Abstracts tagged "pathogenesis"

Abstract Number: 1963 • 2014 ACR/ARHP Annual Meeting
Hierarchical Role of PI3K/Akt/mTOR Signaling Cascade on: Tissue Inflammation, Organization and Angiogenesis in Autoimmune Arthritis
Siba Raychaudhuri¹, Anupam Mitra², Ananya Datta Mitra³, Christine Abria⁴ and Smriti K. Raychaudhuri³, ¹Med/Rheumatology, Univ California Davis/VA Sac, Davis, CA, ²Dermatology, VA Sacramento Medical Center, Mather, CA, ³Rheumatology, VA Sacramento Medical Center, Mather, CA, ⁴Research, VA Sacramento Medical Center, Mather, CA
Background/Purpose: The PI3K/Akt/mTOR signaling proteins are pro-growth/pro-survival and thus likely to regulate inflammatory cascades in autoimmune diseases (1). The key pathologic outcome in psoriatic arthritis…
Abstract Number: 1740 • 2014 ACR/ARHP Annual Meeting
Predicting the Evolution of Inflammatory Arthritis in ACPA-Positive Individuals: Can T-Cell Subsets Model Help?
Laura Hunt¹, Agata Burska², Elizabeth M.A. Hensor¹, Jackie L. Nam¹, Frederique Ponchel¹ and Paul Emery¹, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds., Leeds, United Kingdom
Background/Purpose: ACPA+ individuals with non-specific musculoskeletal symptoms are at high risk of developing rheumatoid arthritis (RA). We previously demonstrated dys-regulation of T-cell subsets with loss…
Abstract Number: 1466 • 2014 ACR/ARHP Annual Meeting
Patients with Active Rheumatoid Arthritis Display an Expanded Population of GM-CSF Expressing Peripheral B Cells
Sofia Adamidi, Anastasia Makris, Christos Koutsianas, Christina Tsalapaki, Emilia Hadziyannis and Dimitrios Vassilopoulos, 2nd Department of Medicine and Laboratory of Clinical Immunology-Rheumatology, Hippokration General Hospital, University of Athens Medical School, Athens, Greece
Background/Purpose GM-CSF has been implicated in rheumatoid arthritis (RA) pathogenesis and is being investigated as a novel therapeutic target. B cells secreting GM-CSF have been…
Abstract Number: 1457 • 2014 ACR/ARHP Annual Meeting
Stem Cell Growth Factor Expression in Rheumatoid Arthritis
Youn Jung Woo¹, Young Ae Baik¹, Yong-Beom Park², Soo-Kon Lee³, William H. Robinson⁴ and Jason Jungsik Song³, ¹Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ³Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ⁴Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Stem cell growth factor (SCGF) is a member of the C-type lectin superfamily, encoded by gene CLEC11A. SCGF is not related to stem cell…
Abstract Number: 1434 • 2014 ACR/ARHP Annual Meeting
The Longitudinal Association Between Inflammation and Blood Pressure in Rheumatoid Arthritis
Chih-Chin Liu¹, Daniel H. Solomon², Rishi Desai³, Seoyoung C. Kim⁴ and Katherine Liao⁵, ¹Rheumatology & Immunology, Brigham & Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³PharmacoEpidemiology & PharmacoEconomics, Brigham and Women's Hospital, Boston, MA, ⁴Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose Inflammation is hypothesized to have direct effects on arterial endothelial and vasomotor function, functions which regulate blood pressure (BP). While inflammation has been implicated…
Abstract Number: 449 • 2014 ACR/ARHP Annual Meeting
Citrullinated-Vimentin-Specific Regulatory T-Cell Responses Associate with ACPA Positive Individuals with Non-Specific Musculoskeletal Symptoms
Aamir Aslam¹, Jackie L. Nam¹, Laura Hunt¹, Chadi Rakieh¹, Ann W. Morgan² and Paul Emery¹, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom
Background/Purpose: The pathogenesis of RA can be conceptualised by sequential phases that precede the development of synovitis. Autoimmune antibody responses, including ACPA, can precede clinical…
Abstract Number: 433 • 2014 ACR/ARHP Annual Meeting
Bronchiectasis: A Model for Chronic Bacterial Infection Inducing Autoimmunity in Rheumatoid Arthritis
Anne-Marie Quirke¹, Elizabeth Perry², Alison Cartwright¹, Clive Kelly³, Anthony De Sozya^4,5, Paul Eggleton⁶, David Hutchinson² and Patrick Venables⁷, ¹Kennedy Institute, Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Rheumatology, Royal Cornwall Hospital, Truro, United Kingdom, ³Rheumatology, Queen Elizabeth Hospital, Gateshead, United Kingdom, ⁴Institute for Cellular Medicine, Newcastle University, Newcastle, United Kingdom, ⁵Sir William Leech Centre, The Freeman Hospital, Newcastle, United Kingdom, ⁶Medical School, University of Exeter, Exeter, United Kingdom, ⁷Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom
Background/Purpose Anti-citrullinated peptide antibodies (ACPA) are associated with smoking in patients with rheumatoid arthritis (RA). Bronchiectasis (BR), which tends to occur in non-smokers, has been…
Abstract Number: 338 • 2014 ACR/ARHP Annual Meeting
Bombina Variegate peptide8/Prokineticin 2: A Novel Arthritis-Inducible Chemokine
Haruyasu Ito, Ken Yoshida, Kentaro Noda and Daitaro Kurosaka, Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Background/Purpose Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by the joint destruction. Chemokines play important roles as monocyte and neutrophil recruiters in RA.…
