ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "pathogenesis"

  • Abstract Number: 2394 • 2013 ACR/ARHP Annual Meeting

    In Rheumatoid Arthritis, Smoking Is Not Primarily Associated With Anti-Citrullinated Protein Antibodies, But With The Presence Of Multiple Autoantibodies

    Ammar Muhammad1, Tineke van Wesemael2, Yuta Kochi3, Maria Mjaavatten4, Kirsten Wevers-de-Boer1, Cornelia F. Allaart1, Leendert A. Trouw1, Akari Suzuki3, Kazuhiko Yamamoto5, Annette H.M. van der Helm-van Mil1, Tom W.J. Huizinga1, René E.M. Toes1 and Diane van der Woude1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, 4Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Department of Allergy and Rhaumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Background/Purpose: Smoking is associated with the presence of several autoantibodies in various autoimmune diseases. In rheumatoid arthritis (RA), smoking has been described to be specifically…
  • Abstract Number: 1773 • 2013 ACR/ARHP Annual Meeting

    The Contribution Of Environmental Factors To Familial Risk Of Rheumatoid Arthritis By Serologic Phenotypes Among Women In a Longitudinal Cohort Study

    Jeffrey A. Sparks1, Chia-Yen Chen2, Linda T. Hiraki3, Susan Malspeis4, Karen H. Costenbader4 and Elizabeth W. Karlson1, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Epidemiology, Harvard School of Public Health, Boston, MA, 3Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, 4Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Familial risk of RA is composed of shared genetic and environmental factors. Previous studies exploring familial risk of RA have not incorporated environmental factors…
  • Abstract Number: 1629 • 2013 ACR/ARHP Annual Meeting

    Functional Effect Of NR1H3 (LXRA) Promoter Polymorphisms In Korean Patients With Systemic Lupus Erythematosus

    Ja-Young Jeon1, Hyoun-Ah Kim1, Ju-Yang Jung1 and Chang-Hee Suh2, 1Department of Rheumatology, Ajou University School of Medicine, Suwon, South Korea, 2Department of Rheumatology, Ajou University Hospital, Suwon, South Korea

    Background/Purpose: Liver X receptor alpha (LXRA, NR1H3) and beta (LXRB, NR1H2) can influence macrophage biology by modulation of lipid metabolism and by effects on innate…
  • Abstract Number: 1394 • 2013 ACR/ARHP Annual Meeting

    Self Reported Dental Symptoms Do Not Predict Periodontal Status In Patients With Rheumatoid Arthritis

    Gurpal Buttar1, Anastasia Zelekis-Cholakis2, Robert Schroth2, Hani S. El-Gabalawy3, Christine A. Peschken4 and Carol A. Hitchon5, 1Department of Periodontics, University of Manitoba, Winnipeg, MB, Canada, 2Dental Diagnostics and Surgical Sciences, University of Manitoba, Winnipeg, MB, Canada, 3Arthritis Centre, University of Manitoba, Winnipeg, MB, Canada, 4RR 149G, University of Manitoba, Winnipeg, MB, Canada, 5University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: Periodontal disease (PD) and inflammatory arthritis (IA) share features of inflammation and bone loss and are linked in epidemiologic studies.  Severe PD may be…
  • Abstract Number: 1152 • 2013 ACR/ARHP Annual Meeting

    Ligation Of TLR5 Promotes Myeloid Cell Infiltration and Differentiation Into Mature Osteoclasts In RA Patients and Experimental Arthritis

    Seung-jae Kim1, Zhenlong Chen1, Nathan D. Chamberlain1, Michael V. Volin2, Suncica Volkov1, William Swedler3, Shiva Arami4, Anjali Mehta5, Nadera J. Sweiss6 and Shiva Shahrara1, 1Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, 2Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, 3Section of Rheumatology, University of Illinois at Chicago, Chicago, IL, 4Medicine - Rheumatology, University of Illinois at Chicago, Chicago, IL, 5University of Illinois at Chicago, Chicago, IL, 6internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL

    Background/Purpose: The aim of this study was to examine the importance of TLR5 ligation in the pathogenesis of rheumatoid arthritis (RA) and experimental arthritis. Methods:…
  • Abstract Number: 943 • 2013 ACR/ARHP Annual Meeting

    Synergism Between Granulocyte-Macrophage Colony Stimulating Factor and Interleukin-17 Causes Joint Damage Via The Production Of Interleukin-23, Receptor Activator Of NF-κB Ligand and S100A8

