Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Inflammation Division, Walter & Eliza Hall Institute of Medical Research, Melbourne, Australia, ⁶Department of Rheumatology, The Royal Melbourne Hospital, Melbourne, Australia, ⁷Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
Background/Purpose: T helper-17 (Th17) cells are important mediators of inflammatory diseases, and are the main pathogenic cell type in many animal models of autoimmunity. Recent…
Abstract Number: 809 • 2013 ACR/ARHP Annual Meeting
IgM Rheumatoid Factor As a Potentiator Of Anti-Citrullinated Protein Antibody Mediated Inflammation In Rheumatoid Arthritis
Jeremy Sokolove¹, Danye Cheng², Dannette S. Johnson³, Ted R. Mikuls⁴ and William H. Robinson⁵, ¹VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ²VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ³Rheumatology, Jackson VA and University of Mississippi Medical Center, Jackson, MS, ⁴Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁵Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: The co-occurrence of rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) is well described in rheumatoid arthritis (RA), and has been associated with…
Abstract Number: 2656 • 2013 ACR/ARHP Annual Meeting
Performance Of Prediction Models For Rheumatoid Arthritis Serologic Phenotypes Among Women Using Family History, Genetics and Environmental Factors
Jeffrey A. Sparks¹, Chia-Yen Chen², Xia Jiang³, Linda T. Hiraki⁴, Lars Klareskog⁵, Lars Alfredsson³, Karen H. Costenbader⁶ and Elizabeth W. Karlson¹, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Epidemiology, Harvard School of Public Health, Boston, MA, ³Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, ⁵Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁶Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Family history (FH) of autoimmunity, genetics, and environmental factors have been associated with RA. The area under the receiver operating characteristic curve (AUC) can…
Abstract Number: 692 • 2013 ACR/ARHP Annual Meeting
Characterization Of Lower Limb Cutaneous Ulcers In Systemic Sclerosis: The Analysis of 424 Lesions
Jelena Blagojevic^1,2, Guya Piemonte¹, Laura Benelli¹, Francesca Braschi¹, Ginevra Fiori¹, Felice Galluccio¹, Francesca Bartoli¹, Lorenza Busco³, Alberto Pignone³, Giulia Carnesecchi¹, Gemma Lepri⁴, Serena Guiducci¹ and Marco Matucci Cerinic¹, ¹Department of Biomedicine, Division of Rheumatology, University of Florence, Florence, Italy, ²Doctorate in Genetics, Oncology and Clinical Medicine, University of Siena, Siena, Italy, ³Department of Internal Medicine, University of Florence, Florence, Italy, ⁴Department of Internal Medicine, Section of Rheumatology, Transition Clinic, University of Florence, Florence, Italy
Background/Purpose: Cutaneous ulcers reppresent one of the most frequent complications in course of systemic sclerosis (SSc). They are often disabling and difficult to treat. The…
Abstract Number: 2642 • 2013 ACR/ARHP Annual Meeting
A Novel Genetic Basis For Systemic Vasculitis: Polyarteritis Nodosa Caused By Recessive Mutations In An Immune-Related Gene
Reeval Segel^1,2, Pnina Elkan-Navon³, Sarah B. Pierce⁴, Tom Walsh⁴, Judith Barash⁵, Shay Padeh⁶, Avraham Zlotogorski⁷, Yackov Berkun⁸, Isabel Voth⁹, Philip Hashkes¹⁰, Liora Harel¹¹, Eduard Ling¹², Fatos Yalcinkaya¹³, Ozgur Kasapcopur¹⁴, Paul F. Renbaum¹⁵, Ariella Weinberg-Shukron¹⁵, Barbara Schormair¹⁶, Mordechai Shohat¹⁷, Alan A. Rubinow¹⁸, Elon Pras¹⁹, Juliane Winkelmann²⁰, Mustafa Tekin²¹, Yair Anikster²², Mary-Claire King⁴ and Ephrat Levy-Lahad¹⁵, ¹Medical Genetics and Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel, ²Hebrew University Medical School, Jerusalem, Israel, ³Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel, ⁴Medical Genetics, University of Washington, Seattle, WA, ⁵Pediatric Day Care, Kaplan Medical Center, Rehovot, Israel, ⁶Pediatrics, Sheba Medical Center, Ramat Gan, Israel, ⁷Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, ⁸Pediatrics, Hadassah Medical Center, Mount Scopus, Jerusalem, Israel, ⁹Department of Neurology, Technische Universitat Munchen Klinikum rechts der Isar, Munich, Germany, ¹⁰Pediatric Rheumatology, Shaare Zedek Medical Center, Jerusalem, Israel, ¹¹Pediatric Rheumatology unit, Schneider Children's Medical Center, Tel Aviv University, Petach Tikvah, Israel, ¹²Rheumatology Unit, Soroka University Medical Center and Ben-Gurion University, Beer-Sheva, Beer Sheva, Israel, ¹³Pediatric Nephrology and Rheumatology, Ankara University, Ankara, Turkey, ¹⁴Ankara University, Ankara, Turkey, ¹⁵Medical Genetics, Shaare Zedek Medical Center, Jerusalem, Israel, ¹⁶Helmholtz Zentrum Munchen, Munich, Germany, ¹⁷Rafael Recanati medical genetics Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikvah, Israel, ¹⁸Hadassah Medical Center, Jerusalem, Israel, ¹⁹Institute of Human Genetics, Sheba Medical Center, Ramat Gan, Israel, ²⁰Genetics, Stanford University, San Francisco, CA, ²¹Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, ²²Metabolic Disease Unit, Sheba Medical Center, Ramat Gan, Israel