Abstract Number: 2512 • 2013 ACR/ARHP Annual Meeting
Smoking Is Associated With More Severe Skin Disease In Subjects With Moderate To Severe Systemic Lupus Erythematosus (SLE)
Victoria P. Werth¹, Munther A. Khamashta², Gabor G. Illei³, Stephen Yoo³, Liangwei Wang⁴ and Warren Greth³, ¹Department of Dermatology, Veteran Affairs Medical Center, Philadelphia, PA, ²Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, ³Clinical Development, MedImmune, LLC, Gaithersburg, MD, ⁴Biostatistics, MedImmune, LLC, Gaithersburg, MD
Background/Purpose: The influence of smoking on the severity of cutaneous manifestations in adults with moderate to severe SLE was assessed in an ongoing international, multi-center,…
Abstract Number: L12 • 2013 ACR/ARHP Annual Meeting
Cetrorelix, a Gonadotropin-Releasing Hormone Antagonist, Demonstrates Efficacy and Significantly Reduces Proinflammatory Cytokines in Patients with Active Longstanding Rheumatoid Arthritis with High Gonadotropin Levels: A Proof-of-Concept, Double-Blind, Randomized Trial
Anita Kåss^1,2, Ivana Hollan³, Peter Torjesen⁴, Hans Christian Gulseth⁵ and Øystein T. Førre⁶, ¹Faculty of Medicine, University of Oslo, Oslo, Norway, ²Dept. of Rheumatology, Betanien Hospital, Skien, Norway, ³Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ⁴Department of Endocrinology, Oslo University Hospital, Oslo, Norway, ⁵Rheumatology, Betanien Hospital, Skien, Norway, ⁶Oslo University Hospital, Oslo, Norway
Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is unclear, and treatment options can be improved. Gonadotropin-releasing hormone (GnRH) stimulates immune responses (1). Inhibiting GnRH, by…
Abstract Number: 2412 • 2013 ACR/ARHP Annual Meeting
Anti-CCP Antibodies and Increased Cartilage Turnover In Patients Developing Rheumatoid Arthritis
Carl Turesson¹, Christina Book², Ulf Bergström², Lennart Truedsson³, Lennart Jacobsson² and Tore Saxne⁴, ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ³Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden, ⁴Section of Rheumatology, Deparment of Clinical Sciences, Lund, Lund University, Lund, Sweden
Background/Purpose: Autoantibodies may be detected years before the onset of rheumatoid arthritis (RA). We have previously shown that levels of Cartilage oligomeric matrix protein (COMP),…
Abstract Number: 2414 • 2013 ACR/ARHP Annual Meeting
Elevated Serum Resistin Levels In Rheumatoid Arthritis With Periodontitis
Byoong Yong Choi¹, Jin-Hee Kim², Kyung Hwa Kim², Kyong Rok Kim³, Sang Hyun Joo⁴, Myeong Jae Yoon³, Hye Jin Oh⁵, Hye Won Kim³, Sung Hae Chang⁶, Eun Young Lee³, Eun Bong Lee⁷, Yong-Moo Lee² and Yeong Wook Song³, ¹Division of Rheumatology, Department of Internal Medicine, Seoul Medical Center, Seoul, South Korea, Seoul, South Korea, ²Department of Periodontology, School of Dentistry, Seoul National University, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, ⁵Seoul National University, Seoul, South Korea, ⁶Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁷Division of Rheumatology, Department of Internal Medicine,, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose: Epidemiological relationships between rheumatoid arthritis (RA) and periodontitis (PD) have been revealed recently. However, the pathologic link between RA and periodontitis has remained unclear.…
Abstract Number: 2417 • 2013 ACR/ARHP Annual Meeting
Antibodies To Porphyromonas Gingivalis Peptidylarginine Deiminase In Rheumatoid Arthritis Are Not Directed Against The Autocitrullinated Enzyme
Maximilian F. Konig¹, Alizay Paracha², Malini Moni¹, Clifton O. Bingham III¹ and Felipe Andrade¹, ¹Division of Rheumatology, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²The University of Oklahoma, Norman, OK
Background/Purpose: Porphyromonas gingivalis (Pg) has received considerable attention by investigators trying to explain the striking association of periodontal disease (PD) and rheumatoid arthritis (RA). Bacterial…
Abstract Number: 2418 • 2013 ACR/ARHP Annual Meeting
The Transmembrane Protein Tyrosine Phosphatase Kappa Promotes Aggressiveness Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Stephanie M. Stanford¹, William B. Kiosses², Amanda M. Campbell³, Michael F. Maestre³, David L. Boyle⁴, Gary S. Firestein⁴ and Nunzio Bottini³, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²The Scripps Research Institute, La Jolla, CA, ³La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). In RA these cells…
Abstract Number: 2425 • 2013 ACR/ARHP Annual Meeting
Impaired TNFá Production By Dendritic Cells From Rheumatoid Arthritis Patients Upon Contact With Porphyromonas Gingivalis
Kim CM Santegoets^1,2, Mark H. Wenink^1,2, Wim B van den Berg³ and Timothy RDJ Radstake^2,4, ¹Department of Rheumatology & Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴Rheumatology & Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: The prevalence of periodontitis is increased in patients with rheumatoid arthritis (RA) and the severity of periodontitis can affect the level of arthritis. Porphyromonas…

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