Abstracts tagged "pain"

Abstract Number: 375 • 2016 ACR/ARHP Annual Meeting
Persistent Tactile Allodynia in Male Arthritic Mice Is Accompanied By Sprouting of Sensory and Sympathetic Nerve Fibers
Sarah Woller¹, Arisai Martinez-Martinez², Juan Miguel Jimenez-Andrade², Tony Yaksh³ and Maripat Corr⁴, ¹Anesthesiology, UCSD, La Jolla, CA, ²Unidad Academica Multidisciplinaria Reynosa-Aztlan, Reynosa, Mexico, ³Anesthesiology 0818, UCSD, La Jolla, CA, ⁴Division of Rheumatology, Allergy, and Immunology, UCSD, La Jolla, CA
Background/Purpose: Joint pain is the primary reason individuals with arthritis seek medical care. Unfortunately, arthritic pain is difficult to treat and current treatments are fraught…
Abstract Number: 377 • 2016 ACR/ARHP Annual Meeting
Pain and Quality of Life Profiles in Colombian Patients with Rheumatoid Arthritis: A Mixed Cluster Analysis
Juan Manuel Cotte¹, Nicolás Molano-González², Deisy Hernández-Parra³, Yenifer Delgado-Scarpetta³, Adriana Rojas-Villarraga², Juan-Manuel Anaya¹ and Ricardo Pineda-Tamayo³, ¹Center for Autoimmune Diseases Research (CREA). School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia., Bogotá, Colombia, ²Center for Autoimmune Diseases Research (CREA). School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia., Bogotá D.C., Colombia, ³Artmédica IPS, Medellin, Colombia, Medellin, Colombia
ABSTRACT Background/Purpose: Among the symptoms of Rheumatoid Arthritis (RA), pain is often regarded as a critical factor related to quality of life (QoL) by patients,…
Abstract Number: 379 • 2016 ACR/ARHP Annual Meeting
Pain Catastrophizing Decreases in RA Patients Starting, Adding or Switching a DMARD
Ezra Cohen¹, Alyssa Wohlfahrt², Robert R. Edwards³, Clifton Bingham III⁴, Marcy Bolster⁵, Larry W. Moreland⁶, Tuhina Neogi⁷, Kristine Phillips⁸ and Yvonne C. Lee⁹, ¹Boston Children's Hospital, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ³Anesthesiology, Brigham & Womens Hospital, Chestnut Hill, MA, ⁴Divisions of Rheumatology and Allergy, Department of Medicine, Johns Hopkins University, Johns Hopkins University, Baltimore, MD, ⁵Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ⁶Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷Clinical Epidemiology, Boston University School of Medicine, Boston, MA, ⁸Rheumatology, University of Michigan, Ann Arbor, MI, ⁹Rheumatology Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: In individuals with RA, catastrophizing is associated with poor pain outcomes. It is not known whether catastrophizing can be altered by treating RA…
Abstract Number: 64 • 2015 ACR/ARHP Annual Meeting
Nociceptive Flexion Reflex Threshold: Possible Surrogate Marker of Symptom Severity in Fibromyalgia
Dennis Ang¹, Christopher France² and James Slaven³, ¹Section on Rheumatology and Immunology, Wake Forest University, Winston Salem, NC, ²Psychology, Ohio University, Athens, OH, ³Biostatistics, Indiana University, Indianapolis, IN
Background/Purpose: Central sensitization has been demonstrated in patients with fibromyalgia (FM) using an objective assessment of spinal nociception called the nociceptive flexion reflex (NFR). This…
Abstract Number: 2307 • 2015 ACR/ARHP Annual Meeting
Relationship of Sleep Quality and Fibromyalgia Outcomes in a Phase 2b Randomized, Double-Blind, Placebo-Controlled Study of Bedtime, Rapidly Absorbed, Sublingual Cyclobenzaprine (TNX-102 SL)
Harvey Moldofsky¹, R Michael Gendreau², Daniel J. Clauw³, Judith Gendreau⁴, Benjamin Vaughn⁵, Bruce Daugherty⁴, Amy Forst⁶, Gregory Sullivan⁷ and Seth Lederman⁸, ¹Ctr for Sleep & Chronobiology, Centre for Sleep/Chronobiology, Toronto, ON, Canada, ²Gendreau Consulting LLC, Poway, CA, ³Anesthesiology, University of Michigan, Ann Arbor, MI, ⁴Tonix Pharmaceuticals, New York, NY, ⁵Statistics, Rho, Chapel Hill, NC, ⁶Clinical Development, Tonix Pharmaceuticals, San Jose, CA, ⁷Clinical Development, Tonix Pharmaceuticals, NEW YORK, NY, ⁸Research and Development, Tonix Pharmaceuticals, Inc., New York, NY
Background/Purpose: The importance of nonrestorative sleep in the pathophysiology of fibromyalgia (FM) suggests that treatments that improve sleep quality would address global symptoms. TNX-102 SL1a…
Abstract Number: 70 • 2015 ACR/ARHP Annual Meeting
Data from Brazilian Fibromyalgia Patients Registry (EPIFIBRO) in 2014