    Annemarie E.M. Van Nieuwenhuijze1, Fons A.J. Van de Loo2, Birgitte Walgreen3, Miranda B. Bennink4, Monique M. Helsen3, Liduine Van den Bersselaar1, Ian P. Wicks5,6, Wim B. Van den Berg7 and Marije I. Koenders7, 1Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research and Advanced Therapeutics, Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 4Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 5Inflammation Division, Walter & Eliza Hall Institute of Medical Research, Melbourne, Australia, 6Department of Rheumatology, The Royal Melbourne Hospital, Melbourne, Australia, 7Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands

    Background/Purpose: T helper-17 (Th17) cells are important mediators of inflammatory diseases, and are the main pathogenic cell type in many animal models of autoimmunity. Recent…
  • Abstract Number: 809 • 2013 ACR/ARHP Annual Meeting

    IgM Rheumatoid Factor As a Potentiator Of Anti-Citrullinated Protein Antibody Mediated Inflammation In Rheumatoid Arthritis

    Jeremy Sokolove1, Danye Cheng2, Dannette S. Johnson3, Ted R. Mikuls4 and William H. Robinson5, 1VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, 2VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 3Rheumatology, Jackson VA and University of Mississippi Medical Center, Jackson, MS, 4Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 5Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose:   The co-occurrence of rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) is well described in rheumatoid arthritis (RA), and has been associated with…
  • Abstract Number: 2656 • 2013 ACR/ARHP Annual Meeting

    Performance Of Prediction Models For Rheumatoid Arthritis Serologic Phenotypes Among Women Using Family History, Genetics and Environmental Factors

    Jeffrey A. Sparks1, Chia-Yen Chen2, Xia Jiang3, Linda T. Hiraki4, Lars Klareskog5, Lars Alfredsson3, Karen H. Costenbader6 and Elizabeth W. Karlson1, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Epidemiology, Harvard School of Public Health, Boston, MA, 3Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 4Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, 5Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 6Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Family history (FH) of autoimmunity, genetics, and environmental factors have been associated with RA. The area under the receiver operating characteristic curve (AUC) can…
  • Abstract Number: 692 • 2013 ACR/ARHP Annual Meeting

    Characterization Of Lower Limb Cutaneous Ulcers In Systemic Sclerosis: The Analysis of  424 Lesions

    Jelena Blagojevic1,2, Guya Piemonte1, Laura Benelli1, Francesca Braschi1, Ginevra Fiori1, Felice Galluccio1, Francesca Bartoli1, Lorenza Busco3, Alberto Pignone3, Giulia Carnesecchi1, Gemma Lepri4, Serena Guiducci1 and Marco Matucci Cerinic1, 1Department of Biomedicine, Division of Rheumatology, University of Florence, Florence, Italy, 2Doctorate in Genetics, Oncology and Clinical Medicine, University of Siena, Siena, Italy, 3Department of Internal Medicine, University of Florence, Florence, Italy, 4Department of Internal Medicine, Section of Rheumatology, Transition Clinic, University of Florence, Florence, Italy

    Background/Purpose: Cutaneous ulcers reppresent one of the most frequent complications in course of systemic sclerosis (SSc). They are often disabling and difficult to treat. The…
  • Abstract Number: 2642 • 2013 ACR/ARHP Annual Meeting

    A Novel Genetic Basis For Systemic Vasculitis: Polyarteritis Nodosa Caused By Recessive Mutations In An Immune-Related Gene

    Reeval Segel1,2, Pnina Elkan-Navon3, Sarah B. Pierce4, Tom Walsh4, Judith Barash5, Shay Padeh6, Avraham Zlotogorski7, Yackov Berkun8, Isabel Voth9, Philip Hashkes10, Liora Harel11, Eduard Ling12, Fatos Yalcinkaya13, Ozgur Kasapcopur14, Paul F. Renbaum15, Ariella Weinberg-Shukron15, Barbara Schormair16, Mordechai Shohat17, Alan A. Rubinow18, Elon Pras19, Juliane Winkelmann20, Mustafa Tekin21, Yair Anikster22, Mary-Claire King4 and Ephrat Levy-Lahad15, 1Medical Genetics and Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel, 2Hebrew University Medical School, Jerusalem, Israel, 3Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel, 4Medical Genetics, University of Washington, Seattle, WA, 5Pediatric Day Care, Kaplan Medical Center, Rehovot, Israel, 6Pediatrics, Sheba Medical Center, Ramat Gan, Israel, 7Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, 8Pediatrics, Hadassah Medical Center, Mount Scopus, Jerusalem, Israel, 9Department of Neurology, Technische Universitat Munchen Klinikum rechts der Isar, Munich, Germany, 10Pediatric Rheumatology, Shaare Zedek Medical Center, Jerusalem, Israel, 11Pediatric Rheumatology unit, Schneider Children's Medical Center, Tel Aviv University, Petach Tikvah, Israel, 12Rheumatology Unit, Soroka University Medical Center and Ben-Gurion University, Beer-Sheva, Beer Sheva, Israel, 13Pediatric Nephrology and Rheumatology, Ankara University, Ankara, Turkey, 14Ankara University, Ankara, Turkey, 15Medical Genetics, Shaare Zedek Medical Center, Jerusalem, Israel, 16Helmholtz Zentrum Munchen, Munich, Germany, 17Rafael Recanati medical genetics Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikvah, Israel, 18Hadassah Medical Center, Jerusalem, Israel, 19Institute of Human Genetics, Sheba Medical Center, Ramat Gan, Israel, 20Genetics, Stanford University, San Francisco, CA, 21Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, 22Metabolic Disease Unit, Sheba Medical Center, Ramat Gan, Israel