Background/Purpose: Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis. Disease pathogenesis and possible genetic factors are poorly understood. We identified familial, mostly pediatric PAN, in…
Abstract Number: 111 • 2013 ACR/ARHP Annual Meeting
Identifying Groups At Increased Risk Of Developing Rheumatoid Arthritis Using Family History and Genetic Risk Scores
Jeffrey A. Sparks¹, Chia-Yen Chen², Xia Jiang³, Johan Askling⁴, Linda T. Hiraki⁵, Lars Klareskog⁶, Lars Alfredsson³, Karen H. Costenbader⁷ and Elizabeth W. Karlson¹, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Epidemiology, Harvard School of Public Health, Boston, MA, ³Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, ⁶Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁷Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: The identification of high risk groups is crucial for RA prevention strategies. Individuals with family history (FH) of autoimmunity are at increased risk for…
Abstract Number: 1201 • 2012 ACR/ARHP Annual Meeting
Anti-Citrullinated Protein Antibody Specific Fc Glycosylation Patterns in Arthralgia Patients
Hans Ulrich Scherer¹, Yoann Rombouts², Ewoud Ewing³, Lotte van de Stadt⁴, Maurice H.J. Selman⁵, André M. Deelder³, Tom W.J. Huizinga², Manfred Wuhrer⁵, Dirkjan van Schaardenburg⁶ and René E.M. Toes², ¹Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands, ⁴Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ⁵Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands, ⁶Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) exhibit a specific, pro-inflammatory Fc glycosylation profile characterized by a low content of galactose and sialic acid residues. The absence…
Abstract Number: 1204 • 2012 ACR/ARHP Annual Meeting
Porphyromonas Gingivalis Antibody Responses and Clinical Associations in Patients with Early Rheumatoid Arthritis
Sheila L. Arvikar¹, Klemen Strle², Deborah S. Collier³, Mark C. Fisher¹, Gail McHugh⁴, Toshihisa Kawai⁵, Alpdogan Kantarci⁶ and Allen C. Steere⁷, ¹Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Rheumatology, Massachusetts General Hospital, Boston, MA, ⁴Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ⁵Forsyth Institute, Cambridge, MA, ⁶Forsyth Institute, Forsyth Institute, Cambridge, MA, ⁷Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA
Background/Purpose: Three prior studies have demonstrated an increased frequency of antibody responses to P. gingivalis (Pg), a leading agent of periodontal disease (PD), in RA…
Abstract Number: 1177 • 2012 ACR/ARHP Annual Meeting
Talin Is Cleaved and Expressed As a Short Form in Patients with Rheumatoid Arthritis
Kensei Tsuzaka¹, Masako Takao¹, Naoshi Shinozaki² and Jiro Nishida¹, ¹Dept of Internal Medicine, Ichikawa General Hospital,TDC, Ichikawa, Chiba, Japan, ²Cornea Center, Ichikawa General Hospital, TDC, Ichikawa, Japan
Methods: Western Blot analysis showed that the N-terminal 32kDa and the C-terminal 15kDa of calpain1 fragment of talin (32kDa and 15kDa short-talin, respectively) was expressed…
Abstract Number: 1181 • 2012 ACR/ARHP Annual Meeting
The Role of á-Defensin-1 and Its Signal Transduction Mechanisms in the Production of IL-6, IL-8 and MMPs in Rheumatoid Fibroblast-Like Synoviocytes
Joong Kyong Ahn¹, Bo Huang², Eun-Jung Park², Jiwon Hwang³, Jaejoon Lee², Chan Hong Jeon⁴, Eunmi Koh² and Hoon-Suk Cha⁵, ¹Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³Department of Medicine,Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea, ⁵Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose: Fibroblast-like synoviocytes (FLS) play an essential role in the pathophysiology of rheumatoid arthritis (RA). Also, neutrophils are the most abundant cell type of synovial…

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