Jose Eduardo Martinez^1,2, Marcelo C. Rezende^3,4, Eduardo Paiva^4,5, Daniel Pollak^4,6, Milton Helfenstein Jr^4,7, Jose Roberto Provenza^4,8, Aline Ranzolin^4,9, Roberto E Heymann^4,10, Eduardo L. Ribeiro^4,11, Marcos Renato Assis^4,12 and Eduardo J. R. Souza^4,13, ¹Sociedade Brasileira de Reumatologia, Sorocaba, Brazil, ²Medicine, Pontifical Catholic University of Sao Paulo, Sorocaba, Brazil, ³Santa Casa de Campo Grande, Campo Grande, Brazil, ⁴Sociedade Brasileira de Reumatologia, São Paulo, Brazil, ⁵Rheumatology, Universidade Federal do Parana, Curitiba, Brazil, ⁶Rheumathology, Universidade Federal de São Paulo, São Paulo, Brazil, ⁷RUA JOAO DE LACERDA SOARES, 90, Unifesp, Sao Paulo, Brazil, ⁸Rheumatology, Pontifícia Universidade Católica de Campinas, Campinas, Brazil, ⁹Hospital das Clínicas - Universidade Federal de Pernambuco, Recife, Brazil, ¹⁰Universidade Federal de São Paulo, São Paulo, Brazil, ¹¹Instituto de Previdência dos Servidores do Estado de Minas Gerais, Belo Horizonte, Brazil, ¹²Faculdade de Medicina de Marilia, Marilia, Brazil, ¹³Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
Background/Purpose: –The Brazilian registry on fibromyalgia syndrome (EPIFIBRO) included 810 patients who satisfied the American College of Rheumatology Classification Criteria for Fibromyalgia (ACR1990) at the…
Abstract Number: 2308 • 2015 ACR/ARHP Annual Meeting
Responder Compared to Mean Change Analyses in a Fibromyalgia Phase 2b Clinical Study of Bedtime Rapidly Absorbed Sublingual Cyclobenzaprine (TNX-102 SL)
R Michael Gendreau¹, Daniel J. Clauw², Judith Gendreau³, Bruce Daugherty³ and Seth Lederman⁴, ¹Gendreau Consulting LLC, Poway, CA, ²Anesthesiology, University of Michigan, Ann Arbor, MI, ³Tonix Pharmaceuticals, New York, NY, ⁴Research and Development, Tonix Pharmaceuticals, Inc., New York, NY
Background/Purpose: Fibromyalgia (FM) is characterized by symptoms that include widespread pain and sleep disruption. Clinical studies that rely on patient self-reported outcome measures such as pain…
Abstract Number: 388 • 2015 ACR/ARHP Annual Meeting
Pain, Fatigue and the Psychological Impact on Health-Related Quality of Life in Childhood-Onset Lupus
Jordan T. Jones¹, Natoshia Cunningham², Catherine Donnelly³, Susmita Kashikar-Zuck⁴ and Hermine I. Brunner⁵, ¹Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Behavioral Medicine & Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Internal Medicine, University of Cincinnati, Cincinnati, OH, ⁴Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Pediatric Rheumatology Collaborative Study Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Childhood-onset lupus (cSLE) is a chronic autoimmune disease that has negative impact on health-related quality of life (HRQoL), especially when increased disease activity and…
Abstract Number: 2309 • 2015 ACR/ARHP Annual Meeting
Bedtime, Rapidly Absorbed Sublingual Cyclobenzaprine (TNX-102 SL) for the Treatment of Fibromyalgia: Results of a Phase 2b Randomized, Double-Blind, Placebo-Controlled Study
Seth Lederman¹, R Michael Gendreau², Daniel J. Clauw³, Lesley M. Arnold⁴, Judith Gendreau⁵, Bruce Daugherty⁵ and Amy Forst⁶, ¹Research and Development, Tonix Pharmaceuticals, Inc., New York, NY, ²Gendreau Consulting LLC, Poway, CA, ³Anesthesiology, University of Michigan, Ann Arbor, MI, ⁴Psychiatry, University of Cincinnati, Cincinnati, OH, ⁵Tonix Pharmaceuticals, New York, NY, ⁶Clinical Development, Tonix Pharmaceuticals, San Jose, CA
Background/Purpose: Fibromyalgia (FM) is characterized by chronic widespread pain and sleep disturbance. Treatments that improve sleep quality in FM patients may improve fibromyalgia by a…
Abstract Number: 417 • 2015 ACR/ARHP Annual Meeting
Gender Differences in Pediatric Localized Scleroderma: Clinical and Patient-Reported Outcomes
Kaveh Ardalan¹, Nicole Hershey¹, Jonathan Yabes², Eveline Wu³, Suzanne C. Li⁴, Robert C. Fuhlbrigge⁵, C. Egla Rabinovich⁶, Kathryn S. Torok¹ and The CARRA Registry Investigators, ¹Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²Department of Medicine, University of Pittsburgh, Pittsburgh, PA, ³Pediatrics, University of North Carolina - Chapel Hill, Chapel Hill, NC, ⁴Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack University Medical Center, Hackensack, NJ, ⁵Program in Rheumatology, Division of Immunology, Boston Children’s Hospital, Boston, MA, ⁶Pediatric Rheumatology, Duke University Medical Center, Durham, NC