    Background/Purpose: Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis. Disease pathogenesis and possible genetic factors are poorly understood.  We identified familial, mostly pediatric PAN, in…
  • Abstract Number: 111 • 2013 ACR/ARHP Annual Meeting

    Identifying Groups At Increased Risk Of Developing Rheumatoid Arthritis Using Family History and Genetic Risk Scores

    Jeffrey A. Sparks1, Chia-Yen Chen2, Xia Jiang3, Johan Askling4, Linda T. Hiraki5, Lars Klareskog6, Lars Alfredsson3, Karen H. Costenbader7 and Elizabeth W. Karlson1, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Epidemiology, Harvard School of Public Health, Boston, MA, 3Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 4Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden, 5Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, 6Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 7Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: The identification of high risk groups is crucial for RA prevention strategies. Individuals with family history (FH) of autoimmunity are at increased risk for…
  • Abstract Number: 1201 • 2012 ACR/ARHP Annual Meeting

    Anti-Citrullinated Protein Antibody Specific Fc Glycosylation Patterns in Arthralgia Patients

    Hans Ulrich Scherer1, Yoann Rombouts2, Ewoud Ewing3, Lotte van de Stadt4, Maurice H.J. Selman5, André M. Deelder3, Tom W.J. Huizinga2, Manfred Wuhrer5, Dirkjan van Schaardenburg6 and René E.M. Toes2, 1Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands, 4Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 5Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands, 6Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) exhibit a specific, pro-inflammatory Fc glycosylation profile characterized by a low content of galactose and sialic acid residues. The absence…
  • Abstract Number: 1204 • 2012 ACR/ARHP Annual Meeting

    Porphyromonas Gingivalis Antibody Responses and Clinical Associations in Patients with Early Rheumatoid Arthritis

    Sheila L. Arvikar1, Klemen Strle2, Deborah S. Collier3, Mark C. Fisher1, Gail McHugh4, Toshihisa Kawai5, Alpdogan Kantarci6 and Allen C. Steere7, 1Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA, 3Rheumatology, Massachusetts General Hospital, Boston, MA, 4Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, 5Forsyth Institute, Cambridge, MA, 6Forsyth Institute, Forsyth Institute, Cambridge, MA, 7Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA

    Background/Purpose:  Three prior studies have demonstrated an increased frequency of antibody responses to P. gingivalis (Pg), a leading agent of periodontal disease (PD), in RA…
  • Abstract Number: 1177 • 2012 ACR/ARHP Annual Meeting

    Talin Is Cleaved and Expressed As a Short Form in Patients with Rheumatoid Arthritis

    Kensei Tsuzaka1, Masako Takao1, Naoshi Shinozaki2 and Jiro Nishida1, 1Dept of Internal Medicine, Ichikawa General Hospital,TDC, Ichikawa, Chiba, Japan, 2Cornea Center, Ichikawa General Hospital, TDC, Ichikawa, Japan

    Methods: Western Blot analysis showed that the N-terminal 32kDa and the C-terminal 15kDa of calpain1 fragment of talin (32kDa and 15kDa short-talin, respectively) was expressed…
  • Abstract Number: 1181 • 2012 ACR/ARHP Annual Meeting

    The Role of á-Defensin-1 and Its Signal Transduction Mechanisms in the Production of IL-6, IL-8 and MMPs in Rheumatoid Fibroblast-Like Synoviocytes

    Joong Kyong Ahn1, Bo Huang2, Eun-Jung Park2, Jiwon Hwang3, Jaejoon Lee2, Chan Hong Jeon4, Eunmi Koh2 and Hoon-Suk Cha5, 1Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, 2Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 3Department of Medicine,Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 4Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea, 5Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Background/Purpose: Fibroblast-like synoviocytes (FLS) play an essential role in the pathophysiology of rheumatoid arthritis (RA). Also, neutrophils are the most abundant cell type of synovial…
  • « Previous Page
  • 1
  • …
  • 6
  • 7
  • 8
  • 9
  • 10
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

Copyright Policy

View ACR Policies.

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology