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Abstracts tagged "PANS"

  • Abstract Number: 155 • Pediatric Rheumatology Symposium 2020

    Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) Is Characterized by a Novel Subset of Monocytes with Markers Associated with Crossing the Blood Brain Barrier (BBB)

    Shamma Rahman1, Fabian Gaertner 1, Jessica Houghton 1, Claudia Macaubas 1, Avis Chan 2, Laurie Columbo 1, Jennifer Frankovich 3 and Elizabeth Mellins 1, 1Stanford University, Stanford, 2Stanford University School of Medicine, Palo Alto, 3Stanford

    Background/Purpose: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by abrupt onset of obsessive-compulsive disorder (OCD) and/or food restriction with other specified neuropsychiatric symptoms.  65% of…
  • Abstract Number: 147 • Pediatric Rheumatology Symposium 2020

    Familial Clustering of Immune-mediated Diseases in Children with Abrupt-onset OCD

    Avis Chan 1, Tiffany Phu 1, Bahare Farhadian 2, Theresa Willett 3, Melissa Silverman 1, Paula Tran 1, Margo Thienemann 3 and Jennifer Frankovich4, 1Stanford University School of Medicine, Palo Alto, 2Stanford Immune Behavioral Health Clinic and PANS Research Program at Lucile Packard Children's Hospital, Palo Alto, 3Stanford University School of Medicine, Palo Alto, California, 4Stanford

    Background/Purpose: Recent epidemiologic studies have reported increased rates of immune-mediated comorbidities among first-degree relatives of patients with OCD and tic disorders.(Mataix-Cols et al., Mol Psychiatry…
  • Abstract Number: 148 • Pediatric Rheumatology Symposium 2020

    Chronic Fatigue Symptoms in Children with Abrupt Early-onset OCD And/or PANS

    Avis Chan 1, Angeline Truong 2, Bahare Farhadian 3, Theresa Willett 2, Melissa Silverman 1, Paula Tran 1, Margo Thienemann 2 and Jennifer Frankovich4, 1Stanford University School of Medicine, Palo Alto, 2Stanford University School of Medicine, Palo Alto, California, 3Stanford Immune Behavioral Health Clinic and PANS Research Program at Lucile Packard Children's Hospital, Palo Alto, 4Stanford

    Background/Purpose: Chronic Fatigue Syndrome (CFS)/Myalgic encephalomyelitis (ME) affects roughly 2.5 million people in the United States, and is challenging both in diagnosis and treatment. Many…
  • Abstract Number: 149 • Pediatric Rheumatology Symposium 2020

    Low C4 Copy Number of Total C4 Gene, C4B Gene and C4BL Gene in Children with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)

    Agnieszka Kalinowski 1, Justin Lee 2, Haley Hedlin 2, Reenal Pattini 2, Hanna Ollila 2, Emmanuel Mignot 1, Douglas Levinson 2, Susan Swedo 3, Tanya Murphy 4, Avis Chan 5, Margo Thienemann 1, Alexander Urban 2 and Jennifer Frankovich6, 1Stanford University School of Medicine, Palo Alto, California, 2Stanford University, Palo Alto, California, 3National Institute of Mental Health, Bethesda, Maryland, 4University of South Florida, Tampa, Florida, 5Stanford University School of Medicine, Palo Alto, 6Stanford

    Background/Purpose: Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) is characterized by sudden-onset OCD and additional neuropsychiatric symptoms. Imaging studies point to inflammation in the basal ganglia as…
  • Abstract Number: 150 • Pediatric Rheumatology Symposium 2020

    The Killer Immunoglobulin-like Receptor KIR3DL1 in Combination with HLA-Bw4 Is Associated with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)

    Jennifer Frankovich1, Kirstin Anderson 2, Gonzalo Montero-Martin 3, Avis Chan 4, Margo Thienemann 5, Bahare Farhadian 6, Theresa Willett 5, Elizabeth Mellins 7, Alicia Madden 5, Tanya Murphy 8, Susan Swedo 9, Marcelo Fernandez-Vina 3 and Jill Hollenbach 2, 1Stanford, 2University of California San Francisco, San Francisco, California, 3Stanford University, Palo Alto, California, 4Stanford University School of Medicine, Palo Alto, 5Stanford University School of Medicine, Palo Alto, California, 6Stanford Immune Behavioral Health Clinic and PANS Research Program at Lucile Packard Children's Hospital, Palo Alto, 7Stanford University, Stanford, 8University of South Florida, Tampa, Florida, 9National Institute of Mental Health, Bethesda, Maryland

    Background/Purpose: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by abrupt onset of obsessive-compulsive disorder (OCD) and/or food restriction with other specified neuropsychiatric symptoms. Patients with…

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