Background/Purpose: Localized scleroderma (LS) is an autoimmune disease of the skin and underlying tissue that leads to progressive fibrosis and disability in growing children. Pediatric…
Abstract Number: 2444 • 2015 ACR/ARHP Annual Meeting
Accelerometer-Assessed Daily Physical Activity in Relation to Pain Cognitions and Quality of Life in Juvenile Idiopathic Arthritis
Mette Noergaard¹, Johanne Lomholt², Mikael Thastum², Morten Herlin³, Marinka Twilt⁴ and Troels Herlin⁴, ¹Department of Physiotherapy, Aarhus University Hospital, Aarhus, Denmark, ²Psychology and Social Sciences, Aarhus University, Aarhus, Denmark, ³Pediatrics, Aarhus University Hospital, Aarhus, Denmark, ⁴Pediatric Rheumatology Clinic, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) has been associated with decreased physical activity (PA). However, accurate, objective measurements of PA related to potential factors limiting PA…
Abstract Number: 1002 • 2015 ACR/ARHP Annual Meeting
Aiming for Remission in Early RA: Impact on Pain during the First Year of Treatment
Ellen Moholt¹, Anna-Birgitte Aga¹, Inge C Olsen¹, Hilde Berner Hammer², Till Uhlig³, Anne Katrine Kongtorp⁴, Heidi Lunoe⁴, Elin Mejdell Styrmoe⁴, Tore K. Kvien¹, Espen A. Haavardsholm¹ and the ARCTIC study group, ¹Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Diakonhjemmet Hospital, Oslo, Norway, ⁴Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Pain is the symptom people with rheumatoid arthritis (RA) have prioritized highest for improvement [1]. Treating to target and aiming for remission in early…
Abstract Number: 2613 • 2015 ACR/ARHP Annual Meeting
Patient Reported Physical Capacity Correlates with Phenylalanine Serum Levels in Patients with Early Untreated Rheumatoid Arthritis
Aulikki Kononoff¹, Leena Arstila^1,2, Hannu Kautiainen^3,4, Pia Elfving¹, Elina Savolainen⁵, Helena Niinisalo^6,7 and Oili Kaipiainen-Seppanen¹, ¹Department of Medicine, Kuopio University Hospital, Kuopio, Finland, ²Iisalmi Hospital, Iisalmi, Finland, ³Unit of Primary Health Care, Kuopio University Hospital, Kuopio, Finland, ⁴Unit of Primary Health Care, Helsinki University Central Hospital, Helsinki, Finland, ⁵Kuopio Municipal Hospital, Kuopio, Finland, ⁶Suonenjoki Health Center, Suonenjoki, Finland, ⁷Varkaus Hospital, Varkaus, Finland
Background/Purpose: Lipolysis is increased in rheumatoid arthritis (RA), and lipid-induced insulin resistance coincides with anabolic resistance. Ability to maintain skeletal muscle mass is impaired in…
Abstract Number: 1015 • 2015 ACR/ARHP Annual Meeting
Contribution of TNF and Type I Interferon to the Development of Persistent Post-Inflammatory Mechanical Allodynia in Arthritic Mice
Sarah Woller¹, Cody Ocheltree², Tony Yaksh¹ and Maripat Corr², ¹Anesthesiology, UCSD, La Jolla, CA, ²Division of Rheumatology, Allergy, and Immunology, UCSD, La Jolla, CA
Background/Purpose: Male C57Bl/6 (WT) mice develop transient inflammation in response to K/BxN serum transfer and show a corresponding pain state, which persists beyond the resolution…
Abstract Number: 2637 • 2015 ACR/ARHP Annual Meeting
Prevalence of Unacceptable Pain and the Risk of Fatigue and Sleeping Problems in Early Rheumatoid Arthritis Patients
Joakim Lindqvist¹, Maria Sandberg^2,3, Saedis Saevarsdottir⁴, Reem Altawil⁴, Lars Klareskog⁵, Lars Alfredsson⁶ and Jon Lampa⁷, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden, ²Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Karolinska Institutet, Stockholm, Sweden, ³The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁵Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden, ⁶Unit of Cardiovascular Epidemiology, Institute of Enviornmental Medicine, Karolinska Institutet, Karolinska Institutet, Stockholm, Sweden, ⁷Dep of Medicine, Rheumatology unit, Karolinska Institute, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Pain is a commonly reported cause of affliction in RA-patients, also after adequate anti-rheumatic treatment. The objective of this study was to investigate the…

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